229 results about "Albendazole" patented technology

The invention relates to an albendazole suspension containing ivermectin nanoemulsion, which is characterized by comprising the following components in parts by weight: 1-30 parts of albendazole, 0.01-1 part of ivermectin, 1-10 parts of oil phase, 1-20 parts of cosurfactant, 1-25 parts of dispersant (emulsifier), 0.01-10 parts of suspending agent, 0.01-10 parts of thickening agent and 0.1-10 parts of preservative. The invention ingeniously uses the oil phase of the ivermectin nanoemulsion as a wetting agent for wetting albendazole, thereby reducing the consumption of the surfactant and solvent, enhancing the safety of the preparation and greatly lowering the cost of the preparation.

The invention discloses a new preparation method of an insect repellent albendazole and provides a brand-new synthesis route of albendazole. The new preparation method adopting m-dichlorobenzene as the starting material is used for obtaining high-purity albendazole through nitration, amination, condensation, reduction and cyclization reaction; the new preparation method is characterized in that an unstable intermediate condensation compound 2-nitryl-4-propyl sulfenyl aniline in the existing industrial route is changed into 2-nitryl-5-propyl sulfenyl aniline with stable quality. The reducing process is changed into a clean and efficient reducing process by virtue of sodium sulfide. The synthesis process is simple and efficient, less in pollution, high in quality and suitable for industrial production.

The invention relates to an anthelmintic drug for livestock, and particularly relates to albendazole / ivermectin powder for livestock, which is convenient to use and remarkable in drug effect. Every 100g of albendazole / ivermectin powder comprises 5-15g of albendazole, 0.1-0.2g of ivermectin, 10-20g of sodium chloride, 5-10g of sodium citrate, 2-4g of sodium carboxymethyl cellulose, 2-4g of flavoring agent and the balance of other acceptable auxiliary material, wherein the other auxiliary material is soluble starch or microcrystalline cellulose. The drug provided by the invention is a dry suspension, can be proportionally added in a drinking fountain directly for use, and facilitates the all-round dosing in a large-size livestock farm; the drug avoids the toxic and side effect caused by uneven feed mixing and is more convenient to use; and the drug effect is remarkably enhanced, and the cost is obviously lowered in comparison with the prior art, thereby ensuring that the drug has wide application prospects.

The invention relates to a synthetic methodsynthesis method for albendazole, which is characterized in that benzimidazole -2 - methyl carbamate (carbendazim) is taken as raw material to generare 5-nitrobenzene and imidazole -2-methyl carbamate through nitration reaction, or generare 5- amino benzimidazole -2 - methyl carbamate through reduction reaction, or generate 5 - amino benzimidazole -2 - methyl carbamate through diazotization and substitution reaction, or generate albendazole through alkylation reaction. The method of the invention has simple and convenient synthetic route, mild conditions and high product quality, with the total yield reaching more than 58%.

The invention discloses a pesticide / bactericide for tree daubing. The pesticide / bactericide is prepared from the following components in mass: 1-10% of albendazole, 60-70% of Chinese herbal extract and 20-39% of assistants. A preparation method comprises the following steps of: firstly, mixing the Chinese herbal medicine materials of stemona tubers, celastrus angulatus maxim and melia toosendan according to the mass ratio of 1:1:1, and extracting the mixture with 45% ethanol to obtain an extract for later use; adding the albendazole, the Chinese herbal extract and the assistants according to the formulation into a mixer, and mixing and stirring for 30 min; and treating by a colloid mill, shearing for 50 min, sanding twice, filtering, bottling and packaging to prepare the medicinal product. The pesticide / bactericide has the characteristics of simple and convenient medicine application, easy operation, high medicine utilization ratio and significant medicine application cost and medicine cost. The pesticide / bactericide has obvious effect and long effect acting on aphids, scale insects, red spiders and other pests and anthracnose, canker and other diseases of peach trees, pear trees, waxberry trees, apple trees, orange trees and loquats. The pesticide / bactericide is applicable to tree cultivation.

Methods for the treatment of a helminthic infection, by the administration, in either single or multiple dosages, of a synergistic combination comprising albendazole according to formula (I): and nitazoxanide according to formula (II): in which the efficacy and range of parasites treated is enhanced by the instant combination compared to the sum of the effects of the subject drugs administered separately.

