235 results about "Hydrogel coating" patented technology

The invention discloses a preparation method of a curing agent with biological self-healing capability, which comprises the following steps: preparing a bacillus pasteurii bacterial solution, preparing the bacillus pasteurii bacterial solution into an endophytic spore solution, immersing polyvinyl alcohol fibers into a sodium alginate / endophytic spore solution, taking out the polyvinyl alcohol fibers, immediately immersing the polyvinyl alcohol fibers into a calcium acetate solution, drying the polyvinyl alcohol fibers to obtain core fibers with a hydrogel coating, and curing the core fibers with the hydrogel coating to obtain the curing agent with biological self-healing capability. The preparation method comprises the following steps: taking magnesium phosphate cement as a raw material, immediately immersing the magnesium phosphate cement into a chloroform solution of a polystyrene and polylactic acid polymer blend, drying to obtain a coated microbial liquid, premixing urea and glucose, doping the premixed urea and glucose into the magnesium phosphate cement, uniformly stirring, adding the coated microbial liquid, and uniformly stirring to obtain the product. According to the invention, phosphate cement is adopted as the curing agent, has the advantages of high strength, short setting time, strong durability, low alkalinity, good biocompatibility and the like, and compared with the curing agent in the prior art, the curing agent not only has a good curing effect, but also has a crack self-healing function, and is especially suitable for reinforcing foundation soil.

The invention provides an anticoagulant coating for medical instruments, which can be used in the field of regenerative medical instruments. The prepared anticoagulant coating has short-term and long-term anticoagulant performance, and in addition, the thrombin responsive nanoparticles wrapped in the hydrogel coating can selectively release a factor Xa (FXa) inhibitor apixaban according to needs, so that thrombosis is inhibited in the middle stage of implantation. In-vitro and in-vivo experimental evidences show that after the material is implanted for a long time, an organized endodermis can be seen on the surface of the material, and the material has a special antithrombotic characteristic. The dynamic adjusting system has a multi-layer protection mechanism, and a new thought can be provided for designing the surface of a contact blood material adapting to environmental conditions.

The invention discloses a magnetic hydrogel, a surface modified Ti implant with an anisotropic magnetic hydrogel coating and application of the surface modified Ti implant. Fe3O4 nano-particles are uniformly deposited on carboxylated cellulose nano-fibers and are modified with polydopamine, and the magnetic cellulose nano-particles with high biocompatibility and superparamagnetism are prepared; the particles can sensitively respond to a weak magnetic field; the preparation method comprises the following steps: preparing a polydopamine modified Ti material, doping the polydopamine modified Ti material and a calcium phosphate oligomer into a GelMA hydrogel solution, coating the polydopamine modified Ti material with the solution, forming an anisotropic structure in a magnetic field, and carrying out photo-crosslinking to finally obtain the surface modified Ti implant with an anisotropic magnetic hydrogel coating. The magnetic hydrogel coating has an anisotropic structure and mechanical properties, and can simulate the anisotropy of bones to a certain extent.

The invention discloses a super-smooth, anti-corrosion and anti-coagulation hydrogel composite coating on the surface of a medical instrument as well as a preparation method and application of the super-smooth, anti-corrosion and anti-coagulation hydrogel composite coating, and the super-smooth, anti-corrosion and anti-coagulation hydrogel composite coating is a surface hydrogel composite coating formed by taking N-(3, 4-dihydroxyphenethyl)-2-benzoylbenzamide (BPDA) as a primer and grafting a hydrophilic polymer on the primer. BPDA is deposited on the surface of the substrate, then hydrophilic monomer surface graft polymerization is initiated by light, and a hydrogel coating is constructed on the surface of the BPDA substrate. The BPDA primer provides excellent corrosion resistance, the corrosion rate of a metal substrate is effectively reduced, and benzophenone derivatives with photoreaction activity on BPDA molecules can mediate firm combination of the hydrogel layer; after meeting water, a stable and compact hydrated layer is formed, the super-lubricating property is achieved, adhesion of protein and cells can be remarkably inhibited, and thrombus formation is effectively prevented. The anti-corrosion and anti-blood coagulation coating has excellent anti-corrosion and anti-blood coagulation properties, and is widely applicable to anti-blood coagulation and anti-corrosion surface modification in the fields of medical instruments and the like.

