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Application of triacetyl-3-hydroxyphenyl adenosine in preparing medicines for treating atherosclerosis

A technology of hydroxyphenyl adenosine and atherosclerosis, which is applied in the application field of preparing drugs for preventing or/and treating atherosclerosis, and achieves the effects of safe use, significant curative effect, and small toxic and side effects

Inactive Publication Date: 2017-11-10
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the application of this compound in the treatment of atherosclerotic inflammatory mononucleosis

Method used

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  • Application of triacetyl-3-hydroxyphenyl adenosine in preparing medicines for treating atherosclerosis
  • Application of triacetyl-3-hydroxyphenyl adenosine in preparing medicines for treating atherosclerosis
  • Application of triacetyl-3-hydroxyphenyl adenosine in preparing medicines for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0037] Experimental Example 1: Application of Triacetyl-3-Hydroxyphenyladenosine (IMM-H007) in the Treatment of Mononucleosis Accompanied by Hyperlipidemia

[0038] 1. Experimental materials

[0039] 1. Reagents

[0040] Abbott CD3700 whole blood analysis reagents, including diluent, hemolytic agent, sheath fluid, washing solution, enzyme cleaning solution; EDTA-2K anticoagulant

[0041] 2. Instrument

[0042] Complete blood cell analyzer (USA, Abbott).

[0043] 3. Experimental animals

[0044] 20 6-8-week-old Syrian golden hamsters (LVG hamster, introduced from Charles River Laboratories), weighing 90-120 g, male, SPF grade, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. II. Experimental methods

[0045] 1. Animal grouping and feeding

[0046] After 7 days of adaptive feeding, the animals were randomly divided into normal control group (n=13), high-fat diet group (n=13), IMMH007 low-dose group (50mg / kg, n=13), IMMH007 medium-dose group...

experiment example 2

[0055] Experimental example 2. Application of triacetyl-3-hydroxyphenyladenosine (IMM-H007) in the treatment of circulating blood mononucleosis in mouse model of atherosclerosis

[0056] 1. Experimental materials

[0057] 1 reagent

[0058] OCT frozen section embedding agent, American cherry; pentobarbital sodium, sigma company; PEG6000, sigma company; glycine, sigma company; paraformaldehyde,; oil red O, sigma company; HE staining solution, Taiwan Beso company;

[0059] 2. Instrument

[0060] Multi-purpose low-temperature high-speed centrifuge, Eppendorff, Germany; cryostat, Leica, Germany; water-proof constant temperature water bath; En Vision multi-functional microplate reader, PerkinElmer Co., Ltd. of the United States; small animal anesthesia machine, Matrx products of the United States;

[0061] 3. Experimental animals

[0062] apoE- / - mice (C57BL background), 5-7 weeks old, weighing 18-22g, male, SPF grade; purchased from Beijing Institute of Experimental Animals

...

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PUM

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Abstract

The invention discloses an application of an adenosine derivative shown as a formula (I) (as shown in the Description) in preparing medicines for preventing or / and treating hyperlipidaemia accompanied mononucleosis, and an application of the adenosine derivative in preparing medicines for preventing or / and treating atherosclerosis, wherein the prevention or / and treatment of the atherosclerosis is / are to prevent or / and treat atherosclerosis-associated inflammatory mononucleosis. Specifically, triacetyl-3-hydroxyphenyl adenosine, in vivo, can obviously reduce the number of monocytes of inflammatory monocytes Ly6Chi in circulating blood of apoE- / - mice and golden hamsters which are fed with high-lipid diet, so that an anti-inflammatory effect can be achieved.

Description

technical field [0001] The present invention relates to the application of triacetyl-3-hydroxyphenyl adenosine and the pharmaceutical composition containing it in the preparation of drugs for the prevention or / and treatment of mononucleosis accompanied by hyperlipidemia, and in the preparation of drugs for the prevention or / and treatment of mononucleosis The invention relates to the application in medicines for treating atherosclerosis and belongs to the technical field of medicine. Background technique [0002] Whether in western developed countries or China, due to changes in eating habits and living standards, cardiovascular disease has become the number one killer of human health and life. [0003] Atherosclerosis is one of the main pathological bases of cardiovascular and cerebrovascular diseases. During the formation of atherosclerosis, it is always accompanied by exacerbated immune and inflammatory responses, and lymphocytes and lipids accumulate in the aortic intima....

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P9/10A61P29/00
CPCA61K31/7076A61P9/10A61P29/00A61P3/06A61K9/50
Inventor 朱海波王晶
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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