The invention relates to an albendazole suspension and a preparation method thereof. The albendazole suspension is prepared from 1-30 parts of albendazole, 1-20 parts of wetting agent, 1-25 parts of dispersant (emulsifier), 0.1-10 parts of suspending agent, 0.01-10 parts of thickening agent and 0.1-10 parts of preservative. The preparation method comprises the following steps: 1. mixing the wetting agent and dispersant, adding the albendazole, and stirring into paste; 2. adding the thickening agent into the wetting agent, and evenly stirring; 3. dissolving the suspending agent and preservative in water; and 4. adding the paste in the step 1 into the mixture in the step 3, and adding the mixture in the step 2 and the rest of purified water, thereby obtaining the albendazole suspension. The invention greatly lowers the cost of the medicine, and correspondingly lowers the toxicity of the medicine.

The invention belongs to the field of pesticide, and particularly relates to a sterilization composition for preventing a rice sheath blight disease. The sterilization composition includes effective ingredients of thifluzamide and albendazole, and the mass ratio of the thifluzamide to the albendazole is (1:20) to (20:1). The sterilization composition disclosed by the invention has good control effect on the banded sclerotial blight of the rice, and has the following significant effects and advantages that 1, the sterilization effect is improved after the thifluzamide and the albendazole are mixed, and the use dosage is reduced; 2, agent characteristics are subjected to complementary advantages after the thifluzamide and the albendazole are mixed, and drug use of a peasant is facilitated; and 3, the thifluzamide and the albendazole have a little of poison without residue and have significance in resistance and comprehensive treatment of a disease.

The invention discloses a medicament for treating rice blast. The medicament is prepared from 10 to 20 percent of albendazole, 70 to 75 percent of Chinese herbal medicament extracting solution and 5 to 30 percent of auxiliary agent, wherein the Chinese herbal medicament extracting solution is prepared by mixing Chinese herbal medicinal materials such as indigowoad root, baical skullcap root and weeping forsythia according to a mass ratio of 1:1:1 and then extracting the mixture by using 65 percent alcohol; the auxiliary agent is an emulsifying agent and a thickening agent; the emulsifying agent is 4 to 25 percent based on the total mass of all the materials; the thickening agent is 1 to 5 percent based on the total mass of all the materials; the model number of the emulsifying agent is 2201 or 4203; and the thickening agent is amylin or xanthan gum. The medicament for treating rice blast has the characteristics that: the medicinal effect is good and is better than the indoor biological test effect of the conventional medicament for treating rice blast; the bacteriostatic rate reaches 100 percent; field tests prove that the preventing effect reaches to over 90 percent; medicament resistance is difficult to generate; and the medicament cost is low. The medicament for treating the rice blast is suitable for preventing and treating rice blast.

The invention discloses an agricultural composition containing albendazole for preventing and controlling plant root-knot nematodes. It is a solid preparation or a liquid preparation, and its components include 1% to 49.7% of albendazole and 0.3% to 0.3% of auxiliary active ingredients. 49%, functional additives 1% to 20%, solid preparations include the rest of the filler, liquid preparations include the rest of the solvent, and the auxiliary active ingredients are selected from abamectin, emamectin benzyl ester One or two of salt, thiazophos, triazophos, chlorazophos, phoxim, Bacillus thuringiensis, and diphenhydramine. The composition of the invention has the advantages of obvious insecticidal effect, high activity, good safety, broad spectrum and high efficiency, and the like.

The invention relates to the technical field of medicinal materials, in particular to nanoscale albendazole micropowder and a preparation method thereof. The method comprises the following steps: 1. dissolving albendazole into a good solvent to obtain a first solution; 2. adding a surfactant, a polymeric substance and sodium hydroxide to a poor solvent to obtain a second solution; 3. fully mixing the first solution with the second solution to obtain an albendazole slurry; and 4. carrying out centrifugal separation on the albendazole slurry obtained in step 3 to obtain a centrifugal precipitate, and then freeze-drying the centrifugal precipitate to obtain the nanoscale albendazole micropowder. The invention has the advantages that the particle size of the albendazole raw material is obviously reduced and the solubility and dissolving-out speed of a drug are effectively improved, thus improving the absorption and bioavailability of the albendazole well, overcoming a series of defects of low bioavailability, poor absorption and the like of the traditional albendazole non-nanometer raw material or preparation, and effectively giving play to therapeutic effect of the albendazole in resisting parasites in tissues and organs.