The invention discloses a multi-layer composite thermal response battery diaphragm based on a basalt fiber reinforced substrate and a preparation method of the multi-layer composite thermal response battery diaphragm, and belongs to the technical field of lithium ion batteries. The diaphragm comprises the following structures: (a) a polypropylene (PP) matrix layer for providing electrolyte wettability and ionic conductivity; (b) the basalt fiber reinforced layer and the matrix layer are alternately overlapped, and the mechanical strength and the thermal stability of the diaphragm are remarkably improved through hot-pressing compounding; and (c) the intelligent temperature sensing hydrogel coating is formed by copolymerization of poly (N-isopropylacrylamide) (PNIPAm) and acrylamide (Am), reversible phase change of a temperature threshold of 50-70 DEG C is realized by adjusting a copolymerization ratio, an ion channel is closed at a high temperature to prevent thermal runaway, and ion conduction is recovered at a low temperature. The preparation method comprises the steps of material compounding, surface modification, hydrogel preparation, coating and the like. The lithium ion battery has excellent mechanical properties and a high-temperature self-protection function, and the safety and the reliability of the battery can be effectively improved.

The invention discloses a novel marine antifouling gel coating material. The novel marine antifouling gel coating material comprises an antifouling gel monomer, a hardness modifier, an initiator and water, the antifouling gel monomer is an acrylamide series derivative compound or a polyethylene glycol derivative; the hardness modifier is a high polymer capable of providing a hydrogen bond donor or acceptor; the initiator is an organic initiator capable of initiating free radical polymerization of double bonds. The coating material provided by the invention is covalently bonded with an engineering bottom surface needing antifouling through a siloxane compound. A coating prepared from the marine antifouling hydrogel coating material provided by the invention has an excellent antifouling effect and also has excellent physical properties and adhesion strength, and the stability and durability of the antifouling coating can be ensured. In addition, due to the environmental friendliness of the material, the material has a wider application range, and powerful support is provided for the anti-fouling requirement of engineering in the ocean field.

The invention belongs to the field of medical coatings, and particularly relates to a coating with anesthesia and antibacterial functions and a preparation method thereof. The preparation method comprises the following steps: (I) preparation of a substrate coating, (II) preparation of a drug-loaded hydrogel coating, and (III) preparation of the coating with anesthesia and antibacterial functions. According to the preparation method, on one hand, the problems that nano-particles are insufficient in drug loading capacity, easy to fall off, irritant, non-uniform in release and the like are solved, and on the other hand, the problem that the long-term release performance of hydrogel is not ideal is solved. A plurality of functions (anesthesia and antibiosis) are integrated by pre-treating a substrate material (such as a medical catheter), a commodity suitable for multiple scenes can be prepared, the clinical use is convenient, the adverse reaction of an organism can be greatly reduced, and the risks of secondary intubation and tracheotomy are reduced.

The invention discloses a hydrogel coating for a hemodialysis catheter as well as a preparation method and application of the hydrogel coating. The functional hydrogel coating material is prepared from substances such as polyvinyl alcohol, acrylamide and sulfobetaine methacrylate in a thermal polymerization manner. The invention further discloses application of the hemodialysis catheter coating to improvement of lubrication, antibacterial and anticoagulation functions of a hemodialysis catheter, and the hemodialysis catheter coating has good stability and blood compatibility. Experimental results show that the hydrogel coating technology of the hemodialysis catheter can significantly improve the lubrication, bacterial adhesion resistance and thrombosis resistance functions of the hemodialysis catheter, and shows excellent bonding strength and blood compatibility.

