502results about How to "Good anticancer effect" patented technology

The invention relates to a process for preparing brassica vegetable seedling powder chewable tablets and a brassica vegetable seedling powder chewable tablet product, belonging to the technical field of deep processing of agricultural products. The process is characterized by comprising the following steps of: with brassica vegetable seedling powder, such as broccoli and the like as a main basic stock, compounding, preparing a soft material, granulating, drying, tabletting, sterilizing and packing to prepare the brassica vegetable seedling powder chewable tablet with the advantages of clean appearance, green color and crispness. The process for preparing the brassica vegetable seedling powder chewable tablet, disclosed by the invention, is simple, has high industrial degree and can realize complete utilization on the brassica vegetable seedling, such as broccoli and the like, thereby increasing the additional value of the brassica vegetable seedling. The brassica vegetable seedling powder chewable tablets, including the broccoli and the like, prepared by the process disclosed by the invention have functions of resisting oxidation, slowing aging and resisting inflammation and cancer and the like of human bodies, and is a kind of casual healthcare food. According to the product of the process for preparing the brassica vegetable seedling powder chewable tablets, disclosed by the invention, the content of 4-methylsulfinylglucosinolate is up to 185.0-413.0mg / 100g, and the content of sulforaphane provided by each chewable tablet is equal to that provided by 30-75g of fresh brassica vegetable, such as broccoli and the like.

The invention relates to wild honeysuckle flower extract, which mainly comprises the following compositions: macranthoside A,II b, macranthoside B,IIIb, 3-O-alpha-L-pyran rhamnose (1-2)-alpha-L-pyran arabinose-hederagenin and 3-O-beta-D-glucopyranose (1-4)-beta-D-glucopyranose (1-3)-alpha-L-pyran rhamnose (1-2)-alpha-L-pyran arabinose -oleanolic acid. The invention also relates to a method for preparing the compound and application of the compound in the aspect of cancer.

The invention discloses a carrier-free co-assembled tumor targeting anti-cancer nano medicine as well as a preparation method and application thereof. The carrier-free dual anti-cancer nano medicine is prepared from a hydrophobic medicine, namely ursolic acid, together with board-spectrum anti-tumor medicines such as doxorubicin in water through co-assembling, in addition, a fluorescence labeling nucleic acid aptamer, a molecular target, an antibody or polypeptide and the like with tumor targeting functions are adsorbed to the surface of the medicine through mutual electrostatic functions, then the carrier-free co-assembled tumor targeting anti-cancer nano medicine with tumor targeting and tumor microenvironment response is prepared, a synergic anti-tumor function is achieved, diagnosis and treatment integration is achieved, particularly the medicine has outstanding functions in preventing tumor transfer, and more importantly the problems that a conventional nano carrier is complex in system, indefinite in in-vivo metabolism and the like are solved.

The invention discloses liquid shampoo and a preparation method thereof. The liquid shampoo comprises, by mass, 30-80 parts of black rice, 3-7 parts of lemon, 5-20 parts of pipal tree seeds, 3-10 parts of wild ginseng, 3-15 parts of tea seeds, 15-30 parts of saponin, 2-11 parts of platycodon grandiflorum, 2-10 parts of rhizoma anemarrhenae, 3-10 parts of polygonum multiflorum, 2-13 parts of fresh ginger, 2-18 parts of folium mori, 2-15 parts of angelica sinensis, 2-15 parts of saffron, 2-10 parts of coptis chinensis, 2-13 parts of lucid ganoderma, 2-10 parts of eclipta, 3-8 parts of medlar, 2-12 parts of astragalus membranaceus, 2-10 parts of ligusticum chuanxiong hort and 2-10 parts of aloe. The liquid shampoo is prepared according to the reasonable ratio, the effects of all the raw materials are remained, the synergistic interaction function is played through reasonable matching, and the liquid shampoo has the functions of hair cleaning, hair care, hair nourishing, hair reinforcing, hair loss preventing, hair generation, dandruff removal, itching relieving, radiation protection and dandruff generation prevention and the like.

Methods for treating neoplasm, tumors and cancers, using one or more tumor treating drug carriers, haptens and anticancer drugs, alone or in combination with other antineoplastic agents or treatments, are provided. Also provided are compositions, and kits containing the composition for affecting the therapy.

