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Herpesviridae is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word herpein ("to creep"), referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster (shingles). In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established Herpesvirus as a genus with 23 viruses among four groups. Latent, recurring infections are typical of this group of viruses, though the family name does not refer to latency. Herpesviridae can cause latent or lytic infections.
An engineered enucleated mesenchymal stem cell, its preparation method and application
An engineered enucleated mesenchymal stem cell (EMC) and its preparation method and application are disclosed, which can effectively solve the problem of preparing engineered enucleated EMC and realize its application in the preparation of drugs for treating herpesvirus infections. The steps are as follows: Lentiviral transfection is used to obtain EMC overexpressing Nectin-1, the overexpression being achieved through genetic engineering, including transfection of EMC using a lentiviral vector or adenovirus vector; then, enucleation is performed using discontinuous density gradient centrifugation to obtain the engineered enucleated EMC. The engineered enucleated EMC of this invention acts as "bait" to competitively capture viruses; the enucleation design fundamentally eliminates the risk of viral replication and leakage within cells; and the captured viruses are subsequently cleared along with the engineered enucleated EMC's own programmed apoptosis and subsequent macrophage phagocytosis, thereby achieving safe and efficient virus capture and physical clearance.
Owner:ZHENGZHOU UNIV