185 results about "Hydrogel coating" patented technology

Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and a water soluble polymer in the solvent, evaporating the solvent to provide a polymeric coating on the wire, and crosslinking the polymeric coating to provide a hydrogel coating layer on the wire. The coated wire can be fabricated into stents, which preferably have substantially uniform coatings with low surface roughness. Preferably the coatings have hydrophilic properties and provide a biocompatible surface. The coatings may also provide for the delivery of biologically active agents into the body.

The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.

The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.

A microflow device for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts which are arranged across the width of a collection region in an irregular or set random pattern so as to disrupt streamlined flow. Sequestering agents, such as Abs, are attached to all surfaces in the collection region via a hydrophilic permeable hydrogel coating. The collection region is formed as a cavity in a body molded from PDMS, which flexible body is sandwiched between a glass slide or comparable flat plate and a rigid top cap plate, both of which are pressed into abutting relation with the PDMS body by a heat-shrunk polymeric sleeve. Following cell separation and washing, cells can be released from the sequestering agents and the device centrifuged to force said cells to collect adjacent the hydrogel-coated slide or plate. Slitting the polymeric sleeve allows the body to then be peeled from the slide or plate, using an integral tab, to expose the separated cells on the top surface thereof for ready microscopic examination.

A microflow device for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts which are arranged across the width of a collection region in an irregular or set random pattern so as to disrupt streamlined flow. Sequestering agents, such as Abs, are attached to all surfaces in the collection region via a hydrophilic permeable hydrogel coating. The collection region is formed as a cavity in a body molded from PDMS, which flexible body is sandwiched between a glass slide or comparable flat plate and a rigid top cap plate, both of which are pressed into abutting relation with the PDMS body by a heat-shrunk polymeric sleeve. Following cell separation and washing, cells can be released from the sequestering agents and the device centrifuged to force said cells to collect adjacent the hydrogel-coated slide or plate. Slitting the polymeric sleeve allows the body to then be peeled from the slide or plate, using an integral tab, to expose the separated cells on the top surface thereof for ready microscopic examination.

Disclosed herein is an elastomeric article having a hydrogel donning coating. The hydrogel donning coating is made of a copolymer of hydroxy ethyl acrylate (HEA), hydroxy ethyl methacrylate (HEMA), and acrylic acid. The hydrogel donning coating is applied to the elastomeric article using an aqueous hydrogel dipping solution containing the hydrogel donning coating copolymer. The aqueous hydrogel dipping solution demonstrates thixotropic characteristics which allows for better manufacturing process control.

The invention encompasses a modified proppant comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant. The invention also encompasses formulations comprising the modified proppant as well as methods for the manufacture and methods for the use of the modified proppant.

The invention encompasses a modified proppant comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant. The invention also encompasses formulations comprising the modified proppant as well as methods for the manufacture and methods for the use of the modified proppant.

Spheroidal beads present an exterior surface of a hydrophilic hydrogel, which is an isocyanate-functional polymer that is polymerized by urethane bonds and cross-linked by urethane and urea bonds. Sequestering agents present at the surface are covalently bound to isocyanate groups or to intermediate linkers that are so bound. These beads allow sequestering agents to retain their native three-dimensional configuration, and as a result of such surface characteristics and hydrophilicity, they achieve highly effective capture of very small subpopulations of rare cells from bodily fluids or the like and very effectively deter nonspecific binding of other biomaterials present in such bodily fluid. They may be all-hydrogel spheroids or hydrogel-coated substrates.

Spheroidal beads present an exterior surface of a hydrophilic hydrogel, which is an isocyanate-functional polymer that is polymerized by urethane bonds and cross-linked by urethane and urea bonds. Sequestering agents present at the surface are covalently bound to isocyanate groups or to intermediate linkers that are so bound. These beads allow sequestering agents to retain their native three-dimensional configuration, and as a result of such surface characteristics and hydrophilicity, they achieve highly effective capture of very small subpopulations of rare cells from bodily fluids or the like and very effectively deter nonspecific binding of other biomaterials present in such bodily fluid. They may be all-hydrogel spheroids or hydrogel-coated substrates.

The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.