The invention discloses an anti-sticking nozzle hydrogel coated particle and a preparation method and application thereof, the anti-sticking nozzle hydrogel coated particle comprises hydrogel particles and a coating layer from inside to outside, the mass of the hydrogel particles accounts for 50%-99% of the total mass of the anti-sticking nozzle hydrogel coated particle, and the coating layer accounts for 50%-99% of the total mass of the anti-sticking nozzle hydrogel coated particle. The coating layer accounts for 1%-50% of the total mass of the anti-sticking hydrogel coating particle; the coating layer comprises a film-forming substrate and a plasticizer, the film-forming substrate accounts for 50-100% of the mass of the coating layer, the plasticizer accounts for 0-50% of the mass of the coating layer, and the coating layer of the prepared anti-sticking hydrogel coating particle is insoluble in the oral cavity within a short time. According to the invention, the hydrogel particles are coated by a film coating technology, so that the defects that the hydrogel particles are easy to stick to the mouth when being directly drunk and easy to absorb moisture when being exposed to air for a short time are overcome, the original water swelling performance of the hydrogel particles is not influenced, and the taste of the hydrogel particles is improved.

The invention discloses a piezoelectric double-network hydrogel coating modified titanium material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The piezoelectric double-network hydrogel coating modified titanium material provided by the invention comprises a titanium substrate, an adhesion layer and a piezoelectric double-network hydrogel coating, wherein the adhesion layer and the piezoelectric double-network hydrogel coating are compounded on the titanium substrate; the adhesion layer is compounded on the titanium substrate, and the adhesion layer is positioned between the titanium substrate and the piezoelectric double-network hydrogel coating; and the piezoelectric double-network hydrogel coating is prepared from methacrylic acid modified gelatin, sodium alginate and whitmanite nanoparticles. According to the prepared modified titanium material, electric signals can be generated on the surface of the piezoelectric material under the action of polarization or stress, recovery of charge transfer of a bone defect part is facilitated, a good electroactive microenvironment is created for bone regeneration, the osseointegration capacity of the modified titanium material is enhanced, and bone regeneration is effectively promoted; the method has a wide application prospect in preparation of bone graft materials and bone repair materials.

The invention discloses a preparation method and application of an environment-friendly easily-degradable hydrogel coating, and relates to the technical field of hydrogel coatings. The coating is a coating comprising chitosan, acrylic acid, sericin, silk fibroin, silk peptide, tea polyphenol, a photoinitiator, a plasticizer and a leveling agent. The preparation method comprises the following steps: (1) preparing the coating containing the components; (2) coating the surface of food packaging paper with the coating liquid in a slit coating manner; and (3) performing ultraviolet light initiation to obtain the coating. The hydrogel coating has a synergistic effect with the sericin, the silk fibroin, the silk peptide and the tea polyphenol to form a compact and uniform network structure, so that the water-retaining property, the mechanical strength, the flexibility and the antibacterial property are enhanced; the preservative not only has the advantages of environmental protection and degradability, but also has the functions of moisturizing, antibiosis and preservation, and can significantly prolong the shelf life of food and improve the quality. The environment-friendly packaging paper is applied to food packaging paper, not only conforms to the green packaging trend, but also expands the use scenes of environment-friendly materials in the fields of fresh food, baking and the like.

The invention discloses a medical catheter surface strong interface bonding hydrogel coating method based on subsurface initiated polymerization. The method comprises the steps that firstly, a mixed solvent of an organic solvent and water is adopted for conducting swelling pretreatment on the surface of a catheter base material, so that polymer chains on the surface layer of the base material are relaxed; a solution containing initiator molecules is injected into the inner cavity of the catheter, so that the initiator is diffused and anchored in the subsurface area of the base material; preparing a hydrogel monomer solution containing a hydrophilic monomer, a cross-linking agent and a catalyst, and pouring the hydrogel monomer solution into the inner cavity of the catheter; and finally, sealing the two ends of the conduit, and initiating polymerization reaction under a specific temperature condition, so that the initiator anchored on the subsurface is decomposed to generate free radicals. The hydrogel coating and the catheter base material form a double combination effect of physical interlocking and chemical bonding through a subsurface initiated polymerization mechanism, the firmness and stability of the coating are remarkably improved, and the method is particularly suitable for modification of the inner surfaces of various medical catheters with complex structures.

