138results about How to "Solve the problem of water solubility" patented technology

The invention relates to drug-loading nano-micelles, and a preparation method and an application thereof. According to the to drug-loading nano-micelles, a polyethylene glycol derivative-polylysine-polyleucine amphiphilic triblock copolymer is adopted as a carrier, and self-assembly is carried out in a water solution, such that nano-micelles with a three-layer structure transferring gene and medicine are formed. With the hydrophobic effect between polyleucine, the copolymer forms a core of the micelles in water, such that a hydrophobic medicine docetaxel is entrapped. With polylysine, the nano-micelles are positively charged, such that negatively charged anti-apoptotic protein small interfering RNA can be bonded. Polyethylene glycol is used for protecting the stability of the nano-micelles loading the medicines and gene, and a cycle time of the nano-micelles in vivo is prolonged. The nano-micelles are used for loading both an anti-apoptotic protein small interfering RNA gene medicine and a docetaxel medicine, such that the gene treatment medicine and the chemotherapeutic medicine cooperates in treating cancer, and a synergetic effect of the two medicines can be developed. Therefore, a direction is provided for better treatment of breast cancer.

The invention discloses a process for extracting ginkgolide, ginkgolide injection and process for preparing same, wherein the extracting process consists of disintegrating the ginkgo leaves, leaching by diluted acetone solution, recovering acetone, removing impurities, extracting and purifying with acetic ether, removing impurities with sodium acetate again, reclaiming acetic ether, recrystallizing in ethanol or methanol, filtering, low temperature drying, solubilizing the bilobalide with hydroxypropyl-beta-cyclodextrin to obtain the bilobalide injection.

The invention relates to the field of nano materials and discloses a preparation method of a water-soluble ferroferric oxide magnetic nanoparticle with functional amidogen, comprising the following steps of: coordinating carboxyl on n-(1,3-dioxoisoindolin-2-yl) alkyl acid (n is equal to 3-18) with ferrum; pyrolyzing a precursor of n-(1,3-dioxoisoindolin-2-yl) alkyl acid iron at high temperature to obtain an oil-soluble magnetic nanoparticle with lipophilicity and a surface ligand, i.e. the n-(1,3-dioxoisoindolin-2-yl) alkyl acid; then removing phthalic anhydride for protecting amino by a deammoniation protective reagent (hydrazine hydrate) by using a deammoniation protection method, and converting the oil-soluble magnetic nanoparticle into the water-soluble ferroferric oxide magnetic nanoparticle with functional amidogen. The water-soluble ferroferric oxide magnetic nanoparticle with functional amidogen can be excellently dissolved in a water solution and has favorable biocompatibility and paramagnetism.

The invention discloses a carrier-free co-assembled tumor targeting anti-cancer nano medicine as well as a preparation method and application thereof. The carrier-free dual anti-cancer nano medicine is prepared from a hydrophobic medicine, namely ursolic acid, together with board-spectrum anti-tumor medicines such as doxorubicin in water through co-assembling, in addition, a fluorescence labeling nucleic acid aptamer, a molecular target, an antibody or polypeptide and the like with tumor targeting functions are adsorbed to the surface of the medicine through mutual electrostatic functions, then the carrier-free co-assembled tumor targeting anti-cancer nano medicine with tumor targeting and tumor microenvironment response is prepared, a synergic anti-tumor function is achieved, diagnosis and treatment integration is achieved, particularly the medicine has outstanding functions in preventing tumor transfer, and more importantly the problems that a conventional nano carrier is complex in system, indefinite in in-vivo metabolism and the like are solved.

A garlicin injection with greatly improved water solubility is prepared through adding hydroxypropyl beta-cyclodextrin in the water for injection, stirring, adding garlicin, stirring, grinding or ultrasonic pulverizing to obtain the garlicin inclusion compound solution, preparing injection or drying and preparing injection. Its advantages are high safety and stability and less irritation.

The invention discloses a chitosan-based self-assembled nano micelle solution loaded with beta-carotene and a preparation method thereof. An imidazoles ionic liquid is used as an effective solvent of chitosan, and under the action of a catalyst, lactide is subjected to ring opening polymerization and is grafted to a chitosan macromolecular chain to obtain a chitosan-grafted polylactic acid; then a self assembly action of the chitosan-grafted polylactic acid in an aqueous solution is utilized to achieve effective embedding of hydrophobic beta-carotene. The water solubility and the oxidation resistance of beta-carotene can be effectively improved, moreover, the preparation process is simple, and conditions are mild; and the prepared nano micelle solution has good stability, and is expected to provide a natural and effective stable carrier and a water-phase dispersant for the cosmetic field or the functional food field.

