39 results about "Sodium Cholate" patented technology

The application provides a topical traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof. The composition is composed of traditional Chinese medicinal materials such as angelica, cortex psoraleae and barks of dictamnus dasycarpus, and a penetration enhancer, an activating agent and a moisturizing agent. The penetration enhancer is composed of soybean lecithin, phosphatidylethanolamine and cholesterol, the activating agent is sodium cholate, sodium deoxycholate and sodium taurocholate, and the moisturizing agent is eucalyptus oil. The drugs are compatible to exert the effects of clearing heat and drying dampness, cooling blood and nourishing yin, activating blood and resolving stasis, warming yang and dispelling cold and supporting healthy qi and tonifying the body resistance. The traditional Chinese medicine composition is prepared through supercritical extraction, micronization treatment, solution preparation and intermittent ultrasonic homogenization. The traditional Chinese medicinal materials are used for treating the etiology, pathogenesis and symptoms of vulvar leukoplakia, the penetration enhancer reduces the skin barrier function, the activating agent enhances the drug activity and permeability, and the moisturizing agent maintains the skin moisture and assists in anti-inflammation. The clinical application effectively relieves the symptoms of patients with vulvar leukoplakia, improves the pathological state of local skin and improves the treatment effect, thereby providing a new effective option for the treatment of vulvar leukoplakia.

The application provides a preparation method and application of a near-infrared two-region fluorescent sensor, and chiral single-walled carbon nanotubes are separated by using a double water phase extraction method; materials in the separation process include deionized water, polyethylene glycol, dextran, sodium dodecyl sulfate, sodium deoxycholate and cholic acid sodium hydrate; the chiral single-walled carbon nanotubes are dispersed and mixed with 4-nitrobenzene tetrafluoroboric acid diazonium salt to obtain the fluorescent sensor; high-purity (6,5)-SWCNT is efficiently and simply separated by using the double water phase extraction technology, the prepared SWCNT-NBD nanomaterial has good optical performance, including bright light emission in the near-infrared two-region, has good penetration capacity on biological tissues, the fluorescent detector (SWCNT-NBD) has low detection line, wide linear range, good selectivity on DA, and is convenient to prepare and low in cost.

The invention discloses a probiotic with the characteristic of high yield of bile salt hydrolase and application of the probiotic in a preparation for preventing or improving cholestatic jaundice, and is characterized in that the probiotic is at least one of a bifidobacterium longum subsp. Infantis QS033 strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35879 and a lactobacillus delbrueckii subsp. Lactis QS021 strain with the preservation number of CGMCC No.35880; according to the present invention, the Chukrasone A has the application of the Chukrasone A in the preparation of the product for preventing, relieving or regulating the cholestatic jaundice, and has the advantages of effective degradation of sodium glycocholate, sodium glycodeoxycholate, sodium glycochenodeoxycholate and sodium glycoursodeoxycholate, effective regulation of bile acid metabolism disorder in the cholestatic jaundice, and improvement of the cholestatic jaundice.

The invention provides a rain wash resistant and long-acting antibacterial liquid-liquid condensed phase and a preparation method and application thereof.The liquid-liquid condensed phase comprises polyethyleneimine, sodium deoxycholate and metal chloride salt, the concentration of the polyethyleneimine is 0.5 g / L-5 g / L, and the molecular weight of the polyethyleneimine is 600-25000; the concentration of the sodium deoxycholate is 0.5 mM to 50 mM.

The invention discloses wheat malt seedling functional dietary fibers as well as a preparation method and application of the wheat malt seedling functional dietary fibers. The soluble dietary fiber and the insoluble dietary fiber of the wheat malt seedlings are extracted by adopting a wall breaking-extraction mode of synergy of biological enzyme and free radicals. The wheat malt seedling soluble dietary fibers can prolong the life of caenorhabditis elegans in an oxidative stress state, improve the antioxidant enzyme activity and improve the anti-apoptosis capability; the intestinal flora of the obese C57BL / 6J mouse induced by the high-fat feed is regulated; the wheat malt seedling insoluble dietary fiber has better binding water capacity, water-holding capacity and cholesterol and sodium cholate adsorption capacity, and can be used as a functional food additive for improving the texture and nutritional characteristics of food; and the wheat malt seedlings can also be used for assisting in reducing serum cholesterol level, preventing arteriosclerosis, promoting defecation, preventing constipation, colorectal cancer and the like in the field of health medical treatment, so that high-quality reutilization of the wheat malt seedlings is realized.