The present disclosure relates to the field of endovascular treatment. More particularly, the present invention uses a modified hydrogel intrasaccular occlusion device designed to implement an endovascular treatment to ameliorating or eliminating aneurysm recurrence, which hydrogel may optionally be impregnated with pharmaceutical compounds. The present invention also teaches the use of thin hydrogel coatings to ameliorate endovascular treatment related difficulties.

The present invention provides hydrogel coated, implantable medical devices and methods of coating hydrogels onto implantable medical devices. In one embodiment, a hydrogel coated medical device is formed by physically treating a surface of the medical device, chemically treating the surface, applying a hydrogel precursor and then crosslinking the hydrogel precursor to form a hydrogel coating on the surface of the medical device. The present invention may be particularly applicable for coating articulating surfaces on implantable medical devices such as artificial joints.

The invention provides for modified proppants, comprising a proppant particle and a hydrogel coating, wherein the hydrogel coating localizes on the surface of the proppant particle to produce the modified proppant, methods of manufacturing such proppants and methods of use.

The invention discloses a responsive oil and water separation net film with an underwater super lipophobicity property and a preparation method thereof. The method comprises the following steps of: (1) dissolving a polymer monomer, a photoinitiator, a cross-linking agent and a thickening agent in water so as to obtain a mixed solution; (2) soaking a fabric net in the mixed solution; and (3) taking out the fabric net, carrying out a polymerization reaction on the soaked fabric net in ultraviolet light the wavelength of which is 365nm so as to obtain a polymer hydrogel coating layer in the fabric net, and then obtain the responsive oil and water separation net film with the underwater super lipophobicity property. The responsive oil and water separation net film with the underwater super lipophobicity property, provided by the invention, has the advantages that the oil-contaminated water can be separated, meanwhile, the temperature and pH dual responsive characteristics are realized, the controllable oil and water separation is realized, a separation device is simplified, and the separation cost is saved.

An elastomeric article (e.g., glove, condom, and so forth) coated with a hydrogel is provided. The hydrogel coating facilitates dry and / or damp donning. In addition, due its low coefficient of friction, the hydrogel allows stripping of a dip-formed article without the use of an antiblocking powder. Thus, the present inventors have discovered that certain treatment steps, such as chlorination and / or lubrication, conventionally conducted “off-line” (i.e., after stripping) are no longer required. Moreover, even when such treatments are used, they may conducted “in-line” (i.e., before stripping). The ability to eliminate certain off-line treatment steps provides a significant improvement in the efficiency of the forming process.

The invention discloses a cryoablation probe shell covered by expandable hydrogel and a preparation method thereof. The cryoablation probe shell is characterized by comprising a cryoablation probe shell made of metal and a hydrogel coating covering the probe shell, wherein the cryoablation probe shell comprises integrated working section and non-working section; the hydrogel coating is uniformly coated on the non-working section of the cryoablation probe shell, and the thickness of the hydrogel coating is 50 mu m to 500 mu m. The hydrogel coating comprises degradable porous hydrophilic hydrogel and absorbs water to rapidly expand to form a hydrogel isolating membrane to isolate the cryoablation probe from normal tissue, and plays the function of protecting the normal tissue of a non-target area.

The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning / disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon. This method has a minimized adverse impact on the mechanical properties of silicone hydrogel lens body.

A method for providing negative pressure wound healing in a deep wound having a cavity includes the steps of (a) fashioning at least a first part of a therapeutic dressing to fit generally within the cavity, (b) operably associating a fluid moving means with the therapeutic dressing for enabling one of compressing the therapeutic dressing and transferring fluid across at least part of the therapeutic dressing, and (c) enabling the fluid moving means in a manner to deliver therapy to the patient. A therapeutic member for use in negative pressure wound healing includes a porous member formed and includes a hydrogel coating on a side thereof.

A method of preparing a protein-resistant reactive solid support surface is disclosed. The method comprises the steps of providing a solid support having a hydrogel coating with a plurality of binding elements, coupling a protein resistant compound to the hydrogel via a first fraction of the binding elements, and coupling at least one binding agent to the hydrogel via a second fraction of the binding elements, whereby the protein resistant compound and the at least one binding agent are co-immobilized to the hydrogel. Also the use of the reactive surface in analysis, such as immunogenicity assays, is disclosed.