The invention discloses a water-soluble paint, and a preparation method and spraying technique thereof. Modified acrylic resin is added into the formula of the water-soluble paint, so that the baking film-forming temperature of the paint is dropped from common 180 DEG C to 110-160 DEG C; a coupling agent is added, so that the film-forming attachment of the water-soluble paint can be greatly improved, and the hardness of the paint film achieves or exceeds National Standard 5B; and the product coated with the paint can keep the favorable paint film attachment effect for a long time. The spraying technique-wet-on-wet technique effectively overcomes the defects of low production efficiency and high energy consumption due to repeated spraying and repeated baking in the existing technique, greatly enhances the production efficiency of the spraying construction, and greatly saves the energy consumption.

The invention provides a preparation method of a carrier free nano drug for chemotherapy/light treatment. The drug is prepared by assembling a hydrophobic anticancer drug, a water soluble target, andan amphipathic photosensitizer through a self-assembly technology. The assembled carrier free nano drug is formed through phi-phi accumulation, hydrophobic force, and electrostatic force, is used forchemotherapy and light treatment, and solves the problems that in the prior art, the action mechanism of an artificially synthesized carrier is undefined, and metabolism and most of tumors cannot be inhibited effectively by a single treatment method and still grows slowly.

The present invention relates to five grain and coarse cereal powder and a manufacture method thereof, and belongs to the technical field of health-preserving food. Raw materials are divided into Chinese yam and purple sweet potato types, water-soluble starch types, fungus types, plant types, fruit and vegetable types, non-water-soluble plant types, oil plant type and residual materials, the materials are manufactured into powder, according to inherent characteristics of each edible material, the materials are processed into powder separately and small molecular materials and nutrients in theraw materials are preserved to the maximum. The manufacture method solves problems of water solubility and nutrient absorption rate. The powder materials are reasonably combined according to principles of traditional Chinese medicines, so that the five grain and coarse cereal powder combines bitterness and sweetness, and dryness and coolness. The five grain and coarse cereal powder is suitable fora variety of populations: populations with diabetes, and cardiovascular and cerebrovascular diseases, and populations who want to lose weight and slim body, whiten and nourish skin, promote intelligence and blacken hair, dispel alcoholism and protect liver, etc. Dietary therapeutic health preserving is changed from former simple five grain and coarse cereal powder into a whole new height of medicinally and edibly homogenous brewing powder which is precise in formula, can be quickly absorbed and is mellow in taste.

A scutelloside-cyclodextrin inclusion compound prepared from scutelloside and cyclodextrin or its derivative (beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin), its various preparations including oral-applied ones, suppository, spray, injection, etc. and their preparing process are disclosed. Its advantages are high water solubility, stability and curative effect and low by-effect.

The invention provides a skin care cosmetic composition with a whitening effect. The skin care cosmetic composition comprises: (a) at least more than 0.5% of whitening agent which is resveratrol nanoemulsion; and (b) a carrier of the resveratrol nanoemulsion, which can be accepted by skin. According to the skin care cosmetic composition provided by the invention, the resveratrol is used as a main effect additive ingredient, and specifically, and the resveratrol nanoemulsion is used as a main effect additive; since the resveratrol nanoemulsion has excellent water solubility and oil solubility, excellent stability and high bioavailability, the use difficulty that unwrapped resveratrol is water-insoluble and oil-insoluble is avoided effectively, so that the resveratrol can be applied to various types of cosmetics conveniently. The resveratrol nanoemulsion is applied to cosmetics and capable of removing free radicals, resisting oxidation and inhibiting activity of tyrosinase, thus achieving the effect of whitening.

The invention discloses a small-molecule modified target paclitaxel precursor medicament, as well as a preparation method and application thereof. The molecular structure of the precursor medicament comprises folic acid, amino acid and paclitaxel, wherein the folic acid is used as a targeting ligand, and the amino acid is used as a connexon. The precursor medicament also comprises a fluorescent dye. Compared with the prior art, the precursor medicament has the advantages that the problem of water solubility and targeting of paclitaxel can be solved, the toxicity of the paclitaxel medicament can be reduced, the treatment effect of the paclitaxel medicament can be improved, body immunogen toxin caused by macro-molecular protein can be avoided, and the defects of poor encapsulation rate, unstable structure and the like caused by using lipidosome as an insoluble medicinal carrier can be overcome.

The invention relates to a nanoscale emulsion with high transdermal absorbency. The nanoscale emulsion contains the following components in parts by weight: 0.01 to 5 parts of salidroside, 0.5 to 20 parts of nonionic surfactant, 1 to 20 parts of phospholipid, 5 to 15 parts of oil and 60 to 90 parts of dispersion medium. Due to the existence of lipid and corneum of the skin, hydrophilic molecules are difficult to pass through the skin barrier to be absorbed by the body. The existing related preparations of salidroside are poor in stability, while according to the invention, the salidroside is wrapped in the phospholipid microcapsule nano emulsion, so that the lipid solubility of the salidroside can be effectively improved, the transdermal absorbency of the salidroside can be improved, and the application of the salidroside in the field of external use of skin can be enhanced. The lipid nanoscale emulsion containing the salidroside is high in enveloping rate, the particle size is less than 150nm, the transdermal absorbency of the salidroside can be promoted, and the nanoscale emulsion is better than that in the prior art.