The invention discloses an albendazole artificial antigen and a preparation method and an application thereof. The albendazole artificial antigen provided by the invention is an antigen obtained by coupling albendazole hapten represented by the formula I with a vector protein. The albendazole artificial antigen provided by the invention has the advantages of simple synthetic method, high purity and high yield, and has great value to preparation of the albendazole antibody and detection of albendazole drug residues.

The invention belongs to the technical field of pharmaceutic preparation and discloses a compound ivermectin sustained release tablet and a preparation method thereof. The compound ivermectin sustained release tablet is prepared by 1 to 15 parts by weight of ivermectin, 20 to 50 parts by weight of albendazole, 110 to 153 parts by weight of diluents, 20 to 30 parts by weight of sustained-release materials, 0.5 to 0.7 part by weight of lubricating agents and an appropriate quantity of adhesion agents. The ivermectin, the albendazole, the sustained-release materials and the diluents are fully and uniformly mixed in a mixing machine to obtain a mixture, the uniformly mixed mixture is placed in a one-step granulator, the adhesion agents are sprayed to form particles, the particles are dried, the lubricating agents are added in the particles to be fully and uniformly mixed, and the particles are prepared into tablets in a tablet machine. The compound ivermectin sustained release tablet and the preparation method thereof have the advantages that the antibacterial spectrum is wide, the action time is long, the drug resistance can not be easily generated, and the curative ratio is high; compared with common compound tablets, the tablet has better therapeutic effect; and compared with simple recipe drugs, the compound ivermectin sustained release tablet has the advantages that the curative effect is remarkable, simultaneously the dosage is reduced, and the treatment costs are lowered.

The invention relates to synthesis, refinement and application of albendazole. The invention firstly provides a synthesis method of albendazole, which adopts a mixed solvent (water and ethanol)-mixed acid (formic acid and acetic acid) refinement system; and the refined albendazole has higher purity and solubility. The invention further provides a preparation method of a colon targeted microcapsule, which comprises the following steps: coating albendazole with amido polylactic acid-hydroxyacetic acid copolymer (PLGA-NH2) to prepare drug-carried nanoparticles, and simultaneously coating the drug-carried nanoparticles and a disintegrant with a pH-sensitive enteric material to obtain the albendazole colon targeted microcapsule. The colon targeted microcapsule has the triple effects of colon targeting, quick disintegration and slow drug release, prolongs the in-vivo circulation time of the oral albendazole, and enhances the absorption efficiency of albendazole.

The invention belongs to the field of veterinary medicines, and discloses an albendazole nanoemulsion and a preparation method thereof. The albendazole nanoemulsion is prepared from the following raw materials by weight: 0.07-2.0% of albendazole, 31.8-38.3% of a surfactant, 0-12.7% of a cosurfactant, 0.54-9.9% of a solubilizer, 2.3-4.0% of oil, and 46.0-49.5% of water. The albendazole is completely dissolved in the solubilizer, and then the surfactant is added. The cosurfactant and the oil are mixed for using. Water is added to the solution prepared by the above steps at room temperature, while the solution is stirred constantly until the formation of a uniform and transparent system. The albendazole nanoemulsion is obtained. Compared with the prior art, the nanoemulsion of the present invention has the following advantages: 1) safety, efficiency and low drug resistance; 2) good stability, filtration sterilization, and easy storage; 3) rapid absorption, high bioavailability, targeted drug delivery, low side effects, small and uniform particle size, and good through-membrane absorption; 4) low-viscosity nanoemulsion, and little injection pain; and 5) easy use, and infinite dilution with water.

The invention discloses an albendazole synthesis method. The albendazole synthesis method includes reacting ammonium thiocyanate with chlorine gas in a lower alcohol solvent to obtain chlorothiocyanate, reacting ortho-nitroaniline with the chlorothiocyanate in the lower alcohol solvent to obtain 4-thiocyano-2-nitroaniline, reacting the 4-thiocyano-2-nitroaniline with a sodium hydroxide solution toobtain 4-sodium sulfonate-2-nitroaniline, performing hydrochloric acid acidification to obtain 4-mercapto-2-nitroaniline, subjecting the 4-mercapto-2-nitroaniline and propylene to Markovnikov addition reaction to obtain 4-propylthio-2-nitroaniline, and reacting 4-propylthio-o-phenylenediamine with methylcyanocarbamate to obtain albendazole. The albendazole synthesis method has the advantages thata novel synthetic route is applied to prepare the albendazole, the defects of high impurity quantity and low yield in the current production process are overcome, the chlorothiocyanate is prepared toserve as an intermediate and then reacts with the ortho-nitroaniline, and impurities can be avoided effectively; the propylene is introduced for the addition reaction, raw materials are clean and free from pollution, introduction of highly toxic sodium cyanide is avoided, the total yield is high, and the albendazole synthesis method has a good industrialization prospect.

