81 results about "Sodium Cholate" patented technology

The invention discloses RVG29 peptide modified tripterine transfersome nasal in-situ gel and a preparation method and application thereof.The in-situ gel is mainly prepared from tripterine, soybean phospholipid, cholesterol, mPEG2000-DSPE, mPEG2000-DSPE-RVG29, sodium deoxycholate and DGG, the RVG29 peptide modified tripterine transfersome nasal in-situ gel can increase the solubility of indissolvable drugs, and the RVG29 peptide modified tripterine transfersome nasal in-situ gel has the advantages that the solubility of the indissolvable drugs is improved; and the RVG29 peptide which can be specifically recognized with a dopaminergic neuron high-expression acetylcholine receptor is modified on the surface of a carrier, so that efficient active targeting endocytosis can be effectively realized, and the RVG29 peptide can be used for treating the Parkinson's disease.

The present disclosure provides solid forms of sodium chenodeoxycholate (NaCDC), as well as compositions thereof, and methods of use and preparation thereof. In some embodiments, the provided solid forms are useful for treating gastrointestinal disorders, such as constipation (e.g., IBS-C). In some embodiments, the provided solid forms are useful for preparing new formulations of NaCDC, such as formulations uniquely designed to address certain problems of prior formulations of CDCA or salts thereof.

The invention provides an Eutogliflozin tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the tablet comprises Eutogliflozin, erythritol, a stabilizer, a diluent, a disintegrating agent and an adhesive; the stabilizer is sodium cholate. According to the Eutogliflozin tablet, the erythritol and the stabilizer sodium cholate are matched, so that the defects of instability and poor solubility of Eutogliflozin can be overcome, and the problems of slow dissolution and poor stability of the prepared Eutogliflozin tablet are avoided.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

The application provides a topical traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof. The composition is composed of traditional Chinese medicinal materials such as angelica, cortex psoraleae and barks of dictamnus dasycarpus, and a penetration enhancer, an activating agent and a moisturizing agent. The penetration enhancer is composed of soybean lecithin, phosphatidylethanolamine and cholesterol, the activating agent is sodium cholate, sodium deoxycholate and sodium taurocholate, and the moisturizing agent is eucalyptus oil. The drugs are compatible to exert the effects of clearing heat and drying dampness, cooling blood and nourishing yin, activating blood and resolving stasis, warming yang and dispelling cold and supporting healthy qi and tonifying the body resistance. The traditional Chinese medicine composition is prepared through supercritical extraction, micronization treatment, solution preparation and intermittent ultrasonic homogenization. The traditional Chinese medicinal materials are used for treating the etiology, pathogenesis and symptoms of vulvar leukoplakia, the penetration enhancer reduces the skin barrier function, the activating agent enhances the drug activity and permeability, and the moisturizing agent maintains the skin moisture and assists in anti-inflammation. The clinical application effectively relieves the symptoms of patients with vulvar leukoplakia, improves the pathological state of local skin and improves the treatment effect, thereby providing a new effective option for the treatment of vulvar leukoplakia.

The invention belongs to the technical field of veterinary drugs, relates to a veterinary albendazole tablet, and provides a preparation method of the preparation. The tablet consists of albendazole, trehalose, sodium taurocholate and other pharmaceutically acceptable adhesives, disintegrating agents and lubricating agents. The albendazole is fully dispersed by spray-drying a mixed solution of albendazole, trehalose and sodium taurocholate, and the dosage of trehalose and sodium taurocholate is controlled, so that the dissolution and stability of the product are improved.

The application provides a preparation method and application of a near-infrared two-region fluorescent sensor, and chiral single-walled carbon nanotubes are separated by using a double water phase extraction method; materials in the separation process include deionized water, polyethylene glycol, dextran, sodium dodecyl sulfate, sodium deoxycholate and cholic acid sodium hydrate; the chiral single-walled carbon nanotubes are dispersed and mixed with 4-nitrobenzene tetrafluoroboric acid diazonium salt to obtain the fluorescent sensor; high-purity (6,5)-SWCNT is efficiently and simply separated by using the double water phase extraction technology, the prepared SWCNT-NBD nanomaterial has good optical performance, including bright light emission in the near-infrared two-region, has good penetration capacity on biological tissues, the fluorescent detector (SWCNT-NBD) has low detection line, wide linear range, good selectivity on DA, and is convenient to prepare and low in cost.

