52 results about "Fatty acids.polyunsaturated" patented technology

The disclosure provides methods for increasing saturated, monounsaturated, and poly unsaturated fatty acid production using the PUFA gene cluster plasmid and the gene regulator pfaR.

The application discloses a method for screening superior parents of carp with high total content of polyunsaturated fatty acids. The method comprises obtaining training characteristic data and training target data, wherein the training characteristic data comprises SNP genotype information of training samples, and the training target data comprises total content information of polyunsaturated fatty acids of the training samples; training a ridge regression model by using the training characteristic data and the training target data to obtain a prediction model; obtaining SNP genotype information of a to-be-tested sample; obtaining a breeding value of the to-be-tested sample according to the SNP genotype information of the to-be-tested sample and the prediction model; and screening superior parents of carp with high total content of polyunsaturated fatty acids according to the breeding value. By the method, the breeding value of the to-be-tested sample can be directly obtained according to the SNP genotype information of the to-be-tested sample and the prediction model, and then the superior parents of carp with high content of polyunsaturated fatty acids can be screened from the to-be-tested sample, thereby providing excellent materials for new germplasm identification and breeding of carp.

This invention relates to the field of fatty acid detection technology, specifically to a method for determining 11 polyunsaturated fatty acids based on LC-MS / MS. The method includes: preparing a calibration solution; hydrolyzing bound fatty acids in a blood sample, adding a precipitant, centrifuging, and collecting the supernatant as the test sample; detecting the test sample using liquid chromatography-tandem mass spectrometry, and substituting the detection results into the calibration curve equation to obtain the content of the 11 polyunsaturated fatty acids in the test sample. This method can rapidly and accurately detect the content of 11 polyunsaturated fatty acids, providing a more accurate basis for clinical diagnosis and assisting in the early detection and treatment of diseases; at the same time, it can also provide more targeted nutritional advice to individuals, promoting health management.

To provide a means effective in suppressing oxidative deterioration of fats and oils containing polyunsaturated fatty acid containing DHA and to provide a method capable of determining near olfactory sense of human being by specifying a component that becomes an index of oxidative deterioration of fat and acid containing DHA.SOLUTION: A lipid composition containing lipids composed of polyunsaturated fatty acids as constituent fatty acids, wherein a composition ratio of polyunsaturated fatty acids among all constituent fatty acids of the lipids is 15% or more, the moisture content is 600 ppm or less, perfluorooctanesulfonic acid is 0.1 ppb or less, and perfluorooctanoic acid is 0.1 ppb or less. It is preferable that the composition contains 2-(2-pentenyl)furan at less than 0.0095 ppm, and 2,4-heptadienal at less than 2.600 ppm.SELECTED DRAWING: None

The invention provides a method for producing polyunsaturated fatty acid, and belongs to the technical field of biological fermentation. The method for producing polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid from schizochytrium limacinum comprises the following steps: activating schizochytrium limacinum in a seed culture medium to obtain a schizochytrium limacinum seed culture solution; inoculating the schizochytrium limacinum seed culture solution into a fermentation culture medium for culturing, wherein the fermentation culture medium comprises rapeseed protein powder; and extracting the culture solution in the cultured fermentation culture medium to obtain the polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. According to the present invention, the yield of polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid can be significantly improved.

Fatty acids with one or more unsaturations and an odd-numbered hydrocarbon chain are described, wherein these fatty acids have the chemical structure of the therapeutically active metabolites of alpha-hydroxylated mono- or polyunsaturated fatty acids with an even-numbered chain. The compositions comprising these fatty acids, their medical uses, and their use as indicators of a patient's efficacy and / or response to treatment with the alpha-hydroxylated mono- or polyunsaturated fatty acids with an even-numbered chain from which they are derived are also described.

This invention relates to a method for rapidly screening filamentous fungi that produce high levels of triglycerides and polyunsaturated fatty acids, belonging to the field of microbial technology. The method employs a two-stage screening strategy of "resistance primary screening – fluorescence secondary screening." In the primary screening stage, strains with strong lipid synthesis capabilities are initially screened by adding a combination of phytocyanin and quizalofop-p-ethyl inhibitors to the culture medium. In the secondary screening stage, cellophane culture technology and Nile red fluorescence staining are combined to quantitatively assess the triglyceride content of the colonies, achieving rapid and non-destructive screening. This method is simple to operate, highly efficient, and shows a significant positive correlation between fluorescence intensity and triglyceride content. It is suitable for mutagenesis breeding and industrial strain selection of oil-producing filamentous fungi such as *Morchella alpineensis*.