The invention discloses a compound ivermectin solid dispersion. The compound ivermectin solid dispersion is prepared from the following raw materials in parts by weight: 0.1-5 parts of ivermectin, 1-20 parts of albendazole, 10-80 parts of an organic solvent, 5-90 parts of a macromolecular carrier and 2-15 parts of a surfactant. The invention also discloses a preparation method of the compound ivermectin solid dispersion. The preparation method comprises the following steps: solving the albendazole and the surfactant in the organic solvent to obtain a mixed solution; adding the ivermectin in the macromolecular carrier and heating for melting to obtain a melted liquid; mixing the mixed solution and the melted liquid, then heating and stirring to fully volatilize the organic solvent; and solidifying at low temperature, grinding and sieving to obtain a finished product. By virtue of a solid dispersion technology, the solubility of the ivermectin and the albendazole in water is enhanced, the oral bioavailability of the ivermectin and the albendazole is improved, the medicine dosage is reduced and the toxic and side effects are lowered; in addition, the compound ivermectin solid dispersion has good stability and excellent application prospect.

The invention belongs to the technical fields of antiparasitic drugs for animals, and preparation methods thereof, and concretely relates to a suspension containing albendazole, and a preparation method thereof. The above preparation comprises an albendazole bulk drug, a suspending aid, a wetting agent, an antiseptic and a flocculating agent. The suspension containing albendazole is prepared through a dispersion process, and is an off-white sticky water suspension. The suspension containing albendazole developed in the invention has the advantages of good stability, good palatability, long elimination half life, and high bioavailability, and can be used by animals as an oral preparation.

The invention belongs to the technical field of preparation of medicament for livestock, and particularly relates to a compound ivermectin albendazole transdermal agent for livestock and an application method thereof. The transdermal agent is a mixture of two or three components below at any proportion: ivermectin, albendazole, solubilizer tween-80, a laurocapram transdermal accelerant, a 95% ethanol diluent, an N-methyl-pyrrolidone and propylene glycol. When the transdermal agent is used for treating parasitic diseases of animals such as pigs and sheep, the transdermal agent is flow-coated from the head part to the tail root part along a dorsal line after hairs at the back part are uniformly pushed aside towards two sides, and good treatment effect can be obtained after the transdermal agent is used continuously for three days. The preparation method of the compound ivermectin albendazole transdermal agent for livestock is simple; in comparison with other dosage form in the prior art, the medicine use way is simpler and more convenient, and more dosage is saved; as no liver first-pass effect exists, influence from gastric emptying rate and the like is avoided, the irritability reaction degree of the animals is low, the treatment effect is better, the treatment way is convenient and fast, and the operation is easy.

The invention discloses an albendazole suspension. The albendazole suspension is composed of the following raw materials in parts by weight: 1.75g of albendazole, 0.3g of sodium carboxymethylcellulose, 0.0125mL of polysorbate-80, 0.3g of citric acid, 0.075g of sodium benzoate and purified water is added until the whole weight is 25mL. By adopting the albendazole suspension disclosed by the invention, albendazole medicine is more convenient to use, meanwhile the anthelmintic effect is greatly improved and the administration times is reduced.

The invention relates to a sterilization composition containing metconazole and albendazole. The effective active ingredients of the sterilization composition comprise the metconazole and the albendazole. When the weight ratio of the metconazole and the albendazole is 40-1:1-40, the sterilization composition has the synergistic effect on inhibition of growth of gibberella saubinetii. The sterilization composition is wide in bacteriocidal spectrum. Preparations processed according to different proportions can be used for controlling wheat scab, powdery mildew, the rust disease, grey mould fruit rot of strawberries and the rice sheath blight disease, the control efficiency of the sterilization composition to different diseases can reach more than 75%-99%, and the sterilization composition has the advantages of having fast-acting property and being good in persistence, and can improve the wheat yield and the wheat quality. The sterilization composition is novel in action mechanism and multiple in acting site, and can govern pesticide resistance of the gibberellic disease to carbendazim and erysiphe cichoracearum to triadimefon and delay occurrence and development of pesticide resistance of pathogenic bacteria to triazole bactericides.

