29 results about "Digestive disorder" patented technology

The invention relates to the technical field of the Internet of Things, and discloses an animal physiological feature data acquisition system and analysis method based on the Internet of Things, and the method comprises the following steps: cleaning and standardizing original sensor data, including filling missing data, eliminating noise interference through a dynamic filtering technology, unifying the dimension of multi-source data, and analyzing the data; the method comprises the following steps of: acquiring a Beidou time service time reference, eliminating redundant features, interpolating and aligning asynchronous sampling data to the Beidou time service time reference, correcting a time sequence phase difference of physiological and behavior data through a dynamic path matching technology, and correcting GPS / Beidou positioning drift in combination with Kalman filtering. Through multi-source sensing fusion and an edge-fog-cloud cooperative computing architecture, the effective collection rate of animal physiological data is achieved, abnormal response is delayed and compressed, the flexible energy supply technology and dynamic communication optimization are combined, the endurance and communication success rate is maintained in a pasture, and the false alarm rate is reduced compared with a traditional method; common diseases such as abnormal body temperature, digestive system diseases and the like are accurately warned and covered.

A method and apparatus for treating digestive system diseases, the method comprising: subcutaneously implanting a pulse generator and a plurality of electrodes into the abdomen of a patient, the plurality of electrodes being in electrical contact with a plurality of target areas of the abdomen of the patient; and applying an electrical stimulus to activate the plurality of target regions.

The application relates to a kind of intelligent question and answer methods of digestive system disease based on knowledge graph, specifically to disease learning and question and answer field, through fusing deep semantic understanding and knowledge graph reasoning, the accurate response of complex multi-round question and answer in digestive system disease field is realized;It first aligns the user dialogue with the medical knowledge graph in depth, dynamically focuses on the relevant knowledge subgraph, then explores the logically coherent reasoning path in the subgraph through reinforcement learning, and finally generates traceable answers based on the path and dialogue history;This process ensures that the reply is not only accurate in information, clear in logic, but also has good interpretability;More importantly, by feeding back the quality of the generated answer to the optimization process of the reasoning path, it realizes the end-to-end collaborative optimization from semantic understanding, knowledge retrieval, logical reasoning to language generation, significantly improving the overall performance and practicality of the system.

Helicobacter pylori (HP) is a chronic bacterium that infects the gastric mucosa. It is widespread in the general population, with an infection rate between 55% and 70%. HP is closely related to gastric ulcers and gastritis. Western medicine treatment for HP infection is relatively complex, including bismuth substituents and proton pump inhibitors plus two antibiotics. Gastric ulcers and gastritis are common digestive system diseases. Compound 1, "Exterminate the Ghost," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Scutellaria baicalensis and Fraxinus chinensis, which can eradicate HP. Compound 2, "Ulcer Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Rheum palmatum and Bletilla striata, which can cure gastric ulcers. Compound 3, "Gasitis Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Glycyrrhiza uralensis or Taraxacum mongolicum, made into a tea bag, which can cure chronic gastritis.

The invention relates to the technical field of biological medicine manufacturing, discloses an ancient herbal enzyme oral liquid for treating digestive system diseases and a preparation method, and aims to solve the problems that in the prior art, adaptability of strains and herbal fibers is insufficient, directional enzyme production induction is deficient, probiotic activity retention is poor, and a flora, fiber and enzyme cooperative closed loop cannot be constructed. The preparation method comprises the following steps: by taking genuine hemp seeds, Chinese herbaceous peony and the like as raw materials, matching with rhizosphere-separated saccharomyces cerevisiae Y-01, lactobacillus acidophilus L-03 and bacillus coagulans C-05, carrying out three-step directional fermentation of substrate pretreatment, flora colonization and enzymatic synthesis to produce CAZymes and SCFA, embedding probiotics through trehalose-chitosan, compounding a stabilizer adaptive preparation, and adjusting the ratio of the raw materials according to an IBS subtype. The fiber degradation efficiency and the functional product synthesis efficiency are improved, the gastric acid tolerance and the storage stability of the probiotics are enhanced, different IBS subtype requirements are met, and an effective means is provided for treatment of digestive system diseases.