Genetically engineered yeast cells having disruption of pex3, pex5 or pex20 genes and combinations thereof having reduced beta-oxidation and methods for increasing polyunsaturated fatty acids are disclosed.

The present application relates to the technical field of microcapsules, and in particular to a polyunsaturated fatty acid oil microcapsule, a preparation method therefor, and a use thereof. The present application provides a polyunsaturated fatty acid oil microcapsule, the raw material of which comprises polyunsaturated fatty acid oil, wherein an anisidine value of the polyunsaturated fatty acid oil is not greater than 10. It is found in the present application that the anisidine value of the polyunsaturated fatty acid oil will affect the solubility of the microcapsule containing the polyunsaturated fatty acid oil, and the solubility of the polyunsaturated fatty acid oil microcapsule can be effectively improved by controlling the anisidine value of the polyunsaturated fatty acid oil within a range of not higher than 10, thereby solving the problems that a product containing the polyunsaturated fatty acid oil microcapsule has poor solubility and is prone to generation of insoluble particles, and improving the quality of the product containing the polyunsaturated fatty acid oil microcapsule.

To provide an oil which does not become cloudy when stored at a low temperature while containing a specific amount of palmitic acid.SOLUTION: An oil containing a specific amount of palmitic acid has at least one characteristic selected from the group consisting of (i) a predetermined triglyceride content, (ii) a predetermined PUFA content, (iii) a predetermined stearic acid content, (iv) a predetermined content of C18 fatty acids, and (v) a predetermined DHA / EPA ratio. The oil does not become cloudy during low-temperature storage.SELECTED DRAWING: Figure 1

A frozen aerated confection comprising water and a fat component, wherein the fat component is present in an amount of from 1 to 15 wt%, and wherein the fat component comprises i) a fat blend having a triglyceride composition of from 30 to 80% saturated fatty acids, less than 30% polyunsaturated fatty acids and the remainder being monounsaturated fatty acids, and ii) a wax ester.

The application provides a polyunsaturated fatty acid oil microcapsule and a preparation method. The preparation method of the polyunsaturated fatty acid oil microcapsule comprises the following steps: (1) adding a water retention agent into an aqueous solution of a water-soluble protein wall material, and uniformly mixing to obtain an aqueous phase; (2) adding polyunsaturated fatty acid oil into the aqueous phase, and shearing and emulsifying; (3) adding cellulose and a derivative thereof into the system obtained in the step (2), and shearing to obtain an emulsion; the content of the cellulose and the derivative thereof in the polyunsaturated fatty acid oil microcapsule is 0.05-0.3 wt%; the content of the polyunsaturated fatty acid oil in the polyunsaturated fatty acid oil microcapsule is not less than 40 wt%, and the content of a fatty acid with a carbon chain length of more than 20 and an unsaturated double bond of more than 4 in the polyunsaturated fatty acid oil is not less than 40%. The high oil-loading microcapsule product obtained by the preparation method has good sensory and good stability during a shelf life.

The application provides a medicine for treating an immune checkpoint inhibitor-resistant tumor, comprising a polyunsaturated fatty acid, an ACLY inhibitor and an immune checkpoint inhibitor. The polyunsaturated fatty acid comprises one or more of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids. The ACLY inhibitor is selected from one or more of the following: Bempedoic acid, SB 204990, NDI-091143, BMS-303141, small interfering RNA targeting the ACLY gene and short hairpin RNA targeting the ACLY gene. The medicine has good treatment effect on the immune checkpoint inhibitor-resistant tumor.

A method of preparing rumen-protected polyunsaturated fatty acids (RuPUFAs) for use in ruminant feeds by inducing the Maillard reaction between a reducing carbohydrate source and de-oiled lecithin in the presence of a PUFA under reduced pressure conditions is disclosed. Products made by the process, as well as methods for enhancing performance, assisting the induction of pregnancy, alleviating inflammation, modulating fetus growth, improving immune system function, and modulation of the fatty acid composition of meat and milk of ruminant animals are also disclosed.

The present invention relates to a process for producing ethyl esters of polyunsaturated fatty acids, comprising transesterifying triacylglycerols in extracted plant lipid.

Disclosed herein are methods for preparing isotopically modified polyunsaturated lipids containing 1,4-diene systems, comprising selective isotopic modification of one or more bis-allylic positions of the polyunsaturated lipid in the presence of a transition metal catalyst.

