53 results about "Fucoxanthin" patented technology

The invention discloses a nucleic acid aptamer OUC-Fx11-5T of fucoxanthin and application of the nucleic acid aptamer OUC-Fx11-5T, and belongs to the technical field of nucleic acid aptamers. The nucleic acid aptamer OUC-Fx11-5T of the fucoxanthine has a nucleotide sequence as shown in SEQ ID NO. 19. The nucleic acid aptamer OUC-Fx11-5T of the fucoxanthine has a nucleotide sequence as shown in SEQ The invention further discloses the application of the nucleic acid aptamer OUC-Fx11-5T of the fucoxanthin in identification or detection of the fucoxanthin. According to the nucleic acid aptamer OUC-Fx11-5T of the fucoxanthine, the affinity and dissociation constant of the nucleic acid aptamer OUC-Fx11-5T and the fucoxanthine is determined to be 68.2 nM through an isothermal titer thermal method, the nucleic acid aptamer OUC-Fx11-5T has no obvious affinity to structural analogues of the fucoxanthine such as violaxanthin, neoxanthin, zeaxanthin and beta-carotene, has high affinity and good specificity to the fucoxanthine, and can be used for preparing the fucoxanthine aptamer OUC-Fx11-5T of the fucoxanthine. The method can be used for identification or detection of fucoxanthine.

The invention discloses a preparation method and application of a targeted delivery system of a metal polyphenol nano system. The invention discloses a targeted delivery system of a metal polyphenol nano system, and a preparation method of the targeted delivery system comprises the following steps: taking the metal polyphenol nano system formed based on epigallocatechin gallate and iron ions as a carrier, and loading fucoxanthin to prepare fucoxanthin nano particles with active oxygen response characteristics; then, after chondroitin sulfate capable of targeting macrophages and (5-carboxyl amyl) triphenyl phosphorus bromide capable of targeting mitochondria are coupled, the fucoxanthin delivery system with the active oxygen response characteristic and the targeting characteristic is further prepared through a double emulsion anti-solvent evaporation method. The system can realize release of fucoxanthin under stimulation of active oxygen, and realizes aggregation of a targeted delivery system in mitochondria of a specific inflammation site. The carrying system can effectively improve or relieve the inflammatory bowel disease, and the raw materials used in the carrying system are low in cost, the preparation conditions are mild, and large-scale production is easy.

The invention belongs to the technical field of biology, and particularly relates to a method for increasing the fucoxanthine accumulation amount by using microcystis subjected to depolymerization treatment to feed palmarthria formosana. According to the method, microcystis subjected to depolymerization treatment are added in the culture process of the palmitothecium for heterotrophic culture, meanwhile, continuous inflation is conducted, the microcystis subjected to depolymerization treatment are swallowed by the palmitothecium, and the higher fucoxanthine accumulation amount in the palmitothecium is obtained by means of the culture mode. The experiment proves that after the microcystis is subjected to pretreatment and depolymerization, the removal efficiency of the microcystis is higher by the brown algae, the limitation of treatment of harmful cyanobacteria and ingestion of protozoa is made up, and meanwhile, an integrated solution is provided for biological treatment of cyanobacterial bloom and resource utilization of the microalgae; meanwhile, a new way is provided for obtaining fucoxanthine with higher accumulation amount.

The application discloses a fucoxanthin-maltodextrin delivery system based on ultrasonic-assisted encapsulation and a preparation method thereof. The delivery system comprises a maltodextrin derivative obtained by hydrophobic modification of maltodextrin with octanoyl chloride and fucoxanthin encapsulated therein. The preparation method of the fucoxanthin-maltodextrin delivery system based on ultrasonic-assisted encapsulation disclosed in the application can graft octanoyl chloride onto a maltodextrin chain through esterification to prepare an amphiphilic maltodextrin derivative which can self-aggregate into aggregates. The ultrasonic-assisted encapsulation can load more fucoxanthin and target the delivery of the fucoxanthin to the intestinal tract. The method has the advantages of short encapsulation time, high efficiency of embedding and delivery of hydrophobic substances, etc. The maltodextrin aggregates prepared by the method have high efficiency of encapsulating and delivering fucoxanthin, have a more compact structure, a smaller particle size and a larger specific surface area, so that the maltodextrin aggregates have a higher drug loading capacity. The maltodextrin derivative prepared has acid stability and can be released in the intestinal tract in a targeted manner, and has great application value in the transportation of nutrients of food and the design of functional food.