The invention discloses a composite emulsifier and a preparation method and application thereof, belonging to the technical field of emulsifiers. The cationic starch-sodium cholate composite emulsifier is prepared by the following method: sodium cholate and cationic starch are mixed, distilled water is added, and the mixture is heated and stirred at 50-60 DEG C in an oil bath for 0.5-2h to obtain the cationic starch-sodium cholate composite emulsifier solution, and then the obtained cationic starch-sodium cholate composite emulsifier solution is sealed and stored at 4 DEG C for 3-5h, and then vacuum freeze-dried at -30 DEG C for 24-36h to obtain the cationic starch-sodium cholate composite emulsifier. The preparation process of the invention is simple, the raw material source is abundant, the cost is low, and the use of industrial production is easy; the composite emulsifier provided by the invention has stable properties and strong emulsification ability; the invention uses cationic starch and sodium cholate as raw materials, is safe and non-toxic, has no problems such as phytotoxicity and pollution, and is green and environmentally friendly.

The invention discloses a probiotic with the characteristic of high yield of bile salt hydrolase and application of the probiotic in a preparation for preventing or improving cholestatic jaundice, and is characterized in that the probiotic is at least one of a bifidobacterium longum subsp. Infantis QS033 strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35879 and a lactobacillus delbrueckii subsp. Lactis QS021 strain with the preservation number of CGMCC No.35880; according to the present invention, the Chukrasone A has the application of the Chukrasone A in the preparation of the product for preventing, relieving or regulating the cholestatic jaundice, and has the advantages of effective degradation of sodium glycocholate, sodium glycodeoxycholate, sodium glycochenodeoxycholate and sodium glycoursodeoxycholate, effective regulation of bile acid metabolism disorder in the cholestatic jaundice, and improvement of the cholestatic jaundice.

The invention provides a lipopeptide-containing fat dissolving product as well as a preparation method and application thereof, and relates to the field of medical cosmetology. According to the invention, the lipopeptide is applied to the preparation of the fat-dissolving medicine for the first time, and the lipopeptide can be selected from one or more of surfactin, iturin, interleukin, abrumogen, daptomycin, polymyxin, bacitramycin L, phospholipid rhzomorph and bacitramycin D. According to the invention, the lipopeptide is directly injected into the subcutaneous adipose tissue for the first time, so that the accumulation of the local adipose tissue is reduced, and a new active ingredient is provided for the fat dissolving needle; the invention also proves that compared with sodium deoxycholate, the lipopeptide has higher fat-dissolving activity and lower effective dose when being used as a fat-dissolving component; lipopeptide is adopted as a new effective component of the fat-dissolving needle, so that the fat-dissolving needle is safer and more effective, the rupture of an injection part can be reduced, the fat-dissolving needle better fits the pH value of a human body, and the pain in the injection process is reduced.

The invention provides a rain wash resistant and long-acting antibacterial liquid-liquid condensed phase and a preparation method and application thereof.The liquid-liquid condensed phase comprises polyethyleneimine, sodium deoxycholate and metal chloride salt, the concentration of the polyethyleneimine is 0.5 g / L-5 g / L, and the molecular weight of the polyethyleneimine is 600-25000; the concentration of the sodium deoxycholate is 0.5 mM to 50 mM.

The invention discloses wheat malt seedling functional dietary fibers as well as a preparation method and application of the wheat malt seedling functional dietary fibers. The soluble dietary fiber and the insoluble dietary fiber of the wheat malt seedlings are extracted by adopting a wall breaking-extraction mode of synergy of biological enzyme and free radicals. The wheat malt seedling soluble dietary fibers can prolong the life of caenorhabditis elegans in an oxidative stress state, improve the antioxidant enzyme activity and improve the anti-apoptosis capability; the intestinal flora of the obese C57BL / 6J mouse induced by the high-fat feed is regulated; the wheat malt seedling insoluble dietary fiber has better binding water capacity, water-holding capacity and cholesterol and sodium cholate adsorption capacity, and can be used as a functional food additive for improving the texture and nutritional characteristics of food; and the wheat malt seedlings can also be used for assisting in reducing serum cholesterol level, preventing arteriosclerosis, promoting defecation, preventing constipation, colorectal cancer and the like in the field of health medical treatment, so that high-quality reutilization of the wheat malt seedlings is realized.

