26 results about "Iodized oil" patented technology

The invention relates to the field of medicine emulsifying devices, in particular to a microfluidic iodine oil and chemotherapeutic medicine emulsifying device which comprises an emulsifying unit and an intelligent driving handle which are detachably connected with each other, the emulsifying unit comprises two syringes and a microchannel reaction module, the microchannel reaction module is connected with outlets of the two syringes, and the microchannel reaction module is connected with the outlets of the two syringes. The intelligent driving handle comprises a gun type handle shell and two electric push rods, a mounting groove is formed in the top of the gun type handle shell, the mounting groove is used for clamping and fixing the emulsifying unit, the electric push rods are embedded into the gun type handle shell, and a piston rod clamping seat used for being connected with a piston rod of the injector is mounted on an execution part of each electric push rod. A doctor can select the emulsification unit of a proper model according to the diameter of a tumor blood supply artery, so that emulsion with the droplet size range meeting the requirement is formed, meanwhile, the intelligent driving handle is used for automatically and quantitatively injecting iodophol and chemotherapeutic drugs at a constant speed, and the variable number of clinical proportioning can be eliminated.

The invention relates to the technical field of radiotherapy auxiliary instruments, in particular to an injectable calcium sodium alginate hydrogel spacer for radiotherapy and a preparation method of the injectable calcium sodium alginate hydrogel spacer. Nano calcium carbonate is used as an adjusting switch, an adjustable mechanical and degradation performance foundation of the hydrogel is laid, and the material is endowed with unique bifunctional characteristics through the synergistic effect of the nano calcium carbonate, a contrast agent iodized oil and a degradation liquid diethylenetriamine pentaacetic acid. The hydrogel can quickly form gel after being injected, keeps long-term structural stability and clear CT imaging capability in vivo, and can monitor the position and form of the hydrogel in a lossless manner; and when the radiotherapy period is finished, the on-demand and rapid degradation of the hydrogel can be realized only by injecting the diethylenetriamine pentaacetic acid, so that the risk of long-term retention is avoided. In-vitro and in-vivo experiments prove that the material has good biocompatibility, can significantly reduce the radiation dose of normal tissues such as rectum and the like, realizes the technical span from invisibility and difficult degradation to visibility and degradability, and has great clinical transformation value.

The present invention relates to the field of clinical radiotherapy technology, and in particular to a test system and method for the effect of an iodized oil area on photon radiotherapy dose. The system comprises: a plurality of iodized oil samples, each of which is made by mixing minced pig liver and iodized oil in different proportions; a cylindrical sample tube, each of which is composed of a plurality of detachably connected sample chambers, each of which is provided with the iodized oil samples in the sample chambers, each corresponding to the iodized oil sample. The linear accelerator irradiates an abdominal simulation phantom into which the sample tube is inserted. The CT scanner is connected to a radiotherapy planning system, which simulates the irradiation of the sample tube with a photon beam based on a CT image and obtains a simulated dose of electron density. The present application can characterize the effect of the iodized oil area on the photon radiotherapy dose by comparing the simulated dose of electron density obtained by the radiotherapy planning system with the actual dose of electron density obtained by an ionization chamber detector.

The invention relates to the technical field of analysis and detection, in particular to a method for analyzing an aluminum element in peanut iodized oil. The analysis method specifically comprises the following steps: sample pretreatment: fully reacting a to-be-detected sample with nitric acid, treating the to-be-detected sample in a water bath environment at 80-120 DEG C for 1-2 hours, and then carrying out microwave digestion; after the digestion is completed, treating in a water bath environment at 60-80 DEG C for 1-2 hours, and fixing the volume. Performing inductively coupled plasma mass spectrometry determination: respectively adding internal standard ISTD elements with the same concentration into the standard solution, the test solution and the blank solution, and performing determination; and preparing a standard curve by using the standard solution, and calculating the concentration of the aluminum element in the test solution by using the standard curve. Compared with the prior art, the analysis method provided by the invention not only has lower requirements on the sample dosage, but also has higher accuracy and lower detection limit.