The invention relates to the field of microalgae active component extraction, and discloses a method for extracting fucoxanthine and polyunsaturated fatty acid from microalgae and an extracted product thereof, the method comprises the following steps: S1, carrying out first extraction on the microalgae by using a low-concentration alcohol solution, and carrying out solid-liquid separation to obtain a first algae cake and a first extracting solution; and S2, carrying out second extraction on the first algae cake obtained in the step S1 by using a high-concentration alcohol solution, and carrying out solid-liquid separation to obtain a second algae cake and a second extracting solution. According to the method, the low-concentration alcoholic solution and the high-concentration alcoholic solution are matched for extraction, the method is simple, efficient, low in cost and suitable for large-scale production, the problem of residues of toxic solvents such as n-hexane is avoided, the alcoholic solution can be recycled, the proportion of the low-concentration alcoholic solution and the high-concentration alcoholic solution in a final finished product is close to that in natural microalgae cells, and the method is suitable for large-scale production. And the composition does not need to be compounded again.

The application discloses a nucleic acid aptamer OUC-Fx11-5T of fucoxanthin and application thereof, and belongs to the technical field of nucleic acid aptamer. The nucleic acid aptamer OUC-Fx11-5T of fucoxanthin has a nucleotide sequence as shown in SEQ ID NO. 19. The nucleic acid aptamer OUC-Fx11-5T of fucoxanthin is applied to the recognition or detection of fucoxanthin. The nucleic acid aptamer OUC-Fx11-5T of fucoxanthin has an affinity dissociation constant of 68.2 nM with fucoxanthin by isothermal titration calorimetry, has no obvious affinity to structural analogs of fucoxanthin such as violaxanthin, neoxanthin, zeaxanthin and beta-carotene, has high affinity and good specificity to fucoxanthin, and can be used for the recognition or detection of fucoxanthin.

The invention belongs to the technical field of health-care food and traditional Chinese medicine preparation, and discloses a medicinal and edible drink for treating prostatitis and a preparation method thereof.The drink is prepared by taking houttuynia cordata, dandelion, purslane and endive as monarch drugs, matching lalang grass rhizome, reed stem root, talc and yam rhizome as ministerial drugs, assisting saffron, and supplementing astragalus membranaceus, Chinese yam, fructus lycii and oyster; and meanwhile, lycopene and fucoidan are added. The preparation method comprises the following steps: pretreatment of raw material cleaning, drying and grouped crushing; carrying out low-temperature cold extraction by adopting water or an ethanol-water mixed solvent at 0-10 DEG C; the cold extraction liquid is heated to 80-95 DEG C and kept for 10-30 min, and high-temperature glowing is completed; the obtained liquid is sequentially subjected to rough filtration, fine filtration and vacuum concentration, instant high-temperature sterilization is conducted under the condition of 121 DEG C, and finally a liquid beverage, a concentrated solution or instant powder is prepared. Through combination of a reasonable formula and a specific technology, stable extraction and retention of various effective components are achieved, and the product quality consistency is good.

The present application relates to a kind of by chrysophyte fermentation-light coupling high-efficiency production of fucoxanthin method, comprising: chrysophyte is inoculated into fermenter and is carried out heterotrophic culture, while the algal liquid is continuously or intermittently lighted;Culture medium includes basic medium and feed medium, C / N is 4:1-40:1, nitrogen source uses organic nitrogen source or inorganic ammonium nitrogen;The glucose concentration in basic medium is 5-15g / L, temperature is 25-32℃, dissolved oxygen is controlled at 5-80%, pH is 4-8, light intensity 5-600 μmol m ‑2 s ‑1 ;Glucose concentration is monitored in time during the cultivation process, when glucose concentration is reduced to 0.5-3g / L, using peristaltic pump to flow feed medium is added to flow culture, control the glucose concentration in whole flow culture process in 1-10g / L;After 100h of cultivation, every 1-5h is sampled to detect the biomass dry weight contained in the culture medium in fermenter, when the detection value is unchanged or begins to drop, fermentation is finished, harvest, and the harvested product is used for extracting fucoxanthin.The present application establishes the feasibility basis of fermentation-light coupling chrysophyte cultivation to scale production of fucoxanthin.

