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63 results about "Monosodium dihydrogen phosphate" patented technology

Non-spherical polymer particles uniform in particle size as well as preparation method and application of non-spherical polymer particles

The invention provides non-spherical polymer particles uniform in particle size as well as a preparation method and an application of the non-spherical polymer particles. The non-spherical polymer particles are in the form of ellipsoids, short rods or fibers, and the interiors of the non-spherical polymer particles are of solid, hollow or porous structures; the short diameter of the non-spherical polymer particles ranges from 100nm to 30[micron]m, the long diameter of the non-spherical polymer particles is 1-60[micron]m, the ratio of the long diameter to the short diameter is 2-40, and the particle size distribution coefficient of the particles is less than 20%. The non-spherical polymer particles disclosed by the invention, which are uniform and controllable in particle size, are prepared by taking disodium hydrogen phosphate and / or sodium dihydrogen phosphate as a deformation inducing agent and by taking the influence of such conditions as the concentration of the disodium hydrogen phosphate and / or sodium dihydrogen phosphate, self-properties of a polymer, mass concentration of the polymer in an oil phase, the size of emulsion drops and the like into comprehensive consideration; the non-spherical polymer particles can be applied to various fields such as biological drug delivery, vaccine adjuvants, enzymatic catalysis, bio-separation, human tissue engineering field and the like; and the preparation method is simple to operate, mild in condition and easy for industrial enlarged production.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI

Colloidal gold method detecting reagent for extrauterine pregnancy and number of pregnancy days, and preparation thereof

InactiveCN101294966AResolve detectionSolve time-consuming and costly problemsBiological testingCelluloseObstetrics
The invention discloses an ectopic pregnancy and pregnant days colloid gold detection agent and manufacturing method thereof used for the problem of fast detection for pregnancy, comprising a piece of detecting test paper and urine sample treatment solution; wherein, the detecting test paper consists of a base plate, a cellulose nitrate membrane, a gold label anti-Beta HCG monoclone antibody layer, an Alpha-HCG monoclone antibody line, a sheep anti-rat polyclonal antibody line, an absorbing pad and a sample pad; the matching composition of the urine sample treatment solution is that: 12.5 to 18.0 portions of disodium hydrogen phosphate dodecahydrate, 1.2 to 1.7 portions of sodium dihydrogen phosphate dihydrate, 40.0 to 48.0 portions of sodium chloride and 4600 to 5300 portions of distilled water; the ectopic pregnancy and pregnant days colloid gold detection agent and manufacturing method of the invention are characterized by fast and simple detection, the operation of blood-drawing detection for 2 to 6 hours can be replaced by 2 to 3 minutes with time-saving, manual-saving and cost-saving; besides, the ectopic pregnancy and pregnant days colloid gold detection agent and manufacturing method thereof have the advantages of detecting ectopic pregnancy and pregnant days in a semiquantitative way, etc., and can be used for external detection of the pregnant condition and artificial abortion and assisted diagnosis.
Owner:崔学礼

Lysostaphic complex enzyme oral cavity disinfectant and preparation method thereof

The invention discloses a lysostaphic complex enzyme oral cavity disinfectant and a preparation method thereof. The lysostaphic complex enzyme oral cavity disinfectant comprises the following components in parts by mass: 20-40 parts of lysostaphin, 21-41 parts of antibacterial peptide, 21-41 parts of chlorhexidine acetate, 31-42 parts of sorbitol, 21-31 parts of sodium dihydrogen phosphate and 21-30 parts of disodium hydrogen phosphate. The oral cavity disinfectant can be used for treating oral cavity diseases, has the advantages of remarkable curative effect and no alcohol and drug resistance. The invention further discloses a preparation method of the oral cavity disinfectant. The preparation method comprises the following steps: 1) dissolving the lysostaphin, the ntibacterial peptide and the hlorhexidine acetate into distilled water, stirring to completely dissolve the lysostaphin, the ntibacterial peptide and the hlorhexidine acetate; 2) dissolving sorbitol into distilled water, and stirring to completely dissolve the sorbitol; 3) dissolving the sodium dihydrogen phosphate and the disodium hydrogen phosphate into distilled water, and stirring to completely dissolve the sodium dihydrogen phosphate and the disodium hydrogen phosphate; and 4) uniformly mixing solutions obtained in the steps 1), 2) and 3), and then filling the mixed solution. The preparation method has the advantages of simple process and strong operability.
Owner:杨陈

Papaverine hydrochloride pharmaceutical composition for injection and preparation method

