876results about "Male contraceptives" patented technology

A waterborne dispersion of a polyurethane polymer is disclosed, which is useful as a film having improved mechanical properties. More particularly, the film has properties comparable to rubber; including, a percentage elongation greater than 700%; a tensile strength greater than 3500 psi; a 100% modulus below 450 psi; a 300% modulus below 700 psi; and, a 500% modulus below 1500 psi. The film can be prepared in the absence of a solvent, thus making it attractive for a variety of protection products for medical and industrial applications such as gloves, condoms, catheters, and the like. The polymer is useful as a coating for textiles, such as backcoatings, fabric or fiber saturants, finishes, or transfer coatings, or other textile and non-textile applications where good elastomeric properties would be useful.

The invention described is directed to an intracorporeal occluding device having elements with non-traumatic ends and devices, systems and methods for occluding the lumens of anatomical passageways and/or for delivering drugs or other substances to the bodies of human or animal subjects.

A medical device including a body portion configured and dimensioned to be associated with a vessel of a patient and a responsive component associated with the body portion wherein the responsive component is switchable between a first configuration and a second configuration.

Disclosed are occluders and methods of their use. The occluders comprise shape-memory polymeric materials which, when heated above their crystalline melting temperatures, may be deformed from a first configuration into a second configuration. The occluder is then held in the deformed shape until it cools to a temperature below its crystalline melting temperature (T.sub.m) whereby it holds the deformed shape of the second configuration by virtue of the recrystallization of the polymeric occluder material. Upon reheating the occluder above its T.sub.m, the occluder will resume its original shape. In this manner, an occluder which has been deformed to reduce its diameter may be inserted into and positioned within a target lumen in the body and then allowed to warm to body temperature whereby it resumes its original diameter and results in the occlusion of the lumen. The occluders, according to preferred embodiments, may be used for reversible sterilization of mammals, among other surgical and non-surgical uses.

The invention is drawn to silane copolymers prepared from the reaction of one or more polyisocyanates with one or more lubricious polymers having at least two functional groups, which may be the same or different, that are reactive with an isocyanate functional group and with one or more organo-functional silanes having at least two functional groups, which may be the same or different, that are reactive with an isocyanate functional group and at least one functional group reactive with a silicone rubber substrate. The silane copolymer coatings of the invention are elastic, lubricious, and resist wet abrasion. They are useful as coatings for polysiloxane (rubber) and other difficult to coat substrates, especially for medical devices, such catheters.

The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect, various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment, beneficial substances may be delivered, according to certain embodiments, through the stratum corneum of the skin into the body. Beneficial substances include, but are not limited to, pharmaceutical agents, drugs, vitamins, co-factors, peptides, dietary supplements, and others. The beneficial effects disclosed include, for instance, relief of pain and inflammation, prevention and healing of ulcers of the skin, relief of headache, improved sexual function and enjoyment, growth of hair on the scalp, improving muscle size and/or function, removing body fat and/or cellulite, treating cancer, treating viral infections and others. A hostile biophysical environment may also be used in conjunction with systems and methods for increasing local blood flow, according to one set of embodiments. For example, by using a nitric oxide donor such as L-arginine, local blood flow may be increased, e.g., by transdermally delivering the nitric oxide precursor. The nitric oxide donor may be the sole cause of increased blood flow, or it may be supplemented with an adjunct such as theophylline.

A multi lumen endotracheal tube having a balloon cuff to seal a patient's trachea during intubation. The ET tube having a main lumen for the exchange of respiratory and medicinal gases consequent to a medical procedure, a secondary lumen for inflation of the balloon cuff, and a tertiary lumen for transmission of sound waves via air medium contained therein, permitting ausculatory monitoring of a patient's breath sounds during intubation and subsequent monitoring of cardiac and respiratory activity after sealing of the ET tube. The ET tube is particularly a adapted for utilization by an anesthetist by including temperature sensor to permit remote monitoring of body core temperature and body cavity ausculation of cardiac and respiratory activity.

There is provided a method for controlling a flow of fluid in the vas deferens in order to obtain a controlled male contraception. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the flow vas deferens, and stimulating the constricted wall portion to cause contraction of the wall portion to further influence the flow in the vas deferens. The method can be used for restricting or stopping the flow in the vas deferens, or for actively moving the fluid in the vas deferens, with a low risk of injuring the organ.

An inflatable structure comprising an inflation compartment defining an enclosed interior volume and an anti-reflux valve having an outlet end positioned in the interior volume. The anti-reflux valve includes an elongate inflation passage including opposedly facing film layers that are bonded to one another at their edges to form an interior gas flow channel. The elongate inflation passage is bonded to the inflatable compartment to form an opening for introduction of gas into the passage, for inflation of the inflation compartment, and arranged so that upon termination of gas flow into the interior volume, after pressure in the interior volume has been raised above exterior pressure on the inflatable compartment, gas pressure in the interior volume collapses the opposedly facing film layers against one another to form a seal against the interior volume gas pressure and maintain the inflation compartment in an inflated state.

The invention is drawn to silane copolymers prepared from the reaction of one or more polyisocyanates with one or more lubricious polymers having at least two functional groups, which may be the same or different, that are reactive with an isocyanate functional group and with one or more organo-functional silanes having at least two functional groups, which may be the same or different, that are reactive with an isocyanate functional group and at least one functional group reactive with a silicone rubber substrate. The silane copolymers of the invention can be used as coatings that are elastic when dry, lubricious when wet, and resist wet abrasion. These copolymers are useful as coatings for polysiloxane (rubber) and other difficult to coat substrates, especially for medical devices, such as catheters. These silane copolymers can contain active agents such as antimicrobials, pharmaceuticals, herbicides, insecticides, algaecides, antifoulants, and antifogging agents.

Isocyanate-functional polyurethane prepolymers and aqueous dispersions therefrom which are useful for the production of flat materials having excellent resistance to alcoholic solvents are described. The prepolymers are prepared by reacting:

• • A) an isocyanate selected from the group consisting of
    • i) an aliphatic and/or a cycloaliphatic isocyanate,
    • ii) a mixture of an aromatic isocyanate and an aliphatic and/or a cycloaliphatic isocyanate,
  • B) a di- or polyhydroxy compound having a number average molecular weight of from 700 to about 16,000, and
  • C) optionally, a dihydroxy and/or polyhydroxyl compound having a number average molecular weight of less than 700, with the provisos that
    • a) at least one of components A), B or C) has a functionality of more than 2 and
    • b) if both component A) and component B) are difunctional, component C) cannot be a trihydroxy component of the formula:

R—(OH)₃

 where R is a saturated straight chain or branched chain aliphatic group of from 2 to 8 carbon atoms.