138results about How to "Solve the problem of water solubility" patented technology

The invention discloses application of an ursolic acid conjugate having the anticancer activity and serving as a drug carrier or a molecular probe carrier. The ursolic acid conjugate is characterized by being a conjugate formed by connecting of carboxy groups of ursolic acid or derivatives of ursolic acid with amino groups of guanidine drugs in the form of amido bonds. According to the specific application, a drug or a molecular probe is encapsulated and carried with the ursolic acid conjugate to form nanoparticles. When serving as the carrier, the referred conjugate has a certain anticancer effect without too high cytotoxicity and is easy and convenient to synthesize; the nanoparticles are self-assembled through a solvent exchange method, when the ursolic acid conjugate serves as the carrier of an anticancer drug or a fluorescent material, the problem on water solubility of a series of anticancer drugs is effectively solved.

The invention provides a water-soluble carbon composite nano-material for double phototherapy. The composite nano-material is a pi-pi planar conjugated complex formed by single-walled carbon nano-horns or monolayer curl-free graphene and water-soluble phthalocyanine. A preparation method of the water-soluble carbon composite nano-material comprises the following steps (1) dissolving the water-soluble phthalocyanine with secondary water to prepare a 10-15% aqueous solution, adding the single-walled carbon nano-horns or monolayer curl-free graphene accounting for 45-65 percent of the mass of the water-soluble phthalocyanine, and performing ultrasonic treatment for 30-180 minutes by using an ultrasonic device; and (2) centrifuging, carrying out suction filtering, washing and drying the prepared dispersant. The composite material has photo-thermal and photodynamic double treatment effects in the action of an infrared source, so that the efficiency for killing tumor cells can be strengthened; the preparation method is simple and convenient; the one-step ultrasonic method not only can solve the problem of water solubility of single-walled carbon nano-horns or monolayer curl-free graphene, but also enables the photodynamic treatment preparation to be loaded, and the surface characteristics of the carbon composite nano-material cannot be destroyed by adopting non-covalent modification.

The invention discloses a preparation method of carotenoid emulsion and microcapsules. The method is characterized in that the electrostatic force interaction of emulsifier molecules on an emulsion interface is utilized, and a two-step homogenization method is applied to preparing carotenoid bilayer emulsion which can be further dried to prepare carotenoid microcapsules. The method disclosed by the invention is simple, convenient and feasible for preparation, the used emulsifier and microcapsule wall materials have favorable biocompatibility and can be biodegraded, and a material source range is wide; and the carotenoid emulsion and microcapsules have the characteristics of good physical and chemical stability, long shelf life and the like, the carotenoid loading capacity of the emulsion can reach 2%, and the carotenoid loading capacity of the microcapsules can reach 10%.