The invention discloses a compound targeting AT1R, which is composed of a target head molecule targeting AT1R, a PEG linker, an aspartic acid linker and a chelating agent, and can be used as a component of a PET tracer agent targeting AT1R. A target head molecule can be embedded into a hydrophobic'pocket 'of AT1R protein, so that high-affinity and high-selectivity targeted binding is realized; the PEG connexon can prolong the residence time of the PET tracer agent targeting the AT1R at the tumor part; different numbers of aspartic acids can regulate and control the pharmacokinetic properties of the PET tracer agent targeting the AT1R, reduce the liver and gall and intestinal signal backgrounds of the PET tracer agent targeting the AT1R, and improve the target-to-cost ratio. Therefore, accurate diagnosis and treatment of digestive system diseases such as digestive tract tumor and liver cancer can be realized. The invention further discloses a PET tracer agent targeting AT1R as well as a preparation method and application of the PET tracer agent.

Described herein are methods for treating or preventing a disease or disorder of the pulmonary system (e.g., cystic fibrosis), respiratory or digestive system in a subject, the methods comprising administering compounds or compositions comprising water soluble polyglucosamine and derivatized polyglucosamine.

Provided herein are methods of treating ST-elevation myocardial infarction (STEMI) and diseases of the digestion system using β-1,3 / 1,6-D-glucan derived from mycellium extract of Ganoderma lucidum. Methods of treating ST-elevation myocardial infarction (STEMI) and diseases of the digestion system using a polysaccharide comprising β-1,3 / 1,6-D-glucan are also provided.

This invention belongs to the field of multi-omics data integration technology. It discloses a system for screening multiple disease biomarkers from the gut microbiota metabolome. The system performs batch-to-batch drift correction based on the comparison values ​​of internal reference metabolites on metabolomic mass spectrometry data from multiple disease and healthy control groups. Then, it calculates the covariant stability index between metabolites and microbial species, and constructs a constrained metabolite association network by combining metabolic pathway topological distance. Based on this, the system integrates pathway constraint betweenness centrality and disease effect size to calculate network-enhanced discriminant scores, performs dimensionality reduction according to the principle of maximum coverage and minimum redundancy, and simultaneously evaluates the stability baseline values ​​of biomarker-related ecological functional modules. Finally, using ecological stability as a constraint, the system optimizes the discriminative power of multiple diseases through marginal contribution evaluation, outputting a balanced and efficient biomarker panel. This invention achieves systematic integration of microbiome and metabolome data, providing a reliable tool for the accurate diagnosis of digestive system diseases.

The application provides a method for establishing a digestive system disease multi-modal information diagnosis and treatment system, S1, collecting multi-modal information for labeling and preprocessing; S2, extracting a feature vector and embedding a label to the multi-modal information according to the labeled information; S3, splicing and mapping the feature vector and the label to a unified dimension to obtain an enhanced feature vector; S4, fusing the enhanced feature vector to form a multi-modal feature matrix, performing linear mapping on the multi-modal feature matrix, obtaining a global fusion vector after weighted aggregation, and generating a fusion vector sequence; S5, enhancing the time sequence information of the global fusion vector sequence and the spatial information of the spatial correlation of the part-specific feature; interactive fusion to obtain a space-time joint feature; S6, classifying and predicting the disease stage or specific pathological type, and outputting a diagnosis result; S7, realizing semantic association between the diagnosis result and a medical knowledge graph, sharing data to an online health wisdom platform, and providing personalized decision-making basis for clinical doctors.

The application provides a traditional Chinese medicine composition for improving digestive system diseases caused by brain-gut disorder, which is made of the following traditional Chinese medicines in parts by weight: Gastrodia 1-35 parts, Astragalus 1-35 parts, Fructus Alpiniae oxyphyllae 1-20 parts, Atractylodes 1-20 parts, Hypericum 1-20 parts, Cinnamomum 1-10 parts, and Dried Ginger 1-10 parts, and further provides a preparation method and application of the composition. The traditional Chinese medicine composition can intervene in the brain-gut disorder related digestive system diseases from the perspective of brain-gut interaction, has the effects of improving anxiety and depression-like behaviors, reducing visceral pain sensitivity, protecting and repairing intestinal mucosal barrier, reducing intestinal local inflammatory response, and regulating intestinal flora structure, so as to realize the comprehensive regulation of emotional abnormalities and digestive system symptoms in brain-gut disorder related digestive system diseases, and has a good clinical application prospect.

The invention discloses an anti-helicobacter pylori monoclonal antibody as well as preparation and application thereof, and belongs to the technical field of medical detection. The antibody is prepared by taking inactivated helicobacter pylori ATCC 43504 whole bacteria as an immunogen, immunizing a New Zealand white rabbit and then carrying out single B cell sorting, limited dilution, gene cloning, plasmid construction and eukaryotic cell expression, has a specific CDR core sequence, is high in specificity and affinity, can accurately recognize a helicobacter pylori specific antigen, and can be used for preparing a specific antibody. The cross reaction with other bacteria or tissue impurities is effectively avoided. The kit can be used for detecting the helicobacter pylori, and a new tool and method are provided for pathological diagnosis of helicobacter pylori infection and related digestive system diseases.