This invention relates to a midazolam nanocrystal suspension, which, by weight-volume percentage, comprises 5%–45% midazolam, 1%–10% Tween, and 0.1%–10% sodium deoxycholate (SDC). The midazolam nanocrystal suspension of this invention exhibits superior blood-brain barrier permeability and bioavailability, making it suitable for needle-free injection administration.

The present application belongs to the technical field of veterinary medicine, and relates to a kind of veterinary albendazole tablets, and the preparation method of the preparation is provided.The tablet is composed of albendazole, trehalose, sodium taurocholate and other pharmaceutically acceptable binders, disintegrants and lubricants.By spray drying the mixed solution of albendazole, trehalose and sodium taurocholate, the albendazole is fully dispersed, and the amount of trehalose and sodium taurocholate is controlled, which improves the dissolution and stability of the product.

The invention discloses a brain-targeted nasal-spray amphotericin B phospholipid complex and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the brain-targeted nasal-spray amphotericin B phospholipid complex is prepared by adopting a film dispersion method, and the preparation method comprises the following steps: dissolving 15-hydroxystearic acid polyethylene glycol ester, phospholipid, cholesterol, amphotericin B and optional other auxiliary components in a solvent, removing the solvent until a film is formed, and drying to obtain the brain-targeted nasal-spray amphotericin B phospholipid complex. And carrying out hydration dispersion to obtain the amphotericin B-loaded phospholipid complex. According to the amphotericin B sodium deoxycholate injection, the problems that the traditional amphotericin B sodium deoxycholate injection is high in renal toxicity, the intrathecal injection is poor in solubility, and low in bioavailability and patient compliance, large in side effect and the like due to the fact that the traditional amphotericin B sodium deoxycholate injection is difficult to penetrate through a blood brain After nasal administration, the drug is quickly delivered into the brain, so that the slow release of the drug is realized, the intracerebral bioavailability of the drug is improved, high brain targeting and low systemic toxic and side effects are realized, and good clinical application value and market prospect are achieved.

The invention discloses a ceramide transdermal enhanced transporter preparation as well as a method and application thereof, and belongs to the technical field of transdermal delivery preparations. The preparation comprises the following components in parts by mass: 5-15 parts of hydrogenated lecithin, 1-5 parts of ceramide, 2-8 parts of cholesterol, 1-3 parts of stearic acid, 0.5-5 parts of an edge activator, 20-50 parts of absolute ethyl alcohol and 100-200 parts of ultrapure water, and the edge activator is selected from one of sodium cholate, SP60 or sucrose stearate and has a specific concentration gradient. The preparation method comprises the steps of organic phase preparation, water phase pretreatment, mixed hydration and particle size adjustment. The edge activator is used for regulating and controlling a lipid bilayer structure, the deformation index of the preparation is remarkably increased, the problems that ceramide is poor in water solubility, prone to crystallization and low in transdermal efficiency are solved, the preparation is excellent in stability, the intradermal retention amount and the skin permeation amount are remarkably higher than those of traditional lipidosome, deep skin delivery of ceramide can be achieved, and the application prospect is wide. And the composition has no skin irritation and is suitable for preparing skin barrier repairing, moisturizing or anti-inflammatory external products.

The present application provides a method for separating single chiral carbon nanotube mirror bodies, comprising the following steps: (1) dispersing carbon nanotube raw materials into a solution of a composite surfactant to obtain a carbon nanotube dispersion liquid; (2) using gel chromatography for stepwise elution to separate the carbon nanotube dispersion liquid, and collecting the separation product to obtain single chiral carbon nanotube mirror bodies; wherein the solution of the composite surfactant comprises cholic acid, a first surfactant and an optional second surfactant, and a solvent; the first surfactant is selected from one or more of sodium octyl sulfate, sodium decyl sulfate, sodium dodecyl sulfate and sodium n-hexadecyl sulfate; the second surfactant is selected from one or more of sodium cholate, sodium hydrate cholate, sodium dehydrocholate, sodium deoxycholate, sodium lithocholate, sodium hyodeoxycholate and sodium chenodeoxycholate. The method of the present application can separate and prepare single chiral carbon nanotube mirror bodies with a diameter of less than 0.69 nanometers.