The invention discloses a seabuckthorn fruit juice and a preparing method thereof, and belongs to the field of juice processing. The preparing method includes the following steps of (1) raw seabuckthorn juice preparing; (2) material taking, wherein 40-75 by weight parts of the raw seabuckthorn juice, 10-30 by weight parts of white sugar, 1-5 by weight parts of xanthan gum, 3-8 by weight parts of honey, 0.5-3 by weight parts of gelatin, 1-3 by weight parts of aspartame, 40-100 by weight parts of water and 10-30 by weight parts of raw apple juice are taken; (3) preparing and clarifying; (4) sterilizing, wherein sterile clarified liquid is obtained through high-voltage pulse electric field sterilization; (5) seabuckthorn fruit juice obtaining, wherein the seabuckthorn fruit juice is obtained in a sterile-filling mode. By means of the eabuckthorn fruit juice and the preparing method thereof, nutrient ingredients and flavor substances in seabuckthorn fruits can be effectively reserved.

The invention relates to a nutritious and healthy unit edible vegetable oil, which is characterized by adopting unit vegetable oil and fat rich in Omega-3 type polyunsaturated fatty acid and Alpha-linolenic acid as main materials, and adding algae oil rich in EPA and DHA. In the unit edible vegetable oil, the content of the algae oil is 0.05 percent to 5 percent of the weight of edible oil, and the content of the Omega-3 type polyunsaturated fatty acid is 8 percent to 70 percent of the weight of edible oil; and simultaneously the edible oil also adds an oxidizing agent as an additive. The nutritious and healthy unit edible vegetable oil has the advantages that: 1. by a reasonable formula of the edible oil, increasing the intake of the Omega-3 type polyunsaturated fatty acid, and further adding an effective path; 2. solving the defects of bad flavor and mouthfeel and poor stability of the edible oil added with algae oil; 3. adding a novel brain-strengthening health-care product, thus meeting the requirements of people for health diet; and 4. having strong market prospect.

The invention provides a camptothecin prodrug. The camptothecin prodrug is a prodrug formed bycamptothecin or a derivative thereof and Evans blue, the structural formula of the prodrug is represented by formula (I); and in the formula, R<1> is camptothecin or a derivative group thereof, R<2> is one of -CH2- and -O-, R<3> is one of -CH2-, -O-CO- and -O-CO-NH-, X is one of S and -CH2-, and n1 and n2 are the repeating unit number, and are integers in a range of 0-10. The camptothecin prodrug has an excellent tumor cell uptake effect in vivo and in vitro, and a part of the prodrug has a substantial cancer cell inhibition effect. The invention also provides a preparation method of the camptothecin prodrug and an application of the camptothecin prodrug in the preparation of cancer treatment drugs.

Provided is a monoclonal antibody which specifically recognizes B cell lymphoma cells and a use thereof. More specifically, provided are the monoclonal antibody; a pharmaceutical composition for preventing or treating B cell lymphoma including the monoclonal antibody; a composition for diagnosing B cell lymphoma including the monoclonal antibody; a method for providing information for diagnosing B cell lymphoma using the monoclonal antibody; a chimeric antigen receptor (CAR) protein including i) the antibody, ii) a transmembrane domain, and iii) an intracellular signaling domain; a recombinant vector which expresses the CAR protein; a CAR-modified T cell transformed with the recombinant vector; a pharmaceutical composition for preventing or treating B cell lymphoma including the CAR-modified T cell; and an antibody-drug conjugate wherein the monoclonal antibody and a drug are conjugated.

The invention provides a health Fuzhuan brick tea. The health Fuzhuan brick tea is prepared from the following components in percentage by weight: 80 to 98% of Anhua black tea, and 2 to 20% of sweet potato leaves, wherein eurotium cristatum develops on the Anhua black tea and the sweet potato leaves. According to the health Fuzhuan brick tea, the acrid odor of the sweet potato leaves and general Anhua black tea is removed; in addition, eurotium cristatum contains Fuzhuan brick tea theine A, Fuzhuan brick tea theine B, carotene and vitamin C which are easily absorbed by a human body and have obvious effects on lowering three highs, softening and purifying blood vessel, preventing anemia and high blood pressure, strengthening vision, eliminating constipation, expelling toxin, resisting cancer, and enhancing the immunity; the health Fuzhuan brick tea is mellow in taste, the tea soup is transparent and orange red and is easily accepted by customers. The invention further provides a preparation method of the health Fuzhuan brick tea.

