107 results about "Hydrogel coating" patented technology

The invention discloses a multi-layer composite thermal response battery diaphragm based on a basalt fiber reinforced substrate and a preparation method of the multi-layer composite thermal response battery diaphragm, and belongs to the technical field of lithium ion batteries. The diaphragm comprises the following structures: (a) a polypropylene (PP) matrix layer for providing electrolyte wettability and ionic conductivity; (b) the basalt fiber reinforced layer and the matrix layer are alternately overlapped, and the mechanical strength and the thermal stability of the diaphragm are remarkably improved through hot-pressing compounding; and (c) the intelligent temperature sensing hydrogel coating is formed by copolymerization of poly (N-isopropylacrylamide) (PNIPAm) and acrylamide (Am), reversible phase change of a temperature threshold of 50-70 DEG C is realized by adjusting a copolymerization ratio, an ion channel is closed at a high temperature to prevent thermal runaway, and ion conduction is recovered at a low temperature. The preparation method comprises the steps of material compounding, surface modification, hydrogel preparation, coating and the like. The lithium ion battery has excellent mechanical properties and a high-temperature self-protection function, and the safety and the reliability of the battery can be effectively improved.

The invention discloses a piezoelectric double-network hydrogel coating modified titanium material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The piezoelectric double-network hydrogel coating modified titanium material provided by the invention comprises a titanium substrate, an adhesion layer and a piezoelectric double-network hydrogel coating, wherein the adhesion layer and the piezoelectric double-network hydrogel coating are compounded on the titanium substrate; the adhesion layer is compounded on the titanium substrate, and the adhesion layer is positioned between the titanium substrate and the piezoelectric double-network hydrogel coating; and the piezoelectric double-network hydrogel coating is prepared from methacrylic acid modified gelatin, sodium alginate and whitmanite nanoparticles. According to the prepared modified titanium material, electric signals can be generated on the surface of the piezoelectric material under the action of polarization or stress, recovery of charge transfer of a bone defect part is facilitated, a good electroactive microenvironment is created for bone regeneration, the osseointegration capacity of the modified titanium material is enhanced, and bone regeneration is effectively promoted; the method has a wide application prospect in preparation of bone graft materials and bone repair materials.

The invention discloses a medical catheter surface strong interface bonding hydrogel coating method based on subsurface initiated polymerization. The method comprises the steps that firstly, a mixed solvent of an organic solvent and water is adopted for conducting swelling pretreatment on the surface of a catheter base material, so that polymer chains on the surface layer of the base material are relaxed; a solution containing initiator molecules is injected into the inner cavity of the catheter, so that the initiator is diffused and anchored in the subsurface area of the base material; preparing a hydrogel monomer solution containing a hydrophilic monomer, a cross-linking agent and a catalyst, and pouring the hydrogel monomer solution into the inner cavity of the catheter; and finally, sealing the two ends of the conduit, and initiating polymerization reaction under a specific temperature condition, so that the initiator anchored on the subsurface is decomposed to generate free radicals. The hydrogel coating and the catheter base material form a double combination effect of physical interlocking and chemical bonding through a subsurface initiated polymerization mechanism, the firmness and stability of the coating are remarkably improved, and the method is particularly suitable for modification of the inner surfaces of various medical catheters with complex structures.

The invention discloses a method for in-situ rapid growth of a dual-network hydrogel coating on the surface of a base material by a one-step method, which comprises the following steps: putting the base material with an adhesion initiation layer on the surface into a hydrogel precursor solution, and carrying out in-situ polymerization for 0.1-10 minutes under light irradiation, wherein the adhesion initiation layer comprises an adhesive compound based on a catechol group and a first photoinitiator, and the hydrogel precursor solution comprises a natural polymer containing tyrosine, an acrylic monomer, a cross-linking agent and a second photoinitiator, and wherein the first photoinitiator and the second photoinitiator are different from each other and are independently selected from a divalent ruthenium compound and a persulfate. Compared with the prior art, the natural / synthetic polymer double-network gel coating with biological activity and mechanical property can grow on the surfaces of different substrates more quickly and efficiently through a one-step method; and the base material, the surface of which is modified by the in-situ grown double-network hydrogel coating, obtained by the method can be applied to in-vivo medical apparatuses and instruments.

