43 results about "Iodized oil" patented technology

The invention discloses embolization particles developable under X-rays. The particles contain a biocompatible material and iodized oil, and the iodized oil is coated by the biocompatible material to form microcapsule particles. The particles have high biocompatibility, can be monitored in embolization, and are convenient for checking the embolization effect after embolization, and the like; during entrapment of medicaments, the medicaments can be released slowly from the particles; relatively high medicament concentration can be kept for a long time on an embolization part; and compared with perfusion treatment, the embolization particles have the advantages: the toxic and side effects of medicaments on a whole body can be lowered, and treatment effect of embolization can be improved. Moreover, a preparation process of the embolization particles is simple, has low cost, and is suitable for large-scale industrial production.

The invention belongs to the field of medical health and relates to a model for carrying out virtual navigation and assisting the tumor tissue biopsy process being unable to be displayed ultrasonically, and the model comprises tumor gelatin and substantial gelatin, wherein the substantial gelatin is made of carrageenan; and the tumor gelatin is formed by adding iodized oil, a surfactant and milk into the carrageenan. The model is prepared by using the substantial gelatin to warp one or more cut tumor gelatin blocks with the volume of 0.5-2cm3. The model can accurately simulate tumor tissues and peripheral normal tissues thereof which can not be displayed ultrasonically in the virtual navigation technology, effectively guide the virtual navigation technology to assist the positioning of the tumor tissues which can not be displayed ultrasonically during the biopsy, lead the tissue biopsy result obtained through the model to be accurate, lead the operation process to be simple and achieve the purposes of being applied in the virtual navigation technology for learning and training.

The invention relates to a preparation method of glucan embolism microspheres with a CT (computed tomography) visualization function. The preparation method is characterized by comprising the steps of dissolving polymethyl vinyl ether maleic anhydride grafted with beta-CD and modified glucan in water; uniformly stirring and then dropwise adding the solution into dimethyl silicone oil, wherein the volume ratio of a water phase to an oil phase is 1:5; under the condition of magnetic stirring, heating to 60-120 DEG C to react for 16-48 hours; after the reaction, standing and then removing supernatant fluid; cleaning microspheres deposited at the bottom of a container by using n-hexane; removing the remaining dimethyl silicone oil; and performing vacuum drying to remove the n-hexane on the surface to obtain gel microspheres with the particle size of 30+/-5 microns and good dimensional homogeneity. The gel microspheres are added into a developer iodine solution or iodized oil, and the microspheres are discovered to have an obvious gray level through micro-CT observation.

The invention belongs to the technical field of medicine, and discloses a visualized iodized oil-5-fluorouracil loaded polylactic acid microsphere preparation with a controlled-release effect and a preparation method thereof. The preparation comprises the main components of 5-fluorouracil, iodized oil injecta, polyvinyl alcohol and polylactic acid, and is characterized in that the preparation process is simple, the drug-loading rate is large, the drug release is stable and lasts for a long time, and the in-vitro continuous effective drug release time can be longer than 4 weeks. In the invention, the liquid preparation is prepared into solid microsphere preparation, thus compared with the traditional method, the invention has the advantages that controlled-release drug administration is realized; the toxic and side effect of chemotherapeutic drugs is reduced; the embolism time is prolonged; the microsphere preparation can durably act on focus; the drug therapy effect is enhanced; and the curative effect can be tracked according to the visualized position of the iodized oil in the later stage, thus waste of drugs can be reduced, and the physical damage and economic burden of patients can be lightened.

The present invention is biodegradable nanometer medicine capsule with CT trace effect and its preparation process. The nanometer level capsule is a core-shell structure and has shell layer of biodegradable polymer material and core with distributed CT contrast agent and hydrophilic or water soluble medicine. The CT contrast agent is ionic or non-ionic iodine contrast agent, the ionic iodine contrast agent is meglumine iodipamide or meglumine diatrizoate, and the non-ionic iodine contrast agent is amnipague, utravist or iodized oil injection. The capsule has several functions, high medicine carrying amount, targeting and controllable release, capacity of in vitro monitoring and other features. The present invention provides one effective medicine carrier for raising curative effect, monitoring the in vivo medicine distribution and developing new medicine.