The invention relates to a papaverine hydrochloride pharmaceutical composition for injection and a preparation method. Specifically, the pharmaceutical composition provided by the invention comprisespapaverine hydrochloride and pharmaceutic adjuvants, wherein the pharmaceutic adjuvant comprises mannitol and edetate, and the weight ratio of the papaverine to the mannitol to the edetate is 30: (15-500): (2-10); the pharmaceutical composition further comprises an acid-base regulator, and the dosage of the acid-base regulator is that when the freeze-dried powder injection is dissolved into a solution containing papaverine hydrochloride with the concentration of 15mg/ml by using water for injection, the pH value of the solution is within the range of 2.5-4.0, the acid-base regulator is selected from sodium hydroxide, potassium hydroxide, sodium dihydrogen phosphate, disodium hydrogen phosphate, monopotassium phosphate, dipotassium phosphate, hydrochloric acid, phosphoric acid, nitric acid,sulfuric acid or a combination thereof, especially a 1M hydrochloric acid solution or a 1M sodium hydroxide solution. The invention also provides a preparation method of the papaverine hydrochloridepharmaceutical composition for injection. The papaverine hydrochloride pharmaceutical composition for injection is prepared by a method for freeze-drying powder injection. The papaverine hydrochloridepharmaceutical composition disclosed by the invention has excellent technical effects as described in the specification.
Owner:山东北大高科华泰制药有限公司

Method for measuring contents of cationic surface active substances by bromothymol blue spectrometry

The invention provides a method for measuring contents of cationic surface active substances in solid alkali metal salts, alkaline-earth metal salts or alkaline-earth metal hydroxides by a bromothymol blue spectrometry, which comprises the following steps: using nitric acid to dissolve a sample to be measured to prepare solution of alkali metal or alkaline-earth metal with ion concentration of 0.1 to 0.5 mol/L; adding bromothymol blue solution into the prepared solution, adjusting the pH of the solution to between 7.6 and 7.8 by using monosodium orthophosphate and disodium hydrogen phosphate buffer solution, allowing the solution to stand for 20 to 26 hours, and measuring the absorbency of the sample solution; after the absorbency A of the sample solution is deducted from blank absorbency Ao, forming a linear relation with the content of a complex compound formed by the reaction of the cationic surface active substances and the bromothymol blue in the sample solution; and obtaining the contents of the cationic surface active substances in the sample solution to be measured through a standard curve, and then obtaining the contents of the cationic surface active substances in the solid alkali metal and the alkaline-earth metal salts through conversion. The analysis process is simple and quick, the analysis result accuracy is high, and the repeatability is good.
Owner:QINGHAI INST OF SALT LAKES OF CHINESE ACAD OF SCI

Method for synthesizing phytosterol ester in reverse micelle enzyme system

The invention discloses a method for synthesizing phytosterol ester in a reverse micelle enzyme system based on lipase interface activation characteristics. The specific synthesis method comprises thefollowing steps: constructing a reverse micelle enzyme system, wherein a non-immobilized water-soluble lipase buffer aqueous solution (50 mmol/mL sodium dihydrogen phosphate-disodium hydrogen phosphate, pH 6.5-8) into an isooctane solution of 2-ethylhexyl succinate sodium sulfonate (AOT), a clarified reverse micelle enzyme system is obtained through energy-gathered ultrasound, and a ratio of [enzyme] (mg/mL) to [water] (mmol/mL) to [AOT] (mmol/mL) is (3-8):(200-600):(20-30); adding 50-100 mmol/mL phytosterol and C12-C18 fatty acid accounting for 2-4 times the molar mass of the phytosterol into the reverse micelle enzyme system, and carrying out a reaction for 3-6 hours at a temperature of 35-55 DEGC under an enzyme loading capacity accounting for 1.5-3% of the total substrate, wherein theprocess is assisted by divergent ultrasonic action, and the yield of the esterification product measured by an HPLC method is 85.79-92.82%; and purifying the product by a solvent crystallization method, wherein the purity is 98.56-99.43% measured by the HPLC method. The method has the advantage of high efficiency and high yield production of phytosterol ester.
Owner:NANCHANG UNIV