The invention discloses an antibiotic-loaded lubricating antibacterial medical coating as well as a preparation method and application thereof. The preparation method comprises the following steps: coating a polymer substrate embedded with an initiator with a prepolymer solution, and carrying out ultraviolet irradiation reaction to prepare a lubricating hydrogel coating; the preparation method comprises the following steps: sequentially carrying out ultrasonic cleaning in an ethanol solution and an aqueous solution, drying, soaking in an antibiotic solution, regulating and controlling the loading capacity of antibiotics by controlling the pH value of the antibiotic solution, taking out, washing with the aqueous solution, and drying to obtain the lubricating antibacterial coating. According to the method, a hydrogel coating loading platform for loading the antibiotics only through post-adsorption is constructed, the loading capacity of the antibiotics in the coating can be regulated and controlled through the pH value of an antibiotic solution in the post-adsorption process, and the method effectively widens the adjustable range of the loading capacity of the antibiotics such as rifampicin; according to the invention, on-demand regulation and control of antibiotic load and related release curves in the hydrogel coating under different application scenes can be realized, and an effective multifunctional strategy is provided for reducing related infection of interventional medical catheters.

The invention discloses a hydroxyapatite microbead capable of loading multiple active components and a preparation method thereof, and relates to the technical field of biomedical material preparation, the hydroxyapatite microbead comprises the following raw materials: hydroxyapatite micron powder, an active composition containing hyaluronic acid, and a hydrogel coating of fucoidin; the preparation method comprises the following steps: performing amination modification on hydroxyapatite micron powder, dispersing the hydroxyapatite micron powder in an active composition containing hyaluronic acid, performing freeze drying to obtain a hydroxyapatite microbead precursor capable of loading multiple active components, and grafting a hydrogel coating of fucoidin on the surface of the hydroxyapatite microbead precursor capable of loading multiple active components, so as to obtain the hydrogel coating. The hydroxyapatite microbeads capable of loading the multiple active ingredients are obtained. The hydroxyapatite microbead capable of loading multiple active components provided by the invention has excellent drug loading rate and dispersion stability, the average particle size reaches 1-10mm, and the hydroxyapatite microbead adapts to the application requirements of tissue repair.

The invention discloses an antibacterial and antithrombotic medical catheter and a preparation method thereof. According to the medical catheter, a hydrogel coating is prepared on the surface of the medical catheter, the hydrogel coating contains a three-layer structure, and the medical catheter has low swelling property and excellent mechanical property, stability, durability, platelet adhesion resistance, antibacterial property and biocompatibility. The preparation method disclosed by the invention is simple, efficient and environment-friendly; the dopamine layer provides strong adhesion performance, glucose oxidase entrapped in FDA provides longer-term antibacterial performance, and finally the carboxylic acid betaine zwitterionic coating is introduced to further enhance the antithrombotic performance of the hydrogel coating, so that the hydrogel coating medical catheter is produced. The invention provides a new strategy for the low-expansion amphiphilic ion hydrogel coating with antithrombotic and antibacterial properties in the field of biomedical materials, especially as a medical catheter, and the coating can be applied to biomedical equipment in contact with blood.

The invention relates to the technical field of biomedical materials, and discloses an active oxygen responsive hydrogel coating for resisting vascular restenosis as well as a preparation method and application thereof, the active oxygen responsive hydrogel coating is a hydrogel coating obtained by crosslinking an active oxygen responsive-scavenging polymer prodrug and dopamine modified oxidized dextran; the hydrogel coating is transferred to the inner wall of a blood vessel along with high-pressure expansion of the balloon, responsively degrades under the stimulation of excessive active oxygen in lesion tissues, releases antioxidant drugs, effectively removes local excessive active oxygen, improves the inflammatory microenvironment and inhibits restenosis of the blood vessel.

The invention discloses a synergistic dual-mode anticoagulation and anti-inflammatory central venous catheter BC-BCD double-layer bionic hydrogel coating and a preparation method thereof. BSA / CBAA hydrogel formed by copolymerizing bovine serum albumin and carboxyl betaine acrylamide is used as an outer coating of the catheter, dopamine containing catechol groups is introduced as a main chain network, and BSA / CBAA / DA hydrogel is obtained and used as an inner coating of the catheter. The two layers are combined through a two-step impregnation method to obtain the BC-BCD double-layer bionic coating, thrombus can be defended on a catheter interface in an active mode and a passive mode, oxidation factors in a body can be removed, oxidative stress and bacterial infection can be reduced, and the BC-BCD double-layer bionic coating can be tightly attached to a base material. Experimental results show that the prepared bionic hydrogel coating has excellent anticoagulation and anti-inflammatory performance and long-term stable adhesion performance, the main defects of a traditional central venous catheter are remarkably overcome, and the bionic hydrogel coating has a positive effect on clinical prevention of thrombus and infection.

