Povidone-iodine solution with enhanced stability and preparation method thereof

A technology of povidone-iodine and solution, applied in the field of medicine, can solve the problems of not examining the influence of preparation stability, and the effect of stability is not obvious, and achieve the effect of maintaining bactericidal efficacy and ensuring stability

Active Publication Date: 2021-02-05
乐泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method proposes that adding sodium hydroxide can keep the available iodine content in the preparation relatively stable, but this method does not investigate the impact of different pH values ​​on the stability of the preparation, and this method only adds sodium hydroxide as a pH regulator, which is important for maintaining its stability. The effect of stability is not obvious

Method used

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  • Povidone-iodine solution with enhanced stability and preparation method thereof
  • Povidone-iodine solution with enhanced stability and preparation method thereof
  • Povidone-iodine solution with enhanced stability and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the preparation of the povidone-iodine solution that stability strengthens

[0025] The povidone iodine solution with enhanced stability in this example is made from the following raw materials: povidone iodine 10g, sodium dihydrogen phosphate 4g, disodium hydrogen phosphate dodecahydrate 0.9g, potassium iodate 0.5g, dodeca Add 5 g of sodium alkyl sulfate, adjust the pH to 5.3 with sodium hydroxide, and add purified water to 1000 mL.

[0026] Its preparation method is carried out according to the following steps:

[0027] (1) Take each raw material according to the following weights:

[0028] Povidone iodine 10g, sodium dihydrogen phosphate 4g, disodium hydrogen phosphate dodecahydrate 0.9g, potassium iodate 0.5g, sodium lauryl sulfate 5g;

[0029] (2) Preparation of solution 1: Add the weighed sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, and potassium iodate into purified water to dissolve it, and it is solution 1;

[0030] (...

Embodiment 2

[0033] Embodiment 2: the preparation of the povidone-iodine solution that stability strengthens

[0034] The povidone iodine solution with enhanced stability in this example is made from the following raw materials: 5 g of povidone iodine, 2 g of sodium dihydrogen phosphate, 1.5 g of disodium hydrogen phosphate dodecahydrate, 0.3 g of potassium iodate, Add 2.5 g of sodium alkyl sulfate, adjust the pH to 5.2 with sodium hydroxide, and add purified water to 1000 mL.

[0035] Its preparation method is carried out according to the following steps:

[0036] (1) Take each raw material according to the following weights:

[0037] Povidone iodine 5g, sodium dihydrogen phosphate 2g, disodium hydrogen phosphate dodecahydrate 1.5g, potassium iodate 0.3g, sodium lauryl sulfate 2.5g;

[0038] (2) Preparation of solution 1: Add the weighed sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, and potassium iodate into purified water to dissolve it, and it is solution 1; ...

Embodiment 3

[0042] Embodiment 3: the preparation of the povidone-iodine solution of stability enhancement

[0043] The povidone-iodine solution with enhanced stability in this example is made from the following raw materials: povidone-iodine 15g, sodium dihydrogen phosphate 6g, disodium hydrogen phosphate dodecahydrate 2.0g, potassium iodate 1.0g, dodeca Alkyl sodium sulfate 8.5g, sodium hydroxide to adjust pH5.25, purified water was added to 1000mL.

[0044] Its preparation method is carried out according to the following steps:

[0045] (1) Take each raw material according to the following weights:

[0046] Povidone iodine 15g, sodium dihydrogen phosphate 6g, disodium hydrogen phosphate dodecahydrate 2.0g, potassium iodate 1.0g, sodium lauryl sulfate 8.5g;

[0047] (2) Preparation of solution 1: Add the weighed sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, and potassium iodate into purified water to dissolve it, and it is solution 1;

[0048](3) Preparation ...

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Abstract

The invention discloses a povidone-iodine solution with enhanced stability and a preparation method thereof. The povidone-iodine solution consists of povidone iodine, sodium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, potassium iodate, lauryl sodium sulfate and purified water, and the concentrations of the raw materials are as follows: 5-20 g/L of povidone iodine, 1-10 g/L ofsodium dihydrogen phosphate, 0.5-2 g/L of disodium hydrogen phosphate dodecahydrate, 0.2-1.0 g/L of potassium iodate, and 1-10 g/L of lauryl sodium sulfate, and the pH of a sodium hydroxide solution is adjusted to 5.20-5.30. The sodium dihydrogen phosphate and the disodium hydrogen phosphate dodecahydrate are used as a pH value adjusting buffer pair, so that the acid-base balance of the solution can be maintained, and a buffer effect can be achieved. The potassium iodate and the lauryl sodium sulfate are used as pH stabilizers, the sodium hydroxide is used as a pH regulator, and the pH value of the povidone-iodine solution can be controlled within a specified range, so that the stability of the effective iodine content is ensured, and the bactericidal efficacy of the povidone-iodine solution is maintained.

Description

technical field [0001] The invention relates to a stability-enhanced povidone-iodine solution and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Povidone-iodine (PVP-I) is a yellow-brown to reddish-brown amorphous powder, which is formed by polyvinylpyrrolidone (Povidone, PVP) and iodine in the form of complexation with the help of hydrogen bonds and other external forces. Amorphous complex iodine. PVP forms a micro-cavity carrier, and complexes iodide ions in the cavity of the microcapsule to form PVP-I. In the aqueous solution state, due to the affinity of PVP to the cell membrane, iodine can be directly introduced to the surface of the bacterial membrane, and iodine molecules are slowly released to destroy the cell membrane and protein, thereby playing the role of disinfection and sterilization. Povidone-iodine has the characteristics of film formation, adhesion, detoxification, slow release, strong water solubi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K31/79A61K47/02A61K47/20A61P17/00A61P31/04A61P17/02A61P31/10
CPCA61K33/18A61K31/79A61K47/02A61K47/20A61P17/00A61P31/04A61P17/02A61P31/10Y02A50/30
Inventor 郎伟君
Owner 乐泰药业有限公司
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