68results about How to "Maintain antimicrobial activity" patented technology

The invention provides a nano-silver antibacterial fabric and a preparation method thereof. The nano-silver antibacterial fabric has the characteristics that a zinc oxide nano line grows on the fabric; and silver nano particles are deposited on the zinc oxide nano line. The zinc oxide nano line is synthesized by a solution chemical method; and the silver nano particles are deposited on the zinc oxide nano line by a simple 'immersion-illumination' method. The nano-silver antibacterial fabric prepared by the method has extremely obvious long-time antibacterial performance; the silver nano particles are small in size and cannot be accumulated; a synthesis process is environment-friendly; and the nano-silver antibacterial fabric can be recycled and reused. The nano-silver antibacterial fabric can be used for single-point water treatment to reduce microorganism content in water and can be suitable for medical surgical dressing and medical fabrics; and the nano-silver antibacterial fabric can be used as an antibacterial air filtration device for preventing bio-aerosol from being gathered on a ventilating, heating and air conditioning system.

The present invention provides durable and regenerable antimicrobial fibers and methods for preparing the same. These fibers have excellent colorfastness and washfastness, and are environmentally friendly. The antimicrobial fibers of this invention are suitable for a variety of purposes, including medical uses, sportswear, and uniforms.

The present invention relates to the conjugation of antimicrobial agents to water-soluble polymers to improve their clinical properties in terms of their pharmacokinetics, pharmacodynamics, and reduced immunogenicity. More specifically, the present invention relates to the conjugation of antimicrobial agents such as lysostaphin to poly(alkylene oxides), such as poly(ethylene glycol) (PEG).

The invention relates to an antibacterial combination and a preparation method thereof as well as application of the antibacterial combination in preparation of antibacterial paper. The antibacterial combination contains atractylodes oil and an inorganic silver antibacterial agent. The antibacterial combination disclosed by the invention is sprayed on the surface of a piece of proper paper to prepare the antibacterial paper; the antibacterial paper can be used as food packaging paper, tobacco tipping paper and the like.

The invention discloses an antibacterial ceramic tile. The antibacterial ceramic tile comprises an antibacterial glaze layer arranged on the upper surface of a ceramic tile; the antibacterial glaze layer is composed of a basic transparent glaze and a zirconium phosphate loaded composite antibacterial agent; the zirconium phosphate loaded composite antibacterial agent comprises a zirconium phosphate carrier and a composite antibacterial agent; the zirconium phosphate loaded composite antibacterial agent is accumulated at the upper part of the antibacterial glaze layer, and antibacterial effective components of the composite antibacterial agent are antibacterial oxides and antibacterial ions. According to a preparation method, zirconium phosphate is introduced into the antibacterial glaze layer on the surface of the ceramic tile; by utilizing the characteristic of low density of zirconium phosphate, zirconium phosphate is accumulated at the upper part of the glaze layer after being sintered at a high temperature to form a surface with a porous structure, so that the zirconium phosphate is used as a carrier to which the composite antibacterial agent is attached, the binding force of antibacterial materials and the ceramic tile is enhanced, the ceramic tile is endowed with long-acting and excellent antibacterial performance, and meanwhile, the surface appearance decoration effect of the ceramic tile is not influenced. The invention further discloses a preparation process of the antibacterial ceramic tile, and the preparation process is simple in step, high in controllability and beneficial to large-scale industrial production.

An antimicrobial composition comprising an ionic complex of an anionic polyester with an antimicrobial metal, wherein the anionic polyester has an ion exchange capacity from about 0.19 meq / g to about 1.0 meq / g.

