6 results about "Phosphatidal Compounds" patented technology

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an albendazole dispersing agent and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing and dispersing a modified phospholipid compound, a membrane regulator, albendazole and absolute ethyl alcohol, and performing rotary evaporation to obtain the lipid membrane, and adding normal saline into the lipid membrane, mixing and hydrating to obtain the albendazole dispersing agent. Through the technical means of the invention, the albendazole dispersing agent not only has good encapsulation efficiency and storage stability, but also has good in-vitro release performance, and the drug effect can be quickly exerted.

A phosphatidylamine compound including a plurality of tertiary amino group structures and the composition thereof are provided. The phosphatidylamine compound is a phospholipid compound including two or more tertiary amino group structures, the structure of which is represented by the following formula (I). The compound works together with other lipid components such as cholesterol, DSPC / DOPE, DMG-PEG2000, and other helper lipids to form lipid nanoparticles (LNPs), which may be used for efficient delivery of drug molecules such as nucleic acids (siRNA, mRNA, pDNA), thereby realizing diagnosis and treatment of diseases such as cancer, fibrosis (e.g., liver, lung, kidney).

The invention provides a preparation method and application of double-end-group functionalized bionic rubber. The preparation method comprises the following steps: (1) preparing an isoprenyl triblock copolymer from a conjugated monomer containing side group double bonds, isoprene and a hydroxyl isoprene precursor protected by alkyl aluminum under the action of a rare earth catalyst; 2) modifying polar hydroxyl of the copolymer obtained in the step 1) by using a phospholipid compound to obtain single-ended phospholipid functionalized polyisoprene; 3) chemically modifying side group double bonds of the triblock copolymer obtained in the step 2) by using a thiol compound containing amino or / and hydroxyl through thiol-ene click to obtain amino or / and hydroxyl modified phospholipid functionalized polyisoprene; and 4) initiating anhydride ring-opening polymerization by the amino group or / and hydroxyl group introduced in the step 3), and introducing a polypeptide structure into a block at one end of the triblock copolymer to obtain the polypeptide and phospholipid double-end functionalized bionic rubber which has high tensile breaking strength and high 300% stress at definite elongation.

To provide a method for treating a disease. [Solution] Disclosed are a compound for the treatment of viral infections, a method of using the compound alone or in combination with additional agents, and a pharmaceutical composition of the compound (Formula (I)). Surprisingly, remarkable effects are achieved according to the present invention, as described in detail and demonstrated concretely in this specification, and these remarkable effects could not be easily predicted by those skilled in the art from the prior art. JPEG2026086627000413.jpg40133