The invention relates to the field related to biomedical materials and medical apparatuses and in particular relates to a method for preparing a carbon nanotube composite conductive hydrogel coating modified electrode by adopting an electrophoretic deposition method. The method comprises the following steps of: 1. preparing carbon nanotube dispersion liquid; 2. preparing a carbon nanotube composite polymer sol body; 3. pretreating a metal electrode; 4. preparing a composite conductive hydrogel coating through electrophoretic deposition; and 5. crosslinking the composite coating and finally forming the carbon nanotube composite conductive hydrogel coating modified electrode, wherein the prepared electrode is put in phosphate buffered solution for standby use. The method has the advantages that various carbon nanotube surface treatment methods and various sol-gel phase transformation or crosslinking methods are adopted, thus solving the problems that the carbon nanotube and the composite material thereof are difficult to disperse in the water solution systems, are easy to agglomerate and have potential biosafety risks and the like.

A medical device, for example, an endoscope or catheter, includes local drug delivery capabilities for selectively delivering at least one drug in vivo. The local drug delivery may occur as the medical device is advanced through tortuous passageways of the patient's body or may occur after the medical device has reached its targeted destination. The medical device includes a drug agent, for example, carried in or on a hydrophilic or hydrogel coating disposed on the outside thereof. When the hydrogel or drug agent receives an appropriate signal, e.g., solution containing a triggering agent or triggering condition, e.g., heat or light, the hydrogel contracts or expands to squeeze out the drug from hydrogel. If electric current is provided as the signal, and the drug agent is charged, the drug agent is released by electrophoretic forces.

Articles such as catheters or balloons that have an ester-linked poly(ester-block-amide) substrate have a lubricious hydrogel coating which suppresses particle development under accelerated aging conditions. A polymerizable coating composition is applied to the substrate without application of an intervening primer layer and cured. The coating composition comprises an uncrosslinked polyvinylpyrrolidone polymer that is free of attached photoinitiator groups and at least one polyfunctional ethylenically unsaturated monomer.

The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.

An elastomeric glove that contains a hydrogel coating is provided. The present inventors have discovered that the hydrogel coating is capable of improving donning (damp and / or dry) and also imparting certain other benefits to a wearer of the glove. Specifically, the hydrogel coating includes an active agent that is retained within a crosslinked hydrogel network. When the hydrogel coating is exposed to an aqueous environment, it swells, allowing the active agent to diffuse through pores and contact the skin of a wearer.

A method is disclosed herein for treating a polymeric surface to define an improved cell culture surface. The method includes the steps of: coating the polymeric surface with a hydrogel; and attaching proteins to the hydrogel-coated surface. Advantageously, a method is provided which consistently produces improved cell culture surfaces that generally avoid bare spots and possible undesired protein absorption or cell differentiation.

The invention relates to a preparation method of an oil-water separation omentum with underwater ultra oleophobicity. The method comprises the steps that by using a woven fiber net of 400-2000 mesh as the substrate, and combining the inorganic nano particles with hydrogel, the surface roughness of the hydrogel is improved to enhance the surface hydrophilicity of the omentum; by using the method of photo polymerization, the meshes of the woven fiber net are coated with a hydrogel coating layer which has a nanocomposite structure and is formed with cross-linked polymer and inorganic nanoparticles, and then the oil-water separation omentum with underwater ultra oleophobicity is obtained. The oil-water separation omentum prepared by the method has the advantages of a large water flux, a fast speed of oil-water separation, and no need to modify the woven fiber net.

Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and a water soluble polymer in the solvent, evaporating the solvent to provide a polymeric coating on the wire, and crosslinking the polymeric coating to provide a hydrogel coating layer on the wire. The coated wire can be fabricated into stents, which preferably have substantially uniform coatings with low surface roughness. Preferably the coatings have hydrophilic properties and provide a biocompatible surface. The coatings may also provide for the delivery of biologically active agents into the body.

Medical devices with a hydrogel layer covalently attached to a portion of the outer surface of the medical device are provided along with methods for applying the coating. The hydrogel layer can include a first polymer species comprising polyethylene glycol (PEG) and a second polymer species. Examples of the second polymer species include PEG and polyacrylamide (PAM). The first and second species can be at least partially cross-linked. Methods for forming the hydrogel coatings on the medical devices are provided including nucleophilic conjugate reactions, such as Click reactions.