EB virus BFRF3-BZLF1 fusion protein, gene, vector containing same, host cell, test strip and production method and application thereof

A technology of BFRF3-BZLF1 and Epstein-Barr virus, applied in the field of bioengineering, can solve the problems of not being able to obtain high sensitivity and high specificity at the same time, easily causing missed diagnosis, and increasing specificity, so as to achieve improved specificity and sensitivity, high specificity, Effects with low specificity
CN109929040AActive Publication Date: 2019-06-25北京贝思泰生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
北京贝思泰生物科技有限公司
Publication Date
2019-06-25

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Abstract

The invention provides an EB virus BFRF3-BZLF1 fusion protein, a gene, a vector containing the BZLF1 fusion protein, a host cell, a test strip, a production method and application thereof. The EB virus BFRF3-BZLF1 fusion protein is obtained by connecting the EB virus BFRF3 protein or an EB virus BFRF3 protein fragment with an EB virus BZLF1 protein or EB virus BZLF1 protein fragment through a connecting peptide, and preferably, the EB virus BFRF3-BZLF1 fusion protein has an amino acid sequence shown in SEQ ID NO:1. The EB virus BFRF3-BZLF1 fusion protein can be used as a target antigen for detecting an EB virus, provides a basis for screening and early diagnosing nasopharyngeal carcinoma, infectious mononucleosis and Burkitt lymphoma, and has the advantages of simplicity, rapidness, sensitivity and specificity.
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Description

technical field

[0001] The invention belongs to the technical field of bioengineering, and in particular relates to an Epstein-Barr virus BFRF3-BZLF1 fusion protein, a gene, a carrier containing the same, a host cell, a test strip and a production method and application thereof. Background technique

[0002] Epstein-Barr (EB) virus is the only lymphofollicular virus in the Gamma subfamily of the Herpesviridae family that can cause human infection. Epstein-Barr virus has the characteristics of B lymphocytes, can establish a recessive infection in B lymphocytes, and stimulate cell proliferation and transformation. In recent years, it has been found that there are structures similar to Epstein-Barr virus receptors on the surface of epithelial cells in the parotid duct, oropharynx and external os of the cervix. Epstein-Barr virus is closely related to human infectious mononucleosis, Burkitt's lymphoma and nasopharyngeal carcinoma (Nasopharyngeal carcinoma, NPC) and other diseas...

Claims

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