The invention discloses an integrated extraction device for fucoxanthine, and relates to the technical field of extraction equipment. Due to the fact that materials on the bottom layer and materials on the upper layer cannot be exchanged in the heating and stirring process of solvents and materials in an extraction container, heating is uneven, and the extraction effect is affected, according to the fucoxanthine integrated extraction device, due to the fact that the zigzag appearance of a bottom scraper is matched with an inner guide plate, in the process of stirring and shoveling the materials at the bottom of a tank body, the materials on the bottom layer cannot be exchanged; the zigzag appearance of the bottom scraper is used for driving a solvent and a material, centrifugal force in a rotating state is matched with the inner guide plate, so that the material and the volume of the bottom layer move towards the outer side, and the side scraper and the outer guide plate are matched, so that the internal material and the solvent circularly flow in the tank body, the heating uniformity is improved, and the extracted fucoxanthine is uniformly fused into the solvent.

The application discloses a culture method for enhancing the body color of Eaststar Prawn and relates to the technical field of aquaculture. The method comprises the following steps: (1) light induction: white-red-blue-yellow light sources are alternately used for irradiation, (2) color enhancer feeding: the color enhancer is fed simultaneously with the basic feed, and the components of the color enhancer include Camellia nitidissima polysaccharide, Sargassum fusiforme polysaccharide, fucoxanthin, scallop peptide, silymarin, guanidino acetic acid and sodium butyrate, and (3) water flow stimulation. Through the regulation of physiological metabolism, nutrient absorption and environmental adaptability, the method jointly acts on the body color performance of Eaststar Prawn, is favorable for enhancing the body color of Eaststar Prawn and improving the economic value of Eaststar Prawn.

The present invention relates to a water-soluble fucoxanthin and a preparation method thereof. The water-soluble fucoxanthin is a water-soluble particle formed by self-assembly of fucoxanthin, fatty acids, bovine serum albumin, and water-soluble chitosan. The preparation method comprises the following steps: (1) preparing water-soluble chitosan; (2) preparing a fucoxanthin-fatty acid mixture; (3) preparing alkaline electrolyte water; (4) preparing a fucoxanthin-protein complex by electrolysis water coupling ultrasound technology; (5) preparing a chitosan-protein-fatty acid-fucoxanthin complex; and (6) obtaining water-soluble fucoxanthin. The present invention adopts alkaline electrolysis water coupling ultrasound technology and non-covalent self-assembly technology to prepare water-soluble fucoxanthin with good stability and high absorption rate. The preparation process is simple, the embedding rate is high, the safety is good, the production cost is low, the fucoxanthin is suitable for industrial production, and the fucoxanthin can be widely used in food systems as a nutritional enhancer.

The application belongs to the field of microalgae biotechnology, and particularly relates to a brownish chrysochromulina and a method for producing fucoxanthin by using the brownish chrysochromulina. The brownish chrysochromulina is named PCSM-1, and was preserved in China Center for Type Culture Collection on January 11, 2024, with a preservation number of CCTCC NO: M 2024076. The content of fucoxanthin in the brownish chrysochromulina is as high as 1.58 wt%, and the brownish chrysochromulina can grow under photoautotrophic conditions and heterotrophic conditions. The brownish chrysochromulina is first subjected to heterotrophic fermentation to rapidly proliferate and ferment, and then is subjected to induction under photoautotrophic and heterotrophic conditions to rapidly accumulate fucoxanthin. The whole process has a short cycle, low energy consumption, and a far higher yield of fucoxanthin than existing microalgae, and can solve the problems of low production efficiency and high cost of fucoxanthin.

The invention discloses an MIE3 gene for improving the fucoxanthin content in phaeodactylum tricornutum and application thereof, and is characterized in that the nucleotide sequence of the MIE3 gene is shown as SEQ ID NO.1, the amino acid sequence of protein coded by the MIE3 gene is shown as SEQ ID NO.2, the MIE3 gene in the phaeodactylum tricornutum is knocked out, so that the content of synthesized fucoxanthin is improved, and the content of fucoxanthin in the phaeodactylum tricornutum is increased. The sgRNA sequence adopted for knocking out the MIE3 gene in the phaeodactylum tricornutum is as follows, the nucleotide sequence of sgRNA1 is as shown in SEQ ID NO.5, and the nucleotide sequence of sgRNA2 is as shown in SEQ ID NO.6. The method has the advantages that the MIE3 is found and proved to be a key negative regulation factor for synthesis of the fucoxanthin, and the content of the fucoxanthin in the phaeodactylum tricornutum can be remarkably increased through gene modification.