The invention provides a united autonomous breath control on-line alignment technique using iodized oil image to guide image-guided radiotherapy, wherein, the autonomous breath control technique (ABC) is employed to control the liver to move with the breath in the process of radiation treatment, meanwhile, the iodized oil image is employed to carry out 3-D-registration-based image-guided on-line alignment positioning errors between a planned CT and a conical beam CT (CBCT); in addition, strengths of both aspects are combined to maximize accuracy in the radiation treatment in the liver cancer, thus overcoming the defect of depending on the musculus diaphragm, the vertebral body and the liver to conduct 2-D registration to indirectly reflect movement of liver neoplasm and providing a novel radiation treatment technology with high accuracy which can improve radiation treatment dosage for liver neoplasm while reducing harm caused by normal liver organization radiation treatment for liver cancer patients who are not suitable for operations.

The invention relates to an improved method for preparing an artery embolic agent, which comprises the following steps: mixing 8ml of a doxorubicin hydrochloride solution containing 15-20 percent (by volume) of Span-80 used as a surface active agent and having concentration of 5-10g/L with 16ml of iodized oil used as an oily contrast agent at 23-25 DEG C; adding calcium carbonate to 10ml of a sodium alginate solution with concentration of 1-2 percent expressed in percentage by weight so as to enable the calcium carbonate to have the concentration of 2-3 percent expressed in percentage by weight; mixing the solutions prepared in the two steps according a volume ratio of 1:1.3; and mixing an obtained solution with liquid paraffin according to a volume ratio of 1:1.9-1:5 to obtain a product. Shown by testing, compared with a contrast group, the embolic agent obviously slows down tumor growth, and the tissue of a visible tumor has liquefactive necrosis, thus the embolic agent can obviously prolong the life time of a liver cancer animal model.

The invention relates to an embolic material, particularly a phase-change-controllable embolic material applicable to medicine and a preparation method thereof. The phase-change-controllable embolic material is prepared from a temperature-sensitive polymer water solution and a mixed developer, and is characterized in that the mixed developer comprises Iohexol and iodized oil; the mass percent of the mixed developer in the liquid embolic material is 30-80%; and the iodized oil accounts for 3-60% (volume percent) of the embolic material liquid solution. When the ambient temperature reaches the body temperature, the phase-change-controllable embolic material precipitates into solid to perform the embolic function, and the imaging appearance of the solid in the operation is clear, so that the clinician can directly observe and determine the position and flow direction of the embolic material, thereby avoiding ectopic embolism and greatly enhancing the safety of the operation.

The invention relates to a suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process, wherein the suspension wherein the suspension is prepared by fully mixing 50um-300um Fe3O4 particles with non-limited specification and iodized oil by the proportion of 85-110mg : 1ml.

The invention relates to a stable water-in-oil emulsion composition containing: 20% to 40% (v/v) aqueous phase in the form of droplets and containing an anti-cancer agent; and 60% to 80% (v/v) lipid phase containing an iodized oil and at least one surfactant, having Formula (I), in a proportion, of surfactant mass relative to the total volume of the composition, of 0.3% to 5%, formula (I) for said surfactant being the following in which: s has a value of 0 or 1; m is a whole number from 2 to 30; R1 is a Formula (II) grouping wherein n is a whole number from 4 to 10, o is a whole number from 1 to 4, p is a whole number from 3 to 7; q is a whole number from 2 to 10, and r has a value of 0 or 1; R2 is a hydrogen atom or is identical to R1; and each R3 is, separately, a hydrogen atom or is identical to R1. The invention also relates to an emulsion obtained from said composition, to the preparing method thereof, and to the use thereof for treating cancer and the metastases thereof.

The invention relates to a 5-fluorouracil iodized oil derivative and a salt thereof. The 5-fluorouracil iodized oil derivative and the salt thereof have the chemical structure shown in the following chemical general formula (described in the specification), wherein n is 2, 3, 4 or 5. The invention also provides a preparation method and application of the 5-fluorouracil iodized oil derivative and the salt thereof. According to the invention, a novel 5-fluorouracil iodized oil derivative is provided for preparation of a liver cancer resisting medicament. The preparation method has the advantage of high yield; the 5-fluorouracil iodized oil derivative has the advantages of good tumor resisting effect, targeting, low toxicity and the like; primary pharmacodynamic and toxicological experiments indicate that the novel iodized oil derivative can cause tumor vessel embolization and can release 5-fluorouracil to inhibit the proliferation of cancer cells simultaneously.