A method for preparing mustard sauce with full-bodied flavor without additional mustard oil belongs to the field of fruit and vegetable food processing and comprises the steps: (1) grinding horseradish, namely performing coarse grinding and air-flowing type superfine grinding after drying the horseradish at low temperature; (2) processing mustard sauce, adding and stirring an appropriate amount of sodium carboxymethylcellulose, sodium alginate and soy protein in hot water to be dissolved, continuing to add lactose, ascorbic acid (Vc), citric acid and flavorings, finally adding horseradish powder and pigment mixed liquid, and performing homogeneity, sealing and enzymolysis to achieve the purpose of improving the flavor of the mustard sauce. The method for preparing the mustard sauce with full-bodied flavor without the additional mustard oil has the advantages that the low temperature drying and the air-flowing type superfine grinding are performed to the horseradish to improve the activity of myrosinase in the horseradish from 1.5U / mL to4.0-4.5 U / mL, glucosinolate in the horseradish is subjected to complete hydrolysis into an isothiocyanate material, the temperature, the time, the potential of hydrogen (pH) and the Vc adding amount in the mustard sauce processing are controlled to obtain the best hydrolysis conditions of the horseradish, good flavor can be obtained without additional mustard oil, product taste is full-bodied, and the quality guarantee period is prolonged.

The invention discloses a selfheal polysaccharide zinc chelate as well as a preparation method and application thereof to an anti-cancer drug. The method comprises the following steps: crushing selfheal clusters, decolorizing by use of ethanol, adding distilled water, performing reflux extraction, deproteinizing the extracting solution, performing ultrafiltration, and freeze-drying the retained liquid to obtain polysaccharide; preparing a polysaccharide solution of which the concentration is 10 mg / mL to 40 mg / mL, heating to the temperature of 40-60 DEG C, regulating pH by using sodium hydroxide, slowly adding a zinc salt solution into the polysaccharide solution, reacting for 6-24 hours, simultaneously performing an discontinuous homogenization process by using a high-shear homogenizer, regulating the pH by using hydrochloric acid, centrifuging to obtain supernatant liquor, putting the supernatant liquor into a dialysis bag for dialysis, collecting the solution in the dialysis bag, and performing freeze-drying to obtain the selfheal polysaccharide zinc chelate. The product disclosed by the invention is simple and easy to implement in preparation method, has a remarkable anti-proliferation effect on human cancer cells and also causes no cytotoxicity to normal cells of the human body, so the selfheal polysaccharide zinc chelate is an ideal anti-cancer drug or a health care product and also has a zinc replenishment effect.

The invention belongs to the technical field of medicine, and relates to an acridine derivative, particularly to 2-methyl-9-acridine(p-methoxyphenyl cresol amine)thiourea, a preparation method and uses thereof, wherein the structure formula is represented as the follow. According to the acridine derivative, the acridine mother nucleus is connected with the active group phenol amine thiourea so as to provide the strong potential biological activity. The results of in vitro anti-tumor tests show that the acridine derivative provides the strong inhibition effects on a variety of tumor cells, and can be used as the anti-tumor drug or the lead compound so as to be further development.

The present invention discloses one kind of new compound, polyethylene glycol derivative modified L-asparaginase in the structure as shown. The present invention also provides the preparation of the polyethylene glycol derivative modified L-asparaginase and its medicine composition. The compound of the present invention has homogeneous component, high antitumor effect, high chemical stability, and low immunogenicity.

The invention discloses a prepared traditional Chinese medicinal preparation having anticancer reactivity, which is an extraction containing saponin prepared from Marsdenia tenacissima, a traditional Chinese medicinal Asclepiadaceae plant through refining. The invention also discloses the process for preparing the traditional Chinese medicinal preparation having anticancer reactivity and its use.