Coenzyme A medicament freeze-drying preparation and process for preparing same

The invention discloses a coenzyme A medicament freeze-drying preparation, which adopts disodium hydrogen phosphate and sodium dishydrogen phosphate buffered salt liquor to protect a coenzyme A in the process of preparing the freeze-drying preparation. The freeze-drying preparation selects phosphate buffered salt liquor in the process of preparing medical liquor to enable the coenzyme A to be in the liquor with relatively constant pH values. Simultaneously, the phosphate buffered salt liquor is favorable for stabilizing a coenzyme A molecular structure containing phosphate groups, a coenzyme A potency (marked content) is lowered by no more than 2.5% from the process of preparing and filling to the beginning of freeze-drying.
Owner:MAANSHAN BBCA PHARMA

Serum-free culture medium suitable for large-scale suspension multiplication culture of CHO cells and preparation and application of serum-free culture medium

The invention discloses a serum-free culture medium, a preparation method thereof and an application of the serum-free culture medium to large-scale suspension multiplication culture of CHO cells. The pH value of the serum-free culture medium is 6.9-7.0, and the serum-free culture medium comprises an amino acid composition, an inorganic salt composition, a vitamin composition, a trace element composition, a buffer system composition, a supplementary factor composition and water. On the basis of the serum-free culture medium, the amino acid composition comprises 1-2 mg/L of glutamine dipeptide GlutaMAX-I, the buffer system composition comprises 3-8 g/L of HEPES, 1-5 g/L of sodium bicarbonate, 100-300 mg/L of sodium dihydrogen phosphate, 100-300 mg/L of disodium hydrogen phosphate, 3-10 g/L of sodium chloride and 200-500 mg/L of potassium chloride, and the supplementary factor composition comprises 10-30 g/L of a soybean extract, 10-30 g/L of a yeast extract and 80-100 [mu]g/L of Long-R3-IGF-I. The preparation method comprises the following steps: weighing and mixing the components according to the formula, adjusting the pH value to 6.9-7.0, and performing filtering by using a filter membrane with the pore diameter of 0.22 [mu]m.
Owner:TONGDE HOSPITAL OF ZHEJIANG PROVINCE

Composite solution with combined application of recombinant III-type humanized collagen and hyaluronic acid and preparation process of composite solution

The invention discloses a composite solution with combined application of recombinant III-type humanized collagen and hyaluronic acid and a preparation process of the composite solution, and relates to the technical field of medical cosmetology. A physiological buffer solution is used as a solvent, and comprises the following components by concentration: 0.1-10g / L of recombinant III-type humanized collagen; 1 to 20 g / L of sodium hyaluronate; 1-5 g / L of glutathione; the concentration of tranexamic acid is 0.05 to 0.3 g / L; 8-10g / L of sodium chloride; sodium dihydrogen phosphate is 0.05 to 0.1 g / L; and 0.15 to 0.25 g / L of disodium hydrogen phosphate. According to the composite solution combining the recombinant III-type humanized collagen and the hyaluronic acid, the sodium hyaluronate is used as a filling support, the water absorption and moisturizing performance is excellent, the moisturizing and anti-wrinkle effects are achieved immediately after injection, and the preparation method is simple and easy to operate. Then the occupation effect of the recombinant III-type humanized collagen, glutathione and other substances stimulates the body to synthesize collagen, and tranexamic acid has the effects of resisting allergic reaction and diminishing inflammation, so that the problems of moisturizing and wrinkle resistance of the skin are fundamentally solved.
Owner:湖南精准医疗器械科技有限公司

Oral care composition

An oral care composition is disclosed comprising from 0.01 to 50% by weight of a calcium source, a water soluble phosphate source, a water soluble silicate source and from 0.01 5 to 10% by weight of an amino acid or its physiologically acceptable salt or a mixture thereof, wherein the calcium source is calcium hydroxide, calcium oxide, calcium glycerophosphate, calcium lactate, calcium sulfate, calcium salts of citric acid, calcium chloride, calcium nitrate, calcium acetate, calcium gluconate, calcium formate, calcium malate, calcium propionate, calcium butyrate, calcium bicarbonate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, tricalcium phosphate, octacalcium phosphate, calcium silicate, calcium carboxymethyl cellulose, calcium alginate, calcium carbonate or mixtures thereof; wherein the phosphate source is trisodium phosphate, monosodium dihydrogen phosphate, disodium hydrogen phosphate, ammonium phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, tripotassium phosphate, monopotassium dihydrogen phosphate, dipotassium hydrogen phosphate or a mixture thereof; wherein the silicate source is sodium silicate, potassium silicate, tetraethylorthosilicate, tetraethylsilicate or mixtures thereof; and wherein the amino acid is selected from acidic amino acid, neutral amino acid or a mixture thereof.
Owner:UNILEVER IP HLDG BV
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