67 results about "Sodium Cholate" patented technology

The present disclosure provides solid forms of sodium chenodeoxycholate (NaCDC), as well as compositions thereof, and methods of use and preparation thereof. In some embodiments, the provided solid forms are useful for treating gastrointestinal disorders, such as constipation (e.g., IBS-C). In some embodiments, the provided solid forms are useful for preparing new formulations of NaCDC, such as formulations uniquely designed to address certain problems of prior formulations of CDCA or salts thereof.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

The application provides a topical traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof. The composition is composed of traditional Chinese medicinal materials such as angelica, cortex psoraleae and barks of dictamnus dasycarpus, and a penetration enhancer, an activating agent and a moisturizing agent. The penetration enhancer is composed of soybean lecithin, phosphatidylethanolamine and cholesterol, the activating agent is sodium cholate, sodium deoxycholate and sodium taurocholate, and the moisturizing agent is eucalyptus oil. The drugs are compatible to exert the effects of clearing heat and drying dampness, cooling blood and nourishing yin, activating blood and resolving stasis, warming yang and dispelling cold and supporting healthy qi and tonifying the body resistance. The traditional Chinese medicine composition is prepared through supercritical extraction, micronization treatment, solution preparation and intermittent ultrasonic homogenization. The traditional Chinese medicinal materials are used for treating the etiology, pathogenesis and symptoms of vulvar leukoplakia, the penetration enhancer reduces the skin barrier function, the activating agent enhances the drug activity and permeability, and the moisturizing agent maintains the skin moisture and assists in anti-inflammation. The clinical application effectively relieves the symptoms of patients with vulvar leukoplakia, improves the pathological state of local skin and improves the treatment effect, thereby providing a new effective option for the treatment of vulvar leukoplakia.

The application provides a preparation method and application of a near-infrared two-region fluorescent sensor, and chiral single-walled carbon nanotubes are separated by using a double water phase extraction method; materials in the separation process include deionized water, polyethylene glycol, dextran, sodium dodecyl sulfate, sodium deoxycholate and cholic acid sodium hydrate; the chiral single-walled carbon nanotubes are dispersed and mixed with 4-nitrobenzene tetrafluoroboric acid diazonium salt to obtain the fluorescent sensor; high-purity (6,5)-SWCNT is efficiently and simply separated by using the double water phase extraction technology, the prepared SWCNT-NBD nanomaterial has good optical performance, including bright light emission in the near-infrared two-region, has good penetration capacity on biological tissues, the fluorescent detector (SWCNT-NBD) has low detection line, wide linear range, good selectivity on DA, and is convenient to prepare and low in cost.

The invention discloses a probiotic with the characteristic of high yield of bile salt hydrolase and application of the probiotic in a preparation for preventing or improving cholestatic jaundice, and is characterized in that the probiotic is at least one of a bifidobacterium longum subsp. Infantis QS033 strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35879 and a lactobacillus delbrueckii subsp. Lactis QS021 strain with the preservation number of CGMCC No.35880; according to the present invention, the Chukrasone A has the application of the Chukrasone A in the preparation of the product for preventing, relieving or regulating the cholestatic jaundice, and has the advantages of effective degradation of sodium glycocholate, sodium glycodeoxycholate, sodium glycochenodeoxycholate and sodium glycoursodeoxycholate, effective regulation of bile acid metabolism disorder in the cholestatic jaundice, and improvement of the cholestatic jaundice.

The invention provides a rain wash resistant and long-acting antibacterial liquid-liquid condensed phase and a preparation method and application thereof.The liquid-liquid condensed phase comprises polyethyleneimine, sodium deoxycholate and metal chloride salt, the concentration of the polyethyleneimine is 0.5 g / L-5 g / L, and the molecular weight of the polyethyleneimine is 600-25000; the concentration of the sodium deoxycholate is 0.5 mM to 50 mM.

