The invention discloses a traditional Chinese medicine for treating infectious mononucleosis. The traditional Chinese medicine is prepared by the following medicinal materials: radix bupleuri, pinellia ternate, scutellaria baicalensis, ginseng, cortex moutan, honeysuckle, milfoil, rhizoma phragmitis, fructus forsythia, bamboo leaves, mentha haplocalyx, semen coicis, honeysuckle stem, evodia lepta, radix tetrastigme, herba eupatorii, agastache rugosus, radix isatidis, folium isatidis, radix polygonati officinalis, radix scrophulariae, gypsum, fructus gardeniae, dandelion, indian strawberry, ixeris chinensis, epipremum pinnatum, sarel spleenwort herb, royal paulowinia flower, trollflower, burdock, platycodon grandiflorum, almond, fritillaria cirrhosa, spica prunellae, stiff silkworm, sargassum, kelp, red peony root, peach kernel, artemisia apiacea, turtle shell, adenophora stricta, bupleurum falcatum, radix ophiopogonis, rhizoma picrorhizae, cortex lycii radicis, puerarin, radix trichosanthis, caulis bambusae in taeniam, radix clematidis and radix stemonae. Clinical experiments prove that the traditional Chinese medicine is capable of safely and effectively treating the infectious mononucleosis.