The present invention relates to the preparation and application of a highly water-absorbent hydrogel for heat dissipation of a solar cell back panel. A monomer solution is first prepared, and then an initiator solution is prepared. The monomer solution and the initiator solution are then mixed to obtain a hydrogel prepolymer solution. The hydrogel prepolymer solution is used to cast and gel the solar cell back panel, and finally a highly water-absorbent hydrogel coating is prepared on the solar cell back panel. The water content in the hydrogel coating can be as high as 90% or more. Since water has the highest latent heat (~40 kJ mol ‑1 ), water evaporation can take away a lot of heat, thereby achieving the purpose of heat dissipation. Therefore, the present invention can effectively improve the heat dissipation performance of the solar cell back panel by adding a highly water-absorbent hydrogel coating to the solar cell back panel, and can achieve continuous heat dissipation for a long time.

The invention discloses a biomedical polymer-based wound infection indicating dressing material as well as a preparation method and application thereof, and the dressing material is obtained by modifying a pH responsive dye, performing graft polymerization on the modified pH responsive dye, a cross-linking agent and hydrophilic monomer free radicals to form a hydrogel coating, and then wrapping the hydrogel coating on a biomedical polymer material. The material has a pH responsive infection indication function, can amplify a wound infection condition which is not easy to detect into a color change which is intuitive and distinguishable by naked eyes, can meet the requirement of monitoring the skin wound infection condition in actual clinical application, is beneficial to early detection of wound infection, and has a wide application prospect. And the preparation method can maintain the original texture of the biomedical polymer material to the greatest extent and reduce the risk of dye exudation, and the preparation process is conventional and easy to operate and has wide engineering prospects.

The invention provides a method for firmly modifying the surface of a medical catheter with a hydrophilic lubricating antibacterial hydrogel coating, which comprises the following steps: immersing the cleaned medical catheter in a waterborne polyurethane solution, taking out the medical catheter, and drying the medical catheter in a drying oven to obtain the medical catheter with the surface coated with a waterborne polyurethane layer; the medical catheter with the surface coated with the waterborne polyurethane layer is soaked in the pre-gel solution, the base material is taken out of the solution, and the hydrophilic lubricating antibacterial hydrogel coating is formed on the surface of the medical catheter through ultraviolet-initiated polymerization. The hydrogel coating prepared by the invention shows strong interface bonding force with the surface of the medical catheter due to the existence of the waterborne polyurethane layer, and has good hydrophilicity (WCA = 24.6 degrees) and lower surface friction coefficient (COF = 0.05) at the same time. In addition, the hydrogel coating has excellent antibacterial performance on escherichia coli (gram-negative bacteria) and bacillus subtilis (gram-positive bacteria) under the synergistic effect of zinc sulfate heptahydrate and quaternary ammonium salt chitosan. The problems of firm modification, hydrophilic lubrication and antibiosis of the hydrogel coating in surface functionalization of the medical catheter are solved.

The invention discloses a method for in-situ rapid growth of a dual-network hydrogel coating on the surface of a base material by a one-step method, which comprises the following steps: putting the base material with an adhesion initiation layer on the surface into a hydrogel precursor solution, and carrying out in-situ polymerization for 0.1-10 minutes under light irradiation, wherein the adhesion initiation layer comprises an adhesive compound based on a catechol group and a first photoinitiator, and the hydrogel precursor solution comprises a natural polymer containing tyrosine, an acrylic monomer, a cross-linking agent and a second photoinitiator, and wherein the first photoinitiator and the second photoinitiator are different from each other and are independently selected from a divalent ruthenium compound and a persulfate. Compared with the prior art, the natural / synthetic polymer double-network gel coating with biological activity and mechanical property can grow on the surfaces of different substrates more quickly and efficiently through a one-step method; and the base material, the surface of which is modified by the in-situ grown double-network hydrogel coating, obtained by the method can be applied to in-vivo medical apparatuses and instruments.