The invention belongs to the technical field of food fresh-keeping and antibacterial materials, and discloses a preparation method and application of a bamboo cellulose-based sprayable hydrogel fresh-keeping film. According to the system, bamboo cellulose is used as a structural support and cooperates with epsilon-polylysine and bamboo polyphenol, and a hydrogel coating with physical barrier, antibacterial and antioxidant functions is formed on the surfaces of fruits and vegetables through in-situ self-assembly and calcium ion crosslinking. The method comprises the following steps: compounding sodium alginate, carboxymethyl chitosan and a bamboo fiber nano dispersion liquid, and adding epsilon-polylysine and bamboo polyphenol to prepare a functional spray; a calcium chloride solution is sprayed after spraying, and a stable and transparent hydrogel film with high adhesive force is rapidly formed through ionic crosslinking. The technical process is simple and convenient, the film forming speed is high, the components are natural, and industrial spraying is easy. Verified by fruits and vegetables such as bananas and the like, the coating can effectively delay decay, and the application blank of the nano bamboo cellulose in a spray fresh-keeping carrier is filled.

In certain embodiments, the present disclosure provides medical graft devices having covalently crosslinked matrix protein hydrogel coatings. In some forms, such coatings are configured to reduce the formation of adhesions upon implantation.

A polyelectrolyte hydrogel coating with strong substrate binding performance and a method of manufacturing the same are provided. The method includes: 1) activating a substrate by applying oxygen plasma; and 2) dissolving a polycationic polymer, a polymeric monomer, a silane coupling agent and an initiator to obtain a precursor solution, vacuumizing the precursor solution to remove air bubbles, applying the vacuumized precursor solution to a surface of the substrate activated by the oxygen plasma, and performing an in-situ polymerization and curing process under nitrogen or rare gas atmosphere. The polymeric monomer includes at least one of: acrylamide, acrylic acid, hydroxyethyl methacrylamide, 2-acrylamido-2-methyl-1-propanesulfonic acid, polyethylene glycol (diol) diacrylate, 2-methacryloxyethylphosphocholine, 3-[[2-(Methacryloyloxy)ethyl]dimethylammonio]propane-1-sulfonate, and 3-[[2-(methacryloyloxy)ethyl]dimethylammonium] propionate. The silane coupling agent has a carbon-carbon double bond functional group.

The invention discloses a medical polyaryletherketone implant and a surface modification method thereof, and the method comprises the following steps: immersing a polyaryletherketone material matrix into a saturated sodium carbonate solution used as a foaming agent, taking out the polyaryletherketone material matrix, and carrying out concentrated sulfuric acid ultrasonic treatment at room temperature; alternately treating with a saturated sodium carbonate solution and concentrated sulfuric acid until a microporous network is formed on the surface of the polyaryletherketone material matrix; carrying out surface phosphorylation on the polyaryletherketone material matrix with the microporous network formed on the surface by using a diazo reaction to obtain a surface phosphorylated matrix; treating the surface phosphorylated matrix by adopting a hydrothermal method and a chemical coprecipitation method, and forming a biomineralization layer doped with antibacterial metal ions on the surface of the matrix; and freeze-drying a hydrogel coating doped with antibacterial fatty acid on the surface of the matrix to obtain the medical polyaryletherketone implant.

The invention provides an interpenetrating network hydrogel coating constructed on the surface of silicone rubber by a one-step method and a product thereof, and the method comprises the following steps: immersing the surface of a clean silicone rubber sheet into a single mixed solution containing a photoinitiator, polyvinyl alcohol (PVA) and hyaluronic acid (HA) containing dynamic hydrogen bonds, a water-soluble monomer and a small amount of solvent; the solvent ratio is controlled, so that the solution viscosity is moderate, and the silica gel is easy to soak but does not excessively swell. Soaking for 1-2 hours at room temperature; the hydrogel is taken out and irradiated under an ultraviolet lamp with the wavelength of 365-395 nm and the power of 20 W, so that the hydrogel forms an interpenetrating network structure and is fixed to the surface of the silicone rubber, and the hydrogel coating is obtained. The characteristics of the silicone rubber are reserved, the hydrophobicity of the silicone rubber is overcome by adopting a most time-saving and labor-saving method, and the silicone rubber can be widely applied to actual life with the advantages of low cost and high performance.

