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Lysostaphic complex enzyme oral cavity disinfectant and preparation method thereof

The technology of lysostaphin and oral disinfectant is applied in the field of lysostaphin multienzyme oral disinfectant and its preparation, which can solve the problems of drug resistance of patients, irritation of oral mucosa and intestinal system, etc., and achieve good disinfection effect , No toxic side effects, fast killing effect

Inactive Publication Date: 2015-04-22
杨陈
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the disinfectants for the treatment of oral diseases all contain components such as ethanol, wetting agent, and metronidazole. Although such disinfectants have antibacterial effects on some pathogenic bacteria in the oral cavity, the chemicals in the components are easily Make patients develop drug resistance, and at the same time have a greater stimulating effect on the oral mucosa and intestinal system

Method used

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specific Embodiment

[0030] A lysostaphin compound enzyme bactericidal spray, comprising the following components in mass fractions: 20-40 parts of lysostaphin enzyme, 21-41 parts of antibacterial peptide, 21-41 parts of chlorhexidine acetate, 31-42 parts of sorbitol , 21~31 parts of sodium dihydrogen phosphate and 21~30 parts of disodium hydrogen phosphate. Concrete composition ratio is as shown in table 1, wherein the lysostaphin composite enzyme oral disinfectant prepared by embodiment 1~4 is respectively marked as: 1#, 2#, 3# and 4#; The oral disinfectant prepared by comparative example is respectively Recorded as: 5#, 6# and 7#.

[0031] The preparation method of above-mentioned lysostaphin composite enzyme oral disinfectant comprises the following preparation steps:

[0032] 1) Dissolve lysostaphin, antimicrobial peptide and chlorhexidine acetate in distilled water, stir to dissolve completely;

[0033] 2) Dissolve sorbitol in distilled water, stir to dissolve completely;

[0034] 3) Sodi...

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Abstract

The invention discloses a lysostaphic complex enzyme oral cavity disinfectant and a preparation method thereof. The lysostaphic complex enzyme oral cavity disinfectant comprises the following components in parts by mass: 20-40 parts of lysostaphin, 21-41 parts of antibacterial peptide, 21-41 parts of chlorhexidine acetate, 31-42 parts of sorbitol, 21-31 parts of sodium dihydrogen phosphate and 21-30 parts of disodium hydrogen phosphate. The oral cavity disinfectant can be used for treating oral cavity diseases, has the advantages of remarkable curative effect and no alcohol and drug resistance. The invention further discloses a preparation method of the oral cavity disinfectant. The preparation method comprises the following steps: 1) dissolving the lysostaphin, the ntibacterial peptide and the hlorhexidine acetate into distilled water, stirring to completely dissolve the lysostaphin, the ntibacterial peptide and the hlorhexidine acetate; 2) dissolving sorbitol into distilled water, and stirring to completely dissolve the sorbitol; 3) dissolving the sodium dihydrogen phosphate and the disodium hydrogen phosphate into distilled water, and stirring to completely dissolve the sodium dihydrogen phosphate and the disodium hydrogen phosphate; and 4) uniformly mixing solutions obtained in the steps 1), 2) and 3), and then filling the mixed solution. The preparation method has the advantages of simple process and strong operability.

Description

technical field [0001] The invention belongs to the field of disinfectants, and in particular relates to a lysostaphin compound enzyme oral disinfectant and a preparation method thereof. Background technique [0002] With the development of industry, problems such as environmental pollution and unqualified air quality have become the main threats to people's health. As an important part of the human respiratory system and digestive system, the oral cavity is unavoidable in contact with the environment, and the incidence of oral diseases has also greatly increased. [0003] There are a large number of pathogenic bacteria in the oral cavity, among which the main proportion of pathogenic bacteria are anaerobic bacteria, hemolytic streptococcus, staphylococcus, Candida albicans, etc. These pathogenic bacteria are the root of oral diseases, they affect the human body The normal absorption of nutrients can also cause oral diseases such as bad breath, oral ulcers, gingivitis, peri...

Claims

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Application Information

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IPC IPC(8): A61K38/51A61K47/26A61K47/02A61P1/02A61P31/02A61P31/04A61K31/155A61K38/00
Inventor 杨陈
Owner 杨陈
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