The invention discloses an orthopedic implant with antibacterial and osteogenesis-promoting characteristics and a preparation method thereof, and belongs to the technical field of medical materials.The preparation method comprises the steps that a titanium stent subjected to acid treatment is placed in a NaOH solution, and a sodium titanate coating is formed on the surface of the titanium stent after alkali heat treatment; after annealing, immersing into a mixed solution of EDTA-CaNa2 and NaH2PO42H2O, and after heating reaction, forming a hydroxyapatite coating on the surface of the sodium titanate coating; immersing the hydroxyapatite coating into a mixed solution of glucolactone and sodium alginate, controlling the pH value of the mixed solution to be 5, and forming a porous hydrogel coating on the surface of the hydroxyapatite coating after reaction; and soaking the loaded medicine to obtain the orthopedic implant. A multi-layer structure of the sodium titanate coating, the hydroxyapatite coating and the porous hydrogel coating is sequentially formed on the titanium alloy stent, and finally, the medicine is loaded, so that the titanium alloy stent has various characteristics of resisting bacteria, promoting osteogenesis and the like.

The invention discloses a pure zwitter-ion dual-network hydrogel coating and a preparation method and application thereof, firstly, a PU substrate is immersed in an acetone solution of a hydrophobic photoinitiator 2959, at the moment, the photoinitiator 2959 is diffused into the swollen PU substrate, and a 2959-PU diffusion layer is formed; then, SBMA monomers in a first network pSBMA precursor solution (high monomer concentration and low cross-linking agent proportion) spread on the surface permeate into the 2959-PU diffusion layer, and under the condition of ultraviolet irradiation, pre-gel solutions between interfaces and on the surface are polymerized at the same time to form a firm pSBMA single-network hydrogel coating (pSBSN-PU). Wherein the hydrophilic photoinitiator 1173 is used for forming pSB hydrogel, the hydrophobic photoinitiator 2959 is used for mediating polymerization of an SBMA monomer in an interface and forming a winding structure with a PU chain, and firm adhesion of the coating is due to chain entanglement of pSBMA and a PU substrate.

The invention discloses a preparation method and application of a biomimetic mineralized hydrogel coating with high adhesiveness, and relates to the technical field of bone implant surface modification. The method comprises the following steps: immersing a bone implant subjected to surface pretreatment into a polyvinyl alcohol solution, then carrying out single freezing and thawing cycle, and then carrying out annealing treatment, alternately soaking the annealed bone implant in a calcium-containing solution and a phosphorus-containing solution, and carrying out surface mineralization treatment; then, inducing a product subjected to surface mineralization treatment to obtain hydroxyapatite; the biomimetic mineralized hydrogel coating with strong adhesiveness is obtained on the surface of the bone implant. According to the method, the surface of the bone implant is coated with the strong-adhesion hydrogel coating by adopting a dip-coating method, and the thickness and the surface flatness of the coating can be controlled by adjusting the dip-coating frequency.

The invention discloses a double-layer hydrogel stent capable of releasing medicine in time sequence as well as a preparation method and application of the double-layer hydrogel stent. The scaffold comprises an inner hydrogel and an outer hydrogel coating the inner hydrogel, the outer hydrogel is loaded with cell factors, and the cell factors have the following effects of collecting neutrophils and promoting polarization of the neutrophils into subtypes with stem cell collection; the inner layer hydrogel is loaded with neurotrophic factors. According to the hydrogel scaffold, ordered slow release of cell factors (such as IL-8) and neurotrophic factors (such as NGF) is achieved through the structural design of the inner hydrogel layer and the outer hydrogel layer, neutrophils and sensory nerves can be activated in sequence in a bone defect area, the neutrophils are collected in the defect area, stem cell homing is promoted, and osteogenesis is started; then, local sensory nerves are induced to grow in through the lagged and continuously released NGF, the sensory nerves are stimulated to play an immune regulation role, inflammation dissipation is promoted, and finally repair and regeneration of refractory bone defects are promoted.