The invention discloses a salbutamol sulfate oral solution and a preparation method thereof.According to the salbutamol sulfate oral solution, a physical barrier is formed through inclusion of hydroxypropyl-beta-cyclodextrin, and a stability synergistic mechanism is formed through the chelating chemical inhibition effect of EDTA-2Na, so that the oxidative degradation rate of salbutamol sulfate is obviously reduced; in addition, sucralose and peppermint essence are used as flavoring agents for taste, high-sweetness taste modification and cool taste modification are performed, and triple taste masking of HP-beta-CD inclusion, sucralose and peppermint essence is performed, so that the taste score is remarkably improved; by destroying intestinal epithelium tight connection through sodium cholate, the transmembrane transport efficiency is improved, the bioavailability is improved, the apparent permeability coefficient (Papp) is remarkably improved, the problem of low availability caused by the first-pass effect is solved, beagle is orally taken, the bioavailability is remarkably improved, and the application prospect is remarkable.

The application discloses a triglyceride and cholesterol mixed quality control liquid and a preparation method and application thereof, relates to the technical field of in vitro diagnostic reagents, and solves the problem of poor compatibility of components of the triglyceride and cholesterol mixed quality control liquid. The triglyceride and cholesterol mixed quality control liquid comprises a mother liquor and a diluent, the mother liquor comprises the following components in percentage by mass: glyceryl trioleate 7-10%, Triton X-100 85-90% and cholesterol 3-5%; and the diluent comprises the following components in percentage by mass: isopropyl alcohol 50-51%, sodium phosphate buffer 39-40%, sodium cholate 9.50-9.75% and sodium benzoate 0.25-0.50%. The mixed quality control liquid is high in stability and accuracy, can detect triglyceride and cholesterol at the same time, and the detection results do not interfere with each other.

The invention discloses a method for improving the cholesterol lowering activity effect of crassostrea hongkongensis polypeptide. According to the method for improving the cholesterol-lowering activity effect of the Crassostrea hongkongensis polypeptide, the Crassostrea hongkongensis polypeptide is prepared under specific conditions through a complex enzyme enzymolysis process with a specific ratio, and the cholesterol-lowering activity of the Crassostrea hongkongensis polypeptide crude extract can be improved; the inhibition rate of cholesterol micelles and the binding rate of sodium cholate, sodium glycocholate and sodium taurocholate are obviously improved, and the polypeptide content and yield are obviously improved; compared with the cholesterol-reducing active polypeptide prepared by the existing enzymolysis method, the Crassostrea hongkongensis polypeptide prepared by the method disclosed by the invention has a better cholesterol-reducing active effect on the basis of keeping higher polypeptide content, and more effective methods and ideas are provided for the oyster polypeptide with a specific active effect; the cholesterol lowering activity of the crassostrea hongkongensis and the yield and the content of the polypeptide are further improved.

To provide a method for improving the visibility of a test line in immunochromatography.SOLUTION: Forming a complex of a detection target substance capturing substance, a detection target substance, and a substance that specifically binds to the labeled detection target substance on the test line on the instrument on which the detection target substance capturing substance is solid-phased, using a substance that specifically binds to a detection target substance labeled with a labeling substance that is a colored particle; An immunochromatographic measurement instrument for detecting a substance to be detected by coloring a test line with a labeling substance, wherein the test line contains at least one compound selected from the group consisting of sodium cholate, CHAPS, digitonin, non-surface-active sulfobetaine (NDSB), guanidine thiocyanate, a copolymer containing a 2-methacryloyloxyethylphosphocholine polymer as a monomer unit, and ethanol.SELECTED DRAWING: None

The invention relates to a cabazitaxel composition and application of the cabazitaxel composition. Embodiments provide a composition comprising cabazitaxel and at least one lipid and / or cougsterol, and / or a cougsterol derivative, and / or sodium cholesterol sulfate, in the form of a tablet or capsule, and administering the composition to a subject.

The present application relates to a kind of experimental mouse non-alcoholic fatty liver model feed and its preparation method and application, belong to animal model feed technical field;The feed includes the following preparation raw materials: casein, fructose, sucrose, cellulose, cholesterol, malt dextrin, L-cystine, mineral mixture, vitamin mixture, choline tartrate, lard, soybean oil, shortening, sodium cholate, traditional Chinese medicine extract and dye agent.The advantage lies in, after using the feed of the present application to feed mouse for a period of time, mouse non-alcoholic fatty liver model can be obtained, the dietary habits of non-alcoholic fatty liver population can be simulated, the modeling process is more gentle, model is more stable, more conducive to the research of disease and drug.The present application can be according to the model index needs, with the feeding mode of automation, customization, to experimental mouse scientific feeding, avoid the situation of not in line with the regulations of feeding time and amount to appear by artificial control, in turn, it is favorable to the integrity and consistency of model, improve the success rate and efficiency of modeling.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

