1results about How to "Maintain antimicrobial activity" patented technology

The present application provides a kind of polypeptide sustained-release hydrogel coating for preventing catheter urinary tract infection and its preparation method, the coating includes the adhesive bottom layer attached to the surface of catheter substrate, and the polypeptide sustained-release hydrogel functional layer compounded outside the adhesive bottom layer;The functional layer includes hydrophilic hydrogel gel-forming matrix, targeted antibacterial polypeptide, polypeptide sustained-release carrier and biocompatible auxiliary agent.The present application solves the interface bonding problem of hydrophobic catheter substrate and hydrophilic hydrogel through the adhesive bottom layer, the coating has strong adhesion, is resistant to urine immersion and rubbing;Through polypeptide sustained-release carrier, antibacterial polypeptide is released for 30 days, and there is no risk of burst release;The targeted antibacterial polypeptide used is specific to urinary tract infection pathogenic bacteria, has no drug resistance induction risk, has excellent biocompatibility, can effectively prevent catheter-related urinary tract infection caused by short-term and long-term indwelling catheter, the preparation process is simple and controllable, is suitable for large-scale production, and can be widely applied to antibacterial modification of urinary intervention medical devices.