The invention discloses nanoparticles targeting systemic multi-stage lymph nodes, which relates to the technical fields of biological science and drug carrier. The nanoparticles include phospholipids,iodized oil, optical probes and alpha-helical polypeptides, which have excellent physical and chemical properties and good biocompatibility. The invention also discloses a preparation method of nanoparticles for targeting systemic multistage lymph nodes, and the preparation process is simple. The invention also discloses an application of the nanoparticles targeting the systemic multi-stage lymphnode, the nanoparticles can be used for preparing a medicine, which carries two or more of a CT contrast agent, a fluorescent substance and a PET contrast agent to target the systemic multistage lymph nodes. The invention also discloses another nanoparticle targeting the systemic multi-stage lymph node, and the nanoparticle further comprises a DMPE-DTPA-Gd phospholipid derivative. The nanoparticle can be used to prepare the medicine that carries two or more of the CT contrast agent, the fluorescent substance, an MRI contrast agent, and the PET contrast agent to target the systemic multi-stagelymph node.

The invention provides an iodized oil embolism agent containing adriamycin and a preparation method of the iodized oil embolism agent. The iodized oil embolism agent is prepared from composite gel powder, an anti-tumor drug and a magnetic nano material and iodized oil; the anti-tumor drug is loaded in composite gel; the magnetic nano material is loaded on the outer side of the composite gel; the preparation method comprises the steps that S1, bletilla striata gelatin, tripropylene gelatin, n-butyl methacrylate, polylactic acid and deionized water are mixed, then initiator alkenyl amide is added, drying and smashing are carried out after a stirring reaction, and composite gel powder is obtained; S2, the anti-tumor drug is added into the composite gel solution, and oscillating and stirring are carried out to obtain drug-loaded gel; S3, the magnetic nano material is dispersed into ultrapure water, a surfactant is added, the drug-loaded microspheres are added, stirring is carried out for reaction, and filtering is performed to obtain magnetic loaded microspheres; and S4, storing and taking are carried out.

The invention discloses folic acid-phosphorylcholine oligomer modified graphene oxide as well as a preparation method and application thereof. The structural formula of the modified graphene oxide is as shown in the specification, wherein two monomers participating in polymerization comprise acrylate containing a phosphorylcholine structure and acrylate containing an amino structure; and a ratio of m to n ranges from 1 to 10. Compared with the prior art, the novel folic acid-phosphorylcholine oligomer modified graphene oxide provided by the invention has the advantages that the modified graphene oxide can be utilized for inducing hepatic artery thrombosis to achieve an effect of embolizing tumor tissues, and adriamycin loaded on the graphene oxide is continuously released so as to achieve an effect of killing cancer cells. Compared with the traditional iodized oil TACE (Transcatheter Arterial Chemoembolization) therapy, the drug-carrying graphene oxide disclosed by the invention is simple in therapy when being used for treating tumors and has an excellent chemotherapy effect. Side effects in the traditional therapy caused by rapid diffusion of chemotherapeutics are avoided.

The invention discloses a nano-drug-iodine oil homogeneous preparation as well as a preparation method and an application thereof. The nano-drug-iodized oil homogeneous preparation is a homogeneous preparation formed by uniformly dispersing a functional nano-drug in an iodized oil injection by using supercritical carbon dioxide, wherein the concentration of the functional nano-drug in the iodized oil is 0.1-20 mg/mL; the functional nano-drug has magnetocaloric performance or photothermal performance, and the surface of the functional nano-drug is modified with oleic acid or oleylamine. The nano-drug-iodized oil homogeneous preparation disclosed by the invention has better dispersity, and the nano-drug can be stably dispersed in the iodized oil during long-time storage without coagulation. After the nano-drug is intervened into a tumor area, the combined effect of embolism treatment and exogenous excitation heat radiation treatment can be achieved.