The invention relates to a florenicol succinic acid monoester and a preparation method thereof, and the florenicol succinic acid monoester can be obtained by the esterification of the florenicol and succinic anhydride. Simultaneously, the invention also relates to acceptable salts and preparation methods thereof of the florenicol succinic acid monoester pharmacy, such as sodium salt, potassium salt, calcium salt and magnesium salt etc., and salts that are formed with basic amino acids and comprises lysine and arginine salts. By testing, the water-solubility of the corresponding salt is more than 500 mg / ml. The water-soluble derivatives disclosed by the invention quickly release the florenicol after being hydrolyzed in bodies and the derivatives can be used as high water-soluble prodrugs of the florenicol.

This invention relates to a method for identifying peptides having antimicrobial activity and to the antimicrobial peptides identified thereby and methods for their use.

Antimicrobial compositions and related methods as can be used to enhance stability and / or maintain antimicrobial activity.

Disclosed herein is a composition comprising a substrate with functionalized surface covalently bound to an anti-infective agent, such as a quaternary phosphonium compound with anti-bacterial activity against a broad range of bacteria, methods of synthesizing an anti-infective composition, and its resultant antimicrobial performance.

The invention discloses plectasin as well as a gene and a preparation method thereof. A nucleotide sequence of the gene of plectasin is shown in SEQ ID No.1 in a sequence table. The invention discloses a gene sequence of plectasin fusion protein, an amino acid sequence, a recombinant expression vector containing the gene of plectasin and a recombinant expression transformant containing a gene coding the plectasin fusion protein, wherein the gene sequence of the plectasin fusion protein contains enzyme digestion sites of His-tag and TEV enzymes. The preparation method of the plectasin comprises the following steps of: cultivating the recombinant expression transformant; separating and purifying the obtained plectasin fusion protein; adding TEV enzyme and carrying out enzyme digestion; and separating and purifying to obtain plectasin protein. By adopting the preparation method of the plectasin, expression quantity of the plectasin is greatly increased, and the plectasin is simpler and easier to separate and purify. The purified plectasin can effectively inhibit growth of gram positive bacteria, bacillus subtilis and methicillin-resistant staphylococcus epidermidis golden yellow staphylococci.

The invention discloses a method for producing a multifunctional antibacterial peptide. The method comprises the following steps of: 1) treating raw materials; 2) preparing the raw materials; 3) sterilizing a solid medium; 4) preparing nutrient solution for solid state fermentation; 5) performing aerobic inoculation and fermentation; 6) performing anaerobic inoculation and fermentation; and 7) drying and sieving to obtain the finished product of the antibacterial peptide. The measured antibacterial peptide content of the finished product of the antibacterial peptide is 100-400 IU per gram and the total number of probiotics is 10-40 billion per gram. The solid state fermentation is performed by four strains including complex yeast, bifidobacterium, lactobacillus and streptococcus faecalis, so the shortcoming that the antibacterial peptide is produced by a single strain is overcome, and a large number of probiotics are maintained while the multifunctional antibacterial peptide is produced; and moreover, the method realizes the coexistence of the large number of probiotics and the antibacterial peptide while keeping the antibacterial activity. The antibacterial peptide produced by the method is applicable to the feed additive industry.

The invention belongs to the field of food packaging, and particularly relates to a full-degradable antibacterial food packaging film and a preparation method thereof. The packaging film is prepared from 20-50 parts of starch, 50-80 parts of biodegradable polyester, 5-40 parts of plasticizer, 1-10 parts of compatibilizer, 2-20 parts of organic modified montmorillonite, 1-5 parts of lubricant and 0.5-12 parts of natural antibacterial agent. The food packaging film is prepared through one-step extrusion granulation, and is obtained by adopting an extrusion blow molding film making process. The full-degradable antibacterial food packaging film produced by the invention has excellent antibacterial property, mechanical property and barrier property, the used antibacterial agent is high in safety, the adopted film preparation mode is continuous and efficient, and the full-degradable antibacterial food packaging film is suitable for commercial production and can be applied to various food packaging scenes.