The application relates to the technical field of disease prediction, in particular to a digestive system severe disease early warning detection method, device and equipment, wherein the method comprises the following steps: acquiring patient multi-modal data information, wherein the patient multi-modal data information comprises clinical symptoms, laboratory examination and imaging examination; a clustering model is constructed and trained to obtain a plurality of clustering sets; the patient multi-modal data information is input into a target clustering set in the clustering model; whether the patient multi-modal data is abnormal is judged; if the patient multi-modal data information is abnormal, a probability model is constructed; the target clustering set is generated to generate a severity label and is input into the probability model to obtain a probability result of severe disease severity evaluation; hierarchical early warning is carried out according to the probability result; and clinical decision is made according to the hierarchical early warning. Therefore, the problems that a same method cannot be used to evaluate a plurality of digestive system diseases, the evaluation results of diseases are different, and diseases are not timely evaluated in the prior art are solved.

A process of manufacturing a children formula in a powder or solution form comprising the steps of mixing homogeneously nutritional components and a supplementary composition containing 2′-fucosyllactose (2′-FL) and fructo-oligosaccharide (FOS), such that when the children formula is fed to the child a chance of the child developing digestive disorders and respiratory infection is reduced, wherein a ratio between 2′-fucosyllactose (2′-FL) and fructo-oligosaccharide (FOS) is 1:(16-100) (w / w); in which the fructo-oligosaccharide (FOS) includes Oligofructose and Inulin, and a ratio between Oligofructose and Inulin is 1:1 (w / w).

A system (100) for health diagnosis using breath of user and lifestyle assessment is disclosed The system includes a breath analyzer device (110) that includes a breath chamber (120) to receive exhaled breath and detect concentration level of acetone, hydrogen, ethanol, hydrogen, ammonia, carbon monoxide, hydrogen sulphide, 5 lung capacity, hydrogen, methane, ammonia and hydrogen sulphide. The plurality of sensors (130) captures a photoplethysmography signal. A receiving module (160) receives data and the photoplethysmography signal. A disorder score generation module (170) analyses the data to generate a diabetic score, liver disorder score, respiratory disorder score, digestive. A nutrient score module (180) calculates a 10 nutrient score. A lifestyle score module (190) calculates a lifestyle score. A display module (200) displays diabetic score, liver disorder score, respiratory disorder score, digestive disorder score, kidney disorder score, nutrition score, lifestyle score, and the plurality of health parameters via a user interface.

This invention discloses a method, device, equipment, and storage medium for monitoring and regulating the feeding of chickens, including: acquiring the physical state characteristics of the chicken's crop; acquiring the chemical composition characteristics of the corresponding chicken excrement after a preset time interval; determining that the chemical composition characteristics of the chicken excrement are higher than the undigested food threshold; and outputting a feed adjustment command when the chicken's health status classification result indicates a digestive disorder. This embodiment achieves digestive disorder monitoring by combining the physical state of the chicken's crop with the chemical composition characteristics of its excrement. By determining that the crop is in a full range, it ensures that the chicken is in a normal feeding state, eliminating pathological abnormalities. Feed adjustment commands are only output promptly when a digestive disorder is detected, correcting nutritional imbalances, reducing waste of high-protein feed, and saving feed costs. Simultaneously, it reduces the nitrogen and undigested protein content in the excrement, lowering manure treatment costs and achieving energy conservation and emission reduction effects.

The application discloses a formula milk powder for piglets, which contains raw cow milk, whey powder, whey protein concentrate powder, casein, nutritional fortifier, oligosaccharide, compound mineral, compound amino acid, compound vitamin and probiotic bacteria. The formula milk powder for piglets is obtained by mixing the raw cow milk, the whey powder, the whey protein concentrate powder, the casein and the nutritional fortifier, adding the compound mineral, the compound amino acid and the compound vitamin, filtering, homogenizing, sterilizing and concentrating, spray drying, fluidized bed drying and adding the probiotic bacteria. The formula milk powder for piglets prepared by the application is rich in probiotic bacteria, nutritional fortifier, vitamin, amino acid, mineral and other nutrients, can meet the nutritional needs of the piglets for rapid growth, and can reduce the probability of digestive disorders, diarrhea and death of the piglets and promote the healthy growth of the piglets.