The invention provides a method for chromatography of meningococcus polysaccharides in groups A, C, Y and W135. Specifically, the invention provides a purification method of meningococcal polysaccharide, which comprises the following steps: 1) respectively pretreating meningococcal polysaccharide A, meningococcal polysaccharide C, meningococcal polysaccharide Y and meningococcal polysaccharide W135 by using 0.5-2% sodium deoxycholate; 2) utilizing a Rigose MMA chromatographic column and a Rigose DEAE chromatographic column which are connected in series, and purifying the polysaccharide pretreated in the step 1); (3) carrying out ultrafiltration desalination on the polysaccharide in the step (2) by using 10-100mM of a phosphoric acid buffer solution to obtain purified refined polysaccharide; wherein the meningococcus polysaccharide is meningococcus group A polysaccharide, meningococcus group C polysaccharide, meningococcus group Y polysaccharide or meningococcus group W135 polysaccharide.

This invention relates to a midazolam nanocrystal suspension, which, by weight-volume percentage, comprises 5%–45% midazolam, 1%–10% Tween, and 0.1%–10% sodium deoxycholate (SDC). The midazolam nanocrystal suspension of this invention exhibits superior blood-brain barrier permeability and bioavailability, making it suitable for needle-free injection administration.

The present application belongs to the technical field of veterinary medicine, and relates to a kind of veterinary albendazole tablets, and the preparation method of the preparation is provided.The tablet is composed of albendazole, trehalose, sodium taurocholate and other pharmaceutically acceptable binders, disintegrants and lubricants.By spray drying the mixed solution of albendazole, trehalose and sodium taurocholate, the albendazole is fully dispersed, and the amount of trehalose and sodium taurocholate is controlled, which improves the dissolution and stability of the product.

The present invention discloses a transfersome composition, its preparation method, and application. The transfersome composition comprises the following raw materials, calculated by mass: 5-20 parts of an active drug; 2-40 parts of lecithin; and 2-40 parts of sodium cholate. The active drug comprises a protein drug or a small molecule drug. The present invention coats the protein drug or small molecule drug with lecithin and sodium cholate, resulting in a drug-coated transfersome composition with higher transdermal efficiency, shortened onset time, improved therapeutic efficacy, and avoided drug side effects.

The invention relates to the technical field of medicines, and provides a semeglutide coated tablet and a preparation method thereof. The chip-coated sheet comprises a chip core layer and a shell layer, the tablet core layer comprises a first absorption enhancer; the shell layer comprises a second absorption enhancer; the first absorption enhancer and the second absorption enhancer are selected from the group consisting of sodium 8-(2-hydroxybenzamido) caprylate, Tween 80, lauryl sodium sulfate, sodium caprate, polyglycerol-3 diisostearate, oleic acid, lauric acid, sodium deoxycholate, sodium cholate, polyoxyethylene (35) castor oil, PEG-vitamin E succinate, PEG-vitamin D3 succinate and pluronic. The invention relates to a preservative which is prepared from the following raw materials: polyethylene glycol, a methoxy polyethylene glycol-polycaprolactone copolymer, sucrose fatty acid ester, 15-hydroxystearic acid polyethylene glycol ester and caprylic / capric acid polyethylene glycol glyceride. The coated tablet provided by the invention adopts a double-layer structure consisting of the tablet core layer and the shell layer, so that the bioavailability of the preparation can be remarkably improved, the oral dosage can be hopefully and greatly reduced, and the medication cost is reduced.

