25results about How to "Reduce efficacy" patented technology

The invention provides a preparation method and application of magnesium L-threonate, and belongs to the technical field of medicines. The preparation method comprises the following steps: dissolving L-ascorbic acid in water, adding magnesium hydroxide and alkaline magnesium carbonate, stirring, dropwise adding hydrogen peroxide, heating, stirring and reacting, filtering a product, purifying and concentrating by temperature-sensitive molecularly imprinted hydrogel while the product is hot, adding an ethanol water solution into a concentrated solution, standing, crystallizing, filtering, washing and drying to obtain the magnesium L-threonate. And cooling the temperature-sensitive molecularly imprinted hydrogel after adsorption to room temperature, washing and repeatedly using the temperature-sensitive molecularly imprinted hydrogel. The magnesium L-threonate is simple in preparation method, high in purity and high in yield, meanwhile, the slow-release magnesium L-threonate is prepared, and the magnesium L-threonate is low in toxicity, good in biocompatibility, large in drug loading capacity, low in economic cost and good in drug effect and has wide application prospects in preparation of anti-depression drugs.

The invention discloses a novel administration method for eye administration. The novel administration method specifically comprises the following steps: S1, filling a special solution bottle with a drug solution; s2, the solution bottle is aligned with the eyes to be used in the spraying process, medicine fog drops enter the eye liquid medicine bottle to be combined with an atomization device to be used, fine fog-shaped liquid drops are sprayed out through the atomization device, the particle size of the fog drops ranges from 0.1 micrometer to 60 micrometers, and the fog drops reach eyeballs and the peripheries of the eyes; s3, administration is performed in a medicine and mechanical combination mode during use, the medicine solution and the atomization device can be separately produced and prepared, and the medicine solution and the atomization device are combined during use. According to the novel administration method and atomization administration mode for eye administration, the medication treatment effect can be improved, the risk of eye infection caused by drugs is reduced, the discomfort of eyes during medication is improved, and the medication compliance of patients is improved.

The utility model discloses a portable insulin preservation cup which is characterized in that an inner ring is fixedly installed in a cup body, a biological ice bag is arranged between the inner ring and the cup body, a fixing seat is fixedly arranged on the inner wall of the inner ring, and the side, away from the inner ring, of the fixing seat is used for storing insulin; the pressing rod is slidably inserted into the fixing base, telescopic blocks are arranged on the two sides of the pressing rod, and a fixing plate is fixedly installed on the surfaces of the telescopic blocks. The support rod is inserted into one side, far away from the inner ring, of the fixed seat; the fixing plate and the supporting rod are arranged in the cup body, after insulin is placed in the cup body, the insulin is fixed through the fixing plate and the supporting rod, insulin damage caused by shaking in the carrying process is avoided, the biological ice bag is placed between the cup body and the inner ring, a low-temperature storage space is formed in the cup body, and the insulin is stored in the low-temperature storage space. Meanwhile, the insulin injection device is convenient to carry when a patient goes out, and the problem that the insulin cannot be injected in time when the patient goes out is solved.

The invention belongs to the technical field of experimental animal models, biomedical research and immunology, and discloses a photocoagulation thymus ischemia animal model, a method and application of the photocoagulation thymus ischemia animal model in rapid simulation of thymus degeneration and immune senescence, and the model shows at least one or more characteristics 1-7 days after induction: thymus atrophy, thymus weight or thymus index is significantly reduced; the cortical-medullary structure of thymus is disordered or disappears; the expression distribution of the Keratin 5 / Keratin 8 is abnormal; thymic cell apoptosis is increased, and lipid deposition is enhanced; the proportion of CD4 + CD8 + double positive T cells is reduced, and the proportion of DN2 / DN3 stage T cells is increased; the initial T cell output is reduced; and the immune function is reduced. The pathological mechanism is clear; the modeling period is short, and the immune senescence phenotype can be stably obtained within several days; the injury focus is controllable, and systemic stress or hormone interference is avoided; the model has high repeatability and is suitable for mechanism research and drug screening.

The invention relates to a wine stain treatment system based on stain characteristics and dual-wavelength parameter matching, and the system comprises a data collection module which is used for collecting a wine stain region parameter, a patient skin parameter and a historical treatment parameter of a patient; presetting a dual-wavelength wine stain treatment method library; the color spot mapping module is used for extracting color spot characteristic parameters from the wine color spot area parameters and determining adaptive matching values of the color spot characteristic parameters and the dual-wavelength treatment methods so as to construct a characteristic mapping matrix; the matrix optimization and adjustment module is used for extracting a core influence factor and a weighting coefficient from the skin parameters of the patient and carrying out weighting operation and adjustment on the core influence factor and the weighting coefficient and the feature mapping matrix; the treatment method matching module is used for matching with a method library according to the feature mapping matrix; and the color spot treatment module is used for setting a dual-wavelength light source to perform color spot treatment according to the acquired dual-wavelength treatment method. Compared with the prior art, the method has the advantage that the safety and the personalized adaptability of a spot treatment scheme are improved.