The invention relates to a fucoidan composition and a preparation method thereof. The fucoidan composition comprises the following components in percentage by weight: 20-30% of nemacystus japonicus fucoidan, 20-30% of almacystus japonicus fucoidan, 20-30% of 25-35% of sporophyll carbohydrate gum of the undaria pinnatifida in the Tasmanni Australian sea area; 25-35% of fucus saccharide gum in the Australian Tasmanni subsea area; 5 to 10% of microalgae fucoidan; and 1-5% of microalgae fucoxanthin. According to the fucoidan composition disclosed by the invention, the effective inhibition rate of the prepared fucoidan composition on human colon cancer, human pancreatic cancer, human liver cancer, human prostatic cancer, human breast cancer or human lung cancer and the like reaches 89% or above through an optimized formula of multiple components.

The present invention discloses a method for preparing fucoxanthin-loaded pectin@β-cyclodextrin, comprising the following steps: (1) preparing a fucoxanthin stock solution; (2) preparing a PBS stock solution; and (3) preparing fucoxanthin-loaded pectin@β-cyclodextrin. The method for preparing fucoxanthin-loaded pectin@β-cyclodextrin of the present invention has simple process steps and strong operability. By loading fucoxanthin on pectin@β-cyclodextrin, the stability of fucoxanthin in vitro and in vivo is improved, so that fucoxanthin can better reach the target site and improve its bioavailability in the gastrointestinal tract. The present invention also provides an application of fucoxanthin-loaded pectin@β-cyclodextrin in lipid-lowering foods, which can provide ideas for the application and further development of fucoxanthin in foods.

Compositions with weight-loss effects and their applications belong to the field of biomedicine. To improve the fat-reducing effect and further solve the off-target effect problem caused by existing weight-loss mechanisms, the composition includes fucoxanthin 0.8%~2.5%, ginsenoside CK 0.6%~1.2%, black ginseng active peptide 0.3%~0.6%, amylase inhibitor 12%~30%, prickly pear cactus extract 6%~15%, allicin 0.2%~0.6%, and excipients. This invention achieves weight regulation through comprehensive synergy of multiple targets.

The invention discloses an industrial application method of smooth nitzschia in biosynthesis of environment-friendly fucoxanthin. A high-yield mutant strain is obtained by combining multiple rounds of ARTP mutagenesis with CRISPR / Cas9 gene editing, and an excellent strain is quickly locked by utilizing intelligent high-throughput screening. High-density culture and efficient synthesis are realized by combining multi-stage dynamic fermentation with metabolic flow regulation and control. The culture is optimized in the intelligent photobioreactor, the energy consumption is reduced, the cyclic utilization of waste liquid and algae residues is realized in cooperation with a green process, and the environmental pollution is reduced. And the high-purity fucoxanthin is extracted by combining supercritical CO2 extraction with a microfluid crushing technology. The content is obviously increased, the cost is reduced, and the method is environment-friendly, is suitable for large-scale production in food, medicine and feed industries, and has a wide market prospect.

The application discloses a preparation method and application of food-derived cellulose-based nanocomposite particles, and belongs to the field of precise nutrition delivery. The preparation method of the food-derived cellulose-based nanocomposite particles comprises the following steps: preparing oxidized food-derived nanocellulose through a TEMPO oxidation method on the basis of food-derived cellulose; mixing a protein aqueous solution with the oxidized food-derived nanocellulose suspension; then adding an ethanol solution containing a hydrophobic active substance, homogenizing, and removing the ethanol to obtain the food-derived cellulose-based nanocomposite particles. The method increases the overall structural stability of the nanoparticles, improves the encapsulation efficiency of fucoxanthin and the stability of the fucoxanthin during storage, and the fucoxanthin encapsulated in the nanoparticles can be effectively absorbed by cells, significantly improves the bioavailability of the fucoxanthin, and effectively inhibits the formation of lipid droplets by activating the Nrf2 / HO-1 / NQO1 signal pathway to reduce oxidative stress.

The present invention relates to a vision protection functional food and its production process, which specifically comprises the following steps: (1) preparing fucoxanthin nanoparticles by alkaline electrolyzed water-ultrasonic coupling technology; (2) mixing the fucoxanthin nanoparticle powder with quercetin, β-sitosterol, docosahexaenoic acid, water or solid filler excipients in proportion to obtain an aqueous solution mixture or a solid mixture; (3) homogenizing and filtering the aqueous solution mixture; or sieving the solid mixture; (4) sterilizing and filling the filtered aqueous solution mixture, or tableting and granulating the sieved solid mixture, and preparing the mixture into products respectively. The present invention can significantly improve the antioxidant capacity of the eyes and retinal function, effectively prevent myopia and reduce the risk of retinal-related ophthalmic diseases; the product can be made into capsules, tablets, granules, oral liquids or beverages, has a simple production process, is low in cost, and is suitable for large-scale industrial production.

