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Sorghum prolamin-fucoidin compound for co-delivery of fucoxanthin and quercetin

A technology of kafirin and fucoxanthin, which is applied in the direction of non-active ingredients of polymer compounds, capsule delivery, drug combination, etc., can solve the problems of limited application, achieve good uniformity, improve bioavailability, and preparation method simple effect

Active Publication Date: 2021-06-04
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Fucoxanthin (fucoxanthin) is a natural pigment of xanthophylls in carotenoids, which has anti-tumor, anti-inflammation, and anti-oxidation effects, but it is insoluble in water and sensitive to light and heat, which limits its application.
Quercetin (quercetin) is also a fat-soluble active substance, which has antioxidant, anticancer and antiviral activities, but it also has similar problems to fucoxanthin

Method used

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  • Sorghum prolamin-fucoidin compound for co-delivery of fucoxanthin and quercetin
  • Sorghum prolamin-fucoidin compound for co-delivery of fucoxanthin and quercetin
  • Sorghum prolamin-fucoidin compound for co-delivery of fucoxanthin and quercetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 Different ratio contrast experiment

[0032] 1 g of kafirin, 100 mg of fucoxanthin, and 100 mg of quercetin were co-dissolved in 100 mL of 80% ethanol aqueous solution, and stirred at 700 rpm for 1 hour;

[0033] Dissolve fucoidan of different qualities (10, 20, 33, 50, 100, 200 mg), see Table 1 for details, in 40 mL of deionized water, stir at 700 rpm for 1 hour, and then adjust its pH to 4 with HCl;

[0034] Subsequently, 10 mL of the solution containing kafirin and the active substance was dropped into 30 mL of HCl solution with a pH of 4 under 700 rpm magnetic stirring for 1 hour, and then the above solution was dropped into 40 mL of fucoidan solution and stirred for 1 hour Finally, use a rotary evaporator (40°C, -0.1MPa) to remove ethanol, and use HCl solution with a pH of 4 to make up the evaporated volume, and adjust the pH to 4;

[0035] Then centrifuge at 3000rpm for 10 minutes to finally obtain a composite system with a mass ratio of kafirin to f...

Embodiment 2

[0043] Embodiment 2 temperature stability experiment

[0044] The newly prepared composite nanosystems with different proportions in Example 1 were heated at 80°C for 0-120 minutes, and samples were taken every 30 minutes. After standing and cooling to room temperature, the retention rates of fucoxanthin and quercetin were tested respectively. see results Figure 5 and Figure 6 .

[0045] Depend on Figure 5 and Figure 6 It can be seen that when the ratio of kafirin to fucoidan is 2:1, the thermal stability of the encapsulated fucoxanthin and quercetin is the best.

Embodiment 3

[0046] Embodiment 3 Salt resistance experiment

[0047] Add NaCl solid to the composite system of different proportions newly prepared in Example 1, make its final concentration be respectively 10mM, 20mM, 50mM, test its particle size after standing for 24 hours, the results are shown in Figure 7 .

[0048] Depend on Figure 7 It can be seen that when the added salt concentration is 50mM, precipitation occurs in the systems with a ratio of 10:1 and 5:1, and the more fucoidan added, the better the salt resistance of the composite system, and the particle size changes The smaller the value, the overall experiment shows that the composite system has better salt resistance.

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Abstract

The invention belongs to the field of foods, and particularly relates to a sorghum prolamin-fucoidin nano compound for co-delivery of fucoxanthin and quercetin. According to the sorghum prolamin-fucoidin nano compound for co-delivery of the fucoxanthin and the quercetin, the mass ratio of sorghum prolamin to fucoidin is 2: 1, the mass ratio of the sorghum prolamin to the fucoxanthin is 10: 1, and the mass ratio of the sorghum prolamin to the quercetin is 10: 1. The preparation method disclosed by the invention is simple and low in production cost, non-toxic or low-toxicity raw materials are selected, and prepared nano drug-loaded particles are high in safety and good in biocompatibility; the prepared nano drug-loaded particles are relatively small in particle size and relatively good in uniformity, and are beneficial to cellular uptake; two active substances can be carried at the same time, and the encapsulation efficiency on the two active substances is relatively high; and the burst release of the active substances in the stomach can be avoided, so that the bioavailability is improved.

Description

technical field [0001] The invention belongs to the field of food, and in particular relates to a kafirin-fucoidan nanocomposite that co-delivers fucoxanthin and quercetin. Background technique [0002] Fucoxanthin (fucoxanthin) is a natural pigment of xanthophylls in carotenoids, which has anti-tumor, anti-inflammation, and anti-oxidation effects, but it is insoluble in water and sensitive to light and heat, which limits its application. . Quercetin (quercetin) is also a fat-soluble active substance, which has antioxidant, anticancer and antiviral activities, but it also has problems similar to fucoxanthin. Contents of the invention [0003] The present invention provides a kafirin-fucoidan nanocomposite that co-delivers fucoxanthin and quercetin. [0004] A kafirin-fucoidan nanocomposite that co-delivers fucoxanthin and quercetin, wherein the mass ratio of the kafirin to the fucoidan is 2:1, and the kafirin and fucoidan The mass ratio of flavin is 10:1, and the mass r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/36A61K31/352A61K31/336A61K9/51A61P35/00A61P29/00A61P39/06A61P31/12
CPCA61K47/42A61K47/36A61K31/352A61K31/336A61K9/5161A61K9/5169A61P35/00A61P29/00A61P39/06A61P31/12A61K2300/00
Inventor 黄莉莉欧阳小琨章宏
Owner ZHEJIANG OCEAN UNIV
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