The invention discloses wheat malt seedling functional dietary fibers as well as a preparation method and application of the wheat malt seedling functional dietary fibers. The soluble dietary fiber and the insoluble dietary fiber of the wheat malt seedlings are extracted by adopting a wall breaking-extraction mode of synergy of biological enzyme and free radicals. The wheat malt seedling soluble dietary fibers can prolong the life of caenorhabditis elegans in an oxidative stress state, improve the antioxidant enzyme activity and improve the anti-apoptosis capability; the intestinal flora of the obese C57BL / 6J mouse induced by the high-fat feed is regulated; the wheat malt seedling insoluble dietary fiber has better binding water capacity, water-holding capacity and cholesterol and sodium cholate adsorption capacity, and can be used as a functional food additive for improving the texture and nutritional characteristics of food; and the wheat malt seedlings can also be used for assisting in reducing serum cholesterol level, preventing arteriosclerosis, promoting defecation, preventing constipation, colorectal cancer and the like in the field of health medical treatment, so that high-quality reutilization of the wheat malt seedlings is realized.

This invention relates to a midazolam nanocrystal suspension, which, by weight-volume percentage, comprises 5%–45% midazolam, 1%–10% Tween, and 0.1%–10% sodium deoxycholate (SDC). The midazolam nanocrystal suspension of this invention exhibits superior blood-brain barrier permeability and bioavailability, making it suitable for needle-free injection administration.

The present application belongs to the technical field of veterinary medicine, and relates to a kind of veterinary albendazole tablets, and the preparation method of the preparation is provided.The tablet is composed of albendazole, trehalose, sodium taurocholate and other pharmaceutically acceptable binders, disintegrants and lubricants.By spray drying the mixed solution of albendazole, trehalose and sodium taurocholate, the albendazole is fully dispersed, and the amount of trehalose and sodium taurocholate is controlled, which improves the dissolution and stability of the product.

The present invention discloses a transfersome composition, its preparation method, and application. The transfersome composition comprises the following raw materials, calculated by mass: 5-20 parts of an active drug; 2-40 parts of lecithin; and 2-40 parts of sodium cholate. The active drug comprises a protein drug or a small molecule drug. The present invention coats the protein drug or small molecule drug with lecithin and sodium cholate, resulting in a drug-coated transfersome composition with higher transdermal efficiency, shortened onset time, improved therapeutic efficacy, and avoided drug side effects.

The invention relates to the technical field of medicines, and provides a semeglutide coated tablet and a preparation method thereof. The chip-coated sheet comprises a chip core layer and a shell layer, the tablet core layer comprises a first absorption enhancer; the shell layer comprises a second absorption enhancer; the first absorption enhancer and the second absorption enhancer are selected from the group consisting of sodium 8-(2-hydroxybenzamido) caprylate, Tween 80, lauryl sodium sulfate, sodium caprate, polyglycerol-3 diisostearate, oleic acid, lauric acid, sodium deoxycholate, sodium cholate, polyoxyethylene (35) castor oil, PEG-vitamin E succinate, PEG-vitamin D3 succinate and pluronic. The invention relates to a preservative which is prepared from the following raw materials: polyethylene glycol, a methoxy polyethylene glycol-polycaprolactone copolymer, sucrose fatty acid ester, 15-hydroxystearic acid polyethylene glycol ester and caprylic / capric acid polyethylene glycol glyceride. The coated tablet provided by the invention adopts a double-layer structure consisting of the tablet core layer and the shell layer, so that the bioavailability of the preparation can be remarkably improved, the oral dosage can be hopefully and greatly reduced, and the medication cost is reduced.

The invention discloses a brain-targeted nasal-spray amphotericin B phospholipid complex and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the brain-targeted nasal-spray amphotericin B phospholipid complex is prepared by adopting a film dispersion method, and the preparation method comprises the following steps: dissolving 15-hydroxystearic acid polyethylene glycol ester, phospholipid, cholesterol, amphotericin B and optional other auxiliary components in a solvent, removing the solvent until a film is formed, and drying to obtain the brain-targeted nasal-spray amphotericin B phospholipid complex. And carrying out hydration dispersion to obtain the amphotericin B-loaded phospholipid complex. According to the amphotericin B sodium deoxycholate injection, the problems that the traditional amphotericin B sodium deoxycholate injection is high in renal toxicity, the intrathecal injection is poor in solubility, and low in bioavailability and patient compliance, large in side effect and the like due to the fact that the traditional amphotericin B sodium deoxycholate injection is difficult to penetrate through a blood brain After nasal administration, the drug is quickly delivered into the brain, so that the slow release of the drug is realized, the intracerebral bioavailability of the drug is improved, high brain targeting and low systemic toxic and side effects are realized, and good clinical application value and market prospect are achieved.