The invention relates to the technical field of natural product extraction, and discloses a fucoxanthin extraction, separation and solvent circulation method based on quaternary ammonium salt-metal salt composite ionic liquid, and the method comprises the following steps: S1, mixing a quaternary ammonium salt cation precursor and metal salt to obtain the composite ionic liquid; s2, mixing the algae powder with a compound ionic liquid, and performing ultrasonic stirring extraction to obtain an extraction mixture; s3, adding a salting-out agent into the extraction mixture, centrifuging and collecting an upper phase rich in fucoxanthin; s4, filtering the upper phase with diatomite or a short silica gel column, and performing vacuum dehydration; separating and purifying the composite ion phase subjected to vacuum dehydration to obtain high-purity fucoxanthin, and recycling the composite ion liquid. According to the scheme, fucoxanthin in algae is extracted with the quaternary ammonium salt-metal salt composite ionic liquid, links such as extraction, primary separation and solvent circulation are integrated, and compared with a traditional organic solvent method, the method has remarkable advantages in the aspects of selectivity, efficiency, product purity and environmental influence.

The invention discloses functional feed for litopenaeus vannamei, and belongs to the field of feed for the litopenaeus vannamei. According to the technical scheme, the functional feed for the litopenaeus vannamei consists of a basal feed and a brown algae source additive, the addition amount of the brown algae source additive in the basal feed is 1-2 g / kg; the brown algae source additive is prepared from fucoxanthin and sodium alginate; fucoxanthin and sodium alginate are extracted from the same brown algae in a co-production manner; the brown algae source additive is a microcapsule formed by wrapping fucoxanthin with sodium alginate as a wall material. In order to solve the technical problems that most of the existing prawn feed additives are from chemical synthesis sources and have certain limitations in the aspects of promoting growth and enhancing immunity, the invention provides the functional feed for the litopenaeus vannamei, which contains natural bioactive substances, has definite and controllable components and can promote the growth of the prawns and improve the immunity of the prawns.

The invention provides nitzschia glauca capable of resisting low temperature and application of the nitzschia glauca, and the provided nitzschia glauca has the preservation number of CCTCC (China Center For Type Culture Collection) NO: M 20252152. According to the invention, the novel nitzschia oryzae strain with remarkable competitive advantages is successfully screened through a 300MeV proton heavy ion physical mutagenesis technology. The growth rate of the strain in a low-temperature environment of 10-15 DEG C is obviously superior to that of a wild type, and the problem of short outdoor culture cycle in high-latitude areas such as northeast is effectively solved; meanwhile, the mutant strain realizes double increase of biomass and high-value components, the fucoxanthin content of the mutant strain is remarkably increased at normal temperature, the lipid and protein content higher than those of a wild type can still be kept at low temperature, and the mutant strain shows extremely high broad-spectrum temperature adaptability and application economic value.

To provide an oil-soluble pigment emulsified preparation which uses alkenylsuccinic acid esterified starch having high emulsion stability and color tone stability during storage.SOLUTION: An oil-soluble pigment preparation is an oil-in-water type emulsified composition including an aqueous phase containing alkenylsuccinic acid esterified starch and a water-soluble polysaccharide, and an oil phase containing an oil-soluble pigment, where a pH of the aqueous phase is 3.5 or lower. The oil-soluble pigment desirably includes xanthophylls such as astaxanthin, capsanthin, canthaxanthin, cryptoxanthin, zeaxanthin, fucoxanthin, lutein, capsicum pigment (alternatively: paprika pigment), marigold pigment, orange pigment, phaffia pigment, and haematococcus algae pigment.SELECTED DRAWING: None

The invention belongs to the technical field of nutritional compositions and biological medicines, and particularly relates to a liver protection composition as well as a preparation method, application and a product thereof. The invention provides a liver protection composition. The liver protection composition is prepared from a silybum marianum extract, a turmeric extract and fucoxanthin. According to the liver protection composition, through the synergistic effect of the three components, the oxidation resistance can be remarkably improved, serum ALT and AST levels and liver indexes of mice in a liver injury model can be reduced, expression of inflammatory factors (IL-6 and TNF-alpha) can be inhibited, the oxidative stress index (SOD) can be improved, the liver protection effect of the liver protection composition is better than that of a single component and a traditional compounding scheme, and the liver protection composition can be widely applied to the field of liver protection. The traditional Chinese medicine composition has the advantages of comprehensive efficacy, strong pertinence and high safety, and has important application value in the field of liver protection.