The invention relates to a biological magnesium alloy containing nano magnesium oxide and nano silver and a preparation method of the biological magnesium alloy. The biological magnesium alloy is prepared from nano magnesium oxide, nano silver and a degradable biological magnesium alloy matrix, wherein the nano magnesium oxide and nano silver contained are distributed on the crystal boundary of the matrix as a second phase; the nano magnesium oxide accounts for 4-6wt% of the biological magnesium alloy containing nano magnesium oxide and nano silver; the nano silver accounts for 0.03-0.08wt% ofthe biological magnesium alloy containing nano magnesium oxide and nano silver. The preparation method comprises the following steps: preparing nano MgO powder, nano Ag powder and degradable biological magnesium alloy matrix powder according to a set proportion, and putting into a ball mill; performing ball milling for 3-6 hours at a ball milling speed of 250-400rpm, in a protective atmosphere; preparing the biological magnesium alloy containing nano magnesium oxide and nano silver by a selective laser melting technology in a protective atmosphere.

The invention provides fungal polypeptides from Trichoderma reesei that possess anti-microbial activity, polynucleotides encoding the polypeptides, compositions comprising the polypeptides and polynucleotides, and methods of use, thereof.

Belonging to the field of biotechnology, the invention in particular relates to an amphotericin B polypeptide hydrogel drug carrier system for treatment of fungal infection. According to the invention, polypeptide hydrogel with great clinical application potential is employed for covalent binding of small molecule hydrophobic antibacterial drug amphotericin B to form the amphotericin B polypeptide hydrogel nano-drug carrier system. The prepared nano-drug carrier system has the characteristics of high drug loading capacity, high biocompatibility and high stability, at the same time has the advantages of sustained or controlled release of drugs, easy degradation of polypeptide carrier, reduced clinical toxic and side effects and obvious antifungal effect. The amphotericin B polypeptide hydrogel nano-drug carrier system can be stored and used in the form of amphotericin B polypeptide hydrogel nano-drug carrier system, also can be diluted with water for injection so as to be suitable for intravenous injection, or can be incorporated with other auxiliary materials to be prepared into tablets, pills, granules or capsules. The amphotericin B polypeptide hydrogel nano-drug carrier system provided by the invention is suitable for the antifungal and fungal infection disease treatment field, and has good application prospect.

The present invention relates to formulations comprising amyris alcohol or an ester of amyris alcohol or combinations thereof to treat acne in humans. These formulations can further comprise a phytoestrogen such as glabridin and miroestrol, an antioxidant such as tetrahydrocurcumin and naturally occurring peroxides such as artemisinin and dihydroartemisinin and combinations thereof for improved effectiveness in treating acne.

The invention discloses an antimicrobial peptide synthesis method with all amino acids being D-type amino acids. The method comprises the following steps: activating resin with dichloromethane and N,N-dimethylformamide, and obtaining a straight-chain peptide KWCFRVCYRGICYRRCR* by a solid-phase synthesis method; cutting the resin with a mixed solution of trifluoroacetic acid, water, phenol and triisopropylsilane, performing rotary evaporation to remove the trifluoroacetic acid, adding frozen diethyl ether to precipitate a white solid, and performing freeze drying with a freezer drier to obtainsolid powder; constructing two pairs of disulfide bonds, wherein mercapto protective groups selected by 3-site,16-site cysteine are triphenylmethyl, mercapto protective groups selected by 7-site, 12-site cysteine are acetamide methyl. The method has the beneficial effect that the hemolytic activity is significantly reduced on the basis of maintaining the original antimicrobial activity.