The present application relates to a curcumin nanocrystal composition, the composition contains 1-18% (m / v) of curcumin nanocrystal, 0.1-10% (m / v) of stabilizer, 0.1-10% (m / v) of surfactant and 0-10% (m / v) of suspending agent in mass volume percentage, wherein the particle size of the curcumin nanocrystal is less than or equal to 100 nm, the stabilizer is selected from any one or combination of hydroxypropyl methyl cellulose (HPMC), polyvinylpyrrolidone PVPK12PF, polyvinylpyrrolidone PVPK15, polyvinylpyrrolidone PVPK17PF, lecithin, polyethylene glycol, poloxamer Pluronics F68, poloxamer Pluronics F108, the surfactant is selected from any one or combination of sodium cholate, sodium deoxycholate, sodium docusate, sodium dodecyl sulfate (SDS), sodium dodecyl sulfonate (SLS), sodium alginate, and the suspending agent is selected from any one or combination of sucrose, dextran, glycerol, povidone, hydroxypropyl cellulose, methyl cellulose, hypromellose, sodium carboxymethyl cellulose, carboxymethyl cellulose, polyvinyl alcohol, gum arabic, dextrin. The composition of the present application has the advantages of fast onset, good stability, high bioavailability, safety and effectiveness.

The invention provides an extracting solution for extracting protein from adipose tissue and an extracting method, so as to make up the defects in the prior art. The extracting solution is a PBS (Phosphate Buffer Solution) added with cane sugar, EDTA (Ethylene Diamine Tetraacetic Acid), SDS (Sodium Dodecyl Sulfate), sodium deoxycholate and Triton X-100; wherein the concentrations of the sucrose, the EDTA, the SDS, the sodium deoxycholate and the Triton X-100 are as follows: 50 mM of the PBS, 0.25 M of the sucrose, 0.5 mM of the EDTA, 0.5 mM of the SDS, 0.05% of the sodium deoxycholate and 0.06% of the Triton X-100. By applying the extracting solution, the yield of protein obtained from fat is higher, and compared with other extracting methods, the extracting solution is simple in formula and easy and convenient to operate, and the extracted protein solution is clear and high in purity.

The invention discloses a ceramide transdermal enhanced transporter preparation as well as a method and application thereof, and belongs to the technical field of transdermal delivery preparations. The preparation comprises the following components in parts by mass: 5-15 parts of hydrogenated lecithin, 1-5 parts of ceramide, 2-8 parts of cholesterol, 1-3 parts of stearic acid, 0.5-5 parts of an edge activator, 20-50 parts of absolute ethyl alcohol and 100-200 parts of ultrapure water, and the edge activator is selected from one of sodium cholate, SP60 or sucrose stearate and has a specific concentration gradient. The preparation method comprises the steps of organic phase preparation, water phase pretreatment, mixed hydration and particle size adjustment. The edge activator is used for regulating and controlling a lipid bilayer structure, the deformation index of the preparation is remarkably increased, the problems that ceramide is poor in water solubility, prone to crystallization and low in transdermal efficiency are solved, the preparation is excellent in stability, the intradermal retention amount and the skin permeation amount are remarkably higher than those of traditional lipidosome, deep skin delivery of ceramide can be achieved, and the application prospect is wide. And the composition has no skin irritation and is suitable for preparing skin barrier repairing, moisturizing or anti-inflammatory external products.