The invention belongs to the technical field of food processing, and particularly relates to a preparation method of thymol microemulsion and application of the thymol microemulsion in margarine. According to the thymol microemulsion provided by the invention, the water solubility and stability of edible oil and the utilization rate of unsaturated fatty acid can be improved, the edible oil is encapsulated in the form of microemulsion, and polyunsaturated fatty acid is embedded through a food delivery system, so that the dispersity of the polyunsaturated fatty acid in a water phase is improved, and oxidation of oil drops is inhibited; therefore, the purposes of protecting, transferring and releasing the functional grease are achieved. According to the margarine prepared by the preparation method disclosed by the invention, in-vitro simulated digestion result analysis shows that oil drops of a test sample are gradually reduced along with the action of stomach and intestine digestive juice, and the total fatty acid content is reduced. According to the phenomenon, positive regulation and control of a system on fat digestion and normal metabolism of fat are optimized, the controllability of fat digestion and absorption is achieved, the requirements of special crowds for slow release of nutritional ingredients of sugar-controlled and fat-controlled people and the like are met, and experimental and theoretical support is provided for functional application.

The invention belongs to the technical field of meat product processing, and discloses a composite nutrition enhancer for a meat product, a nutrition-enhanced meat product and a processing method of the nutrition-enhanced meat product. The composite nutrition enhancer for meat products is an oil-in-water type emulsion, and is prepared by emulsifying the following raw materials: konjac gum gel liquid, which is a gel dispersion liquid obtained by heating konjac gum under an alkaline condition to form gel, neutralizing the gel, and shearing and dispersing the gel; the edible oil and fat is rich in Omega-3 polyunsaturated fatty acid; the invention discloses a jack fruit seed coat extract. The compound nutrition enhancer and the meat product enhanced by the compound nutrition enhancer provided by the invention can still keep an extremely low grease oxidation degree (for example, the peroxide value is obviously lower than that of a control group) and an extremely high nutrient retention rate after being subjected to freeze thawing, heating and long-term storage, so that the most difficult problem of instability in Omega-3 enhancement is fundamentally solved.

The invention discloses a method for preparing high-purity cis-oleic acid through selective hydrogenation of vegetable oleic acid, and belongs to the technical field of preparation of cis-oleic acid. Comprising the following steps: dissolving vegetable oleic acid in a solvent to form a mixed solution, and then introducing the mixed solution and mixed gas consisting of hydrogen and inert gas into a fixed bed reactor filled with a PdPt / C catalyst for hydrogenation reaction, thereby realizing selective hydrogenation of the vegetable oleic acid to generate high-purity cis-oleic acid. By accurately regulating and controlling the partial pressure of hydrogen in the mixed gas and the polarity type of the solvent, polyunsaturated fatty acids such as linoleic acid and the like can be efficiently hydrogenated, meanwhile, side reactions that oleic acid is excessively hydrogenated into stearic acid and a cis-structure is converted into a trans-isomer are remarkably inhibited, and finally, a cis-oleic acid product with high purity and high yield is obtained.

The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs) for use in treating, reducing the risk of developing or preventing a disorder associated with an elevated GDF-15 plasma concentration.

The invention discloses a compound for increasing the content of polyunsaturated fatty acid in pork and application of the compound, and relates to the technical field of biology. The active ingredients of the compound provided by the invention are carvacrol, thymol and cinnamyl aldehyde. Through scientific proportioning, the compound can effectively regulate fat metabolism pathways in live pig bodies and significantly increase the content of polyunsaturated fatty acids in pork. Experimental research shows that when the compound is added into pig feed, the utilization rate of fatty acid in the feed can be increased, and deposition of polyunsaturated fatty acid in muscular tissue can be promoted. The action mechanism provides a new technical means for developing functional feed additives, and is beneficial to improving the nutritional value of pork products. The application range of the compound disclosed by the invention covers the fields of feed processing and livestock breeding, and the compound can be directly used as a feed additive or further prepared into a compound feed product.

A subject of the present invention is a solid cosmetic composition comprising: * 2% to 10% by weight of a filler chosen from cellulose particles; * at least a first polar ester hydrocarbon oil; * optionally, at least a second oil chosen from C15-C30 linear or C17-C30 branched apolar hydrocarbon oils, and preferably squalane; * at least one mixture of polar hydrocarbon waxes comprising sunflower wax, hydrogenated jojoba oil and at least a third polar hydrocarbon wax, other than sunflower wax and hydrogenated jojoba oil, the total content of waxes being less than 20% by weight; * at least one hydrocarbon compound which is solid at 20°C, other than waxes, chosen from plant butters or obtained from plant oils, polyesters obtained at least from a mono- or polyunsaturated fatty acid dimer, the fatty acid comprising from 16 to 22 carbon atoms; the polyester obtained from the condensation of a C6-C10 linear or branched dicarboxylic acid and an ester of diglycerol with C6-C20 linear or branched monocarboxylic acids, optionally hydroxylated; and mixtures thereof; * optionally at least one additional oil, chosen from polar or apolar hydrocarbon oils other than the first and second oils, in an amount not exceeding 5% by weight. Another subject of the invention is a method for making up and / or caring for the lips that comprises applying said composition.