The invention provides a preparation method of a core-shell type nanoparticle. The prepared core-shell type nanoparticle is characterized in that a gold nanorod is used as a core material, an interlayer is composed of silicon dioxide and a surface receptor, and a couplet of CdTe quantum dots and biomolecules is used as a shell. Nanoparticles with magneto-electrical properties are packed layer by layer, the core-shell type nanoparticle synthesized in water phase through a micro compounding method has high quantum yield up to 60%, low toxicity and low cost, so that the problem of water solubility of the nanoparticles is solved, and the stability of the core-shell type nanoparticle is more than 6 months; and thickness of the silicon dioxide and the distance between the silicon dioxide and the gold nanorod are controlled by changing the quantity of ethyl silicate. Simultaneously, optical property and magnetic property of the nano materials are improved, thickness of each interface is up to 3-5 nm, magneto-electrical sensitivity is improved by 10%, and biological compatibility of the compound nanoparticle is improved. The core-shell type nanoparticle is used for preparing a biological developer, a molecular biological probe and a targeting medicine carrier.

A houttuyninum sodium injection is prepared through dissolving hydroxypropyl beta-cyclodextrin in water for injection while stirring, adding houttuyninium sodium, stirring or grinding and vacuum (or spray) drying or freeze drying. Its advantages are high safety and high stability.

A method for preparing sulfur- and nitrogen-doped carbon quantum dots through separation on a column is disclosed. Poly(sodium-p-styrenesulfonate) and o-phenylenediamine are adopted as a carbon source, a nitrogen source and a sulfur source, the sulfur- and nitrogen-doped carbon quantum dots are synthesized by a hydrothermal process and are subjected to chromatographic separation by adopting a silica gel column, and fluorescent quantum dots having different polarity and different colors are collected. The fluorescent quantum dots having low polarity are used for fake prevention of paper or package materials. Through designed colorless transparent patterns such as patterns, characters, quick-response codes, and the like, specific fluoresce appears under excitation by ultraviolet light having a certain wavelength, and can be used as anti-fake marks. The method has an advantage that the prepared carbon quantum dots are insoluble in water so that a water solubility issue of the carbon quantum dots is solved, and an advantage that the carbon quantum dots obtained can show different colors under ultraviolet irradiation and have specific advantages in anti-fake mark recognition.

The invention belongs to the field of medical embolization devices, relates to a sodium alginate microsphere targeted vascular embolization agent containing an antineoplastic drug and a preparation method thereof. Alginic acid is taken as a pharmaceutical carrier, the antineoplastic drug etoposide is a pharmaceutical active ingredient, divalent metal cation or calcium ion solution is taken as a solidifying agent, and the sodium alginate encapsulates the etoposide to prepare ideal particle size-controllable sodium alginate microspheres comprising the etoposide, thus avoiding toxic side effect of traditional etoposide administration such as anaphylaxis and inconvenience. The vascular embolization agent changes the dosage form and route of administration way of the antineoplastic drug etoposide, has high efficacy and low toxicity, and is safely and effectively applied to clinical application. The vascular embolization agent has the advantages of mild preparation condition and simple and convenient operation, and is fit for large-scale production. The vascular embolization agent can be used for vascular embolization, local targeted tumor treatment, and treating small-cell carcinoma of the lung, oophoroma, carcinoma of testis, gastric cancer and liver cancer by administering the vascular embolization agent during operations.

The invention discloses a new thienopyridine compound (shown in a formula I) and a salt thereof. Experiments prove that the new thienopyridine compound can be used for treating and preventing ischemic disease and improving sleep. When R2 represents H, the new thienopyridine compound can react with organic acids (such as phosphoric acid, hydrogen nitrate and sulfuric acid) and organic acids (such as methanoic acid, acetic acid, propanoic acid, oxalic acid, malonic acid, aminoacetic acid, valine, maleic acid, fumaric acid and succinic acid) to generate ester, and further react with acid or basic group to generate a salt. The salt also has the functions of treating and preventing ischemic disease and improving sleep.

A spraying formulation of liposome and antifungal agents. It mainly comprises, antifungal drug chemically synthesized, liposome coating material, lecithin as the transdermal absorbing agent and skin protecting agent, cholesterol, oleinic acid ,Vit-E, alcohol and natural volatile oil. The spraying formulation prepared by the above-mentioned compounds could increase transdermal absorption of drugs,transmit drug to hypodermis.