The invention relates to a composite lysozyme oral spray. The oral spray is characterized by comprising the following components in percentage by weight: 3-7 percent of lysostaphin, 20-25 percent of lysozyme, 0.02-0.4 percent of tea polyphenol, 1.5-5 percent of olive oil, 1-10 percent of vitamin C, 1-3 percent of sorbitol, 0.8-2 percent of lecithin, 0.01-0.07 percent of xanthan gum, and the balance of purified water. The oral spray is remarkable in effects and convenient to use, and does not contain alcohol; all components are extracted from natural products, and enable fresh breath and no toxic or side effect in the action of compatibility of composite lysozyme, tea polyphenol and vitamin C. The composite lysozyme oral spray has good preventing and treating effects on dental ulcer, decayed teeth, aphtha, halitosis, glossitis, sphagitis and other oral diseases; the preparation method is concise and effective and low in cost, and the prepared composite lysozyme oral spray is good in stability.