326 results about "Sodium butyrate" patented technology

Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing; and a dermatologically-acceptable carrier.

The invention relates to a pig feed, in particular to a nursery pig concentrated feed, comprising the following raw materials by weight proportion: 30-50 of sucking pig composite vitamin, 30-50 of low copper mineral element, 60-100 of peeled soybean meal, 100-180 of fermented soybean meal, 100-150 of extruded soybean, 110-180 of steam fish meal, 50-100 of dried porcine soluble, 60-120 of acid whey powder, 80-90 of glucose powder, 5-10 of glutamine, 80-100 of chyle fat powder, 40-49 of calcium carbonate, 12-14 of basic zinc chloride, 4-6 of salt, 55-60 of calcium biphosphate, 6-10 of sodium butyrate, 12-15 of lysine, 6-8 of threonine, 4-6 of TP-100 enzyme, 4-5 of cysteine, 5-7 of se-enriched yeast and 6-10 of copper chloride hydroxide. The nursery pig concentrated feed has the advantages of milk nutrition composition simulation, good palatability, high digestibility, large feed intake because the baby pigs like to eat and improvement of survival rate as well as immunity of the nursery pigs.

The invention relates to a preparation method for enzyme laundry detergent. At present, most detergent in the market is prepared from chemical raw materials, skin irritation, irritability and pruritus are caused, the detergent has certain toxicity, environment is polluted severely, and health of people is harmed. The enzyme laundry detergent is prepared by organically combining natural active ingredients AES, oligose, chitosan, maltase, alkyl glycoside, enzyme, perfume, alcohol ethoxylates, salt, tartaric acid, glutamic acid, acetic acid, sodium butyrate and water. The enzyme laundry detergent has a biodegradation property, decomposes dirty marks automatically, removes various stubborn dirty marks, has the quick-acting and whitening effects, and can carry out sterilization and resist static electricity, harm to clothes and skin is avoided, and the clothes are kept shining and bright.

The invention relates to an antibiotic-free piglet conservation material and a preparation method thereof. The conservation material comprises the following raw materials of puffed corn, wheat, a base material, efficient cream, soybean meal, fermentation soybean meal, whey powder, composite yeast, rice protein powder, stone powder, calcium hydrogen phosphate, lysine, methionine, threonine, choline chloride, liquid phytase, liquid xylanase, a acidifying agent, sodium butyrate and a premix compound. The antibiotic-free piglet conservation material can increase immunity of the piglet, prevents the piglet from generating drug resistance and appearing drug residue problems, maintains stability of intestinal flora, and improves digestion and absorption for forage of the piglet.

A method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), includes administering a histone deacetylase (HDAC) inhibitor in a subject in need thereof. The HDAC inhibitor includes sodium butyrate or sodium phenylbutyrate.

The invention discloses a clostridium butyricum having a diarrhea treating effect. The strain is named as clostridium butyricum Cb-2 which is conserved in China Center for Type Culture Collection with the conservation number of CCTCC M2011384, in November 9th, 2011. A test proves that the clostridium butyricum disclosed by the invention has strong acid producing capability especially butyric acidproducing capability; and the clostridium butyricum has obvious effects on diseases, such as intestinal tract flora infection, acute and chronic diarrhea, irritable bowel syndrome and non-ulcer dyspepsia, caused by various reasons, and has no toxicity and harm. Thus, the clostridium butyricum or clostridium butyricum powder disclosed by the invention is used as a raw material for preparing a micro-ecological preparation and used for replacing sodium butyrate to be applied; and when a specific application is carried out, a clostridium butyricum preparation can be singly used as an active component to be prepared into the micro-ecological preparation together with corn starch, or, the clostridium butyricum preparation is mixed with at least one of other bacterial preparations and the corn starch to prepare a composite micro-ecological preparation.