The invention relates to the technical field of animal model construction, and particularly provides a gavage agent for constructing a metabolism-related fatty liver disease animal model as well as a preparation method and application of the gavage agent. The gavage agent comprises cholesterol, sodium cholate, Tween 80 and corn oil according to a specific ratio, a quantitative gavage administration mode is adopted, and the technical problems that an existing MAFLD animal model is long in modeling period, high in cost and large in individual difference, and a single pathogenic factor cannot be accurately researched are solved. The gavage agent is used for building a rat model and can efficiently and stably induce an MAFLD animal model with typical liver fatty degeneration and lipid disorder characteristics within 8 weeks, the modeling period is shortened by more than 4 weeks compared with that of a traditional high-fat feed method, the individual difference of the model is remarkably reduced through accurate dosage control, and the method is suitable for large-scale popularization and application. And meanwhile, the single-day modeling cost is controlled at a relatively low level.

The application discloses a tea processing technology of small yellow flower tea with high active ingredient reservation, and aims at a rare plant, small yellow flower tea, in China. The optimal processing technology is screened out by comparing the influences of different processing technologies on the quality. The processing technology comprises the following steps: selecting small yellow flower tea leaves as raw materials, naturally wilting for 68-76 hours to reduce the water content of the leaves to 20%-30%, drying at 65 DEG C-75 DEG C for 110-130 minutes, and finally crushing and screening through a 50-70 mesh sieve to obtain the small yellow flower tea. The content of tea polyphenol in the small yellow flower tea prepared by the application is greater than or equal to 12.5%, the content of total flavonoids is greater than or equal to 43.0 mg / g, and the content of EGC is greater than or equal to 130 mg / g. The IC50 of the small yellow flower tea to alpha-glucosidase is less than or equal to 60 mu g / mL, and the sodium cholate binding capacity is greater than or equal to 23.5 mu mol / g. The antioxidant, hypoglycemic and hypolipidemic activities of the small yellow flower tea are significantly better than those of other technologies. The acute toxicity test proves that the small yellow flower tea is safe for eating. The application provides a scientific and feasible reference scheme for resource protection and industrialization development of the small yellow flower tea.

The invention relates to the technical field of breeding, in particular to a senescence delaying type Chinese herbal medicine additive for laying hens in the later egg laying period. The matrix dispersed nano-micelle included traditional Chinese medicine compound extract is prepared from the following raw materials in parts by weight: extracts of eight traditional Chinese medicine raw materials and sodium cholate-chitosan quaternary ammonium salt ionic liquid, and the eight traditional Chinese medicine raw materials are as follows: motherwort, glossy privet fruit, astragalus membranaceus, angelica sinensis, dandelion, fructus lycii, poria cocos and hawthorn. According to the invention, an adjusting network formed by compatibility of the traditional Chinese medicine components realizes accurate release and synergistic effect in the body of the laying hen through efficient delivery of the ionic liquid nano-micelles: leonurine and astragaloside act together, so that the ovarian function decline speed is slowed down, and the laying rate is maintained at 82% or above; polysaccharide and flavonoid components synergistically enhance the oxidation resistance, the serum SOD activity is improved to 240 U / mL or above, the MDA content is reduced to 5.2 nmol / mL or below, and the aging process of an organism is delayed.

The application belongs to the technical field of biological medicine preparation, and particularly relates to an external use ear drop for promoting auditory nerve growth and a preparation method thereof. The composition raw materials comprise the following components: active small molecules, glyceryl stearate, glyceryl monostearate, soybean lecithin, vitamin E succinate, Tween-80, chitosan quaternary ammonium salt, diethylene glycol monoethyl ether, penetration aid, penetrant, sodium cholate, N-acetyl cysteine, F127 surfactant, F68 surfactant and sodium hyaluronate. Through the synergistic effect of the crystalline lipid core, the positive chitosan quaternary ammonium salt shell, the heat-sensitive in-situ gel outer layer and the mild penetration system, the drug is long-acting retained, smoothly released and efficiently penetrated into the inner ear target area under the condition of not puncturing the eardrum, and the synergistic system significantly improves the stability, local exposure and treatment efficiency of the drug.