The invention relates to the technical field of oil and gas field exploitation, in particular to a clay stabilizer and a preparation method and application thereof.The clay stabilizer is prepared from, by weight, 1-2 parts of a main agent, 0.5-0.8 part of inorganic nanoparticles, 0.3-0.5 part of sodium metaaluminate, 0.05-0.1 part of ammonium chloride and 80-100 parts of water; wherein the main agent is a compound as shown in a formula (I); the inorganic nanoparticles comprise at least one of silicon dioxide and aluminum oxide; the main agent with a specific structure is matched with the inorganic nanoparticles and the sodium metaaluminate, so that the prepared clay stabilizer not only can prevent clay from expanding and resist scouring, but also can improve high temperature resistance, pressure resistance and antibacterial performance, and can play a role in stabilizing the clay in soil with various pH values.

The invention relates to a mucous membrane drug delivery device, and belongs to the field of oral cavity treatment instruments, the mucous membrane drug delivery device comprises a first supporting part, a second supporting part and a fixing part, and the fixing part is fixed in the middle between the first supporting part and the second supporting part; a first groove and a second groove are formed by the two sides of the fixing part, the first supporting part and the second supporting part, a plurality of grooves are formed in the outer wall of the first supporting part, and the purpose of improving the curative effect of medicine on the oral mucosa of the upper lip, the lower lip and the cheek is achieved.

The application discloses a kind of characteristic chromatogram detection methods of Qinggan Jieyu granules. After the solvent and microporous filter membrane treatment of Qinggan Jieyu granules, different batches of test solution are obtained, and the chromatogram of each is obtained by preparing the reference solution; the chromatogram of different batches of test solution and reference solution is combined to obtain the characteristic chromatogram and characteristic chromatographic peak of control, and then the relative retention time of the characteristic chromatographic peak and reference berberine hydrochloride peak solution is used to obtain the relative retention time of the control characteristic chromatogram as the specified value; the chromatogram is obtained by detecting the to-be-tested granules, and S peak correction is carried out, and the detection result is obtained by comparing the specified value of relative retention time. The characteristic chromatogram detection method of Qinggan Jieyu granules established by the application is simple in operation, reliable in result, high in stability and precision, and good in repeatability; the characteristic chromatogram of Qinggan Jieyu granules provided by the application can comprehensively and effectively control the quality of the preparation, and ensure the stability, reliability and safety of the preparation.

The invention discloses a composition capable of promoting hair growth and blackening of white hair and application of the composition. The composition comprises an active component, a composite additive and water, the active components comprise an ammonium acryloyldimethyl taurate / beheneth-25 methacrylate cross-linked polymer, fullerene, cyclodextrin, betaine, tocopheryl acetate and sodium hyaluronate. The composition which can be combined with minoxidil can play a role in synergistically enhancing the hair growth effect; the fullerene composition can repair the activity of damaged hair follicle cells, maintain the normal function of hair follicles, reconstruct microcirculation and repair scalp barriers; minoxidil can expand blood vessels and promote nutrition delivery; the combination of fullerene and fullerene can enhance the transdermal absorption of fullerene, accelerate the effect of fullerene, and accelerate and promote hair growth. Meanwhile, the side effects such as dermatitis, rash or skin irritation of minoxidil on scalp are reduced.

The present invention relates to an osmotic pump controlled-release tablet of an insoluble drug and a preparation method therefor. The osmotic pump controlled-release tablet comprises a tablet core, a semi-permeable membrane coating and a drug-release hole, wherein the tablet core comprises a solid dispersion of the insoluble drug and a penetration enhancer, the solid dispersion of the insoluble drug comprises the insoluble drug and a carrier, the insoluble drug is selected from nicardipine, nifedipine and felodipine and pharmaceutically acceptable salts thereof, and the carrier is selected from organic acids. Compared with the prior art, the drug solubility of the osmotic pump controlled-release tablet of the insoluble drug of the present invention is greatly improved, a large amount of penetration enhancers or other excipients do not need to be used in the tablet core, the drug-loading capacity is improved, and the tablet core is not too large; the degree of release in vivo is greatly improved; and the preparation process is simple, has low requirements for equipment and a low cost, and facilitates industrialized production.