The invention discloses an inulin soya-bean milk beverage and a preparation method thereof, belonging to the technical field of food processing. The inulin soya-bean milk beverage disclosed by the invention mainly consists of the following components in parts by weight: 80-120 parts of soya-bean milk, 2-20 parts of inulin, 1-5 parts of honey and 0.1-0.4 parts of a stabilizer, wherein the inulin, which is also called as synanthrin, is linear straight-chain polysaccharide formed by D-fructose through key jointing of beta (1 to 2), the tail end of the inulin is provided with a glucose residue, and the degree of polymerization is 2-60. The inulin, as a soluble dietary fiber different from a starch structure, can selectively promote the growth of colon probiotics and improve the health condition of a host. The inulin soya-bean milk beverage disclosed by the invention is white, is exquisite and smooth in mouth feel, has a low caloric value and can promote the growth of human colon probiotics, inhibit toxic fermentation products, promote the absorption of mineral materials such as calcium, magnesium and iron and improve the physiological functions such as immunity of the organism.

The composite nano preparation with determined anticancer effect includes coix seed oil, java, brucea fruit oil, bean phospholipid, pure glycerin and injectino water, which are prepared into composite emulsion, composite nanometer emulsion, liposome and powder for injectino for intravenous injection, oral taking, perfusion, etc. separately. Each 100 ml of the emulsion for injectino contains coix seed oil 5.0-15.0g, java brucea fruit oil 5.0-15.0 g, bean phospholipid 0.8-1.6 g and pure glycerin 2.0-3.0 g except injection water. The emulsion for injectino has grain size in the range of 0.1-0.8 micron. The coix seed oil and jave brucea fruit oil in the said preparations are extracted through supercritical SFECO2 extracting process and refined to reach the standard for injection.

The present invention provides a combined pharmaceutical composition of paclitaxel and CDKS kinase inhibitors, comprising active ingredients and pharmaceutically acceptable excipients, characterized in that: the active ingredients are composed of paclitaxel and CDK4 / 6 kinase represented by formula I Inhibitors or pharmaceutically acceptable salts thereof, the mass ratio of paclitaxel and CDK4 / 6 kinase inhibitors or pharmaceutically acceptable salts thereof in the active ingredient is (2‑8):1. The pharmaceutical composition has good anticancer curative effect and low toxic and side effects; due to the sensitivity of CDK4 / 6 kinase inhibitors to paclitaxel, the combination of the two produces a synergistic effect, thereby reducing the clinical dosage of capecitabine and reducing the large dosage Toxic and side effects produced by using capecitabine can improve the safety index of clinical treatment and have good clinical application prospects.

The invention provides a taxol and CDKS kinase inhibitor anti-tumor combined pharmaceutical composition. The pharmaceutical composition comprises active components and pharmaceutically acceptable auxiliary materials, and is characterized in that the active components comprise taxol and a CDK4 / 6 kinase inhibitor or pharmaceutically salt; and the mass ratio of the taxol to the CDK4 / 6 kinase inhibitor or pharmaceutically salt in the active components is (2-8):1. The pharmaceutical composition is high in anti-tumor efficacy and low in toxic and side effect; and as the CDK4 / 6 kinase inhibitor has sensibility for the taxol, the combination of the CDK4 / 6 kinase inhibitor and taxol has a synergistic effect, the clinical dose of xeloda is reduced, toxic and side effect caused by the use of large dose of xeloda is reduced, the clinical treatment safety index is improved, and the pharmaceutical composition has a good clinical application prospect.

The invention relates to complex paclitaxel and its derivates docetaxel intralipid which includes the following ingredients: paclitaxel or docetaxel, vegetable oil, solubilizing agent, lecithin, glycerine, and water for injection at a ratio of 0.5-10:10-100:10-100:10-20:20-25:700-950. The preparing method includes the following steps: stirring with high speed homogenating machine or ultrasonic oscillating to get the protogala; preparing the complex paclitaxel intralipid with high pressure homogenizer. The preparation is intralipid in O / W type which packages paclitaxel or docetaxel into the compound oil phase. The compound oil phase has good solubility for paclitaxel or docetaxel which has prevented the phenomenon of precipitation after diluting the emulsion; the ingredients of compound oil has the function of coordinated antitumous effect; it can also release the injecting irritative response, haemolysis and hypersensitiveness; it has the function of targeting which has increased the drug action.

A Chinese medicine for treating liver cancer, lung cancer, breast cancer, stomach cancer, rectum cancer, and other cancers is prepared from 13 Chinese-medicinal materials including trogopterus dung, leech, toad, cyperus tuber, etc.