The invention provides a pharmaceutical composition for treating liver cancer through arterial embolism, the pharmaceutical composition is composed of iodine oil and tirapazamine-loaded nano-vesicles, and the tirapazamine-loaded nano-vesicles comprise nano-vesicles and tirapazamine coated in the inner cores of the nano-vesicles. The invention also provides a preparation method and application of the pharmaceutical composition for treating liver cancer by arterial embolism, the preparation method comprises the following steps: performing liver left artery microcatheter hyperselection on a test rabbit VX2 liver cancer model through in-vivo test, then confirming tumor responsible blood vessels by radiography, and then applying the iodophol and tirapazamine-loaded nano-vesicle compound for embolism until thorough embolism is realized, thereby obtaining the pharmaceutical composition for treating liver cancer by arterial embolism. According to the present invention, the application of the iodophol and the tirapazamine-loaded nano-vesicle compound in the treatment of liver cancer by TAE is safe and effective, the combination with TAE provides the strong synergistic anti-tumor effect, and the TPZ can be promoted to the deep tumor under the action of the UTMD so as to induce the apoptosis of the hypoxia tumor cells;

The application discloses a polymer vesicle-stabilized drug-iodized oil emulsion and a preparation method and application thereof, to realize safe and efficient transarterial chemoembolization (TACE) treatment of hepatocellular carcinoma in situ. The drug-iodized oil emulsion system has the following advantages: simple preparation, convenient size adjustment, excellent stability, near-zero order and sustained controllable drug release rate, low blood drug concentration after transarterial embolization, and the retention time and retention amount of the drug in the liver are superior to those of free drug-iodized oil emulsion used in clinical treatment, the tumor can be completely eradicated, angiogenesis can be effectively inhibited, and adverse reactions can be reduced. In general, the polymer vesicle-stabilized drug-iodized oil emulsion has the advantages of high stability and sustained controllable drug release, and can greatly improve the embolization chemotherapy effect of hepatocellular carcinoma, and provide a safe and efficient TACE strategy.

The invention provides an antigen polypeptide for anti-tumor immunoregulation and a screening method and application thereof. The antigen polypeptide is derived from BCG (Bacillus Calmette Guerin) vaccine, and the amino acid sequence is shown as SEQ ID NO.1-8. According to the screening method, immunomass spectrometry detection is combined with antigenicity prediction, and the antigen polypeptide can activate CD8 + T cells and regulate the tumor immune microenvironment. CD8 + T and DC2.4 cells in a tumor are induced to be increased, and the induction effect of delivering the polypeptide by utilizing iodophol is stronger. The screening method provides technical support for development of a novel BCG anti-tumor preparation, the provided antigen polypeptide enriches the application of BCG in tumor resistance, and a thought is provided for development of tumor immunotherapy materials.

The disclosure relates to a mixing device and a liquid mixing method. The mixing device comprises a first clamping assembly, a second clamping assembly and a driving assembly, the first clamping assembly is used for fixing a first container containing a first liquid, the second clamping assembly is used for fixing a second container containing a second liquid, the first container and the second container are in communication, the driving assembly drives the first liquid and the second liquid to flow back and forth between the first container and the second container to complete a predetermined degree of mixing to form a third liquid. The flow speed of the first liquid and the second liquid driven by the driving assembly is accurately controlled, so that an iodized oil emulsion with better physical and chemical characteristics is prepared, and an emulsion with better emulsifying effect and treatment effect is obtained.