A method for delaying frost sticking of a heat exchanger containing a hydrogel coating layer according to the present invention includes: absorbing moisture by means of the hydrogel coating layer; forming slurry ice inside the hydrogel coating layer that has absorbed the moisture; and regenerating the hydrogel coating layer when the formed slurry ice occupies 50% or more of the total area of the hydrogel coating layer.

The invention belongs to the technical field of medical materials, and provides a nasogastric tube based on synergistic resistance reduction and lubrication of a micro-nano texture and antibacterial hydrogel, and the nasogastric tube comprises an anti-friction resistance-reducing surface with a micro-nano structure and a hydrophilic antibacterial hydrogel coating. A traditional nasogastric tube is mostly made of polymer materials such as polydimethylsiloxane, the hydrophobic surface of the traditional nasogastric tube is prone to generating large insertion resistance in the intubation process, and discomfort and pain of nasopharynx and esophagus and even inflammation infection are brought to a patient. The resistance in the insertion process is remarkably reduced by combining the hydrophilic hydrogel pattern layer, so that the wettability is enhanced, the smoothness during insertion and extraction is improved, and the mechanical stimulation to the nasal cavity and throat tissues is reduced. The hydrophilic antibacterial hydrogel coating is coated on the surface of the nasogastric tube, so that the structural design not only improves the comfort of a patient in the use process, but also endows the tube body with certain antifouling and antibacterial properties, and reduces the risk of occurrence of discomfort related to bacterial infection and friction.

The application discloses an interface-locked anti-swelling hydrogel coating mesh membrane and a preparation method and application thereof, and comprises the following steps: growing a tin dioxide particle layer on the surface of a stainless steel filter mesh in situ, depositing a polydopamine coating on the tin dioxide particle layer, coating an anti-swelling hydrogel coating on the polydopamine coating, and preparing the interface-locked anti-swelling hydrogel coating oil-water separation mesh membrane through heat curing and freeze-thaw cycles; the polydopamine in the mesh membrane has adhesion, and cooperates with sulfuric acid and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide to induce the Hofmeister effect, so that polyvinyl alcohol molecular chains are dehydrated and crystallized, a high-physical-crosslinking anti-swelling hydrogel coating is formed, strong interface bonding is provided, the micro-nano rough structure constructed by the tin dioxide particles and the introduced hydrophilic substances are combined, the problems of easy excessive swelling and interface delamination of the hydrogel coating oil-water separation mesh membrane are overcome, and long-acting and high-performance oil-in-water emulsion separation can be realized.

Provided herein is technology relating to obtaining and testing biological samples for disease biomarkers and particularly, but not exclusively, to hydrogel-coated microneedles, arrays of hydrogel-coated microneedles, and related methods of making stellate microcolumns and hydrogel-coated microneedles and using the hydrogel-coated microneedles for capturing exosomes from subject tissues for diagnosing diseases such as cancer.

The invention relates to the field of medical polymer materials, and provides a TNF-alpha aptamer-loaded Z-MOF anti-inflammatory nanoparticle hydrogel composite coating and a preparation method thereof, and the preparation method comprises the following steps: step 1, preparing an aptamer; step 2, obtaining an aptamer with enriched high affinity; step 3, modifying the aptamer prepared in the step 2; 4, the modified aptamer is connected with MOF, and an MOF-aptamer compound is obtained; step 5, preparing and obtaining the Z-MOF anti-inflammatory nanoparticle hydrogel loaded with the TNF-alpha (tumor necrosis factor-alpha) aptamer; and step 6, preparing the Z-MOF anti-inflammatory nanoparticle hydrogel composite coating loaded with the TNF-alpha aptamer. The surface of the tracheal catheter is coated with the prepared composite coating. According to the preparation method, the hydrogel coating and the tracheal catheter are combined in a covalent bond mode to form the mucous membrane imitating structure, the mucous membrane imitating structure is good in surface mechanical compliance and hydrophilic lubrication performance, more importantly, the stability of the mucous membrane imitating structure is good, and the long-term indwelling requirement of the tracheal catheter is met.