The application belongs to the technical field of in vitro diagnostic reagents, and discloses a cleaning solution for acridinium ester chemiluminescence immunoassay of allergens, a preparation method and application thereof. The cleaning solution is composed of HEPES buffer, a triple surfactant system (poloxamer 188, sodium deoxycholate and octyldecyl glucoside), glycerol, PEG8000, disodium EDTA and a composite preservative of Proclin 950 and BHT. The triple surfactant synergistic system is adopted to reduce non-specific adsorption, the HEPES weak alkaline buffer system avoids the inhibition of phosphates on acridinium ester luminescence, and the composite preservative system solves the toxicity and stability problems of traditional preservatives. The cleaning solution can significantly reduce the background luminescence value, the inhibition rate of hemolysis / lipemia / jaundice interference is less than 5%, the detection accuracy deviation is within ±5% (r>0.99), the precision is less than 3.5%, and the room temperature stability is more than 13 months, and the comprehensive performance is better than that of the commercially available products.

The present application relates to a kind of low permeability oil reservoir injection enhancer by phosphatidylserine, phosphatidylinositol, lecithin, sodium cholate, diethanolamine, 1-dodecylazacycloheptane-2-ketone and tetramethylammonium chloride as raw material preparation method.The present application first phosphatidylserine, phosphatidylinositol, lecithin, cholic acid, 1-dodecylazacycloheptane-2-ketone and diethanolamine are dissolved in anhydrous ethanol according to certain proportion, and the mixed solution of five kinds of substances is prepared;Tetramethylammonium chloride and ammonium chloride are dissolved in water according to certain proportion, and the mixed solution of two kinds of substances is prepared;Then slowly pour the first solution into the second solution under ultrasonic dispersion conditions, and prepare a kind of flexible liposome colloid solution.The injection water configured by the colloid solution has high efficient permeability, can greatly reduce the injection pressure of low permeability core, and the preparation process is reliable, provides a kind of low permeability oil reservoir flexible liposome injection enhancer preparation method.

The invention discloses a dispersing agent based on sensitive dye application, and belongs to the technical field of dispersing agents. The dispersing agent is prepared from the following raw materials in parts by mass: 55 to 65 parts of sodium lignin sulfonate, 4 to 7 parts of sodium taurocholate and 6 to 10 parts of 1-dodecyl-3-methylimidazole mesylate. The preparation method comprises the following steps: carrying out sedimentation, flocculation, filtration and membrane concentration on the papermaking black liquid, introducing sulfur dioxide gas for treatment, and separating out lignin; the method comprises the following steps: pre-oxidizing lignin, and then carrying out sulfonation and methylation reactions to obtain sodium lignin sulfonate; the preparation method comprises the following steps: mixing sodium lignin sulfonate, deionized water, sodium taurocholate and 1-dodecyl-3-methylimidazole mesylate to form a composite dispersion system, and carrying out spray drying to obtain the dispersing agent based on sensitive dye application. The dispersing agent has high thermal stability and high dispersity, can be applied to fabric sensitive dye dyeing, and effectively improves the color fastness of dyed fabrics.

An improved chicken feed-based optimized feeding method, which selects healthy laying hens in the peak egg production period, collects eggs after feeding the customized feed for 4 weeks; the improved chicken feed is composed of a base feed and a functional compound package, wherein the functional compound package is added in an amount of 1000-2000 g / t base feed; components of the functional compound package are phytase, choline chloride, silymarin, soybean phospholipid, deoxycholic acid sodium, glycine, pyrroloquinoline quinone disodium, maltodextrin, whey protein, sodium alginate, sodium hydroxide, vitamin E, organic selenium, folic acid and superfine silicon dioxide. The mutual synergy of various components in the produced eggs promotes, not only realizes nutrition strengthening and quality improvement, but also achieves the purposes of reducing blood lipids and improving fatty liver.

The invention belongs to the technical field of graphene preparation, and particularly relates to an intercalator for graphene preparation and a preparation method and application thereof. The preparation method of the intercalator for graphene preparation comprises the following steps: (1) providing a sodium cholate aqueous solution as a basic solution; (2) adding a microenvironment regulating agent into the basic solution, and regulating and stabilizing the pH value and / or ionic strength I of the system to a preset target value; (3) dropwise adding an aqueous solution containing calcium ions into the solution obtained in the step (2) under the conditions of continuous stirring and temperature control, and controlling the final molar concentration ratio R of the calcium ions to the sodium cholate to a preset value; and (4) curing the mixed solution obtained in the step (3) at a set temperature to obtain the intercalator for graphene preparation. The intercalator system provided by the invention has definite environmental response and self-adaptive characteristics, and is beneficial to obtaining graphene with narrow layer number distribution and high quality when being used for preparing graphene.