The application discloses a stable liver cancer embolism emulsion of raltitrexed drug gel and a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The emulsion is composed of iodized oil embolism agent and raltitrexed drug gel; the raltitrexed drug gel is a nanofiber network hydrogel formed by self-assembly of raltitrexed molecules in an aqueous phase through ultrasonic treatment, and simultaneously serves as an active pharmaceutical ingredient and an emulsion stabilizer. The iodized oil and the raltitrexed drug gel are physically mixed and injected through a three-way valve to form a stable oil-in-water emulsion or a water-in-oil emulsion, and any additional chemical surfactant or cosolvent is not needed. The emulsion has excellent physical stability, and can effectively solve the problems of easy aggregation and sedimentation of a traditional iodized oil emulsion and increased systemic toxicity caused by drug burst release. The emulsion has good embolism effect and drug release behavior, can significantly inhibit tumor growth, and has a wide clinical transformation prospect.

1. The name of the design product: medical iodine oil and glue mixer. 2. The use of the design product: for mixing iodine oil with gelatin particles and other embolization materials. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention discloses an embolism emulsion capable of regulating and controlling tumor pH and inducing potent ferroptosis and a preparation method of the embolism emulsion, and belongs to the technical field of biological medicines.The emulsion is prepared by combining surface-modified iron nanoparticles (FeNPs), iodized oil and a sodium-hydrogen exchanger inhibitor (cariposide) through a Pickering emulsion technology; the problems that a traditional iodinated oil emulsion is poor in stability and insufficient in drug slow release are solved. FeNPs is used as a Fenton reaction catalyst, hydroxyl radicals are efficiently generated in a tumor acidic microenvironment, and ferroptosis is induced; the cariposide inhibits a sodium-hydrogen exchange body, reduces the intracellular pH value, relieves extracellular acidification, and synergistically enhances the Fenton reaction activity. The emulsion is administrated through arterial embolism, and can remarkably inhibit tumor growth, activate anti-tumor immunity and reverse an immunosuppression microenvironment. In-vitro and animal experiments show that the compound has excellent stability, slow release characteristic (the drug release speed is reduced by 50%) and treatment efficiency, and is suitable for treating liver cancer through transcatheter arterial chemoembolization (TACE).

The invention relates to the technical field of developing gold labels, and discloses a near-tumor developing liquid gold label and a using method and application thereof.The near-tumor developing liquid gold label comprises a mixed solution composed of iodine oil and biological hemostatic glue, the iodine content of the iodine oil is not smaller than 40%, and the biological hemostatic glue is selected from fibrin glue and gelatin-based hemostatic glue. The mass ratio of the iodine oil to the biological hemostatic glue is 1: 1-1: 2; the liquid gold label provided by the invention has remarkable economical efficiency, and the production and implantation cost of the gold label is reduced, so that the liquid gold label is widely applied in clinic; meanwhile, due to the adoption of a non-metal material, the risk of in-vivo implantation is reduced, the occurrence rate of complications such as infection and bleeding is reduced, and the safety and acceptance of a patient are improved; besides, the liquid gold label does not generate artifacts in imaging examination, so that accurate judgment of a doctor on the position and the form of the tumor is ensured, and the accuracy and the safety of SBRT are improved.

The invention relates to the technical field of medical materials, and discloses an embolism radiotherapy composition as well as a preparation method and application thereof. The composition comprises a water phase and an oil phase, and the volume ratio of the water phase to the oil phase is (5: 5)-(9: 1); the water phase comprises temperature-sensitive nanogel, a water phase developing agent and ultrapure water; the temperature-sensitive nanogel accounts for 0.1-10.0% of the total mass of the embolism radiotherapy composition, and the water-phase developing agent accounts for 1-50% of the total mass of the embolism radiotherapy composition; the oil phase is radioactive iodine oil. The temperature-sensitive nanogel has an emulsifying effect on radioactive iodized oil, the temperature-sensitive nanogel and the radioactive iodized oil are blended through a medical three-way cock to form a temperature-sensitive iodized oil Pickering emulsion, the temperature-sensitive iodized oil Pickering emulsion is still kept stable under blood flow flushing, and the capability of achieving'conformal embolism + internal irradiation 'synergistic treatment is achieved. After the radioactive iodinated oil disclosed by the invention is gelatinized by the temperature-sensitive nanogel, the embolism is improved, and the problem that the radioactive iodinated oil enters non-targeted tissues to cause radioactive injury is solved.