The invention relates to a preparation method of an animal feed additive microencapsulation diolame sodium butyrate. The method comprises the following steps of: mixing hydroxypropyl methyl cellulose, chitosan and silica, boiling at high temperature of 230DEG C in a fluidized bed; spraying sodium butyrate aqueous solution on a mixture of three materials; drying at a high temperature, solidifying at a low temperature, solidifying and molding sodium butyrate particles; dissolving a coated material Brazil palm wax, palm oil and polyethylene glycol into an organic solvent, carrying out bottom-spraying and coating in a fluidized bed to obtain the evenly-coated sodium butyrate particles of which the mass percent of the sodium butyrate is 30-70%. The microencapsulation process is carried out on feed grade sodium butyrate power to avoid the loss of sodium butyrate in poultry crop and pig stomach, so as to reach the rear section of small intestine and cover the whole intestinal tract, meanwhile, overcomes foul smell, prevents air slaking, and protects sodium butyrate from losing in the process of feed processing.

The invention provides feed for improving the digestive and immunologic ability of chicken, which comprises a feed carrier, choline chloride, lysine hydrochloride, phenylalanine dihydrochloride, pantothenic acid, clostridium butyricum, lactobacillus plantarum, sodium butyrate, stone powder, folic acid, riboflavin, vitamin E, vitamin K, glucolase, amylase, sodium selenate, magnesium sulfate and a Chinese herbal medicine composition additive. The feed has the beneficial effect that a digestion system and an immune system of the chicken can be improved, so that the feeding management and epidemic prevention works during the brooding period are better improved.

The invention discloses a formula feed of broilers and a preparation method thereof. The formula is as follows: 50-65% of corn, 0-2% of fishmeal, 20-25% of soya bean meal, 0-3% of corn protein powder, 0-1% of whole hen egg, 0-5% of wheat middling, 0-5% of rice pericarps, 0-5% of rice bran, 0-3% of cottonseed meal, 0.5-1.5% of bean oil, 0.1-0.3% of acidulant, 0.05-0.1% of sodium butyrate, 0.03-0.05% of compound enzyme preparation and 1.5-2% of compound premix. The feed is prepared by the steps of removing impurities from raw materials, grinding raw materials, weighing raw materials, mixing raw materials, palletizing and packing finished products, etc. in sequence. The invention selects the additives which promote the broilers to grow and develop and the feed materials which improve the immunocompetence, etc. The feed product has moderate metabolic energy value, high nutrition level and good palatability, is easy to digest and absorb and is easy to satisfy the nutritional requirements of 1-7 days of growth, therefore, the broilers grow fast and have high disease resistance, low mortality and low feed coefficient, and the coefficient of the formula feed is 0.8-0.9.

A method for producing viral vectors is described using packaging and producer cell lines is described. The producer cell comprises: (i) a first nucleotide sequence (NS) encoding a toxic viral envelope protein operably linked to a promoter; wherein the promoter is operably linked to at least one copy of a TRE; (ii) a second NS wherein the second NS comprises a sequence encoding a tetracycline modulator; (iii) a third NS encoding a retrovirus nucleocapsid protein; and (iv) a fourth NS comprising a retroviral sequence capable of being encapsidated in the nucleocapsid protein such that the retroviral vector particle titre obtainable from the producer cell is regulatable by tetracycline and an initial stimulus with sodium butyrate or functional analogues thereof.

The invention provides a feed for improving the egg laying performance of laying duck. The feed comprises basal feed components, brewer's grain, vitamin D, vitamin A, fish meal, lysine, methionine, sodium butyrate, calcium hydrophosphate, calcium carbonate, table salt, seasoning additive, bacillus subtilis microecological preparation, microelement additive and traditional herbal medicine composition additive. The feed provided by the invention can perfectly promote the comprehensive absorption of the nutrients by the laying duck, reduce the blood lipid and cholesterol, improve the feed conversion rate, prevent diseases of the laying duck, and increase the immunity level so as to improve the egg laying performance of the laying duck.