The present application provides a method for separating single chiral carbon nanotube mirror bodies, comprising the following steps: (1) dispersing carbon nanotube raw materials into a solution of a composite surfactant to obtain a carbon nanotube dispersion liquid; (2) using gel chromatography for stepwise elution to separate the carbon nanotube dispersion liquid, and collecting the separation product to obtain single chiral carbon nanotube mirror bodies; wherein the solution of the composite surfactant comprises cholic acid, a first surfactant and an optional second surfactant, and a solvent; the first surfactant is selected from one or more of sodium octyl sulfate, sodium decyl sulfate, sodium dodecyl sulfate and sodium n-hexadecyl sulfate; the second surfactant is selected from one or more of sodium cholate, sodium hydrate cholate, sodium dehydrocholate, sodium deoxycholate, sodium lithocholate, sodium hyodeoxycholate and sodium chenodeoxycholate. The method of the present application can separate and prepare single chiral carbon nanotube mirror bodies with a diameter of less than 0.69 nanometers.

The invention discloses a salbutamol sulfate oral solution and a preparation method thereof.According to the salbutamol sulfate oral solution, a physical barrier is formed through inclusion of hydroxypropyl-beta-cyclodextrin, and a stability synergistic mechanism is formed through the chelating chemical inhibition effect of EDTA-2Na, so that the oxidative degradation rate of salbutamol sulfate is obviously reduced; in addition, sucralose and peppermint essence are used as flavoring agents for taste, high-sweetness taste modification and cool taste modification are performed, and triple taste masking of HP-beta-CD inclusion, sucralose and peppermint essence is performed, so that the taste score is remarkably improved; by destroying intestinal epithelium tight connection through sodium cholate, the transmembrane transport efficiency is improved, the bioavailability is improved, the apparent permeability coefficient (Papp) is remarkably improved, the problem of low availability caused by the first-pass effect is solved, beagle is orally taken, the bioavailability is remarkably improved, and the application prospect is remarkable.

According to the application of the sodium taurocholate in preparing the medicine for coordinating the metabolic balance of the bone fat, the sodium taurocholate is used for coordinating the metabolic balance of the bone fat by inhibiting the accumulation of bone marrow adipose tissues. According to the application, the bone marrow adipose tissue can be accurately targeted to inhibit abnormal accumulation of the bone marrow adipose tissue, and normal bone marrow adipose tissue is not influenced. And moreover, by inhibiting abnormal accumulation of bone marrow adipose tissues, the bone fat metabolism balance is synergistically regulated and controlled, and particularly, adipogenesis inhibition and continuous osteogenesis promotion are combined. Sodium taurocholate is an endogenous bile acid derivative, so that the safety is higher, and sodium taurocholate is a micromolecular drug, so that sodium taurocholate can be orally taken compared with the current macromolecular drug injection administration route. In the application of the sodium taurocholate in preparing the medicine for coordinating the metabolism balance of the bone fat, the volume reduction amount of bone marrow adipose tissue is not less than 40%, and the bone mass increase amount is not less than 30%.

The application discloses a triglyceride and cholesterol mixed quality control liquid and a preparation method and application thereof, relates to the technical field of in vitro diagnostic reagents, and solves the problem of poor compatibility of components of the triglyceride and cholesterol mixed quality control liquid. The triglyceride and cholesterol mixed quality control liquid comprises a mother liquor and a diluent, the mother liquor comprises the following components in percentage by mass: glyceryl trioleate 7-10%, Triton X-100 85-90% and cholesterol 3-5%; and the diluent comprises the following components in percentage by mass: isopropyl alcohol 50-51%, sodium phosphate buffer 39-40%, sodium cholate 9.50-9.75% and sodium benzoate 0.25-0.50%. The mixed quality control liquid is high in stability and accuracy, can detect triglyceride and cholesterol at the same time, and the detection results do not interfere with each other.

The invention discloses a method for improving the cholesterol lowering activity effect of crassostrea hongkongensis polypeptide. According to the method for improving the cholesterol-lowering activity effect of the Crassostrea hongkongensis polypeptide, the Crassostrea hongkongensis polypeptide is prepared under specific conditions through a complex enzyme enzymolysis process with a specific ratio, and the cholesterol-lowering activity of the Crassostrea hongkongensis polypeptide crude extract can be improved; the inhibition rate of cholesterol micelles and the binding rate of sodium cholate, sodium glycocholate and sodium taurocholate are obviously improved, and the polypeptide content and yield are obviously improved; compared with the cholesterol-reducing active polypeptide prepared by the existing enzymolysis method, the Crassostrea hongkongensis polypeptide prepared by the method disclosed by the invention has a better cholesterol-reducing active effect on the basis of keeping higher polypeptide content, and more effective methods and ideas are provided for the oyster polypeptide with a specific active effect; the cholesterol lowering activity of the crassostrea hongkongensis and the yield and the content of the polypeptide are further improved.