The invention discloses dinotefuran water dispersible granules and a preparation process thereof, and relates to the technical field of medicament production, and the dinotefuran water dispersible granules comprise dinotefuran raw medicine, a dispersing agent, a wetting agent, an auxiliary agent, a cosolvent, a synergist, a binder, a water-based carrier and a filler in a weight ratio of (10-50): (10-20): (1-3): (2-5): (5-10): (1-3): (2-5): (10-30): (1-3). The preparation method of the binder comprises the following steps: reacting hydroxyethyl cellulose with lauryl sodium sulfate at 60-80 DEG C for 2-4 hours to obtain a grafted product; and carrying out a cross-linking reaction on the grafted product and a calcium citrate complex at 60-90 DEG C for 1-3 h, cooling the reaction product to room temperature, and successively carrying out filtration and centrifugation treatment to obtain the binder. The stability and dispersity of the medicament are greatly improved, and the efficacy of the medicament is improved.

The present invention relates to the technical field of production process of traditional Chinese medicine composition, and discloses a stomach-relieving and analgesic composition capsule and a large-scale preparation method thereof, wherein the medicinal raw materials include 80-120 parts of coptis root, 50-70 parts of amomum villosum, 80-120 parts of bupleurum, 80-120 parts of dandelion, 80-120 parts of corydalis, 40-60 parts of evodia rutaecarpa, 80-120 parts of rhubarb, 80-120 parts of costusroot and 25-35 parts of clove. The present invention adopts acidic conditions percolation extraction, cyclodextrin inclusion of volatile oil, alkali precipitation and filtrate drying in sequence, and fills the capsules after mixing the inclusion compound and powder. In the whole process, no large-scale energy consumption is required, which reduces the production cost and greatly improves the production efficiency; it also solves the technical problems of low yield of berberine in the existing extraction of coptis root, and reducing the berberine content in the product and the utilization rate of coptis root due to the compatibility reaction of berberine with other components, effectively improving the content of berberine in the medicine, and improving the quality and efficacy of the medicine.

Disclosed in the present invention are a PARP inhibitor containing a piperazine structure, a preparation method therefor and pharmaceutical use thereof. Particularly, the present invention relates to novel compounds of general formulas (1), (2), (3), (4) and (5) and / or a pharmaceutically acceptable salt thereof, a composition comprising the compounds of general formulas (1), (2), (3), (4) and (5) and / or the pharmaceutically acceptable salt thereof, a preparation method therefor and use thereof as a PARP inhibitor in the preparation of anti-tumor drugs.

The present invention provides a sildenafil citrate orodisintegrating tablet and a preparation method thereof, and belongs to the field of medical technology. Icariin, tribulus saponin and sildenafil citrate are mixed to prepare liposomes, added to a hydrogel prepared from modified maltodextrin and earthworm protein, mixed evenly, dried, ground to obtain a mixed powder, added to an auxiliary material, and tableted to obtain a sildenafil citrate orodisintegrating tablet. The sildenafil citrate orodisintegrating tablet prepared by the present invention adopts a direct tableting method, has a simple preparation method, does not require coating, has good palatability, good stability, good therapeutic effect, has a good sustained-release effect, prolongs the drug effect time, improves the patient's compliance, and has broad application prospects.

The utility model relates to the technical field of acupuncture and moxibustion, in particular to a moxibustion cake preheating storage box. The storage box comprises a storage box body, a jacking assembly and a cover body, the jacking assembly comprises a first spring, a supporting plate, a pair of guide plates, heat insulation heating plates symmetrically arranged on the tops of the opposite faces of the two guide plates, and second springs symmetrically arranged between the two guide plates, wherein the two ends of each second spring are fixed to the corresponding guide plates correspondingly. Elastic steel plates are symmetrically fixed to the ends, arranged outside the storage box body, of the guide plates, elastic clamping blocks are fixed to the ends of the elastic steel plates, and clamping grooves matched with the elastic clamping blocks are formed in the side walls of the penetrating grooves. According to the device, residual moxibustion cakes can automatically ascend so as to be conveniently taken, meanwhile, the moxibustion cakes located at the top can be independently preheated, loss of effective components in the moxibustion cakes at the bottom is reduced, and reduction of the medicine effect of the moxibustion cakes is avoided.