The invention relates to child care pig compound feed without a tensile body, and the child care pig compound feed is prepared from the following components: corn, peeled soybean meal, puffed soybean meal, fermented soybean meal, steam white fish meal, flour, soybean oil, mountain flour, calcium hydrogen phosphate, edible salt, child car pig compound premix, coated slow-release acidifier, L-lysine hydrochloride, DL methionine, L-thronine, tryptophan, octanoic/decanoic acid glyceride, yeast nucleic acid, xylo-oligosaccharides, sodium glutamate, sodium butyrate, the root of Chinese pulsatilla, coptis chinensis, golden cypress, ash bark, choline chloride and phytase. The child care pig compound feed without the tensile body provided by the invention starts from the physiological characteristics of a child care pig, adopts multiple combinations of raw materials, is complementary in nutrition, designs amino-acid-balanced, calcium-phosphate-balanced and electrolyte-balanced daily ration, adds no antibiotic, adopts medium-chain fatty acid and natural Chinese herbal medicine additive for health protection, and can be used for improving food consumption of the child care pig, reducing the feed conversion ratio, improving intestinal health of the child care pig, improving immunity and drawing a skeleton of the child care pig, so that a good foundation is laid for later-stage growth.

The invention discloses weaned pig transition compound feed, which comprises the following ingredients in parts by weight: 37 to 46 parts of corn, 0 to 19 parts of functional energy and protein feed, 5 to 10 parts of extruded soybean, 7.5 to 8 parts of shelled soybean meal, 8 to 12 parts of lactose, 2 to 3.5 parts of imported fish meal, 0 to 2 parts of concentrated soybean,0.5 to 0.6 parts of mountain flour, 0.71 to 1.8 parts of dicalcium phosphate, 0.9 to 1.1 parts of premix compound, 0.26 to 0.5 parts of lysine, 0.17 to 0.25 parts of methionine,0.2 to 0.3 parts of common salt, 0.24 to 0.26 parts of zinc oxide, 0.06 to 0.15 parts of threonine, 0.02 to 0.05 parts of tryptophan, 0.01 to 0.02 parts of sweetening agents, 0.1 to 0.12 parts of sodium butyrate, 0 to 0.4 parts of emulsifying agents, 0 to 2.5 parts of cane sugar, 0.1 to 0.12 parts of compound microorganism bacterium agents, 0 to 0.02 parts of flavouring agents, 0 to 0.2 parts of acidifying agents,0 to 2 parts of bean oil, 0 to 8 parts of whey powder, 0 to 15 parts of immuno-enhancers and 0 to 3 parts of plasma protein powder, wherein the compound microorganism bacterium agents comprise one kind of several kinds of lactic acid bacteria. The weaned pig transition compound feed provided by the invention is a key measure for ensuring the continuous growth of weaned piglets. Beneficial microorganisms are added into the weaned pig transition compound feed, the occurrence of diarrhea of the weaned piglets can be reduced, in addition, the digestion is easy, and piglets like to eat the feed.

The invention relates to a reprogrammed culture medium and a culture method of a reprogrammed induced multipotential stem cell. The reprogrammed culture medium is composed of a DMEM-F12 basal culturemedium and additive components, wherein the additive components comprise 60-180 microgram/mL of L-ascorbic acid, 5.3-74 micromole/L of hydrocortisone, 3-89 nanogram/mL of sodium selenite, 8-23 micromole/L of Optiferrin, 0.5-7.4 micromole/L of retinyl acetate, 40-60 nanogram/mL plant-derived recombinant human alkaline growth factors, 8-12 microgram/mL of IGF, 0.2-0.6 microgram/mL A-83, 2-6 micromole/L of CHIR99021 and 100-450 micromole/L of sodium butyrate. The use of the reprogrammed culture medium not only can improve the safety of clinical use, but also can improve the efficiency of adult cell reprogramming to induce the multipotential stem cell.

