The invention discloses a cleaning and disinfection treatment device for medical instruments, which comprises a box body, a heater, a water inlet pipe, a liquid level gauge, a medicament adding pipe, an ethylene oxide filling tank, a net basket, a cooling box, a flow guide pipe, and a drain tube, impeller, rotating shaft and camera, the bottom of the box is provided with a guide wheel, a heater is provided in the box, the water inlet pipe is connected to the upper part of the box, the top of the box is provided with a medicament adding pipe, and a rotating shaft is provided in the box , there is a camera on the inner wall of the top of the box, the top of the box is connected with the air pipe, the other end of the air pipe is connected with the cooling box, the gas pump is installed on the air pipe, and the bottom of the box is provided with a drain pipe, which is connected to the box There is a filter. The invention guarantees working efficiency, ensures sufficient disinfection of medical instruments, avoids breeding and spreading of harmful bacteria, ensures environmental safety, has simple structure, is convenient to use, and is beneficial to popularization.