The invention discloses a preparation method of a zinc oxide nano material with a high specific surface area. The method comprises the following steps: firstly, mixing a zinc source and a growth adjuvant according to a molar ratio of 1: 1, preparing a growth base solution with the total concentration of 0.01-0.1 mol / L, adding ammonia water, and adjusting the pH value to 9-11; then adding sodium cholate into the solution, stirring, transferring the solution into a reaction kettle, and growing in a constant-temperature drying box; and finally, taking out the solution from the reaction kettle, adding sodium cholate into the solution again, stirring, transferring the solution into the reaction kettle, and growing in a constant-temperature drying box to obtain the zinc oxide nano material with high specific surface area. The crystal surface energy is controlled by adding sodium cholate in multiple stages, and the specific surface area of the zinc oxide nano material is remarkably increased. The increase of the specific surface area provides a larger active surface for the application of the material in a gas sensitive sensor, so that the sensitivity and response speed of the sensor are improved.

The invention discloses a brain-targeted nasal-spray amphotericin B phospholipid complex and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the brain-targeted nasal-spray amphotericin B phospholipid complex is prepared by adopting a film dispersion method, and the preparation method comprises the following steps: dissolving 15-hydroxystearic acid polyethylene glycol ester, phospholipid, cholesterol, amphotericin B and optional other auxiliary components in a solvent, removing the solvent until a film is formed, and drying to obtain the brain-targeted nasal-spray amphotericin B phospholipid complex. And carrying out hydration dispersion to obtain the amphotericin B-loaded phospholipid complex. According to the amphotericin B sodium deoxycholate injection, the problems that the traditional amphotericin B sodium deoxycholate injection is high in renal toxicity, the intrathecal injection is poor in solubility, and low in bioavailability and patient compliance, large in side effect and the like due to the fact that the traditional amphotericin B sodium deoxycholate injection is difficult to penetrate through a blood brain After nasal administration, the drug is quickly delivered into the brain, so that the slow release of the drug is realized, the intracerebral bioavailability of the drug is improved, high brain targeting and low systemic toxic and side effects are realized, and good clinical application value and market prospect are achieved.

The present application relates to a curcumin nanocrystal composition, the composition contains 1-18% (m / v) of curcumin nanocrystal, 0.1-10% (m / v) of stabilizer, 0.1-10% (m / v) of surfactant and 0-10% (m / v) of suspending agent in mass volume percentage, wherein the particle size of the curcumin nanocrystal is less than or equal to 100 nm, the stabilizer is selected from any one or combination of hydroxypropyl methyl cellulose (HPMC), polyvinylpyrrolidone PVPK12PF, polyvinylpyrrolidone PVPK15, polyvinylpyrrolidone PVPK17PF, lecithin, polyethylene glycol, poloxamer Pluronics F68, poloxamer Pluronics F108, the surfactant is selected from any one or combination of sodium cholate, sodium deoxycholate, sodium docusate, sodium dodecyl sulfate (SDS), sodium dodecyl sulfonate (SLS), sodium alginate, and the suspending agent is selected from any one or combination of sucrose, dextran, glycerol, povidone, hydroxypropyl cellulose, methyl cellulose, hypromellose, sodium carboxymethyl cellulose, carboxymethyl cellulose, polyvinyl alcohol, gum arabic, dextrin. The composition of the present application has the advantages of fast onset, good stability, high bioavailability, safety and effectiveness.

The invention provides an extracting solution for extracting protein from adipose tissue and an extracting method, so as to make up the defects in the prior art. The extracting solution is a PBS (Phosphate Buffer Solution) added with cane sugar, EDTA (Ethylene Diamine Tetraacetic Acid), SDS (Sodium Dodecyl Sulfate), sodium deoxycholate and Triton X-100; wherein the concentrations of the sucrose, the EDTA, the SDS, the sodium deoxycholate and the Triton X-100 are as follows: 50 mM of the PBS, 0.25 M of the sucrose, 0.5 mM of the EDTA, 0.5 mM of the SDS, 0.05% of the sodium deoxycholate and 0.06% of the Triton X-100. By applying the extracting solution, the yield of protein obtained from fat is higher, and compared with other extracting methods, the extracting solution is simple in formula and easy and convenient to operate, and the extracted protein solution is clear and high in purity.