This invention presents a disposable male hydrogel patch designed to delay ejaculation and prolong erection time while minimizing the impact on sexual pleasure. The patch features an ergonomically designed backing with specific curvatures, a drug-loaded strip divided into central and side zones, and an optional hydrogel coating for sustained drug release. The central zone contains a drug mixture that inhibits the dorsal nerve of the penis, while the side zones promote vasodilation related to erection. The backing includes the adjustment hole for adaptive fitting and is made of a multi-layer composite that integrates breathability, waterproofing, moisture absorption, and fixation. The drug-loaded strip incorporates herbal extracts and synthetic compounds to target the nervous system, vascular system, and endocrine system. Discrete protruding arrays at the coronal sulcus recess enhance drug delivery. This novel, multi-angle approach comprehensively improves sexual function and quality of life, making it a significant innovation in male sexual health.

The present application belongs to the field of medical material surface functionalization, and particularly relates to a kind of nano drug-loaded hydrogel catheter coating and its preparation method and application.The present application utilizes PLGA to load antibiotic amikacin sulfate AMK or antibacterial peptide FK13-a1, synthesizes nanoparticle NP-AM and nanoparticle NP-FK, prepares NP-AM / FK@OMV nanoparticle complex with EcN OMV as carrier, then adds poloxamer-hyaluronic acid composite hydrogel to obtain NP-AM / FK@OMV-P / H nano drug-loaded hydrogel, and forms coating after coating and drying.The nano drug-loaded hydrogel coating provided by the present application has the characteristics of enzyme response, antibacterial, prevention of biofilm formation and low toxicity, has great application potential in inhibiting medical catheter surface biofilm, and has important significance for preventing and treating CAUTI, prolonging the use time of indwelling catheter, and reducing the discomfort of patients caused by frequent replacement of catheter.

The present invention provides a method for producing a coated silicone hydrogel contact lens in a cost effective manner. The method comprises: obtaining a preformed silicone hydrogel contact lens, the preformed silicone hydrogel contact lens comprising a bulk silicone hydrogel material, the bulk silicone hydrogel material comprising repeating units of at least one vinyl monomer containing a carboxyl group and at least one vinyl monomer containing an aryl dihydroxy boron group; and a polymer composition comprising a water-soluble and thermally crosslinkable polymer material having an azetidinium group or an epoxy group and a polymer material having 1, 2-or 1, 2, 3, 3, 3, 3-tetrafluoropropene, heating the preformed silicone hydrogel contact lens in an aqueous coating solution of a glycol-containing hydrophilic polymer having a 1, 3-diol moiety to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel coating, the hydrogel coating comprises a cross-linked polymeric material covalently attached to the bulk silicone hydrogel material and a grafted glycol-containing hydrophilic polymer covalently attached to the bulk silicone hydrogel material and distributed in the cross-linked polymeric material.

The invention relates to a balloon catheter (1) to be introduced into the blood vessel system of the human or animal body, said catheter having a longitudinally extending shaft (2), with the balloon catheter (1) comprising a distal portion (A) in which a balloon (3) is arranged that is expandable by the supply of a fluid through a lumen (9) extending through the shaft (2), with the distal tip (8) of the balloon catheter (1) being provided with a coating consisting of a hydrogel (7). The invention provides a balloon catheter (1) capable of easily passing through constricted areas in blood vessels.

The present invention relates to a bio-based hydrogel coating composition for elastomeric articles provided to overcome the issues of sweat accumulation, skin dryness, irritation, and difficulty in donning wet gloves, while offering an alternative to powdered elastomeric articles. The bio-based hydrogel coating is designed to enhance the wearability, comfort, and hygiene of said elastomeric article. This innovative formulation eliminates the need for powder-based coatings while providing a multipronged solution to overcome the issues of sweat accumulation, skin dryness, irritation, and difficulty in donning wet gloves.

The application provides a preparation method of a polyarylether medical material with a hydrogel coating on the surface, which comprises the following steps: firstly, treating a polyarylether sheet by plasma to endow the sheet with reactive functional groups; and then, spin-coating a hydrogel precursor solution onto the surface of the polyarylether sheet treated by plasma, and curing the sheet in an ultraviolet curing box to obtain a polyarylether medical material with a hydrogel coating on the surface; the hydrogel precursor solution comprises the following components in percentage by mass: acrylic acid-N-succinimidyl ester (AAc-N-NHS) 1-5%; methacrylic anhydride modified chitosan (CSMA) 1-3%; methacrylic anhydride modified gelatin (GelMA) 4-8%; alpha-ketoglutaric acid 0.2%; and water in the rest. The hydrogel coating and the polyarylether substrate are combined by chemical bonds, the bonding force between the hydrogel coating and the substrate is enhanced, the biocompatibility of the polyarylether material is improved, the polyarylether material is endowed with antibacterial and adhesive properties, and the polyarylether material has a wide application prospect in bone implant materials.

