16 results about "Hydrogel coating" patented technology

The application discloses an interface-locked anti-swelling hydrogel coating mesh membrane and a preparation method and application thereof, and comprises the following steps: growing a tin dioxide particle layer on the surface of a stainless steel filter mesh in situ, depositing a polydopamine coating on the tin dioxide particle layer, coating an anti-swelling hydrogel coating on the polydopamine coating, and preparing the interface-locked anti-swelling hydrogel coating oil-water separation mesh membrane through heat curing and freeze-thaw cycles; the polydopamine in the mesh membrane has adhesion, and cooperates with sulfuric acid and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide to induce the Hofmeister effect, so that polyvinyl alcohol molecular chains are dehydrated and crystallized, a high-physical-crosslinking anti-swelling hydrogel coating is formed, strong interface bonding is provided, the micro-nano rough structure constructed by the tin dioxide particles and the introduced hydrophilic substances are combined, the problems of easy excessive swelling and interface delamination of the hydrogel coating oil-water separation mesh membrane are overcome, and long-acting and high-performance oil-in-water emulsion separation can be realized.

The present application belongs to the field of medical material surface functionalization, and particularly relates to a kind of nano drug-loaded hydrogel catheter coating and its preparation method and application.The present application utilizes PLGA to load antibiotic amikacin sulfate AMK or antibacterial peptide FK13-a1, synthesizes nanoparticle NP-AM and nanoparticle NP-FK, prepares NP-AM / FK@OMV nanoparticle complex with EcN OMV as carrier, then adds poloxamer-hyaluronic acid composite hydrogel to obtain NP-AM / FK@OMV-P / H nano drug-loaded hydrogel, and forms coating after coating and drying.The nano drug-loaded hydrogel coating provided by the present application has the characteristics of enzyme response, antibacterial, prevention of biofilm formation and low toxicity, has great application potential in inhibiting medical catheter surface biofilm, and has important significance for preventing and treating CAUTI, prolonging the use time of indwelling catheter, and reducing the discomfort of patients caused by frequent replacement of catheter.

The application discloses a phase change latent heat type natural gas hydrate resistant hydrophilic gel coating and belongs to the technical field of protective coating of oil and gas conveying pipelines. The coating is prepared by coating a hydrophilic gel coating containing a phase change calcium chloride hydrate on the inner surface of a pipeline and curing in situ by 365 nm ultraviolet light; the three-dimensional polymer network formed by AM and HEMA copolymerization stably locks the calcium chloride hydrate system and water molecules in the gel network through hydrogen bonds and metal ion coordination, and no leakage, salt precipitation or water loss occurs, and the performance is stable during long-term service; meanwhile, the preparation and curing process is simple, the in-situ curing can be carried out at room temperature by ultraviolet light, the curing time is short, the inner surface coating of the pipeline on site is suitable for rapid construction, the cost of large-scale application is low, the industry pain points of mechanical interlocking and cyclic failure of traditional super-hydrophobic coatings are solved, and the industrial application demand of deep sea oil and gas pipeline hydrate blockage prevention and control is met.

Described herein are hydrogel-coated surgical meshes and their use in hernia repair, reconstructive surgery, and other surgical procedures. In one aspect, the hydrogel-coated meshes comprise at least one antibiotic or antimicrobial agent for the treatment of hernia repair surgery. In one aspect, the hydrogel coated meshes provide localized, sustained antimicrobial activity for the treatment of surgical site infections. In one aspect, the hydrogel coated meshes provide localized, sustained prophylactic antimicrobial activity for the prevention of surgical site infections. In another aspect, the hydrogel coating may optionally include one or more additional therapeutic components, such as anti-inflammatory compounds or growth factors, to facilitate and enhance recovery following hernia repair, reconstructive procedures, or other surgeries.

This invention discloses a method for detecting copper ion concentration based on a hydrogel-coated PMPCF-MZI sensor and a fluorescence colorimetric dual-sensor. The detection device consists of a broadband light source, a single-mode optical fiber, a polarization controller, a flow cell, a PMPCF-MZI sensor, and a spectrometer. In the fiber optic detection path, light emitted from the broadband light source passes through the polarization controller and is input to the hydrogel-coated PMPCF-MZI, transforming into interference peaks of specific wavelengths. These peaks are displayed on the spectrometer. The hydrogel's volume and refractive index change after adsorbing copper ions, manifesting as a shift in the interference spectrum on the spectrometer. By comparing the relationship between different copper ion concentrations and the interference spectrum shift, rapid, accurate, and trace detection of copper ions in the aquatic environment is achieved. In the fluorescence detection path, the fluorescent detection solution is mixed with the test solution and irradiated with an ultraviolet lamp, inducing a change in fluorescence intensity, achieving visual qualitative detection. This invention employs a dual-system collaborative design, combining advantages such as simple structure, low detection limit, fast response time, easy operation, and high visualization. It has significant practical value and promising application prospects for rapid copper ion detection in the future.