The invention discloses a ceramide transdermal enhanced transporter preparation as well as a method and application thereof, and belongs to the technical field of transdermal delivery preparations. The preparation comprises the following components in parts by mass: 5-15 parts of hydrogenated lecithin, 1-5 parts of ceramide, 2-8 parts of cholesterol, 1-3 parts of stearic acid, 0.5-5 parts of an edge activator, 20-50 parts of absolute ethyl alcohol and 100-200 parts of ultrapure water, and the edge activator is selected from one of sodium cholate, SP60 or sucrose stearate and has a specific concentration gradient. The preparation method comprises the steps of organic phase preparation, water phase pretreatment, mixed hydration and particle size adjustment. The edge activator is used for regulating and controlling a lipid bilayer structure, the deformation index of the preparation is remarkably increased, the problems that ceramide is poor in water solubility, prone to crystallization and low in transdermal efficiency are solved, the preparation is excellent in stability, the intradermal retention amount and the skin permeation amount are remarkably higher than those of traditional lipidosome, deep skin delivery of ceramide can be achieved, and the application prospect is wide. And the composition has no skin irritation and is suitable for preparing skin barrier repairing, moisturizing or anti-inflammatory external products.

The present application provides a method for separating single chiral carbon nanotube mirror bodies, comprising the following steps: (1) dispersing carbon nanotube raw materials into a solution of a composite surfactant to obtain a carbon nanotube dispersion liquid; (2) using gel chromatography for stepwise elution to separate the carbon nanotube dispersion liquid, and collecting the separation product to obtain single chiral carbon nanotube mirror bodies; wherein the solution of the composite surfactant comprises cholic acid, a first surfactant and an optional second surfactant, and a solvent; the first surfactant is selected from one or more of sodium octyl sulfate, sodium decyl sulfate, sodium dodecyl sulfate and sodium n-hexadecyl sulfate; the second surfactant is selected from one or more of sodium cholate, sodium hydrate cholate, sodium dehydrocholate, sodium deoxycholate, sodium lithocholate, sodium hyodeoxycholate and sodium chenodeoxycholate. The method of the present application can separate and prepare single chiral carbon nanotube mirror bodies with a diameter of less than 0.69 nanometers.

The invention discloses a culture medium for realizing selective enrichment of salmonella. The culture medium is prepared from a tryptone soybean broth culture medium, sodium citrate, deoxysodium cholate, distilled water and a 0.1% brilliant green aqueous solution. The invention also discloses a preparation method of the culture medium for realizing selective enrichment of salmonella, which comprises the following steps: S1, adding 30.0 g of tryptone soybean broth culture medium, 4.0 g of sodium citrate and 0.7 g of deoxysodium cholate in proportion, adding 1000mL of distilled water, heating and stirring in water bath until dissolving, sterilizing at 121 DEG C under high pressure for 15 minutes to obtain a semi-finished culture medium solution, and storing at normal temperature; and step S2, in a temporary use stage, aseptically adding 0.4 mL of 0.1% brilliant green aqueous solution into every 1000mL of semi-finished culture medium solution in a super clean bench environment, so as to prepare the culture medium for realizing selective enrichment of salmonella. The detection efficiency of pathogenic bacteria is effectively improved.

The invention discloses a salbutamol sulfate oral solution and a preparation method thereof.According to the salbutamol sulfate oral solution, a physical barrier is formed through inclusion of hydroxypropyl-beta-cyclodextrin, and a stability synergistic mechanism is formed through the chelating chemical inhibition effect of EDTA-2Na, so that the oxidative degradation rate of salbutamol sulfate is obviously reduced; in addition, sucralose and peppermint essence are used as flavoring agents for taste, high-sweetness taste modification and cool taste modification are performed, and triple taste masking of HP-beta-CD inclusion, sucralose and peppermint essence is performed, so that the taste score is remarkably improved; by destroying intestinal epithelium tight connection through sodium cholate, the transmembrane transport efficiency is improved, the bioavailability is improved, the apparent permeability coefficient (Papp) is remarkably improved, the problem of low availability caused by the first-pass effect is solved, beagle is orally taken, the bioavailability is remarkably improved, and the application prospect is remarkable.