The invention discloses a traditional Chinese medicine composition for treating wind-cold-dampness arthralgia type lumbago and application thereof. The traditional Chinese medicine composition is prepared by extracting the following raw materials in parts by weight: 20 to 40 parts of radix stephaniae tetrandrae, 20 to 40 parts of radix clematidis, 5 to 15 parts of radix angelicae sinensis, 5 to 15 parts of rhizoma chuanxiong, 20 to 40 parts of fructus chaenomelis, 5 to 15 parts of fructus foeniculi, 5 to 15 parts of frankincense, 20 to 40 parts of herba lycopodii, 5 to 15 parts of lignum sappan, 5 to 15 parts of borneol, 5 to 15 parts of menthol and 20 to 40 parts of vaseline. The traditional Chinese medicine composition has the effects of dispelling cold and wind, eliminating dampness, regulating qi and blood, warming and activating meridians and relieving swelling and pain, clinical experiments show that the traditional Chinese medicine composition can obviously improve clinical symptoms of patients with wind-cold-dampness arthralgia type lumbago and has high clinical application value in the aspect of treating wind-cold-dampness arthralgia type lumbago.

The invention discloses an aneurysm virtual stent implantation simulation method based on a spring analogy method. The method comprises the following steps: reconstructing a three-dimensional model of a preoperative tumor-carrying main blood vessel and a mother blood vessel after aneurysm reduction based on clinical imaging data; extracting a first blood vessel center line, and constructing a virtual stent initialization model; expanding the virtual stent initialization model through a spring analogy virtual stent rapid algorithm, and determining a three-dimensional model of the virtual stent after being expanded in the individualized blood vessel; and calculating curative effect evaluation parameters through a rapid algorithm based on the porosity of the tumor neck cambered surface of the virtual stent. According to the method, the real movement form of stent unfolding can be simulated, the simulation calculation time and the curative effect evaluation duration of the stent unfolding in the blood vessel can be shortened in a large scale, and real-time guidance in the aneurysm virtual intervention process is achieved.

The invention belongs to the field of pesticides, and particularly relates to a high-permeability glufosinate-ammonium compounded flumioxazin nano suspending agent and a preparation method thereof, and the suspending agent comprises the following components: 5wt%-10wt% of glufosinate-ammonium and flumioxazin, 2.32 wt%-6.78 wt% of a functional additive, a pH regulator, 3wt%-7wt% of a nano carrier and the balance of water. The preparation method comprises the following steps: stirring a compound solution of glufosinate-ammonium and flumioxazin, loading the compound solution to the nano-porous silicon dioxide, mixing with a functional additive solution by taking water as a solvent, adjusting the pH value, and effectively sanding to prepare the nano-suspending agent. Compared with a common suspending agent, the nano suspending agent has high permeability, the preparation method is simple and efficient, the particle size is as small as nanoscale, the nano suspending agent has high biocompatibility and bioavailability, and druggability, preparation stability, biological activity and the like of pesticide compounds can be improved to a great extent. The lasting action time of the pesticide and the permeability and the adhesiveness of the pesticide on the leaf surfaces of plants are enhanced, so that the use amount of the pesticide is reduced.

The invention discloses a traditional Chinese medicine composition for treating osteoarthritis and application thereof. The ointment is prepared from the following raw materials in parts by weight: 30 parts of rheum officinale, 30 parts of golden cypress, 30 parts of scutellaria baicalensis, 30 parts of coptis chinensis, 30 parts of bletilla striata, 30 parts of ampelopsis japonica, 30 parts of radix angelicae, 30 parts of sophora flavescens, 15 parts of frankincense, 15 parts of myrrh and 100 parts of sesame oil. The traditional Chinese medicine composition can regulate qi and blood, dredge meridians and collaterals, promote blood circulation to remove blood stasis, clear heat and dry dampness, reduce swelling and promote tissue regeneration to relieve pain, is suitable for patients with qi stagnation and blood stasis syndrome type osteoarthritis caused by trauma or damp-heat, is especially suitable for patients who repeatedly attack for a long time and are difficult to radically cure, and has high clinical application value in the aspect of osteoarthritis treatment.

This invention provides a method for preparing Astragalus colloidal phase, comprising the following steps: Preparing Astragalus decoction: Astragalus slices are extracted by reflux with water, filtered, and concentrated to obtain a standard Astragalus decoction; Phase separation: The standard Astragalus decoction is subjected to differential centrifugation and dialysis to obtain multiple physical phases, including a precipitate phase, a suspension phase, and a colloidal phase; Screening of active phases: The efficacy of each phase is evaluated using a renal edema model, and the phase with significant diuretic and anti-edema activity is selected as the Astragalus colloidal phase. The prepared Astragalus colloidal phase is a brownish-yellow transparent system with a particle size of 88.928 ± 0.683 nm and a PDI of 0.3516 ± 0.0162; the microstructure consists of spherical aggregates with a particle size distribution range of 30-200 nm; the yield is 23%. The colloidal phase of Astragalus membranaceus of this invention has nephroprotective and diuretic effects, and can be used in the preparation of drugs for treating renal edema. It provides a new and highly effective drug option for the treatment of related clinical diseases and the development of a new generation of innovative traditional Chinese medicine drugs for treating renal edema.