The present invention discloses a low-molecular-weight local anesthetic gel, liposomes, and preparation methods thereof. The raw materials of the low-molecular-weight local anesthetic gel include: a local anesthetic, a bile salt, an aqueous solvent, or a buffer; the local anesthetic is selected from an amide local anesthetic; and the bile salt is selected from at least one of sodium cholate, sodium deoxycholate, sodium chenodeoxycholate, sodium lithocholic acid, sodium ursocholic acid, sodium ursodeoxycholate, sodium glycodeoxycholate, sodium taurolithocholic acid, sodium glycotaurocholate, sodium glycochenodeoxycholate, sodium phenylpropanecholate, sodium casocholic acid, sodium leukocholic acid, bile acid dimer, bile acid side chain amino acid conjugate, bile acid side chain PEG conjugate, and bile acid side chain glucose conjugate. The preparation process of the gel and liposome of the present invention is simple and controllable, and can achieve the purpose of postoperative pain management after a single administration.

This invention discloses a molybdenum disulfide thin-film sensor based on Raman detection and its manufacturing method, which can be used for the detection of tumor markers. The molybdenum disulfide thin-film silicon wafer is formed by layer-by-layer self-assembly of a molybdenum disulfide dispersion and a polydiallyl dimethyl ammonium chloride (PDDA) solution onto a clean silicon wafer after pretreatment with an argon plasma gun, forming a molybdenum disulfide thin film. The carboxyl groups provided by sodium cholate added during the ultrasonic activation of the molybdenum disulfide powder are utilized with EDC / NHS solution. Antibodies corresponding to tumor markers are then incubated, and after BSA blocking treatment, the corresponding tumor markers are captured and then Raman detection is performed.

To provide a method for improving the visibility of a test line in immunochromatography.SOLUTION: Forming a complex of a detection target substance capturing substance, a detection target substance, and a substance that specifically binds to the labeled detection target substance on the test line on the instrument on which the detection target substance capturing substance is solid-phased, using a substance that specifically binds to a detection target substance labeled with a labeling substance that is a colored particle; An immunochromatographic measurement instrument for detecting a substance to be detected by coloring a test line with a labeling substance, wherein the test line contains at least one compound selected from the group consisting of sodium cholate, CHAPS, digitonin, non-surface-active sulfobetaine (NDSB), guanidine thiocyanate, a copolymer containing a 2-methacryloyloxyethylphosphocholine polymer as a monomer unit, and ethanol.SELECTED DRAWING: None

The invention relates to a cabazitaxel composition and application of the cabazitaxel composition. Embodiments provide a composition comprising cabazitaxel and at least one lipid and / or cougsterol, and / or a cougsterol derivative, and / or sodium cholesterol sulfate, in the form of a tablet or capsule, and administering the composition to a subject.

The present application relates to a kind of experimental mouse non-alcoholic fatty liver model feed and its preparation method and application, belong to animal model feed technical field;The feed includes the following preparation raw materials: casein, fructose, sucrose, cellulose, cholesterol, malt dextrin, L-cystine, mineral mixture, vitamin mixture, choline tartrate, lard, soybean oil, shortening, sodium cholate, traditional Chinese medicine extract and dye agent.The advantage lies in, after using the feed of the present application to feed mouse for a period of time, mouse non-alcoholic fatty liver model can be obtained, the dietary habits of non-alcoholic fatty liver population can be simulated, the modeling process is more gentle, model is more stable, more conducive to the research of disease and drug.The present application can be according to the model index needs, with the feeding mode of automation, customization, to experimental mouse scientific feeding, avoid the situation of not in line with the regulations of feeding time and amount to appear by artificial control, in turn, it is favorable to the integrity and consistency of model, improve the success rate and efficiency of modeling.