The invention discloses feed additive for improving cad pig growth performance and mixed batch. The feed additive comprises following ingredients by parts of weight: 23 to 25 of pericarpium citri reticulatae, 23 to 26 of hawthorn, 27 to 35 malt, 4 to 8 Chinese rhubarb, 15 to 23 Chinese yam, 0.001 to 0,002 Vb12, 9 to 11 chelate iron and 80 to 120 sodium butyrate. The additive is scientific and reasonable in proportion, can improve cad pig growth performance, improves feed conversion and increases hemoglobin content in blood. Fermented soybean meal containing active small peptide can be absorbed and utilized by intestinal tracts easily. The Chinese herb medicine mainly has the function of regulating qi, tonifying spleen and nourishing the stomach. The sodium butyrate can repair small intestine choria of pigs, increases recess depth, reduces potential of hydrogen (pH) in intestinal tracts and prevents harmful bacteria from breeding.

Culturing cells for the commercial production of proteins for diagnosis and therapy is a costly and time consuming process. The equipment required is expensive, and production cost are high. In order to provide commercially viable processes it is desirable to use cell lines which produce large quantities of product with each production run. However, most cells do not produce large quantities of desired product per se either because they do not produce a large quantity of product per unit of time (specific productivity) or because they do not survive long enough in the culture medium (time). Here, we identified that addition of a valproic acid compound to the culture medium increases overall (batch) yield and titer. More importantly, compared to the widely used sodium butyrate, batch yields using a valproic acid compound as a medium additive are significantly higher.

The present invention discloses a joint production method of (S)-3-hydroxyl-Gamma-butyrolactone and (S)-3-hydroxyl tetrahydrofuran. The production method comprises the following steps: firstly, L-malic acid is added into methanol, inorganic acid is added for catalysis, the solid is dissolved and reflows, and then is decompressed and dried through evaporation, the methanol and thionyl chloride are added, the reaction solution is heated and reflows, and the L-malic acid can be produced; secondly, the L-malic acid and tetrahydrofuran are mixed, a reducing agent and a catalyst are added for catalysis, and the (S)-1, 2, 4-trihydroxybutane aqueous solution and (S)-3, 4-hydroxy sodium butyrate are respectively produced; thirdly, water is vaporized from the (S)-1, 2, 4-trihydroxybutane aqueous solution, and the (S)-3-hydroxyl tetrahydrofuran is synthesized through catalytic ring closure, the pH of the (S)-3, 4-hydroxy sodium butyrate aqueous solution is adjusted, the (S)-3, 4-hydroxy sodium butyrate aqueous solution reflows, is dried through evaporation and extracted with ethyl acetate, and the (S)-3-hydroxyl-Gamma-butyrolactone can be produced. The present invention has the advantages that raw materials are cheap, the dosage of the thionyl chloride is reduced, and the production method has less environmental pollution.

The invention discloses a serum free medium for expressing erythropoietin in CHO (Chinese hamster ovary) cells, and a culture method for high expression of erythropoietin in CHO cells. The serum free medium contains additives D-glucose and sodium butyrate, and also contains one or more of D-galactose, D-mannitose and N-acetylglucosamine. The culture method comprises the steps of: performing serumculture on activated seed cells by using a serum medium, and then performing serum free culture by the serum free medium. By adopting the medium and culture method disclosed by the invention, recombinant human erythropoietin protein of high and stable expression can be obtained, and the glycosylation degree of erythropoietin is improved, i.e. the specific gravity of EPO (erythropoietin) sialic acid is improved. As high as 1.0*107IU recombinant human erythropoietin can be obtained from one liter of culture fluid by the culture method provided by the invention, the expression is stable, and theculture method is simple and suitable for large-scale production.