The invention belongs to the technical field of nano silver antibacterial glue preparation, and discloses nano silver antibacterial glue as well as a preparation method thereof and an intelligent detection system. The intelligent detection system of the nano silver antibacterial glue and the preparation method thereof comprises a weighing module, a time module, a pH detection module, a temperaturedetection module, a main control module, a dissolution module, a mixing and stirring module, a heating module, a detection data storage module and a detection display module. The nano silver antibacterial glue provided by the invention has a better antibacterial effect and is lower in toxicity to human cells; silver in the antibacterial glue provided by the invention is in an atomic state and ata nanometer size, therefore, the loss of silver can be avoided, the oxidation can be delayed, and the antibacterial glue can keep the antibacterial activity for a long time; the invention provides thepreparation of nano silver powder by adopting water as a reaction solvent and an alcohol as a reducing agent, the reaction system is green and environmentally-friendly, high-quality nano silver powder is obtained, and the quality of the nano silver antibacterial glue is improved.

The invention relates to an ancient defense polymer having biological activity. The polymer comprises both discrete hydrophilic blocks containing cationic charge(s) and discrete hydrophobic blocks, making it amphipathic and antimicrobial in a manner analogous to natural antimicrobial peptides that form an ancient defense mechanism employed by many organisms. Such a polymer may be formed into devices designed to resist infection or bound to the surface of an apparatus to lend the biological activity to the surface of the apparatus.

The invention discloses a preparation method for drosophila cecropin, which induces the drosophila adults with bacteria or epiphyte and through acupuncture and culture to produce cecropin; the cecropin is then extracted to get the drosophila cecropin. The obtained cecropin has inhibiting effects on bacteria and epiphyte and has thermal stability. The natural cultured drosophila adults have no cecropin inside the body; the method can be used to induce the drosophila to generate the cecropin which has inhibiting effects on bacteria and epiphyte.

The invention discloses a making method for perilla, clove and shrimp broad bean paste. The purple perilla, clove and shrimp broad bean paste is prepared from plant oil, shrimp meat, salty white broad beans, soybean paste, chilli blocks, raw gingers, edible salt, monosodium glutamate, white sugar, a yeast extract, disodium 5'-ribonucleotide, sesames, clover, perilla powder and fresh perilla leaves. The making method for the purple perilla, clove and shrimp broad bean paste comprises the steps of frying the perilla powder and the clove in the plant oil to obtain perilla powder and clove mixed oil, performing stir-frying other raw materials in the rest of the plant oil, and adding the perilla powder and clove mixed oil for stir-frying. The instant cooked broad bean paste which has seafood fragrance, tastes crispy and is health-protection and nutritional is made by the making method disclosed by the invention and is very convenient to eat and carry; furthermore, the made broad bean paste is in bright fuchsia color, does not contain any preservative and can be preserved for 20 months.

The invention relates to a fresh product cold-chain logistics transport method. The method specifically comprises the steps of pretreatment, cold-chain logistics transport, and cold-chain terminal distribution. According to the technical scheme, the advantages of being low in cost, small in energy consumption and low in product loss are achieved. A dedicated refrigerator car does not need for transport, only a common vehicle can finish cold-chain transport, through use and circulation of a pre-cooling heat preservation storage and transport unit, energy consumption is reduced, and the food preservation loss caused by box opening can be reduced.

A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.

The invention discloses plectasin as well as a gene and a preparation method thereof. A nucleotide sequence of the gene of plectasin is shown in SEQ ID No.1 in a sequence table. The invention discloses a gene sequence of plectasin fusion protein, an amino acid sequence, a recombinant expression vector containing the gene of plectasin and a recombinant expression transformant containing a gene coding the plectasin fusion protein, wherein the gene sequence of the plectasin fusion protein contains enzyme digestion sites of His-tag and TEV enzymes. The preparation method of the plectasin comprises the following steps of: cultivating the recombinant expression transformant; separating and purifying the obtained plectasin fusion protein; adding TEV enzyme and carrying out enzyme digestion; and separating and purifying to obtain plectasin protein. By adopting the preparation method of the plectasin, expression quantity of the plectasin is greatly increased, and the plectasin is simpler and easier to separate and purify. The purified plectasin can effectively inhibit growth of gram positive bacteria, bacillus subtilis and methicillin-resistant staphylococcus epidermidis golden yellow staphylococci.