The application discloses the field of tree maintenance device, a walnut tree disease treatment injection device, including box, the outer top wall of box is fixedly connected with the hook, the inner top wall of box is fixedly connected with the collector, the side fixedly connected with the power supply of collector away from the hook, the side fixedly connected with the singlechip of power supply away from the collector, the side fixedly connected with the injection assembly of the inner wall of box away from the power supply, the bottom of box is communicated with injection port, injection port is located in the injection assembly near the power supply below, the end communicated with infusion tube of injection port away from the power supply, the end communicated with injection head of infusion tube away from injection port. The device has simple structure, is suitable for a variety of trees, according to the periodic occurrence of disease, can automatically implement drug quantitative delivery according to the number of disease occurrence without manual intervention, also can reduce the possibility of drug mixing, ensure that the drug efficacy of each time drug liquid delivery is not affected.

The present application relates to a kind of wine stain treatment systems based on the matching of stain feature and double wavelength parameters, comprising: data acquisition module, for collecting the parameters of patient's wine stain area, patient skin parameters and historical treatment parameters;Pre-set double wavelength treatment wine stain method library;Stain mapping module, for extracting stain feature parameters from wine stain area parameters, determine the matching value of stain feature parameters and each double wavelength treatment method, to construct feature mapping matrix;Matrix optimization adjustment module, for extracting core influencing factors and weighting coefficient from patient skin parameters, and with feature mapping matrix Weighted operation and adjustment;Treatment method matching module, for matching according to feature mapping matrix and method library;Stain treatment module, for setting double wavelength light source according to the double wavelength treatment method obtained, carries out stain treatment.Compared with prior art, the safety and individual adaptation degree of stain treatment scheme are improved.

This invention discloses a bloodletting pen, comprising an outer cylinder with a top plate connected to its top. A linear drive mechanism is mounted on the bottom wall of the top plate. A power transmission mechanism and a rotating plate are disposed inside the outer cylinder. A plurality of bloodletting needles are disposed on the bottom wall of the rotating plate. When the output end of the linear drive mechanism moves downward, it has two strokes. The first downward stroke drives the rotating plate to rotate via the power transmission mechanism, and the second downward stroke drives the rotating plate to move downward via the power transmission mechanism. When the output end of the linear drive mechanism moves upward back to its original position, the rotating plate returns to its initial height during the first upward stroke and remains fixed during the second upward stroke. This device can achieve automatic rotation and repositioning and controllable puncture depth, improving the operational efficiency and treatment consistency of bloodletting at multiple locations.

The invention provides a pericarpium citri reticulatae traditional Chinese medicine formula granular preparation and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine granular preparations. The preparation method comprises the following steps: preparing modified porous starch; preparing secondary modified porous starch; preparing first mixed powder; preparing composite medicine carrying powder; and preparing the traditional Chinese medicine granular preparation. The preparation method comprises the following steps: dissolving chitosan in an acetic acid solution, mixing the solution with an aqueous suspension of porous starch, adding citric acid, carrying out a cross-linking modification reaction to form modified porous starch with a stable three-dimensional network structure, and carrying out secondary modification on the modified porous starch by using octenyl succinic anhydride so as to obtain the modified porous starch with a stable three-dimensional network structure. After water-soluble components and indissolvable components in the traditional Chinese medicine raw materials are respectively loaded by utilizing the secondary modified porous starch, the water solubility of the indissolvable components can be effectively improved, and the bioavailability of the traditional Chinese medicine raw materials is further improved.

The invention discloses a drip irrigation device for soybean cultivation in saline-alkali soil and a use method thereof, belongs to the field of drip irrigation devices, and can solve the problems that an existing drip irrigation device is simple in structure and can only conduct earth surface drip irrigation, earth surface drip irrigation liquid permeates into soil slightly, and soybeans cannot fully absorb nutrients effectively in the prior art. And the existing underground drip irrigation device is easily blocked by soil. The method comprises the steps that S1, a water pipe fixedly communicates with the open end of a water inlet pipe, and water flows into a water tank to be stored after being filtered through a filter screen; s2, an electric telescopic rod is powered on and extends to adjust the distance between the multiple piercing units; s3, piercing a piercing column into the soil, and rotating a spraying pipe orifice to enable a spraying hole to coincide with a piercing column hole; and S4, electrifying the water pump for drip irrigation.