The invention relates to a method for preparing a
gelatin microballoon
embolization agent, which comprises the following steps of dissolving
gelatin or mixture of
gelatin and
medicine at 30-70 DEG C, filtering to obtain gelatin solution with 15%-60% of
solid content, adding gelatin solution into
oil phase liquid paraffin with
mass ratio of 1%-2% of stabilizer Span 80, wherein the volume ratio of water and oil is 1 / 1-1 / 10, stirring for 15 minutes by 200-800r / min, adding cross-linking agent
aldehyde compound with
mass percent of 2%-50% at low temperature of 0-10 DEG C, solidifying for 1-2 hours, washing or
drying the cross-linking agent to obtain the microballoon
embolization agent after
freeze drying or
dehydration. The method has the beneficial effects that the gelatin microballoon
embolization agent has certain elasticity and expansibility, the surface is smooth, the sphere is obvious, the size and the shape of the sphere is uniform, the grain size is controllable, clinical embolization effect can be improved, and
side effect can be lowered, the clinical
controllability is strong, antitumor
drug can be added into the microballoon in manufacture process, so that double therapeutical effect of
medicine treatment and embolization can be realized. The gelatin has good
biocompatibility and biodegradablity, and
clinical safety can be guaranteed.