This invention belongs to the field of biomedical technology, specifically disclosing an injectable embolic agent, its preparation method, and its application. The embolic agent is a hydrocolloid system containing core-shell structured nanoparticles: the core contains Cu... 2+ Salt and ATOX1 inhibitors, where ATOX1 inhibitors can inhibit copper ion efflux and promote intracellular copper accumulation, and interact with Cu 2+ It synergistically induces copper death in tumor cells; the shell is a thermosensitive block copolymer hydrogel that can interact with Cu. 2+ Coordination bonds are formed, enhancing the stability of nanoparticles, while a sol-gel transition occurs at physiological temperatures, enabling precise vascular embolization; the overall core-shell structure allows for the formation of Cu... 2+ The sustained-release effect of ATOX1 inhibitors was observed. In the VX2 rabbit hepatocellular carcinoma model, this embolization agent significantly improved tumor necrosis rate and reduced metastasis rate compared to traditional iodized oil embolization; it also downregulated hypoxia- and angiogenesis-related factors such as HIF-1α, VEGF, and CD31, inhibited MMP9-mediated tumor invasion and metastasis, and promoted CD8+. + T-cell infiltration effectively improves the tumor immunosuppressive microenvironment after transarterial chemoembolization.

The utility model relates to the field of medicine emulsifying devices, in particular to a micro-fluidic emulsifying unit for iodophol and chemotherapeutics, which comprises a micro-channel reaction module and an electronic tag, a micro-channel for emulsifying chemotherapeutics and iodophol is arranged in the micro-channel reaction module, and the electronic tag is arranged in the micro-channel reaction module. Three Luer tapers connected with the micro-channel are arranged outside the micro-channel reaction module, and the electronic tag is installed on the surface of the micro-channel reaction module and used for storing emulsion configuration information. According to the embodiment of the utility model, a doctor can select the micro-channel reaction module with a proper model according to the diameter of a tumor blood supply artery and confirm the model of the micro-channel reaction module by scanning the electronic tag, so that the emulsion with the droplet size meeting the requirement is formed.

The invention discloses a pharmaceutical composition for tumor embolism treatment. The pharmaceutical composition consists of a tirapazamine derivative RTPZ and iodophol. The preparation method comprises the following steps: S1, dissolving tirapazamine and an alkaline substance in a solvent, and adding alkyl acyl chloride for reaction until the raw materials are completely converted; s2, after the reaction in the S1 is finished, performing rotary evaporation to remove the solvent, adding dichloromethane for dissolving, washing with a saturated saline solution, drying with anhydrous sodium sulfate, and finally evaporating to remove the solvent to obtain a crude product; s3, purifying the crude product to obtain RTPZ; and S4, directly dissolving the RTPZ in the iodinated oil until the RTPZ is saturated. According to the invention, the characteristics of a high oil-soluble drug, an iodized oil embolism agent and slow release are integrated, a local, slow-release and target hypoxic tumor treatment system for transcatheter arterial chemoembolization is constructed, an anti-tumor effect far better than that of a raw drug TPZ is achieved on a VX2 rabbit tumor embolism model, and a microenvironment after embolism can be effectively regulated and controlled.

The invention provides a novel iodinated polyunsaturated fatty acid ethyl ester compound as well as a preparation method and application thereof, and DHA or EPA is used as a raw material for esterification reaction to prepare iodinated DHA ethyl ester and iodinated EPA ethyl ester. Compared with the existing iodinated oil, the iodinated polyunsaturated fatty acid ethyl ester has higher iodine content range, lower drug dosage and better stability.