The invention discloses a compound feed for preventing soft-shelled turtle from the white abdominal shell disease. The compound feed comprises the following raw materials of both components and air dry matters by weight percent: 35-40 percent of imported white fish meal, 10-18 percent of steam brown fishmeal, 5-8 percent of soybean protein concentrate, 4-8 percent of fermented soybean meal, 3-6 percent of extruded soybean, 1-2 percent of wheat gluten, 4-8 percent of beer yeast, 18-23 percent of pre-gelatinized starch, 1-2 percent of calcium biphosphate, 0.3-0.6 percent of acid alkaline buffering agent, 0.03-0.08 percent of yeast culture, 0.1-0.4 percent of active strains preparation, 0.05-0.15 percent of sodium butyrate, 0.1-0.3 percent of compound Vitamin, 0.5-1.5 percent of complex ore and 0.2-0.5 percent of choline chloride. The feed provided by the invention can effectively keep the pH value in the intestinal canal of soft-shelled turtle to be stable and conditions the balance of intestinal flora, so that beneficial bacterium is in the ascendance in intestinal canal, the integrity and barrier action of intestinal mucosa are protected, and accordingly, the soft-shelled turtle is effectively prevented from the white abdominal shell disease.

The invention discloses a method for preparing pig neural stem cells by reprogramming. The invention provides a method for preparing mammal neural stem cells by reprogramming. The method comprises the following steps: (1) commonly conducting gene OCT3/4, SOX2, KLF4 (Kruppel-Like Factor 4), LMyc and LIN28 into mammal somatic cells by using a non-integrated type episomal carrier to obtain transgenic cells; and (2) culturing the transgenic cells by using an induction culture system containing sodium butyrate to obtain the neural stem cells. An experiment shows that the non-integrated type episomal carrier is used for conducting factors including the OCT3/4, the SOX2, the KLF4, the LMyc, the LIN28 and the like into pig somatic cells; the somatic cells are transdifferentiated into the neural stem cells through optimizing a cultivation condition; the neural stem cells are further differentiated to obtain neural cells with physiological activity so as to lay foundation to nervous system diseases taking a pig as a model.

The invention discloses a feed additive with piglet stress resistance and intestinal tract improvement effects and a preparation method and application. The feed additive is composed of active components and matrix; the active components comprise 2-4 parts of lysine, 5-10 parts of taurine, 3.5-4 parts of cysteine, 6-12 parts of glutamine dipeptide, 5-10 parts of glucose, 6-12 parts of sodium butyrate, 2-3 parts of selenium yeast, 3-6 parts of vitamin A, 4-8 parts of vitamin E, 5-9 parts of vitamin C, 1-3 parts of N-carbamyl glutamic acid chelate copper, 1-3 parts of N-carbamyl glutamic acid chelate zinc and 1-3 parts of manganese methionine. The active components are uniformly mixed with the matrix to obtain the feed additive. The feed additive has the advantages that the piglet growth property can be effectively improved, the piglet gastrointestinal tract health and the stress resistance capability are improved, medical components are not contained, the cost is low, and the application prospect is wide.

The invention discloses a compound feed for chicks of yellow feather broilers. The compound feed consists of corn protein powder, a DDGS (Distillers Dried Drains with Soluble) feed, fish meal, soybean meal, cottonseed meal, wheat, corn, lard, heavy calcium carbonate powder and auxiliary additives, wherein the auxiliary additives consist of calcium hydrogen phosphate, methionine, salt, zeolite powder, choline chloride, phytase, aureomycin, sodium sulfate, broiler trace element additives, sodium butyrate, broiler multivitamin, Puqiu, antioxidant, Nuonong, threonine, xylanase, Lucantin red and lysine. The corn protein powder and natural yellow pigment are added in the compound feed to enable the broiler carcass coloring to reach the market requirements; the sodium butyrate is added in the compound feed to improve the daily weight growth, feed intake and feed conversion rate; and the xylanase is added in the compound feed, so that soluble lipid components are easier to take.

