Sodium alginate microspheres blood vessel suppository containing etoposide and preparation method and uses thereof

A vascular embolizing agent and sodium alginate technology are applied in the field of sodium alginate microsphere vascular embolizing agent and its preparation to achieve the effects of increasing cell uptake, prolonging action time, eliminating allergic reactions and various inconveniences

Inactive Publication Date: 2009-03-18
BEIJING SHENGYIYAO SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The present invention uses alginic acid as the drug carrier, the antineoplastic drug etoposide as the drug active ingredient, and the water-soluble macromolecular substance as the carrier to connect with the fat-soluble etoposide, which solves the water-solubility problem of etoposide, and makes ideal Sodium alginate microspheres containing etoposide with controllable particle size solve the allergic and other side effects and inconveniences of traditional etoposide drugs, change the dosage form and administration route of etoposide antineoplastic drugs, and achieve high efficiency , low toxicity, safe and effective for clinical application

Method used

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  • Sodium alginate microspheres blood vessel suppository containing etoposide and preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Preparation of sodium alginate microsphere vascular embolism containing etoposide antitumor drug

[0052] ① Handling of glassware:

[0053] Dry the cleaned glassware and bake in a high-temperature oven;

[0054] ② Preparation of antineoplastic drug etoposide liquid:

[0055] Take by weighing 1.5 grams of commercially available etoposide, place in the above-mentioned glass vessel, stir and dissolve with 100 milliliters of dichloromethane to obtain the etoposide drug solution of the required ratio;

[0056] ③ Preparation of sodium alginate solution:

[0057] Weigh 10 grams of sodium alginate, put it in a glass container, add 650 ml of normal saline or water for injection while stirring, until all the sodium alginate is dissolved, and obtain the required ratio of sodium alginate solution;

[0058] ④ Preparation of solidification solution:

[0059] Take 250 grams of calcium chloride, place it in a glass container, add 5000 milliliters of normal saline or water...

Embodiment 2

[0070] Example 2: Preparation of sodium alginate microsphere vascular embolism containing etoposide antineoplastic drug

[0071] 1. the processing of glassware: with 1. in embodiment 1;

[0072] ② Preparation of antineoplastic drug etoposide liquid:

[0073] Take by weighing 15 grams of commercially available etoposide, place in the above-mentioned glass vessel, stir and dissolve with 150 milliliters of dehydrated ethanol, obtain the etoposide drug solution of required ratio;

[0074] ③ Preparation of sodium alginate solution:

[0075] Weigh 150 grams of sodium alginate, put it in a glass container, add 3000 ml of normal saline or water for injection while stirring, until the sodium alginate is completely dissolved, and obtain the required ratio of sodium alginate solution;

[0076] ④ Preparation of solidification solution:

[0077] Take 375 grams of barium chloride, put it in a glass container, add 5000 milliliters of normal saline or water for injection while stirring, un...

Embodiment 3

[0087] Example 3: Preparation of sodium alginate microsphere vascular embolism containing etoposide antineoplastic drug

[0088] 1. the processing of glassware: with 1. in embodiment 1;

[0089] ② Preparation of antineoplastic drug etoposide liquid:

[0090] Take by weighing 30 grams of commercially available etoposide, place in the above-mentioned glass vessel, stir and dissolve with 100 milliliters of dichloromethane, obtain the etoposide drug solution of required ratio;

[0091] ③ Preparation of sodium alginate solution:

[0092] Weigh 100 grams of sodium alginate, put it in a glass container, add 833 ml of normal saline or water for injection while stirring, until the sodium alginate is completely dissolved, and obtain the required ratio of sodium alginate solution;

[0093] ④ Preparation of solidification solution:

[0094] Take 500 grams of calcium lactate, put it in a glass container, add 5000 milliliters of normal saline or water for injection while stirring, until ...

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Abstract

The invention belongs to the field of medical embolization devices, relates to a sodium alginate microsphere targeted vascular embolization agent containing an antineoplastic drug and a preparation method thereof. Alginic acid is taken as a pharmaceutical carrier, the antineoplastic drug etoposide is a pharmaceutical active ingredient, divalent metal cation or calcium ion solution is taken as a solidifying agent, and the sodium alginate encapsulates the etoposide to prepare ideal particle size-controllable sodium alginate microspheres comprising the etoposide, thus avoiding toxic side effect of traditional etoposide administration such as anaphylaxis and inconvenience. The vascular embolization agent changes the dosage form and route of administration way of the antineoplastic drug etoposide, has high efficacy and low toxicity, and is safely and effectively applied to clinical application. The vascular embolization agent has the advantages of mild preparation condition and simple and convenient operation, and is fit for large-scale production. The vascular embolization agent can be used for vascular embolization, local targeted tumor treatment, and treating small-cell carcinoma of the lung, oophoroma, carcinoma of testis, gastric cancer and liver cancer by administering the vascular embolization agent during operations.

Description

technical field [0001] The invention belongs to the field of medical embolization equipment, and relates to a microsphere vascular embolization material containing antineoplastic drugs, in particular to a sodium alginate microsphere vascular embolization agent containing etoposide and a preparation method thereof, and is used in interventional embolization for lung cancer, Liver cancer, ovarian cancer, testicular cancer and gastric cancer, etc. Background technique [0002] It is known that podophyllotoxin is an active ingredient with anti-tumor activity extracted from plants of the Berberidaceae Podophyllum genus. It is characterized by being slightly soluble in acetone, slightly soluble in methanol or chloroform, and very slightly soluble in ethanol. Almost insoluble in water. [0003] As early as 1880, Podwyssotzki first obtained a white crystalline substance, Podophylloloxin, from podophyllum resin. In 1932, Borsche, Niemann and Spath independently proposed the structur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/36A61K31/7048A61L31/16A61P35/00
Inventor 李新建洪宏
Owner BEIJING SHENGYIYAO SCI & TECH DEV
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