The invention discloses a treatment method for intractable pneumothorax under the guidance of CT (Computed Tomography), which comprises the following steps of: 1, carrying out clinical examination before an operation on an intractable pneumothorax patient needing to be treated through clinical consultation, carrying out consultation judgment according to the clinical examination, and signing an informed consent before the operation; the position and the form of the broncho pleural fistulae are accurately displayed through CT three-dimensional reconstruction, the position of the fistulae is accurately punctured through a PTCB needle under local anesthesia, the purpose of plugging the fistulae is achieved by selecting proper plugging materials such as a medical adhesive / iodized oil mixture, a spring ring and gelatin sponge, and the clinical applicability of the intractable pneumothorax plugging operation under CT guidance is high; required CT and plugging materials are conventionally available in primary hospitals; the device is simple in structure, convenient to operate, accurate in plugging and capable of being carried out only under local anesthesia, most patients can tolerate multiple operations, minimally invasive, safe, efficient and instant in effect, has very important diagnosis and treatment significance on treatment of most refractory pneumothorax, and is worthy of clinical application and popularization.

This invention provides an antigenic polypeptide for anti-tumor immune regulation, a screening method thereof, and its application. The antigenic polypeptide is derived from BCG, and its amino acid sequence is shown in SEQ ID NO. 1-8. The screening method combines immunomass spectrometry detection with antigenicity prediction. The antigenic polypeptide can activate CD8. + T cells regulate the tumor immune microenvironment and induce intratumoral CD8. + The increase in T and DC2.4 cells, coupled with the enhanced induction effect of the peptide delivered via iodized oil, provides a strong basis for the screening method of this invention. This invention provides technical support for the development of novel BCG antitumor agents, enriches the application of BCG in antitumor therapy, and offers insights for the development of tumor immunotherapy materials.

This invention relates to the field of tumor treatment technology, and particularly to a radioembolization microsphere, a radioembolization microsphere formulation, its preparation method, and its application. The radioembolization microsphere provided by this invention comprises radioactive particles and an organic phase containing iodized oil. The radioactive particles are coated on an interface with the organic phase containing iodized oil as its core. The radioactive particles comprise a radionuclide and an inorganic matrix, with the radionuclide immobilized in the inorganic matrix. The particle size of the radioactive particles is 0.01~10 μm; the particle size of the radioembolization microspheres is 0.01~1000 μm. Applying the radioembolization microspheres of this invention to embolization therapy can maintain long-term retention at the tumor site and reduce radiation damage to non-tumor sites. The iodine component provides X-ray imaging functionality, enabling integrated diagnosis and treatment, radioactive dose tracking, and accurate measurement of radiation dose.

The invention discloses a preparation method of water-in-oil Pickering emulsion gel loaded with a two-phase medicine and application of the water-in-oil Pickering emulsion gel loaded with the two-phase medicine. According to the method, an amino polymer with positive charges is dissolved in oil to serve as an oil phase, nano-particles with negative charges are dispersed in water to serve as a water phase, the oil phase and the water phase are mixed and emulsified to prepare the water-in-oil Pickering emulsion gel, and the water-in-oil Pickering emulsion gel has good stability and biocompatibility and can serve as an excellent drug delivery platform; the simultaneous loading of hydrophilic and hydrophobic active substances is realized. The degradation rate of the prepared Pickering emulsion gel can be controllably adjusted by adjusting the adding proportion of iodized oil and castor oil in the oil phase, release can be triggered under the ultrasonic action, and controlled release of the water-in-oil Pickering emulsion gel is achieved by adjusting and controlling different oil-water phase compositions, ultrasonic power and ultrasonic time. The prepared Pickering emulsion gel can be used for realizing efficient packaging of a hydrophobic sound sensitive agent, and can be used for realizing anti-tumor treatment through sonodynamic therapy.

This invention relates to the field of correction methods, specifically to a photon beam dose correction method for iodized oil regions. It includes the following steps: S1, placing iodized oil samples with different component ratios in a simulation phantom; S2, using a radiotherapy planning system, irradiating the simulation phantom with a photon beam and performing simulated irradiation, respectively obtaining the actual photon beam dose and the simulated photon beam dose; S3, obtaining a photon beam dose correction function based on the corresponding actual and simulated photon beam doses for iodized oil samples with different component ratios; S4, obtaining a photon beam dose correction factor based on the component ratio of the iodized oil samples and the correction function, and determining the correction value for the required dose in the radiotherapy planning system. The relative electron density of an iodized oil sample with a certain component ratio after photon beam irradiation can be obtained, and then the corresponding photon beam dose correction factor can be obtained through the relative electron density.