The present invention belongs to the field of material technology, and discloses a hydrogel coating, a spraying method and an application. The spraying method comprises the following steps: (1) Using a high-voltage electrostatic spray gun, spraying hydrogel coating powder on the surface of a substrate material; (2) Spraying a solution on the surface of the substrate material to redissolve the hydrogel coating and form a hydrogel coating. In the present invention, the hydrogel coating powder is electrostatically adsorbed and sprayed on the surface of the substrate by electrostatic spraying first, and then water is sprayed to redissolve it. The hydrogel undergoes preliminary self-gelation through hydrogen bond action and binds to the base material, and then further binds through dynamic covalent bonds to form a hydrogel coating. The coating conditions are simple, the coating is fast, and there is no need for ultraviolet light irradiation, anaerobic environment, heating, molds, etc. during the coating process, breaking through the limitations of the polymerization and crosslinking conditions of hydrogels on traditional hydrogel coatings.

The invention discloses a method for preparing a medical catheter by using a hydrogel coating with effective lubrication, long-term antibiosis and antithrombosis. The method comprises the following steps: mixing a vinyl monomer, a vinyl modified monomer, a cross-linking agent and a photoinitiator to form a hydrogel pre-polymerized solution; the preparation method comprises the following steps: carrying out base catalysis balance, grafting a silane coupling agent with double bonds on the surface of a conduit, and immersing the conduit into an ethanol solution containing a hydrophobic initiator, so that the hydrophobic initiator permeates into a substrate for carrying out a subsequent photocuring reaction. The prepared hydrogel pre-polymerized solution covers the surface of a base material with double bonds on the surface, and the medical catheter material with a hydrogel coating which is effective in lubrication, antibacterial for a long time and resistant to thrombosis is obtained through ultraviolet cross-linking curing. A double-bond reactive group is bridged on the surface of a base material through a base catalysis equilibrium method, a bonding layer is formed on the surface, and the double-bond group contained in the bonding layer is covalently connected with a hydrogel coating, so that tight combination between a polymer network and a solid surface is realized.

The invention belongs to the technical field of food fresh-keeping and antibacterial materials, and discloses a preparation method and application of a bamboo cellulose-based sprayable hydrogel fresh-keeping film. According to the system, bamboo cellulose is used as a structural support and cooperates with epsilon-polylysine and bamboo polyphenol, and a hydrogel coating with physical barrier, antibacterial and antioxidant functions is formed on the surfaces of fruits and vegetables through in-situ self-assembly and calcium ion crosslinking. The method comprises the following steps: compounding sodium alginate, carboxymethyl chitosan and a bamboo fiber nano dispersion liquid, and adding epsilon-polylysine and bamboo polyphenol to prepare a functional spray; a calcium chloride solution is sprayed after spraying, and a stable and transparent hydrogel film with high adhesive force is rapidly formed through ionic crosslinking. The technical process is simple and convenient, the film forming speed is high, the components are natural, and industrial spraying is easy. Verified by fruits and vegetables such as bananas and the like, the coating can effectively delay decay, and the application blank of the nano bamboo cellulose in a spray fresh-keeping carrier is filled.

In certain embodiments, the present disclosure provides medical graft devices having covalently crosslinked matrix protein hydrogel coatings. In some forms, such coatings are configured to reduce the formation of adhesions upon implantation.

A polyelectrolyte hydrogel coating with strong substrate binding performance and a method of manufacturing the same are provided. The method includes: 1) activating a substrate by applying oxygen plasma; and 2) dissolving a polycationic polymer, a polymeric monomer, a silane coupling agent and an initiator to obtain a precursor solution, vacuumizing the precursor solution to remove air bubbles, applying the vacuumized precursor solution to a surface of the substrate activated by the oxygen plasma, and performing an in-situ polymerization and curing process under nitrogen or rare gas atmosphere. The polymeric monomer includes at least one of: acrylamide, acrylic acid, hydroxyethyl methacrylamide, 2-acrylamido-2-methyl-1-propanesulfonic acid, polyethylene glycol (diol) diacrylate, 2-methacryloxyethylphosphocholine, 3-[[2-(Methacryloyloxy)ethyl]dimethylammonio]propane-1-sulfonate, and 3-[[2-(methacryloyloxy)ethyl]dimethylammonium] propionate. The silane coupling agent has a carbon-carbon double bond functional group.