216results about How to "Prevent and reduce risk" patented technology

A topical otic composition containing an azalide antibiotic. A topical otic composition containing an azalide antibiotic and an medicament. A topical otic composition containing an azalide antibiotic and a polymer suspending agent. And methods for treating or preventing infections in the ear using azalide antibiotic compositions.

An implant for performing interbody fusion within a human spine, inserters for such an implant, and associated methodology. The implant is preferably formed in situ from at least two separate but lockable members (a base member and a closure member). The base member may be implanted into an interbody space first, after which the end plates may be finally prepared and the base member packed with fusion promoting substances before engaging and locking the closure member. The closure member provides structural support for the adjacent vertebral bodies (along with the base member) and may be selected after implantation of the base member having a specific length, width, height, taper, etc. . . . to ensure an optimal sizing of the implant for desired restoration of disc height, coronal taper, sagittal taper, etc. . . . .

There is provided methods, kits, combinations, and compositions comprising a Aspergillus oryzae protease enzyme, a Bacillus subtilis protease enzyme, and a Aspergillus niger lipase enzyme for treating a digestive disorder in a subject in need thereof. The methods, kits, combinations, and compositions may also be used along with an agent (or combination of agents) for raising the gastric pH, a digestive enzyme useful in enhancing digestive activity, a dietary supplement, or a pharmaceutical agent.

Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastic sites. Personalized dosing regimens are also provided to treat diseases such as cancer efficaciously with reduced adverse side effects.

The present invention provides compounds and methods for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Method and apparatus for beverage extraction needle side holes or apertures. The leading and trailing edges of the apertures may be shaped or otherwise configured to help reduce the possibility of coring or shearing of material as the needle is inserted into and/or withdrawn from material, such as a cork. Convex leading and/or trailing edges may help deflect material away from the aperture, reducing shearing. Concave leading and/or trailing edges may help prevent entry of material into the aperture, again reducing shearing.

A control apparatus for a vehicular drive system including an electrically controlled differential portion having a differential mechanism, and an electric motor which is operatively connected to the differential mechanism and an operating state of which is controlled to control a differential state between input and output shaft speeds, and a transmission portion constituting a part of a power transmitting path between the differential portion and a vehicle drive wheel, the control apparatus including a differential-state switching portion for switching the differential portion between differential-state and non-differential states, a shifting control portion for controlling a shifting action of the transmission portion, and a learning control portion for effecting learning compensation of a control amount of a control element to be controlled during the shifting action, wherein the learning control portion includes a differential-state learning control portion operable to implement the learning compensation of the control amount of the control element when the shifting action takes place in the differential state of the differential portion, and a non-differential-state learning control portion operable to implement the learning compensation when the shifting action takes place in the non-differential state of the differential portion, and the shifting control portion controls the shifting action in a presently selected one of the differential and non-differential states of the differential portion, on the basis of the learning compensation implemented by one of the differential-state and non-differential-state learning control portions which is operable in the other of the differential and non-differential states of the differential portion.

A method and a system in an agricultural machine for the coordination of agricultural machines when refilling substance intended to be disseminated over an agricultural field by generating coordination data indicative of an optimum refill location, comprising a level sensor arranged for generating level data, said level data indicating a volume of a substance in a substance reservoir; a position sensor for generating and storing position data and storing or reading a preplanned route; a communication device arranged for transmitting and receiving data; characterised by: a coordination device generating coordination data, based on said level data, said preplanned route and said position data; and transmitting said generated coordination data via the communication device to a refill vehicle.

The present invention relates to a method for the prognosis of bone metastasis in HER2+ breast cancer, which comprises determining if the MAF gene is amplified in a primary tumor sample. Likewise, the present invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the MAF gene expression level, amplification or translocation. The present invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The present invention also relates to a c-Maf inhibitor as therapeutic agent for use in the treatment of HER2+ breast cancer metastasis. The present invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the present invention relates to a method for typing of a subject suffering breast cancer and for classifying a subject from breast cancer into a cohort.

The electricity distribution network comprises a plurality of interconnection lines for the distribution of electricity among a plurality of interconnection boxes. At least some of said interconnection boxes are combined with a control unit for detection of stray voltage, comprising a transmitter to transmit to a receiver of at least one collecting unit a signal relating to any dispersion.

The present invention is generally related to a method of treating, preventing, or reducing the risk of developing type-2 diabetes, and, more particularly, is related to a method of administering a transdermal hydroalcoholic gel composition to treat or prevent type-2 diabetes and a method of administering a transdermal hydroalcoholic gel composition to increase glycemic control in a subject in need thereof.

The present invention provides methods of treating heart failure and improving renal function, and/or preventing the advancement of heart failure into advanced stages, and methods of counteracting ischemia due to a myocardial infarction by providing improved methods of administering a therapeutically effective amount CGRP as a controlled release formulation. The therapies can be administered on an outpatient or inpatient basis and can further be used as maintenance therapies.