The application discloses a phase change latent heat type natural gas hydrate resistant hydrophilic gel coating and belongs to the technical field of protective coating of oil and gas conveying pipelines. The coating is prepared by coating a hydrophilic gel coating containing a phase change calcium chloride hydrate on the inner surface of a pipeline and curing in situ by 365 nm ultraviolet light; the three-dimensional polymer network formed by AM and HEMA copolymerization stably locks the calcium chloride hydrate system and water molecules in the gel network through hydrogen bonds and metal ion coordination, and no leakage, salt precipitation or water loss occurs, and the performance is stable during long-term service; meanwhile, the preparation and curing process is simple, the in-situ curing can be carried out at room temperature by ultraviolet light, the curing time is short, the inner surface coating of the pipeline on site is suitable for rapid construction, the cost of large-scale application is low, the industry pain points of mechanical interlocking and cyclic failure of traditional super-hydrophobic coatings are solved, and the industrial application demand of deep sea oil and gas pipeline hydrate blockage prevention and control is met.

The ice cap for cooling the head comprises an ice cap body, the ice cap body comprises a forehead cooling area, a head top cooling area, an occipital area and a temperature display module, and the forehead cooling area, the head top cooling area and the occipital area are sequentially and flexibly connected and can deform to define a head containing area. The forehead cooling area comprises an outer layer and a hydrogel adhesion layer coated on the inner surface of the outer layer, the head top cooling area is provided with a plurality of head top ice bag areas, head top ice bags are arranged in the head top ice bag areas in a matched mode, and the temperature display module is arranged in the forehead cooling area. The temperature of the forehead cooling area is monitored and displayed through a temperature display module. The ice cap is simple in structure and convenient to use, the temperature of the cap body can be conveniently mastered in time while the ice cap is attached to the head of a patient, and the cooling efficiency of the patient is improved.

The invention discloses a degradable magnesium alloy intravascular stent based on bionic hydrogel and nitric oxide double-path release and a preparation method and application thereof. The method comprises the steps that a magnesium alloy base material is subjected to alkali heat treatment; immersing the treated magnesium alloy into a silane coupling agent for reaction; the photopolymerization reaction liquid is treated to the surface of the silanization modified magnesium alloy, and polymerization is conducted through ultraviolet irradiation; immersing the magnesium alloy with the hydrogel coating into a polyarginine solution, and grafting polyarginine onto the surface of the hydrogel; a sample is activated through EDC / NHS and then immersed in a selenocystamine solution for a reaction, and the bionic composite coating, with the exogenous / endogenous dual-path nitric oxide release function, of the degradable magnesium alloy intravascular stent is obtained. The invention successfully constructs the bionic coating integrating cell membrane-imitating anti-fouling and exogenous / endogenous dual-path NO release functions, and the coating effectively solves the key problems of corrosion control, thrombus formation resistance, functional re-endothelialization coordinated regulation and the like faced by the degradable magnesium alloy intravascular stent.

The application provides a probiotic-loaded aerogel-hydrogel composite material and a preparation method thereof. The probiotic-loaded aerogel-hydrogel composite material comprises: a sodium alginate-gelatinized high-amylose starch aerogel; an active ingredient, wherein the active ingredient comprises probiotics, and the active ingredient is at least loaded in the pores of the sodium alginate-gelatinized high-amylose starch aerogel; and a sodium alginate-calcium chloride hydrogel coating, which is coated on the surface of the sodium alginate-gelatinized high-amylose starch aerogel loaded with the active ingredient. The probiotic-loaded aerogel-hydrogel composite material provided by the application can protect the active probiotics from passing through the stomach acid environment smoothly, and stably release the probiotics in the distal intestinal region, i.e., the colon, to achieve controllable release of the probiotics.