The invention discloses a medicine for preventing and treating ralstonia solanacearum, which comprises 1% to 5% of albendazole, 2% to 10% of carbendazim, 70% to 80% of Chinese herbal medicine extracting solution and 5% to 27% of auxiliaries, wherein the Chinese herbal medicine extracting solution is prepared by mixing the Chinese herbal medicines such as lightyellow sophora root, common cnidium fruit and rhubarb in the weight ratio of 1 to 1 to 1 and extracting the mixture by utilizing 65% ethanol extracting solution; the using amount of the 65% ethanol extracting solution is 15 times of the total mass of the medicinal materials; the auxiliaries are an emulsifying agent and a thickening agent, wherein the using amount of the emulsifying agent is 4% to 22% of the total mass of the materials, and the amount of the thickening agent is 1% to 5% of the total amount of the materials; the emulsifying agent is 2201 type or 4203 type; and the thickening agent is dextrin or xanthan gum. The medicine for preventing and treating the ralstonia solanacearum has the advantages that the medicine effect is good; the bacteriostatic rate is high; the indoor biological measuring effect is better than that of agricultural streptomycin for treating the ralstonia solanacearum at present; the verification result of a field test proves that the prevention efficiency for preventing and treating the ralstonia solanacearum reaches about 80%; and the medicine is suitable for preventing and treating the ralstonia solanacearum.

The present invention discloses a medicinal bait additive for preventing and treating enterocytozoon hepatopenaei of litopenaeus vannamei. The medicinal bait additive comprises the following components in parts by weight: 8-32 parts of marine red yeast powder, 30-75 parts of albendazole, 8-32 parts of spirulina powder and 5-10 parts of garlic powder. The medicinal bait additive is used in a compound feed for the litopenaeus vannamei and has an addition amount of only 6-12%; and the medicinal bait additive can also be mixed with the feed at a weight ratio of 1:10 for feeding before feeding. Themedicinal bait additive uses an internal administration route, so that a medicine internal environment is formed in a host body, the medicinal bait additive is subjected to blood circulation to reachtarget organs and parasites cannot survive. The medicinal bait additive can effectively kill the enterocytozoon hepatopenaei in the litopenaeus vannamei body, is non-toxic to the litopenaeus vannameibody, does not cause medicine residues in the litopenaeus vannamei body, at the same time also does not cause pollution to the breeding environment, and can effectively play a therapeutic role in thediseased litopenaeus vannamei infected by the enterocytozoon hepatopenaei.

The invention relates to a sausage which can expel parasites inside or outside animals, in particular to a parasite expelling sausage which can be used for cats or dogs. The parasite expelling sausage comprises meat, albendazole, ivermectin and an additive. When the parasite expelling sausage of the invention is used for different animals, the amounts of the added albendazole and the added ivermectin are different; when the sausage is used for the same animal, the amounts of the added albendazole and the added ivermectin are also different according to different types of expelled parasites; and the mixture can be prepared into meat balls, sausages, medicament fragrant balls, grains or powder and the like and the mixture has various formulations. Experiments verify that the parasite expelling sausage can effectively expel the parasites on bodies of animals, and prevent the troubles of injection, wearing of parasite expellant neck rings or spraying and painting of the parasite expellant, is a favorite food of animals and is safe and convenient.

The invention discloses a compound bactericide for preventing and treating wheat scab. The compound bactericide is prepared from albendazole and tebuconazole as base materials according to a mass ratio of albendazole to tebuconazole of 7: 1 to 1: 7. Preferably, a mass ratio of albendazole to tebuconazole is 1:2. The albendazole is a bactericide raw drug having a mass fraction of 97% and the tebuconazole is a bactericide raw drug having a mass fraction of 98.43%. The two reaction base materials in the compound bactericide do not undergo a chemical reaction and produce obvious synergism or combined effects and thus the compound bactericide is safe in use and has good poisoning activity to different types of wheat scab fungi in the field, wherein the poisoning activity is obviously higher than that of an albendazole or tebuconazole single agent. The compound bactericide is suitable for preventing and treating wheat scab in the vast rural areas.

