Artificial cow-bezoar and chlorphenamine maleate granules containing bezoar cultured in vitro and preparation method thereof

A kind of children's aminophenol Huang Namin granules and the technology of cultivating bezoar in vitro are applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, respiratory diseases, etc., and can solve the problems of uniformity meeting the requirements, unresponsiveness, and low content. Achieve the effect of avoiding uneven dispersion, reducing vomiting, and good dispersion effect

Inactive Publication Date: 2011-06-15
汤明昌 +1
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AI Technical Summary

Problems solved by technology

[0008] 2. The existing children's paracetamol Huang Namin granules are made of artificial bezoar, acetaminophen, and chlorpheniramine maleate. Due to the large difference in the amount of therapeutic drugs and auxiliary materials used, the uniformity of the drug is often uneven. It meets the requirements. Due to the strong drug effect and low content of chlorpheniramine maleate, it is difficult to make the uniformity meet the requirements by conventional mixing, extrusion and granulation. Children often take pediatric ammonia that does not meet the requirements. Symptoms of poisoning of Fenhuang Namin Granules: obvious side effects such as coma, unresponsiveness, dry mouth and sore throat

Method used

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Effect test

Embodiment Construction

[0021] Get in vitro cultured Calculus Calculus 5g, paracetamol 125g, chlorpheniramine maleate 0.5g, sucrose 5875g and sweet orange essence 12.5g, the technological process of preparation is as follows:

[0022] Step 1: first take the in vitro cultured bezoar and grind it into fine powder for later use;

[0023] Step 2: Take chlorpheniramine maleate and add it to acetaminophen in the method of equal increase, mix and grind evenly, pass through a 120-mesh sieve for later use;

[0024] Step 3: Take the ultra-fine powder obtained in the first step and add it to the powder obtained in the second step in an equal increment method, grind it evenly, pass through a 120-mesh sieve, and set aside;

[0025] Step 4: Dilute the sucrose on a stainless steel plate, bake at 80°C for 1 hour, cool to room temperature in an oven, crush, and pass through a 120-mesh sieve. Get 1 / 4 powdered sugar, according to the preparation method of syrup in " Chinese Pharmacopoeia " 2005 edition (two), be prepa...

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Abstract

The invention relates to artificial cow-bezoar and chlorphenamine maleate granules containing bezoar cultured in vitro and a preparation method thereof. Based on weight part, the artificial cow-bezoar and chlorphenamine maleate granules are prepared from 5 parts of bezoar cultured in vitro, 125 parts of paracetamol, 0.5 part of chlorphenamine maleate, and a proper amount of cane sugar and essence. The preparation method is to mix and grind medicines by an equal gradual increase process and granulate the ground materials. The invention is characterized in that: the replacement of artificial bezoar by bezoar cultured in vitro can reduce the side effects of vomit and icterus caused by over high free bilirubin content in the artificial bezoar; and the mixing and grinding by the equal gradual increase process can effectively disperse the active ingredients of the medicine and reduce the side effect caused by non-uniform medicine content.

Description

technical field [0001] The invention relates to a granule containing huangnamin containing in vitro cultured bezoar and a preparation method thereof, belonging to the technical field of medicine production. Background technique [0002] The common cold and influenza in children are the most common childhood illnesses, which can cause symptoms such as fever, headache, sore limbs, sneezing, runny nose, nasal congestion, and sore throat. Many doctors or parents in our country often give sick children Huang Namin granules, which are made of artificial bezoar, acetaminophen, chlorpheniramine maleate, sucrose and essence, but there are two problems with this product: It is easy to solve, but the quality is unstable and the side reactions of this product often occur. One is that artificial bezoar is used in the prescription. Since the current standard does not limit the content of the harmful component free bilirubin, the probability of adverse reactions increases; the other is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/16A61P11/00A61K31/167A61K31/4402
Inventor 汤明昌
Owner 汤明昌
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