A medicinal composition combining paclitaxel with a novel phthalazinone compound, provided by the invention, comprises an active component and a pharmaceutically-acceptable auxiliary material, the active component is composed of paclitaxel and the phthalazinone compound with an N crystal form, represented by formula I, and a mass ratio of the paclitaxel to the phthalazinone compound of the formulaI in the active component is (0.1-0.3):1, wherein the chemical name of the phthalazinone compound of the formula I is [2(1H)-butyl-2-enoyl-3,4-dihydroisoquinolin-5-yl]-carbamic acid-4-[8-fluoro-(2H)-phthalazin-1-one]benzyl ester mesylate. The medicinal composition has a good anticancer effect. It is found that the paclitaxel and the phthalazinone compound with an N crystal form, represented by formula I, are combined to greatly enhance the antitumor growth bioactivity and achieve antitumor proliferation synergistic effects, so the medicinal composition is expected to be developed into clinically anti-pancreatic cancer first-line drugs.

An emulsified injection for treating cancers is prepared from brucea fruit oil, medical emulsifier, isotonic agent and water through respectively dissolving oil phase and water phase, emulsifying and homogenizing.

The present invention discloses a preparation method of nut and fruit roasted duck legs, which belongs to the technical field of meat product processing. The preparation method comprises the following steps of: A. preparation of nut and fruit powder; B. treatment of duck legs; and C. preparation of nut and fruit roasted duck legs. The preparation method uses high-quality ginkgo fruits, malus prunifolia, haws and high-quality duck legs as raw materials and combines the materials with nutrient extract liquid, and the prepared nut and fruit roasted duck legs have a golden yellow color and luster, a low salt content, a mellow and thick taste with a fruity fragrance. Meanwhile, the health-care function is provided at the same time, and the extract liquid is added with Chinese sauerkraut to make the prepared duck legs non-greasy. The nut and fruit roasted duck legs are convenient to carry, can be consumed instantly upon opening of bags, have rich nutrition and unique mouthfeel, are full of chewiness, and have effects of preventing fatigue and aging, lowering blood pressure, improving appetite and promoting digestion, building body and tonifying yang, strengthening spleen and nourishing stomach, clearing away heat and cooling blood, promoting blood circulation and removing blood stasis, and improving sleeping quality.

The invention relates to a biscuit containing multiple elements. The biscuit comprises, by weight, 42-50 parts of selenium-enriched red rice powder, 15-17 parts of selenium-enriched rhodomyrti powder, 5-6 parts of red dates, 12-15 parts of milk powder, 4-6 parts of syrup, 8-10 parts of peanut oil, 1-1.2 parts of vitamin and mineral substances, 2-3 parts of swelling agents and 1-1.8 parts of salt. Compared with the prior art, the biscuit is good in tastes, contains multiple elements, is not dry to eat, can be easily digested, and is rich in nutrient and easy to manufacture.

A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and / or a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and an anti-PD-L1 antibody; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and / or B-Raf and / or neutralizing or inhibiting the interaction between PD-L1 and its receptor, e.g. PD-1, is beneficial, eg. cancer.

The present invention provides forms of curcumin and the pharmaceutical compositions thereof. The forms of curcumin disclosed herein are curcumin polymorph Form III, curcumin-2-aminobenzimidazole co-crystal, and curcumin-L-lysine co-crystal. Further, the invention provides methods inhibiting cancer cells and HSV-1 using these curcumin novel solid forms.

Amooranin (AMR) has been found to cause tumor cell death through G2 / m cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for P-glycoprotein. Based on these activities, AMR compounds can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.

An antrodia camphorata liquid fermentation method comprises the following steps: A, using antrodia camphorata strain S-29 as a raw material and firstly culturing on a wort slant medium to obtain an antrodia camphorata slant strain; B, inoculating the antrodia camphorata slant strain into a liquid seed medium for cultivation so as to obtain a liquid seed; and C, inoculating the liquid seed into a liquid fermentation medium for culture, adding hydrogen peroxide during the cultivation process and oxidizing stress-induced mycelium through the hydrogen peroxide to synthesize an antroquinonol compound. The method of the invention is simple and efficient and has important industrial application value. Due to addition of hydrogen peroxide for inducing antrodia camphorata liquid fermentation to generate the antroquinonol and its derivative, efficacy gap between the antrodia camphorata liquid mycelium product and other forms of culture products is greatly narrowed. The antroquinonol and its derivative produced by the method can be applied in the field of medicine and health food.