The invention provides a super-hydrophilic polyethersulfone hollow fiber membrane as well as a preparation method and application thereof. The surface of the hollow polyethersulfone hollow fiber membrane is grafted with a natural hydrogel coating; the PES film is subjected to surface activation through plasma treatment, polar groups such as hydroxyl, carboxyl and amino are introduced, the activated PES film is coated with a hydrogel solution, and a PES matrix film and the hydrogel coating are organically combined through functional group combination, electrostatic interaction, hydrogen-bond interaction and other action modes, so that the interface stability is improved; the hydrophilicity and the biological safety of the PES film are effectively improved.

The invention provides composite hydrogel as well as a preparation method and application thereof. The composite hydrogel comprises powder hydrogel and an antibacterial agent solution, the powder hydrogel is obtained by drying and grinding a hydrogel product obtained by carrying out photo-crosslinking curing on a hydrogel precursor solution containing acrylated beta-cyclodextrin, gelatin and a hydrophobic small molecule drug. The composite hydrogel has a uniform and compact porous network structure, and has excellent mechanical properties, excellent adhesion ability, excellent antibacterial ability and excellent osteogenic differentiation promoting ability. The composite hydrogel is applied to the surface of a base material to form a hydrogel coating, the adhesion strength of the formed hydrogel coating and the surface of the base material is high and can reach 131.64 kPa, and the hydrogel coating is resistant to shearing and impact and not prone to stripping and falling off in the using process, provides a new treatment approach for repairing and treating bone defect parts and has important medical significance.

Hydrogel coating formulations comprising oat-glucan, colloidal oat, a preservative, a carboxylic acid, an initiator, a crosslinking agent, a pH adjusting agent, and a solvent. Gloves coated with at least one layer of a coating prepared from the above hydrogel coating formulation. A process for preparing a hydrogel coating formulation comprising the steps of adding a first pH adjusting agent and oat-glucan to a first solvent, adding a second pH adjusting agent to a carboxylic acid, adding a second mixture obtained from step (ii), a cross-linking agent, and an initiator to the first mixture obtained from step (i), a second solvent is added to the third mixture obtained from step (iii) and colloidal oats and sodium benzoate are added to the fourth mixture obtained from step (iv). A glove is coated with at least one layer of the hydrogel coating formulation prepared by the above process.

This invention belongs to the field of intelligent hydrogel preparation technology, and relates to a hydrogel coating constructed on the surface of titanium alloy and its preparation method. The method for constructing a hydrogel coating on the surface of titanium alloy includes the following steps: (1) preparing hydroxyapatite-coated MXene; (2) adding polyvinyl alcohol and polyacrylic acid to the hydroxyapatite-coated MXene to prepare a sol; (3) spin-coating the sol obtained in step (2) onto the surface of titanium alloy, and performing cyclic freeze-thaw operations, thereby constructing a hydrogel coating on the surface of titanium alloy. Compared with the prior art, this invention improves the tribological properties of the hydrogel coating on the surface of titanium alloy by adding MXene, and the overall process is simple and the effect is outstanding.

The invention relates to the technical field of anti-fouling electrochemical sensors, in particular to a composite hydrogel coating with anti-fouling conductivity, a bionic taste sensor and application. A working electrode of the sensor is modified by a composite hydrogel coating, and a preparation method of the composite hydrogel coating comprises the following steps: mixing and stirring MXene and a tetrachloroauric acid solution to obtain an AuNPs / MXene solution, incubating the AuNPs / MXene solution and T1R1-VFT overnight to obtain AuNPs / MXene / T1R1-VFT, and mixing the AuNPs / MXene / T1R1-VFT with betaine pregel to obtain the composite hydrogel coating. The anti-pollution bionic taste sensor prepared after modification of the composite hydrogel coating can be used for detection of umami substances in fish meat, and is high in pollution resistance, high in sensitivity and good in stability.

Described herein are hydrogel-coated surgical meshes and their use in hernia repair, reconstructive surgery, and other surgical procedures. In one aspect, the hydrogel-coated meshes comprise at least one antibiotic or antimicrobial agent for the treatment of hernia repair surgery. In one aspect, the hydrogel coated meshes provide localized, sustained antimicrobial activity for the treatment of surgical site infections. In one aspect, the hydrogel coated meshes provide localized, sustained prophylactic antimicrobial activity for the prevention of surgical site infections. In another aspect, the hydrogel coating may optionally include one or more additional therapeutic components, such as anti-inflammatory compounds or growth factors, to facilitate and enhance recovery following hernia repair, reconstructive procedures, or other surgeries.