Preparation method of core-shell type nanoparticle

A nanoparticle, core-shell type technology, applied in the field of core-shell type nanoparticle preparation, to achieve the effects of improving optical and magnetic properties, low toxicity, and improving magnetoelectric sensitivity

Inactive Publication Date: 2012-01-18
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The present invention uses water-based quantum dots to wrap gold nanorods layer by layer to prepare composite nanoparticles. This invention has not been reported

Method used

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  • Preparation method of core-shell type nanoparticle
  • Preparation method of core-shell type nanoparticle
  • Preparation method of core-shell type nanoparticle

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Embodiment 1

[0029] Embodiment 1 A method for preparing core-shell nanoparticles, the steps and conditions are as follows:

[0030] Described a kind of core-shell type nanoparticle, see appendix figure 1, the core-shell nanoparticle is that the core material is gold nanorods; the middle layer is silicon dioxide and surface receptors; the outer shell is a coupling body of water-based CdTe quantum dots and biomolecules; the length of the gold nanorods is 50nm, the aspect ratio is 2-3:1; the thickness of the middle layer of silicon dioxide wrapped gold nanorods is 2-10nm, the distance between gold nanorods and silicon dioxide is controlled at 3-5nm; the middle layer introduces The surface receptor is 3-cyanobenzenesulfonyl chloride, parallel mercaptoaminobenzene (pABT), isothiocyanate (RBITC) or 2-naphthalenesulfonol (2-NAT); Combined with gold nanorods; the conjugated biomolecules include immunoglobulin IgG or 8 antibody (anti-CEA8).

[0031] (1) Core material gold nanorods, prepared by se...

Embodiment 2

[0037] Embodiment 2 A method for preparing core-shell nanoparticles, the volume ratio of the gold nanorod solution described in step (2) to the described alcohol ethyl silicate solution is 1: 0.3; Reaction is 50 seconds, and the surface acceptor that intermediate layer introduces is parallel mercaptoaminobenzene; The described reaction time of step (4) is 2 hours; Under the described normal temperature of step (5), react 40 minutes; All the other are with embodiment 1 .

Embodiment 3

[0038] Embodiment 3 A method for preparing core-shell nanoparticles, the volume ratio of the gold nanorod solution described in step (2) to the described alcohol ethyl silicate solution is 1: 0.4; Reaction is 60 seconds, and the surface acceptor that middle layer introduces is isothiocyanate; The described reaction time of step (4) is 6 hours; Under the described normal temperature of step (5), react 45 minutes; All the other are with embodiment 1.

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Abstract

The invention provides a preparation method of a core-shell type nanoparticle. The prepared core-shell type nanoparticle is characterized in that a gold nanorod is used as a core material, an interlayer is composed of silicon dioxide and a surface receptor, and a couplet of CdTe quantum dots and biomolecules is used as a shell. Nanoparticles with magneto-electrical properties are packed layer by layer, the core-shell type nanoparticle synthesized in water phase through a micro compounding method has high quantum yield up to 60%, low toxicity and low cost, so that the problem of water solubility of the nanoparticles is solved, and the stability of the core-shell type nanoparticle is more than 6 months; and thickness of the silicon dioxide and the distance between the silicon dioxide and the gold nanorod are controlled by changing the quantity of ethyl silicate. Simultaneously, optical property and magnetic property of the nano materials are improved, thickness of each interface is up to 3-5 nm, magneto-electrical sensitivity is improved by 10%, and biological compatibility of the compound nanoparticle is improved. The core-shell type nanoparticle is used for preparing a biological developer, a molecular biological probe and a targeting medicine carrier.

Description

technical field [0001] The invention belongs to a method for preparing composite nanoparticles, in particular to a method for preparing core-shell nanoparticles. Background technique [0002] Nanoparticles refer to tiny particles with a particle size ranging from 1 to 100 nanometers. Due to the unique magnetic, electrical, and optical properties and functions of substances at this scale, the research and application of nanoparticles have developed rapidly. Especially in biological imaging and detection, it is more widely used. In order to achieve biological applications as fluorescent labels, it is very necessary to prepare water-soluble, stable and dispersible semiconductor quantum dots. [0003] Gold nanorods have excellent properties such as high stability and low toxicity. The excitation spectrum of II-VI compound semiconductor quantum dots is in the visible light range, and the wavelength can be continuously distributed. It can simultaneously excite different sizes unde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K47/42A61K47/02A61K47/04A61K47/20
Inventor 刘丽炜谭勇吴云李昌立王悦张喜和
Owner CHANGCHUN UNIV OF SCI & TECH
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