The present application relates to the technical field of bioengineering, and particularly relates to a kind of extraction method of Panax quinquefolium seed natural oil body and application thereof.The method comprises the following steps: after Panax quinquefolium seed is crushed, it is mixed with buffer solution to obtain homogenate liquid; the homogenate liquid is subjected to solid-liquid separation, and filtrate is collected; the filtrate is subjected to high-speed centrifugation under low-temperature conditions, and upper oil body phase is collected, to obtain Panax quinquefolium seed natural oil body. 16 kinds of fatty acid compositions in the Panax quinquefolium seed oil body are identified by GC-MS system, and it is found that the proportion of unsaturated fatty acids is extremely high, wherein the content of linoleic acid is as high as 76.34%, and the Panax quinquefolium seed oil body is rich in polyunsaturated fatty acids such as gamma-linolenic acid, alpha-linolenic acid and arachidonic acid, and no trans fatty acids and short-chain saturated fatty acids are detected. The characteristics make it have multiple nutritional functions such as regulating lipid metabolism, reducing cholesterol and antioxidant, and have broad prospects for developing high-nutrition edible oil or functional food additive.

The invention relates to the technical field of biomedicine, in particular to a biomarker for lung cancer diagnosis. The invention discloses a biomarker for lung cancer diagnosis. The biomarker is a ratio of polyunsaturated fatty acid to monounsaturated fatty acid. The invention discloses the obvious positive correlation between the proportion of polyunsaturated fatty acid and monounsaturated fatty acid and the lung cancer disease risk for the first time. Research results show that the biomarker is significantly higher than healthy people in lung cancer patients, and Mendel randomization analysis proves that the biomarker has causal association. The discovery provides a new biomarker for early diagnosis of lung cancer, has higher sensitivity and specificity, and can make up for the defects of the existing diagnosis method.

The present invention relates to a method for determining the content of omega-3 polyunsaturated fatty acids in the retina of a subject comprising the determination of the content of at least one cholesteryl ester in a blood sample from said subject, the content of omega-3 polyunsaturated fatty acids in the retina being correlated to the content of said at least one cholesteryl ester, said at least one cholesteryl ester being cholesteryl 5,8,11,14,17-eicosapentaenoate.

The application discloses a method for preparing high-purity cis-oleic acid through selective hydrogenation of vegetable oleic acid, and belongs to the technical field of cis-oleic acid preparation. The method comprises the following steps: dissolving vegetable oleic acid in a solvent to form a mixed solution, and then passing the mixed solution and mixed gas composed of hydrogen and inert gas into a fixed bed reactor provided with a PdPt / C catalyst to perform a hydrogenation reaction, so that high-purity cis-oleic acid is generated through selective hydrogenation of the vegetable oleic acid. Through accurate regulation of the partial pressure of hydrogen in the mixed gas and the polarity type of the solvent, the method can efficiently hydrogenate polyunsaturated fatty acids such as linoleic acid, while significantly inhibiting the side reactions of excessive hydrogenation of oleic acid into stearic acid and the conversion of cis structure into trans isomer, and finally obtaining a cis-oleic acid product with high purity and high yield.

To provide a vegetable-based lipid composition comprising high levels of at least three different long-chain polyunsaturated fatty acids (typically as fatty acid esters).SOLUTION: The composition typically contains DHA as a principal long-chain polyunsaturated fatty acid. The composition is obtainable from a single source by conventional processing methods, and has improved stability properties.SELECTED DRAWING: Figure 1

The invention relates to the technical field of feed, and particularly discloses embedded particles, a preparation method thereof and application of the embedded particles in livestock feeding. The embedded particle sequentially comprises an inner core, an active ingredient layer and a coating layer from inside to outside, the active ingredient layer is at least partially embedded into the inner core; the inner core comprises hydroxypropyl methyl cellulose, silicon dioxide and a polysaccharide component, and the polysaccharide component comprises chitosan and beta-glucan; the active component layer comprises an antioxidant and a substance containing n-3 polyunsaturated fatty acid; the coating layer comprises carnauba wax, palm oil grease and polyethylene glycol. When the embedded particles are used as a feed additive to feed dairy cows, the rumen passing rate of the n-3 polyunsaturated fatty acid and the conversion rate from feed to dairy products can be increased, and the content of the original n-3 polyunsaturated fatty acid in the dairy products is increased.