The invention relates to the technical field of biomedical materials, in particular to iodinated oil emulsion gel with a slow release function and a preparation method of the iodinated oil emulsion gel. The invention provides iodinated oil emulsion gel with a slow release function, the iodinated oil emulsion gel comprises an oil phase, a water phase and magnetic response amphiphilic particles, the oil phase is prepared by compounding oleic acid modified magnetic nanoparticles and iodinated oil; the water phase is prepared by dissolving a medicine in deionized water; the magnetic response amphiphilic particles are prepared by carrying out amination modification treatment on magnetic nanoparticles. The preparation method comprises the following steps: preparing oleic acid modified magnetic nanoparticles, compounding the oleic acid modified magnetic nanoparticles with iodinated oil to obtain magnetic iodinated oil, synthesizing magnetic response amphiphilic particles through multiple steps, and matching the magnetic response amphiphilic particles with a drug-containing aqueous phase and a gel agent to successfully prepare iodinated oil emulsion gel with a slow release function, and the iodinated oil emulsion gel has good centrifugal stability.

The present invention relates to the field of radiotherapy technology, and in particular to the use of lipiodol emulsion as a radiotherapy sensitizer or lymph node tracer. The lipiodol emulsion comprises: an oil phase and an aqueous phase; the oil phase comprises lipiodol, and the volume percentage of the oil phase in the lipiodol emulsion is: 30-90%; the volume percentage of the lipiodol in the oil phase is above 30%. The present invention unexpectedly discovered during the research process that lipiodol has an excellent radiotherapy sensitization effect after being prepared into an emulsion state, and a single lipiodol emulsion can be used as a radiotherapy sensitizer, which can effectively improve the radiotherapy effect and improve the killing efficiency of X-rays on tumor cells. The use of the lipiodol emulsion provided by the present invention as a radiotherapy sensitizer is of great significance to the existing radiotherapy treatment field.

The invention provides a temperature response type magnetic emulsion embolization agent containing triptolide as well as a preparation method and application of the temperature response type magnetic emulsion embolization agent, and belongs to the technical field of biological medicines. The triptolide temperature response type magnetic emulsion embolization agent comprises triptolide, a temperature-sensitive polymer, iodized oil and magnetic nanoparticles, and the temperature-sensitive polymer can be subjected to phase change at 32 DEG C or above to be gelated. The triptolide temperature response type magnetic emulsion embolism agent provided by the invention can continuously release triptolide and has excellent mechanical properties to realize long-acting tumor vascular embolism, and the magnetic nanoparticles can effectively exert magnetocaloric properties to realize an anti-tumor effect; the iodinated oil has X-ray opaqueness and can be visualized in an embolism operation, the safety in the using process is improved, and then the triple synergistic anti-tumor effect of embolism, chemotherapy and magnetic hyperthermia is achieved.

The present invention relates to the technical field of radioactive therapy, in particular to the use of an iodized oil emulsion as a radiosensitizer or a lymph node tracer. The iodized oil emulsion comprises an oil phase and an aqueous phase, wherein the oil phase comprises an iodized oil and has a volume percentage content in the iodized oil emulsion of 30-90%; and the volume percentage content of the iodized oil in the oil phase is 30% or above. In the present invention, it was unexpectedly discovered during the research process that after being prepared into an emulsion state, the iodized oil has an excellent radiosensitization effect. The iodized oil emulsion alone can serve as a radiosensitizer, and can effectively improve the effect of radiotherapy and increase the killing efficiency of X-rays with regard to tumor cells. The use of the iodized oil emulsion as a radiosensitizer provided in the present invention has important significance for the field of existing radiotherapy treatments.