The invention discloses an application of Armillaria mellea in modifying ginseng insoluble dietary fiber; a preparation method of the modified ginseng insoluble dietary fiber comprises the following steps: 1) preparing a liquid culture medium for bacterial strain activation; 2) preparing a ginseng fermentation culture medium: adding ginseng residue to the liquid culture medium for bacterial strain activation, sterilizing, and cooling; 3) inoculating: inoculating Armillaria mellea into the ginseng fermentation culture medium at an inoculum rate of 6-10%, and culturing for 4-8 days; 4) extracting the modified ginseng insoluble dietary fiber: extracting the fermented ginseng insoluble dietary fiber by an enzymatic method; the results show that the ginseng insoluble dietary fiber obtained by fermentation and modification of Armillaria mellea Am-07-22 has good functional properties, and its water holding capacity, oil holding capacity, water swelling capacity, glucose adsorption capacity, glucose dialysis delay capacity, cholesterol adsorption capacity, sodium cholate adsorption capacity, and nitrite adsorption capacity are significantly improved compared with unfermented samples, and the cation exchange capacity is also significantly improved.

The invention belongs to the technical field of pharmaceutical preparations, and specifically discloses a meloxicam injection and a preparation method thereof, wherein: the raw and auxiliary material components of the meloxicam injection include meloxicam, sodium deoxycholate and polyvidone, the pH value of the sodium deoxycholate solution with a mass concentration of 0.3% is 6.8-8.0 or the sodium content in the sodium deoxycholate is 5.0-5.5wt%. The meloxicam injection of the invention uses sodium deoxycholate and polyvidone as surfactants, and by controlling the pH value of the sodium deoxycholate solution or the sodium content in the sodium deoxycholate, the stability of the meloxicam nanocrystal suspension can be maintained without the addition of sugar or buffer, and almost no flake aggregates are precipitated. At the same time, the preparation method of the meloxicam injection of the invention has stable process and simple operation, almost no flake aggregates are precipitated in the prepared suspension, the system is more stable, and is conducive to industrial production, transportation and storage.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

The invention belongs to the technical field of acupuncture point patch preparation, and relates to a coronary heart storax pill volatile oil nano-liposome / PVA swelling type microneedle patch. Crushing storax, frankincense, sandalwood and elecampane, adding water for soaking, slightly boiling, condensing and refluxing; and drying to obtain the GXSHW-EO. Soybean lecithin, cholesterol, sodium cholate and GXSHW-EO are added into methyl alcohol and trichloromethane, a phosphoric acid buffer solution is added after rotary evaporation, ultrasonic treatment and filtering are conducted after rotary evaporation, and the microneedle patch is obtained after a PVA solution, a PVP solution and a citric acid solution are evenly mixed, subjected to centrifugal vacuum pouring, vacuumized, dried and demoulded. By integrating the targeting delivery advantage of the NLCs, the intelligent swelling characteristic of the PVA microneedle patch and the meridian regulation effect of acupoint stimulation, the triple synergistic effect of physical infiltration promotion, chemical drug release and biological response is achieved. The drug loading capacity and the stability of active ingredients of the traditional Chinese medicine are enhanced.

The invention relates to the technical field of animal model construction, and particularly provides a gavage agent for constructing a metabolism-related fatty liver disease animal model as well as a preparation method and application of the gavage agent. The gavage agent comprises cholesterol, sodium cholate, Tween 80 and corn oil according to a specific ratio, a quantitative gavage administration mode is adopted, and the technical problems that an existing MAFLD animal model is long in modeling period, high in cost and large in individual difference, and a single pathogenic factor cannot be accurately researched are solved. The gavage agent is used for building a rat model and can efficiently and stably induce an MAFLD animal model with typical liver fatty degeneration and lipid disorder characteristics within 8 weeks, the modeling period is shortened by more than 4 weeks compared with that of a traditional high-fat feed method, the individual difference of the model is remarkably reduced through accurate dosage control, and the method is suitable for large-scale popularization and application. And meanwhile, the single-day modeling cost is controlled at a relatively low level.