In this invention process, reaction ligand, protector, radiorhenium, and reducing agent are added into reactor, regulating pH value in the reaction system, under suitable reaction temp. Finally, the reaction product is extracted by iodized oil to obtain radiorhenium-N-alkyldithiodiaza type coordination compound for treating hepatoma by perfusion of iodized oil and said compound solution into hepatic artery, with higher marking rate and high stability.

The invention discloses brucea javanica iodized oil with an anti-cancer effect as well as preparation and application thereof and belongs to the technical field of medicines. The brucea javanica iodized oil is characterized in that hydrogen iodide gas is introduced into brucea javanica oil for reaction to obtain the brucea javanica iodized oil. The brucea javanica iodized oil obtained by the invention has the ability to inhibit the growth of hepatoma carcinoma cells Hepg2 on the basis of having an embolization effect, can have an embolization effect in clinic and stays in a tumor area for cancer fighting.

The invention discloses a hydrogenation method of a C9 < + > fraction for pyrolysis gasoline. By utilizing a hydrogenation process of carrying out staged hydrogenation and enabling one part of a firstproduct flow to be recycled back to a first reactor and one part of a second product flow to be respectively recycled back to a colloid separation tower, a first reactor and a second reactor, and cooperatively using a catalyst with high low-temperature activity, the operation stability of the device and the hydrogenation activity of the catalyst are improved. According to the method, the export bromine value of the finally prepared hydrogenation product can be reduced to below 3g bromine/100g oil, the export diene value reaches 0g iodine/100g oil, and the sulfur content is reduced to below 3mg/kg.

The invention relates to quantum dot iodized oil dispersion and preparation method and use thereof. The dispersion comprises the following components by mass percent: 0.5-30% of quantum dot and 70-99.5% of iodized oil. The preparation method includes that water phase synthesis is adopted to synthesize quantum dot, the quantum dot is precipitated from water solution, dried and then added into iodized oil by formula ratio, and ultrasound or oscillation processing is carried out, thus obtaining the quantum dot dispersion; or organic phase synthesis is adopted to synthesize quantum dot, organic solvent is removed by washing, drying is carried out, and the quantum dot is added into iodized oil by formula ratio, the mixed solution is subject to ultrasonic dispersing processing, thus obtaining the quantum dot dispersion. The invention has the advantages that: the quantum dot is effectively combined with the iodized oil, so as to obtain solution with quantum dot stably dispersed and greatly widen the application of quantum dot being taken as medicine for treating tumour. As the iodized oil can be combined with tumour tissue for a long time, the quantum dot can be mainly remained at the tumour position, local orientation function is realized for inhibiting growth of tumour cell, thus avoiding harming normal body tissue organ.

Carcinogenic iodized oil solution is prepared by dissolving methyl cholanthrene and diethylnitrosamine in iodized oil. Filling the said iodized oil into bronchus of left lung of Wistar rat induces positioned lung scaly cancer. At 3 days after the said iodized oil being filled, hyperplasia is occurred on epithelium mucosae of bronchus. At 5, 6 days, squamous metaplasia is occurred. At 7-9 days, atypical hyperplasia is occurred. At 13-16 days, early invasive carcinoma is occurred. After 22 days, wet ability scaly cancer is formed. The invention can be utilized in researching pathogenesis, new drugs and new therapeutic methods. Advantages of the invention are: inducing lung scaly cancer at specific position, high rate of inducing cancer and high repeatability. The method is easy of operation, economy as a good model for researching lung cancer.

The invention discloses an SMANCS (Styrene Maleic Acid Neocarzinostatin) oily preparation. The SMANCS oily preparation is a single preparation and comprises active ingredients listed in (1): SMANCS, namely styrene maleic acid neocarzinostatin, is a chemically combined body of a neocarzinostatin NCS and a copolymer of styrene and maleic acid SMA; and (2) oily materials with good biocompatibility, comprising iodized oil. The oily preparation disclosed by the invention overcome the defects of complex storage conditions and inconvenient clinical application of the traditional SMANCS and has the effects of being convenient to use and flexible in medicine concentration regulation.