This invention provides a method for preparing a deep vein catheter and its inner and outer walls with zwitterionic hydrogel coatings. The catheter of this invention includes: a catheter substrate; an adhesive coating covering the inner and outer walls of the catheter; an inner wall coating and an outer wall coating (4); wherein the inner wall coating and the outer wall coating are respectively fixed to the inner and outer surfaces of the catheter substrate by the adhesive coating; and both are zwitterionic hydrogel coatings. By simultaneously constructing this hydration barrier on the inner and outer walls of the catheter, this invention can block platelet adhesion and coagulation pathway activation from the initial stage of thrombosis; at the same time, the semi-interpenetrating network or microgel-reinforced structure significantly improves the mechanical stability and durability of the hydrogel, making it suitable for long-term indwelling catheters.

This invention discloses a near-infrared light-responsive thermo-electrically coupled titanium-based implant, its preparation method, and its application, belonging to the field of biomedical materials technology. The near-infrared light-responsive thermo-electrically coupled titanium-based implant provided by this invention comprises a porous titanium substrate and a composite hydrogel coating; the surface of the porous titanium substrate is sequentially disposed from the inside out with TiO2 / SrTiO3 heterojunctions, upconversion nanoparticles, and barium titanate nanoparticles; the upconversion nanoparticles are Yb. 3+ and Er 3+ Co-doped NaYF4 upconversion nanoparticles; a composite hydrogel coating is deposited on the surface of barium titanate nanoparticles, the composite hydrogel coating comprising MXene, pharmaceutically active ingredients, and a hydrogel carrier. This invention achieves synergistic coupling of photothermal and photoelectric-pyroelectric effects under near-infrared light irradiation by constructing a multi-layered synergistic structure on a porous titanium substrate, thereby synergistically realizing multiple functions such as promoting bone growth, antibacterial activity, and antitumor activity.

This invention provides a bio-synergistic rice seed anti-mold and preservation compound and a seed treatment and storage method. The invention utilizes a novel material system of "plant-derived antimicrobial peptides + probiotic polysaccharides + photoresponsive nano-TiO2," combined with liposome encapsulation, pH / humidity dual-responsive hydrogel coating, photoactivation treatment, and intelligent storage technology, to achieve highly efficient anti-mold and preservation of rice seeds. Experimental data show that the compound and related methods of this invention are significantly superior to single-component systems and existing technologies in terms of mold inhibition rate, seed vigor maintenance, environmental safety, and process scalability. A significant synergistic effect exists among the three components; it is not a simple additive effect, demonstrating outstanding inventiveness and practicality. It effectively solves the technical problems of "poor antibacterial effect, serious residues, low utilization rate, and difficulty in large-scale production" in existing rice seed anti-mold and preservation technologies, meeting the needs of green agricultural development.

This invention discloses a method for preparing Ga / Se dual-ion co-modified attapulgite and a corrosion-inhibiting multifunctional silk fibroin-based hydrogel coating. The preparation process is as follows: Attapulgite is activated and surface-modified with a hydrochloric acid solution of a certain concentration; gallium nitrate solution is added and the temperature is controlled; the reaction is carried out for a period of time to obtain Ga / Se dual-ion modified attapulgite; then, it is added to a silk fibroin aqueous solution of a certain mass fraction; subsequently, (1-hydroxyethylidene) bisphosphonic acid and glycine are added, mixed evenly, and coated onto a pretreated substrate, then dried at 37°C to form a film. Compared with the prior art, the hydrogel coating prepared by this invention has good corrosion inhibition, antibacterial, and osteogenic properties, and can be widely used in the surface protection of biomedical magnesium alloys and to impart multifunctionality to them.

This invention relates to the field of ecological protection technology, specifically to a seed composite, its preparation method, and its application. The invention provides a seed composite comprising, from the inside out, a core layer, a middle framework layer, and an outer water-retaining layer; the core layer is a stress-resistant seed; the middle framework layer is an organic-inorganic porous sludge material coating the core layer; and the outer water-retaining layer is a water-supplying sludge-based hydrogel coating the middle framework layer. The seed composite provided by this invention can not only effectively enhance the environmental stress resistance of plant seeds and ensure the survival rate of plants under harsh environmental conditions such as rocky desertification, but also compensate for problems such as insufficient water and nutrient supply, inadequate water and fertilizer retention capacity, and poor stability in rocky desertification soils, achieving the goals of windbreak and sand fixation, and soil improvement.

