Carrier-free co-assembled tumor targeting anti-cancer nano medicine as well as preparation method and application thereof

A nano-drug and tumor-targeting technology, applied in the field of biomedicine, can solve the problems of complex carrier nano-system, unclear mechanism of action, and unclear metabolism, so as to solve the problems of unclear metabolism in vivo, complex solution system, and good tumor treatment effect Effect
CN107158014AInactive Publication Date: 2017-09-15FUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUZHOU UNIV
Publication Date
2017-09-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a carrier-free co-assembled tumor targeting anti-cancer nano medicine as well as a preparation method and application thereof. The carrier-free dual anti-cancer nano medicine is prepared from a hydrophobic medicine, namely ursolic acid, together with board-spectrum anti-tumor medicines such as doxorubicin in water through co-assembling, in addition, a fluorescence labeling nucleic acid aptamer, a molecular target, an antibody or polypeptide and the like with tumor targeting functions are adsorbed to the surface of the medicine through mutual electrostatic functions, then the carrier-free co-assembled tumor targeting anti-cancer nano medicine with tumor targeting and tumor microenvironment response is prepared, a synergic anti-tumor function is achieved, diagnosis and treatment integration is achieved, particularly the medicine has outstanding functions in preventing tumor transfer, and more importantly the problems that a conventional nano carrier is complex in system, indefinite in in-vivo metabolism and the like are solved.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a carrier-free co-assembled tumor-targeting anti-cancer nano-medicine and a preparation method and application thereof. Background technique

[0002] Cancer is one of the diseases that seriously threaten human life and health. Tumor metastasis is the main cause of death of cancer patients. According to data, the proportion of malignant tumor metastasis is as high as 60%-62.5%. Therefore, the control of tumor metastasis is the key to the prognosis of cancer patients. The key factor. To some extent, preventing tumor metastasis can control the death caused by tumor. The process of tumor metastasis involves cell shedding, infiltration, migration, implantation, angiogenesis, etc. In theory, as long as one or more of the above processes can be prevented, tumor metastasis can be inhibited. Therefore, it is urgent to find out anti-tumor metastasis drugs.

[0003] Aptamers are a cl...

Claims

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