The invention provides a mutton sheep feed additive for increasing weight and improving meat quality as well as a preparation method and application thereof, and belongs to the technical field of feed additives. The mutton sheep feed additive comprises Chinese herbal medicines such as dried orange peel, scorched hawthorn fruit, fried malt and radish seed, and lactobacillus plantarum, bacillus licheniformis, candida utilis, neutral protease, xylanase and lipase, and can be added into basic daily feed of mutton sheep for reinforced conditioning feeding. Through the synergistic effect of the Chinese herbal medicine, the beneficial bacteria and the active enzyme, the problems of rumen acidification, digestion disorder and the like caused by high-concentrate fattening are solved, the meat indexes such as muscle tenderness and water-holding capacity are improved while the weight gain rate of mutton sheep is increased, the cost waste of whole-process feeding is avoided, and the feed is suitable for large-scale mutton sheep breeding application.

The application discloses an anti-helicobacter pylori monoclonal antibody and a preparation and application thereof, and belongs to the technical field of medical detection. The antibody is prepared by using inactivated helicobacter pylori ATCC 43504 whole bacteria as an immunogen, immunizing a New Zealand white rabbit, and then performing single B cell sorting, limited dilution, gene cloning, plasmid construction and eukaryotic cell expression. The antibody has a specific CDR core sequence, high specificity and high affinity, can accurately recognize helicobacter pylori specific antigens, and effectively avoids cross reactions with other bacteria or tissue impurities. The antibody can be used for detecting helicobacter pylori, and provides a new tool and method for pathological diagnosis of helicobacter pylori infection and related digestive system diseases.

The present disclosure provides methods of treating disease (e.g., digestive diseases) by administering an antibody or an antigen portion thereof that binds to sLeA and a TNFα inhibitor, as well as pharmaceutical compositions related thereto.

The present invention provides a Bifidobacterium longum LWHK1005.SOLUTION: The Bifidobacterium longum LWHK1005 has effects of preventing and treating cardiovascular diseases and digestive diseases, and functions to reduce trimethylamine oxides in the blood and increase the content of Akkermansia muciniphila in the intestines.SELECTED DRAWING: Figure 1

The invention relates to the technical field of traditional Chinese medicine moxibustion therapy conditioning, in particular to a conditioning method for activating the self-healing capacity of a human body through three-dimensional balanced moxibustion multi-acupoint linkage. The three-dimensional moxibustion therapy network is composed of a core shaft system, four-major-jiao acupoints and abdominal and dorsal reflection area acupoints. Vertical shafts (Tiansheng three-jiao axis) comprise the Baihui acupoint, the perineum acupoint (between the rear joint and the anus) and the Yongquan acupoint, and a vertical Tai Chi and three-jiao energy through channel is formed. A two-axis three-jiao three-dimensional moxibustion network is constructed, full coverage of acupuncture points of the head, the trunk, the feet, the front side and the rear side is achieved, the limitation of traditional single-point moxibustion is broken through, the overall view of traditional Chinese medicine and the multi-acupuncture-point linkage synergistic effect are truly embodied, meridians and collaterals are rapidly penetrated, yin and yang are harmonized, qi and blood circulation is activated, and harmful substances in the body are discharged in a targeted mode in stages; after the three stages, the symptoms of dark complexion, limb weakness, poor sleep, digestion disorder and the like can be obviously improved.

This invention provides an isoquinoline compound, its preparation method, and its applications, belonging to the fields of organic synthesis and medicinal chemistry. Specifically, this invention provides a method for preparing an isoquinoline compound of general formula (I), or its stereoisomers, optically pure isomers, hydrates, solvates, crystals, or pharmaceutically acceptable salts and mixtures thereof, and its pharmaceutical uses. The compound shows promise for treating colorectal cancer, ulcerative colitis, and other tumors and digestive system diseases.

The invention relates to the technical field of health management, in particular to a digestive system disease early warning and management method and system, and the system comprises a household non-sensing layer, a data transmission and network layer, a cloud intelligent analysis and management platform, and a user interaction and application layer. Slow degradation of digestive system functions can be found earlier than subjective feeling and accidental inspection, and early warning is achieved; data comes from non-inductive family environment monitoring, and the daily digestion related behavior state of the user is truly reflected; behavior data of kitchen activities and toilet activities are subjected to correlation analysis, and a more complete digestive system function evaluation view angle is provided; non-video and non-audio sensors are adopted, only whether behaviors occur or not and the duration of time are monitored, specific activity content is not involved, privacy is protected to the maximum extent, active operation of a user is not needed, and continuity and authenticity of data are guaranteed; the used sensors are mature and low-cost Internet of Things equipment, and are easy to install and expand in a common family environment.