The invention provides a mitochondria extracting solution as well as an extracting method, a kit and application thereof. The extracting solution is prepared from the following components: 50 to 150 mM of Tris-HCl with the pH (Potential of Hydrogen) of 7.6, 85 to 130 mM of NaCl, 0.1 to 0.3 mM of sodium cholate, 1 to 2 mmol / L of EDTA (Ethylene Diamine Tetraacetic Acid), 1 to 3 percent of BSA (Bovine Serum Albumin), 50 to 70 g / L of sucrose, 3 to 10 Ku / L of lipoprotein lipase and 0.08 to 0.12 mg / mL of protease inhibitor. The extraction method comprises the following steps: taking a sample, adding a PBS buffer solution, washing, removing residual blood, adding the extracting solution and the steel balls, homogenizing, taking out the steel balls, and centrifuging to remove upper-layer grease; and centrifuging at 4 DEG C, removing supernatant, adding an extracting solution into the precipitate, standing at room temperature, and finally centrifuging at 4 DEG C to obtain the precipitate, namely the mitochondria. When the extracting solution provided by the invention is used for treating a high-fat-content sample, the interference of lipid can be eliminated, meanwhile, turbidity of a detection system is avoided, the mitochondrial structure detection accuracy is improved, and the mitochondrial function detection accuracy, such as mitochondrial compound enzyme activity accuracy and membrane potential, is improved.

The invention discloses a special high-concentration lysate for exosome protein extraction, and belongs to the technical field of exosome lysate. The reagent is mainly prepared by mixing a reagent SDS (Sodium Dodecyl Sulfate), NP-40, sodium deoxycholate, TritonX-100 and NaCl. The specific preparation method comprises the following steps: taking 10ml of 50mM. Tris-HCl buffer solution, adding 1g. SDS, 1g. NP-40, 0.1 g of sodium deoxycholate, 100. Mu l. TritonX-100 and 0.58 g. NaCl, and fully blowing, beating and uniformly mixing. A subversive exosome protein extraction solution is provided by organically integrating the two functional modules of'mild splitting 'and'synchronous concentration' into a whole. According to the formula of the lysate, exosomes can be mildly and specifically lysed under the condition that the concentration of effective components is extremely high, and the integrity of key membrane proteins such as CD9, CD63 and CD81 is perfectly protected; meanwhile, due to the built-in concentration capacity, a high-concentration protein sample can be obtained without relying on tedious steps such as super-separation in the cracking process. The special high-concentration lysate for exosome protein extraction achieves the effect of improving the efficiency and yield of exosome protein extraction.

The present invention relates to a transition metal dichalcogenide having a heterostructure, a method for manufacturing the same, and a photoelectric device including the same. More specifically, the method for manufacturing a transition metal dichalcogenide having a heterostructure of the present invention can form a uniformly, evenly, and continuously grown transition metal dichalcogenide having a heterostructure through hydrophilic treatment of a substrate, pH control of a transition metal precursor solution, and mixing of sodium cholate. Furthermore, by controlling the concentration of the transition metal precursor, it is possible to manufacture hierarchical transition metal dichalcogenides, which exhibit excellent reproducibility and can be applied to photoelectric devices.

The invention discloses lipid vesicles co-loading salvia miltiorrhiza-radix puerariae effective components, a preparation method and application, and the preparation method comprises the following steps: placing egg yolk lecithin, sodium deoxycholate, radix puerariae isoflavone, tanshinone and salvianolic acid in a round-bottom flask according to a weight ratio of 50: (22-27): 10: (0.3-0.9): 7, then adding methanol for fully dissolving, carrying out rotary evaporation under the conditions of 40 DEG C and 50 rpm / min, filtering, washing, and drying to obtain the lipid vesicles. Removing methanol to obtain a film; performing vacuum drying overnight at room temperature to obtain a dry and transparent film framework; adding ultrapure water into the membrane skeleton, and carrying out hydration treatment to obtain a liposome solution; and filtering the liposome solution with a 0.22 [mu] m cellulose acetate membrane to obtain the liposome. Through multi-component synergistic encapsulation, strong hydrophobic tanshinone is encapsulated in a phospholipid bilayer, weak hydrophobic pueraria isoflavone is distributed on a phospholipid layer or interface, and hydrophilic salvianolic acid is contained in a water phase or interface, so that the stability of a lipid vesicle system is enhanced, and the problem of low bioavailability of a preparation is solved.