The invention discloses an antibiotic-free homologous protein-free creep feed for weaned piglets, comprising corn, puffed corn, flour, puffed soybean, Hamlet protein, yeast nucleotide, super steamed fish meal, cheese plus cheese, sucrose, glucose, whey powder, milk powder, whey protein concentrate, calcium monohydrogen phosphate, calcium formate, edible salt, lysine, methionine, tryptophan, threonine, a compound acidifier, coated zinc oxide, coated plant essential oil, coated sodium butyrate, alkaloids, a vitamin complex, trace element premix and a compound enzyme preparation. The Hamlet protein, yeast nucleotide and whey protein concentrate are used herein to replace plasma protein powder and intestine membrane protein; attracting property, palatability and high digestive utilization areguaranteed for the antibiotic-free homologous protein-free creep feed for weaned piglets; piglets can gain smooth transition from breast milk to feed; the comprehensive utilization of the compound acidifier, coated sodium butyrate, coated zinc oxide, coated plant essential oil and alkaloids helps improve immunity in piglets and control diarrhea in the piglets.

The invention relates to the technical field of animal feed, and discloses a health-care food conducive to regulation of intestinal functions of pet dogs and cats. The health-care food comprises the following components in parts by weight: 15-22 parts of sodium butyrate, 2-5 parts of clostridium butyricum, 2-5.5 parts of bacillus subtilis, 2-5 parts of bacillus licheniformis, 20-25 parts of fructo-oligosaccharide, 12-20 parts of yeast, 15-20 parts of lactic acid bacteria, 6-8 parts of a yucca powder, 0.3-0.9 part of magnesium stearate and 10-50 parts of accessories. The product can be processed into a powder or pressed into tablets through stirring and mixing. The various components of the health-care food for regulating the intestinal functions of the pet dogs and cats can cooperate witheach other, so the health-care food can regulate the intestinal functions of the dogs and cats, promotes digestion and absorption of intestines, prevents and cures diarrhea and constipation of the dogs and cats and other problems, helps to restore the normal intestinal functions of the pet dogs and cats, and helps to reduce the fecal odor of the dogs and cats.

The invention provides a duck feed which comprises wheat, wheat bran, soybean cake, fish meal, alga fermentation material, organic manganese microelement additive, phytase, beta-mannase, sodium butyrate, vitamin D, calcium chloride, calcium hydrophosphate, table salt and traditional Chinese medicine composition additive. The feed provided by the invention can avoid the adverse side effects on the duck caused by adding toxic additives such as antibiotics and the like, improve the productivity of the duck, promote the healthy growth of the duck, enhance the virus resistance of the duck and improve the meat quality of the ketone body of the duck.

The invention discloses a granulated feed for 0-4 day broilers and a preparation method thereof. The granulated feed for 0-4 day broilers is prepared from the following raw materials in percentage by weight: 56-61% of corn, 4-6% of flour, 26-28% of peeled bean pulp, 3-6% of dephenolized cotton seed protein, 0.4-0.6% of soybean oil, 1.4-2.0% of calcium biphosphate, 2-4% of calcium formiate, 0.2-0.4% of table salt, 0.02-0.05% of 99% methionine, 0.04-0.08% of 60% choline chloride, 0.02-0.08% of sodium butyrate, 0.2-0.4% of acidifier, 0.04-0.16% of emulsifier, 0.02-0.05% of microecologics, 0.3% of multivitamin premix and 0.2% of compound micro-mineral premix. All the raw materials pass through a 30-mesh standard screen, and are granulated at 80 DEG C until the gelatinization degree reaches 90%. The invention has the advantages of scientific proportioning, comprehensive nutrition and good mouth feel, satisfies the special nutritional demands of 0-14 day broilers, enhances the immunity and anti-irritability of chickens on the premise of not using antibiotics, and ensures the survival percent.