The present application provides a kind of polypeptide sustained-release hydrogel coating for preventing catheter urinary tract infection and its preparation method, the coating includes the adhesive bottom layer attached to the surface of catheter substrate, and the polypeptide sustained-release hydrogel functional layer compounded outside the adhesive bottom layer;The functional layer includes hydrophilic hydrogel gel-forming matrix, targeted antibacterial polypeptide, polypeptide sustained-release carrier and biocompatible auxiliary agent.The present application solves the interface bonding problem of hydrophobic catheter substrate and hydrophilic hydrogel through the adhesive bottom layer, the coating has strong adhesion, is resistant to urine immersion and rubbing;Through polypeptide sustained-release carrier, antibacterial polypeptide is released for 30 days, and there is no risk of burst release;The targeted antibacterial polypeptide used is specific to urinary tract infection pathogenic bacteria, has no drug resistance induction risk, has excellent biocompatibility, can effectively prevent catheter-related urinary tract infection caused by short-term and long-term indwelling catheter, the preparation process is simple and controllable, is suitable for large-scale production, and can be widely applied to antibacterial modification of urinary intervention medical devices.

This invention discloses a method for preparing a highly biocompatible and active filler and its application in water treatment, comprising the following steps: S1, matrix preparation; S2, hydrogel coating solution preparation; S3, coating; S4, surface treatment. This invention significantly improves the biocompatibility and microbial activity stimulation of the filler through coupled magnetic doping, pre-coating with active components, and surface plasma cleaning modification, thereby enhancing the efficiency of microbial metabolic activity enhancement. The resulting filler structure comprises: a polyethylene matrix + an NdFeB magnetic functional core + a biomimetic hydrogel signal coating + a plasma-modified surface, forming a multi-layered, multifunctional integrated filler.

The application provides a kind of polyarylether sulfone ketone surface biomimetic mineralization hydrogel coating, its preparation method and application in bone repair.The biomimetic mineralization hydrogel coating is obtained by simulating body fluid mineralization of hydrogel coating, and apatite layer is formed in the interior and surface of hydrogel coating, the hydrogel coating includes polymer network and calcium phosphate oligomer uniformly dispersed therein, which is anchored to the surface of polyarylether sulfone ketone base.The introduction of calcium phosphate oligomer effectively solves the problem of inorganic phase agglomeration and improves the uniformity of mineralization.The mineralized hydrogel coating can significantly promote the expression of osteoblast MC3T3-E1 osteogenic activity and inhibit the differentiation of RAW264.7 cells into osteoclasts.The biomimetic mineralization hydrogel coating described in the application has dual biological activity of promoting bone formation and inhibiting bone resorption, and is suitable for surface modification of polyarylether ketone bone implants, and has wide application prospect in the field of osteoporotic bone defect repair.

The application discloses a preparation method of an Omega-shaped hydrogel coating optical fiber sensor, and applies to the cross technical field of optical fiber sensing and food safety detection, and comprises the following steps: cutting an optical fiber, stripping a plastic coating at a middle position, and taking the prepared section as a preparation section of an optical fiber sensing area; selecting a corresponding size of a mandrel assembly hole in a preparation device, inserting a preparation mandrel, aligning the preparation section with a fire tank nozzle, preparing around the shaped mandrel, and obtaining an Omega-shaped optical fiber sensing area; performing gold target sputtering treatment on the optical fiber sensing area, immersing the optical fiber sensing area in a cationic photocuring hydrogel precursor solution, and irradiating under ultraviolet light to obtain an optical fiber sensing area with a hydrogel layer; immersing the optical fiber sensing area in a phage solution for incubation, immersing the optical fiber sensing area in a bovine serum albumin neutral solution for incubation at room temperature, and obtaining an Omega-shaped hydrogel coating optical fiber sensor. The prepared hydrogel coating optical fiber sensor has the characteristics of high sensitivity, direction recognition capability, structural stability, compactness and biological compatibility.

This invention relates to the field of soft matter material mechanical property testing technology, specifically to a method for evaluating the dynamic mechanical properties of hydrogel coatings based on in-situ optical observation. The method includes: preparing a hydrogel coating on a transparent substrate using a photocuring method; mechanically calibrating an in-situ optical tribometer; synchronous triggering and data acquisition of multiple parameters; dynamically calculating the actual contact area and transient deformation depth of the hydrogel coating under load; dynamic mechanical parameter calculation; and multi-mode mechanical property evaluation. This application applies a controllable normal load to the hydrogel coating and uses a two-color interferometry system to observe the contact area in real time, simultaneously acquiring load signals and interferometric image sequences. This overcomes the limitation of separating mechanical signals from microscopic morphology observation in traditional testing. Through rigorous synchronous triggering technology, it integrates the measurement of macroscopic mechanical response, mesoscopic contact morphology, and micro / nanoscale surface deformation.

The present disclosure relates generally to compositions and methods for generating hydrogel coatings on features. In some embodiments, hydrogel-coated features are prepared by horseradish peroxidase-mediated gelation of microspheres. Some embodiments relate to methods for generating hydrogel coatings using particle templated emulsification. The disclosure also relates to the use of hydrogel-coated features in arrays for spatial analysis of biological analytes in biological samples.