40 results about "Glycerophospholipid" patented technology

Disclosed herein is a lipid preparation, said preparation comprising a phosphatidylserine moiety, and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and / or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. Said lipid preparations are particularly useful in the treatment of mental and cognitive disorders, e.g. ADHD (attention deficit hyperactivity disorder) and Alzheimer's disease.The disclosed preparations present improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders, as well as for maintenance of normal functions of brain-related systems and processes.

This invention provides a process for producing a high-purity sphingomyelin and a high-purity plasmalogen-form glycerophospholipid from a biological material by simple procedures at high yields. The process comprises the steps of: (A) subjecting dried total lipids extracted from a biological material to extraction treatment with a specific mixture solution to separate an insoluble portion composed mainly of sphingomyelin and a soluble portion; (B) subjecting the insoluble portion, obtained in said Step (A), to washing treatment with a specific mixture solution to obtain crude sphingomyelin; (C) subjecting the soluble portion, obtained in said Step (A), to washing treatment with a water-soluble ketone solvent to obtain crude plasmalogen-form glycerophospholipid; (D) causing an enzyme to act on the crude sphingomyelin, obtained in said Step (B), to obtain sphingomyelin having a purity of 90% or more; and (E) causing an enzyme to act on the crude plasmalogen-form glycerophospholipid, obtained in said Step (C), to obtain plasmalogen-form glycerophospholipid having a purity of 40% or more.

The present invention relates to an albumin nano particle composition and a preparation method thereof. The composition contains 100 parts by weight of the compound of formula (I) or a pharmaceutically acceptable salt thereof and 100-1500 parts by weight of albumin. The albumin is an albumin selected from the following: ovalbumin, bovine blood albumin, human blood albumin, recombinant human albumin, etc., preferably human blood albumin or recombinant human albumin; Optionally contain one or more excipients selected from the following: cholesterol, phospholipids, lecithin, PEGylated phospholipids, phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, glycerophospholipids Acids, synthetic phospholipids and other types of phospholipids. The preparation method and pharmaceutical use of the composition are also provided, and the method of the invention presents excellent technical effects as described in the description.

Methods of treating an inert surface of a substrate to improve the adherence to the treated surface of micro-dimensioned particles including the steps of: contacting the inert surface with in an aqueous dispersion of a construct of the structure F-S-L; and then washing the surface with an aqueous vehicle to provide the treated surface, where F is a polyamine; S is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is a diacyl- or dialkyl-glycerophospholipid.

The invention discloses a preparation method of glycerol phosphatidylcholine, wherein the preparation method comprises: 1) mixing the compound shown in formula (I) with anhydrous sodium carbonate to prepare the mixture M1; 2) mixing The mixture M1 and (R)-(-)-3-chloro-1,2-propanediol are placed in absolute ethanol and refluxed to obtain the mixture M2; 3) the mixture M2 is filtered and treated by membrane separation to remove the chlorination in the mixture M2 After adding sodium, the filtrate M3 is obtained; 4) adding zinc chloride to the filtrate M3 and then adding water to dissolve to obtain the mixture M4; 5) passing the mixture M4 through the ion exchange resin and then filtering the filtrate to obtain glycerol phosphatidylcholine; Wherein, R is Ca2+ or Mg2+. Through the above design, the preparation method of glycerol phosphatidylcholine is not only simple, but also the yield is high, thereby realizing the effect of simple preparation method, high synthesis rate and greatly reducing production cost.

The invention discloses a gene promoter region sequence of glycerophospholipid peptidy transeferace (LPAAT) and application in crop genetic improvement. The gene promoter region sequence of glycerophospholipid peptidy transeferace is shown as SEQ ID NO:1. The application method of the gene promoter of glycerophospholipid peptidy transeferace in crop genetic improvement comprises the following steps of: (1) inserting the gene promoter of glycerophospholipid peptidy transeferace into a promoter verifying expression vector pBI101.3 and starting the expression of a gus reporter gene; and (2) using the expression carrier for plant callus transgenosis research induced by agrobacterium tumefacien and obtaining the transgenosis plant by inducing, dip dyeing, coincubating and taking root of the plant callus. The gene promoter comes from coconut, can specially start expression of target gene in endosperm histiocyte, provides new promoter type in the future crop genetic improvement and has very high stability and operability without transgenic silencing.

An object of the present invention is to provide a technique for masking the bitterness of a collagen peptide-containing composition. Specifically, by compounding glycerophospholipids containing neutral glycerophospholipids and acidic glycerophospholipids at a specific ratio, or compounding glycosphingolipids at a specific ratio with respect to collagen peptides, it is possible to provide a composition containing collagen peptides. way of bitterness.

The invention belongs to the field of pesticide adjuvants, and provides a modified liposome, a composition, a preparation method and an application. The modified liposome is put into the reaction kettle under the action of a catalyst, and the mixture of glycerophospholipids, sterols and polyhydroxy compounds is used as a starter, and the temperature is raised for dehydration, and then ethylene oxide is passed through to carry out ring-opening polymerization and aging. , neutralized, and the polyhydroxy compound is a combination of alcohols and alcohol amines. The present invention also provides a liposome composition prepared from modified liposomes, which has the advantages of easy dispersion in water, good vesicle stability, easy biodegradation, and stable properties when used as a pesticide adjuvant. The advantages of good conduction effect and the ability to facilitate the deposition of liquid medicine on the target can be widely used in the field of pesticides.