According to the application of the sodium taurocholate in preparing the medicine for coordinating the metabolic balance of the bone fat, the sodium taurocholate is used for coordinating the metabolic balance of the bone fat by inhibiting the accumulation of bone marrow adipose tissues. According to the application, the bone marrow adipose tissue can be accurately targeted to inhibit abnormal accumulation of the bone marrow adipose tissue, and normal bone marrow adipose tissue is not influenced. And moreover, by inhibiting abnormal accumulation of bone marrow adipose tissues, the bone fat metabolism balance is synergistically regulated and controlled, and particularly, adipogenesis inhibition and continuous osteogenesis promotion are combined. Sodium taurocholate is an endogenous bile acid derivative, so that the safety is higher, and sodium taurocholate is a micromolecular drug, so that sodium taurocholate can be orally taken compared with the current macromolecular drug injection administration route. In the application of the sodium taurocholate in preparing the medicine for coordinating the metabolism balance of the bone fat, the volume reduction amount of bone marrow adipose tissue is not less than 40%, and the bone mass increase amount is not less than 30%.

The invention discloses artificial excrement and application of the artificial excrement as a reference product of an excrement sample. The artificial excrement is prepared from sodium cholate, bilirubin, calcium chloride, magnesium chloride, amino acid, triglyceride, microcrystalline cellulose, small intestine epithelial cells, escherichia coli and water. The problems that a real excrement sample is difficult to collect, easy to be influenced by heterogeneity of the sample, large in environmental pollution and easy to deteriorate and degrade in the storage process are solved, and the artificial excrement with excellent uniformity, reproducibility and stability is provided; the scene of nucleic acid degradation and gene expression quantity detection of a real excrement sample at normal temperature can be objectively simulated, and long-term storage under a low-temperature condition can be realized.

The application discloses a triglyceride and cholesterol mixed quality control liquid and a preparation method and application thereof, relates to the technical field of in vitro diagnostic reagents, and solves the problem of poor compatibility of components of the triglyceride and cholesterol mixed quality control liquid. The triglyceride and cholesterol mixed quality control liquid comprises a mother liquor and a diluent, the mother liquor comprises the following components in percentage by mass: glyceryl trioleate 7-10%, Triton X-100 85-90% and cholesterol 3-5%; and the diluent comprises the following components in percentage by mass: isopropyl alcohol 50-51%, sodium phosphate buffer 39-40%, sodium cholate 9.50-9.75% and sodium benzoate 0.25-0.50%. The mixed quality control liquid is high in stability and accuracy, can detect triglyceride and cholesterol at the same time, and the detection results do not interfere with each other.

The invention discloses a method for improving the cholesterol lowering activity effect of crassostrea hongkongensis polypeptide. According to the method for improving the cholesterol-lowering activity effect of the Crassostrea hongkongensis polypeptide, the Crassostrea hongkongensis polypeptide is prepared under specific conditions through a complex enzyme enzymolysis process with a specific ratio, and the cholesterol-lowering activity of the Crassostrea hongkongensis polypeptide crude extract can be improved; the inhibition rate of cholesterol micelles and the binding rate of sodium cholate, sodium glycocholate and sodium taurocholate are obviously improved, and the polypeptide content and yield are obviously improved; compared with the cholesterol-reducing active polypeptide prepared by the existing enzymolysis method, the Crassostrea hongkongensis polypeptide prepared by the method disclosed by the invention has a better cholesterol-reducing active effect on the basis of keeping higher polypeptide content, and more effective methods and ideas are provided for the oyster polypeptide with a specific active effect; the cholesterol lowering activity of the crassostrea hongkongensis and the yield and the content of the polypeptide are further improved.

The present invention discloses a low-molecular-weight local anesthetic gel, liposomes, and preparation methods thereof. The raw materials of the low-molecular-weight local anesthetic gel include: a local anesthetic, a bile salt, an aqueous solvent, or a buffer; the local anesthetic is selected from an amide local anesthetic; and the bile salt is selected from at least one of sodium cholate, sodium deoxycholate, sodium chenodeoxycholate, sodium lithocholic acid, sodium ursocholic acid, sodium ursodeoxycholate, sodium glycodeoxycholate, sodium taurolithocholic acid, sodium glycotaurocholate, sodium glycochenodeoxycholate, sodium phenylpropanecholate, sodium casocholic acid, sodium leukocholic acid, bile acid dimer, bile acid side chain amino acid conjugate, bile acid side chain PEG conjugate, and bile acid side chain glucose conjugate. The preparation process of the gel and liposome of the present invention is simple and controllable, and can achieve the purpose of postoperative pain management after a single administration.