The invention discloses application of liver-targeted fucoxanthin nanovesicles in preparation of products for treating alcoholic fatty liver diseases, and relates to the technical field of medicines. According to the invention, the probiotic membrane vesicle is used as a nano-carrier and has good biocompatibility and targeting property, then the probiotic membrane vesicle is modified by galactose to further enhance the liver targeting property and improve the delivery efficiency of the fucoxanthin, and the anti-adipogenesis effect of the fucoxanthin is remarkably improved by enhancing the specific uptake ability of liver cells, so that the anti-adipogenesis effect of the fucoxanthin is improved, and the anti-adipogenesis effect of the fucoxanthin is improved. Therefore, the purpose of treating the alcoholic fatty liver is achieved.

The invention discloses a method for increasing the extraction yield of fucoxanthin in nitzschia virens, which comprises the following steps: carrying out propagation culture on the nitzschia virens, sampling in a logarithmic phase, and carrying out centrifugal enrichment and freeze drying until the weight is constant to obtain dry nitzschia virens powder; the obtained dry algae powder is added into an extraction solvent according to the volume ratio of 400: 1, extraction is conducted at the temperature of 40-60 DEG C, the number of times of extraction is one or two, and the time for each extraction is 5-20 min; the extraction solvent is a mixture formed by mixing any one or two or more of methanol, ethanol, acetonitrile, ethyl acetate and acetone according to any proportion. The method is simple to operate, low in cost, high in speed and suitable for large-scale industrial production of fucoxanthin, the yield of fucoxanthin is greatly increased, and technical support is provided for industrial production of fucoxanthin based on diatom.

Provided is a technology capable of improving antimicrobial properties in a fucoxanthin-containing composition. A method for producing a fucoxanthin-containing composition includes the step of culturing a diatom in a medium at pH 1.0 or more and pH 4.0 or less, wherein the diatom has 18S rRNA composed of the following (a) or (b): (a) a polynucleotide consisting of a nucleotide sequence represented by SEQ ID NO: 1; or (b) a polynucleotide consisting of a nucleotide sequence having 85% or more identity to the nucleotide sequence represented by SEQ ID NO: 1.

The invention pertains to a nutritional composition comprising xanthohumol, fucoxanthin and c- phycocyanin. Further, the invention pertains to a nutritional composition comprising xanthohumol, fucoxanthin and c-phycocyanin for use as a medicament, more particularly for therapeutic use in treating and / or preventing muscle wasting.

The present application belongs to the field of biotechnology, and particularly relates to a method for improving accumulation of fucoxanthin, oleic acid and arachidonic acid in brown flagellate culture. The method is to add microcystis to brown flagellate for mixed culture, and continuously aerate, and the microcystis is phagocytosed by the brown flagellate. The method of phagocytosis of microcystis by brown flagellate is used to realize higher accumulation of fucoxanthin in brown flagellate. Through the experiment, it is proved that the brown flagellate has higher removal efficiency for non-toxic microcystis, and can also effectively ingest toxic microcystis, and a new way for obtaining higher accumulation of fucoxanthin in biological manufacturing is provided.

The invention belongs to the technical field of chemical materials, and particularly relates to fucoxanthin-coated lipidosome as well as a preparation method and application thereof. The fucoxanthin-coated liposome provided by the invention comprises the following components in percentage by weight: 30-50% of water; 30 to 50 percent of polyhydric alcohol; 5-10% of an antioxidant; 1-5% of a solubilizer; 1% to 5% of isosorbide dimethyl ether; 1-5% of lecithin; 1-5% of a dispersant; 0.1-1% of a stabilizer; and the fucoxanthin accounts for 0.05 to 5 percent. The fucoxanthin liposome has the advantages that by optimizing the components of the fucoxanthin liposome, the permeability of the fucoxanthin on the skin surface is enhanced, and the skin is prevented from being stained; meanwhile, the fucoxanthin-coated liposome provided by the invention has very good water solution solubility, can be directly added into a water phase, is small in skin irritation and high in stability, and has a wide practical application value.