Described herein are methods for treating or preventing a disease or disorder of the pulmonary system (e.g., cystic fibrosis), respiratory or digestive system in a subject, the methods comprising administering compounds or compositions comprising water soluble polyglucosamine and derivatized polyglucosamine.

The application discloses a kind of chick crop flexible massage device of analog brooding, including clothes body and massage patch, the side of clothes body is opened with the notch slot corresponding with massage patch, massage patch is detachably connected with clothes body, and massage patch includes base layer, and the side of base layer is sequentially provided with independent atmosphere bag, middle gas bag and small gas bag;The application further discloses a kind of implementation method of chick crop flexible massage device of analog brooding.The present application is inflated and deflated by accurately controlling atmosphere bag, middle gas bag and small gas bag, simulates the natural action of light rubbing along crop of parent bird, solves the problem of food accumulation from two aspects of physical pushing food accumulation and activating crop smooth muscle peristalsis, the massage force and precision of the present application are more accurate, can effectively avoid secondary damage to crop, not only can reduce the risk of young bird digestive system disease, reduce young bird mortality, but also can reduce labor intensity.

Provided are chimeric molecules, compositions, and applications thereof that specifically bind to natriuretic peptide receptor C (NPR-C). The disclosed chimera comprises an NPR-C binding domain and a target-binding domain. Through NPR-C-mediated endocytosis, the chimera enables the intracellular degradation of the target by lysosomal enzymes. The chimeric molecules can rapidly, conveniently, and precisely degrade target proteins. Their modular design permits broad applicability to proteins such as secreted proteins and membrane-associated proteins. These chimeric molecules exhibit high bioavailability and low immunogenicity, thus being broadly applicable for the treatment of diseases including cancer, neurodegenerative diseases, psychiatric disease, central nervous system diseases, inflammatory diseases, autoimmune diseases, metabolic syndrome, tissue fibrotic disease, cardiovascular diseases, respiratory diseases, digestive diseases, renal diseases, hematologic diseases, infectious diseases, rare diseases and aging-related disease.

The invention relates to the technical field of medicine preparation, in particular to a hawthorn pill preparation method and device for digestive system diseases, and relates to a pretreatment mode of dividing hawthorn fruits based on the transverse diameter, the longitudinal diameter and the hardness of the hawthorn fruits. Performing solvent extraction separation on the pretreated hawthorn fruits, and collecting organic acid concentration and flavone concentration to determine whether the pepsin activation rate is qualified or not; in response to the disqualification of the pepsin activation rate, adjusting the pretreatment mode of the hawthorn fruits; concentrating the distilled water eluent under reduced pressure to prepare a coating solution, and spraying the coating solution on the surface of the hawthorn pill core to obtain a molded hawthorn pill; collecting the weight and the dissolution time of a plurality of hawthorn pills, judging the layer thickness degree of the coating based on the weight and the dissolution time, and adjusting the adhesive dosage of the distilled water eluent or adjusting the ethyl acetate concentration of the ethyl acetate eluent based on the judgment result of the layer thickness degree; the accuracy of the preparation method of the hawthorn pill for treating digestive system diseases is obviously improved.

The utility model discloses a centralized feeder for livestock and poultry, which relates to the technical field of livestock and poultry feeding and comprises a feeding trough, one side of the inner wall of the feeding trough is provided with a semicircular guide groove, the other side of the inner wall of the feeding trough is provided with a semicircular through groove, a connecting shaft is slidably arranged in the semicircular through groove, and one end of the connecting shaft is fixedly connected with a semicircular feeding plate. And the other end of the semicircular feeding plate is rotationally installed in the semicircular guide groove, a scraping plate is fixedly installed at the top end of one side of the inner wall of the feeding groove, and the scraping plate abuts against the inner wall of the semicircular feeding plate in a matched mode. A first gear rotates to be meshed with a second gear, then the second gear is driven to rotate, the second gear rotates to drive a connecting shaft to rotate, and the connecting shaft slides in a semicircular through groove to drive a semicircular feeding plate to rotate; and when the semicircular food taking plate rotates, food residues on the inner wall of the semicircular food taking plate are scraped off through the scraping plate. Digestive system diseases caused by re-ingestion of food residues by livestock and poultry after the food residues are decayed are avoided.