The invention discloses an 
analysis method for simultaneously measuring residues of 12 sulfonamide medicaments, 19 
quinolone medicaments and 8 
benzimidazole medicaments and metabolites thereof in 
chicken liver by quick, easy, cheap, effective, rugged and safe (
QuEChERS) extraction and purification-ultrahigh performance liquid 
chromatography-
tandem mass spectrometry (
QuEChERS-UPLC-MS / MS). The method comprises the following steps of: extracting a sample by using 1 percent 
acetic acid-
acetonitrile solution, purifying the sample by using NH2 adsorbent, and 
degreasing the sample by using n-
hexane;and then performing separation by using a Kromasil Eternity C18 
chromatographic column (100mm*2.1mm, 2.5mum), performing 
gradient elution by using 0.1 percent 
formic acid and 
methanol as mobile phases, performing 
ionization in an 
electron spray positive 
ion (ESI<+>) mode, performing detection in a multi-reaction monitoring (MRM) mode, and performing quantification by an 
internal standard method. The 39 medicaments have good 
linearity (r is more than 0.98) in a blank adding concentration range of 5 to 100mug / kg, the average 
recovery rate of the medicaments in the adding level range of 10 to 50mug / kg, the 
relative standard deviation (RSD) is 1.5 to 23.4 percent, the limit of detection (LOD) of the 39 medicaments is 5mug / kg, and the low limit of quantification (LOQ) is 10mug / kg. The method is simple, convenient, quick, sensitive, accurate and rugged, and is suitable for confirmation and 
quantitative determination of the residues of the residues of the sulfonamide, 
quinolone and 
benzimidazole medicaments in the 
chicken liver.