The invention provides wettable albendazole ivermectin powder which is prepared from the following raw materials and auxiliary materials in parts by weight: 5-20 parts of albendazole, 0.1-1.6 parts of ivermectin, 0.5-3 parts of magnesium stearate, 33.9-70.7 parts of powdered sugar, 3-11 parts of sodium dodecyl sulfate, 0-8 parts of xanthan gum, 0.6-1 part of fresh milk essence, 0.6-1 part of saccharin sodium and 10-30 parts of sodium citrate. The invention also provides a preparation method and application of the wettable albendazole ivermectin powder. The wettable albendazole ivermectin powder significantly improves the dispersity of the ivermectin and albendazole in water to ensure that the ivermectin and the albendazole can be uniformly distributed in the water for a long time to facilitate clinical water drinking and administration; and the palatability of the albendazole ivermectin powder is greatly improved, and when used on faunas with sensitive tastes, such as pigs and the like, the albendazole ivermectin powder has a food calling function. The wettable albendazole ivermectin powder is simple in preparation process, low in production cost and suitable for industrial large-scale production.

The invention discloses veterinary albendazole suspension and a preparation method thereof. The albendazole suspension comprises a main drug, a wetting agent, a suspending agent and a preservative. The albendazole suspension can be dosed through intramuscular injection, is convenient to operate, guarantees drug dosage, lightens livestock pains, and is exquisite in preparation process, controllable in quality, safe, reliable, convenient to use, low in cost and suitable to popularization and application in the breeding industry.

The invention discloses a root-knot nematode preventing pesticide. The root-knot nematode preventing pesticide is prepared from the following materials, by weight percentage, 1-2% of albendazole, 50-70% of solvent and 28-49% of auxiliaries. The albendazole is a market raw pesticide with a content of 98%; the solvent is composed of organic solvent and inorganic solvent, wherein the organic solvent is dimethyl formamide or dimethyl solfoxide, and the inorganic solvent is water; the auxiliaries are composed of emulsifier and penetrant, wherein the emulsifier is dodecyl benzene solfonate or alkylphenol polyoxyethylene, and the penetrant is hypertonic azone or market anhydrous penetrant T. The preparation method of the root-knot nematode preventing pesticide comprises dissolving the raw albendazole with the organic solvent, and then adding in and uniformly stirring the emulsifier and the penetrant inside the solution; performing filtering, discarding filter residues, filling the filtered solution into bottles and performing packaging and storage to obtain the root-knot nematode preventing pesticide. The root-knot nematode preventing pesticide achieves significant root-knot nematode killing effects and is safe in application and applicable to preventing root-knot nematode in vast rural areas.

The invention discloses an albendazole-2-amino sulfone residue detection monoclonal antibody as well as a preparation method and an application thereof, and belongs to a hybridoma cell GA / 2A11 with the collection number of CCTCCNO:C201142. The preparation method comprises the following steps: a, coupling hapten albendazole-2-amino sulfone with bovine serum albumin, thereby obtaining an immunogen; b, coupling the hapten albendazole-2-amino sulfone with ovalbumin, thereby obtaining a coating antigen; c, preparing a hybridoma cell strain by using the immunogen; d, coating a solid phase carrier with the coating antigen; e, extracting a sample to be detected by using ethyl acetate under the action of potassium hydroxide, thereby obtaining an object to be detected; f, performing enzyme-linked immunity detection on the object to be detected. A kit comprises: (1) an elisa plate coated with the coating antigen ABZSO2NH2-GA-OVA, (2) an ABZSO2NH2 standard substance solution, (4) a Goat anti Mouse IgG antibody working solution marked by a horse radish peroxidase, (5) a concentrated phosphate buffering solution, (6) a concentrated washing solution, (7) a substrate mixing solution and (9) a stop solution. The invention further discloses the application of the kit in the detection of albendazole-2-amino sulfone residue detection. The kit has the characteristics of being simple, convenient, rapid, sensitive and accurate.

The invention discloses a compound albendazole dry suspension and a preparation method thereof. The dry suspension comprises albendazole, ivermectin, diluting agent, wetting agent, dispersing agent and suspending agent in a weight ratio of 10:0.2:(10-15):1:2:(0.3-0.6). The suspension is simple in preparation process, can be quickly and uniformly dispersed in water in clinical application, is beneficial to clinical administration, is good in absorption and quick in response. Furthermore, addition of ivermectin into albendazole can enlarge the parasite-expelling spectrum of a medicine, and the dry suspension can be used for expelling and killing trematode, cestode, nematode and ectozoa.