5results about How to "Maintain antimicrobial activity" patented technology

The invention relates to the technical field of wood antiseptic and corrosion-resistant treatment, and specifically to a preparation process of a coating for improving the antibacterial and corrosion-resistant performance of wood. In order to improve the antibacterial and corrosion-resistant ability of the prepared coating, the invention prepares and adds a corrosion-resistant antibacterial agent in a coating raw material, and introduces group structures such as quaternary ammonium salts and guanidine groups therein, thereby achieving antibacterial performance against microorganisms such as fungi, and the application also introduces fluorine elements and allyl groups therein. The introduction of fluorine elements can effectively improve the hydrophobicity of the coating, reduce the influence of water vapor on the antibacterial components in the coating, and the introduction of allyl groups can enable the corrosion-resistant antibacterial agent to react and cross-link with raw materials such as butyl acrylate under the action of an initiator, thereby effectively avoiding the loss of the corrosion-resistant antibacterial agent and maintaining the antibacterial activity for a long time.

The invention relates to the technical field of gene engineering, in particular to a method for prokaryotic expression of antibacterial peptide. According to the method provided by the invention, the antibacterial peptide gene is connected to the 3'end or the 5 'end of the fusion tag gene for fusion expression, and the antibacterial activity of the original antibacterial peptide is eliminated by forming a large amount of protein in an inclusion body state, so that host bacteria cannot be killed. By utilizing the method provided by the invention, a large amount of antibacterial peptide can be prepared in a prokaryotic expression system, the method is simple and easy to implement, and the obtained antibacterial peptide has an obvious in-vitro antibacterial effect after enzyme digestion and purification.

The invention discloses a polyethylene clean film, a packaging bag and a preparation method thereof, and relates to the technical field of polyethylene packaging bags, the polyethylene clean film comprises the following components by weight: 75-90 parts of low density polyethylene, 4.5-6 parts of a bacteriostatic agent, 2.5-3.6 parts of functionalized graphene oxide, and 2-3.2 parts of modified nano zinc oxide. According to the polyethylene clean film, the packaging bag and the preparation method of the polyethylene clean film, the bacteriostatic agent and the polyethylene chain interact to form hydrogen bonds or physical entanglement, so that molecular chains are combined more tightly, the tensile strength of the packaging bag is improved, and the risk of breakage is reduced; due to the addition of the bacteriostatic agent, the flexibility and the sliding property of a molecular chain are improved, energy can be dissipated through chain segment movement when the packaging bag is subjected to external force, the impact resistance and the flexibility are improved, and the possibility of embrittlement is reduced; the bacteriostatic agent can also form a barrier layer in a polyethylene matrix or disorganize a gas diffusion channel, increase the tortuosity of the gas diffusion channel and reduce the permeability of gases such as oxygen and carbon dioxide.

The present application provides a kind of polypeptide sustained-release hydrogel coating for preventing catheter urinary tract infection and its preparation method, the coating includes the adhesive bottom layer attached to the surface of catheter substrate, and the polypeptide sustained-release hydrogel functional layer compounded outside the adhesive bottom layer;The functional layer includes hydrophilic hydrogel gel-forming matrix, targeted antibacterial polypeptide, polypeptide sustained-release carrier and biocompatible auxiliary agent.The present application solves the interface bonding problem of hydrophobic catheter substrate and hydrophilic hydrogel through the adhesive bottom layer, the coating has strong adhesion, is resistant to urine immersion and rubbing;Through polypeptide sustained-release carrier, antibacterial polypeptide is released for 30 days, and there is no risk of burst release;The targeted antibacterial polypeptide used is specific to urinary tract infection pathogenic bacteria, has no drug resistance induction risk, has excellent biocompatibility, can effectively prevent catheter-related urinary tract infection caused by short-term and long-term indwelling catheter, the preparation process is simple and controllable, is suitable for large-scale production, and can be widely applied to antibacterial modification of urinary intervention medical devices.

The invention belongs to the technical field of hybrid materials, and particularly relates to a nickel aluminum hydrotalcite-zinc oxide-ethylene glycol chitosan hybrid material as well as a preparation method and application thereof. The invention provides a nickel aluminum hydrotalcite-zinc oxide-ethylene glycol chitosan hybrid material, which is of a core-shell structure, and takes ethylene glycol chitosan as a shell to wrap nickel aluminum hydrotalcite and zinc oxide. According to the nickel-aluminum hydrotalcite-zinc oxide-ethylene glycol chitosan hybrid material (NiAl-LDH-ZnO / GCS), nickel-aluminum hydrotalcite and zinc oxide are wrapped by ethylene glycol chitosan, and the nickel-aluminum hydrotalcite-zinc oxide-ethylene glycol chitosan hybrid material shows efficient antibacterial activity on staphylococcus aureus, escherichia coli and saccharomycetes when the pH value is higher than 6.5, including the pH value in an alkaline environment is as high as 10; under the irradiation of light with the wavelength of about 390 to 420 nm, the NiAl-LDH (at) ZnO / GCS shows strong photocatalytic antibacterial activity.