7results about How to "Reduce efficacy" patented technology

The invention belongs to the technical field of experimental animal models, biomedical research and immunology, and discloses a photocoagulation thymus ischemia animal model, a method and application of the photocoagulation thymus ischemia animal model in rapid simulation of thymus degeneration and immune senescence, and the model shows at least one or more characteristics 1-7 days after induction: thymus atrophy, thymus weight or thymus index is significantly reduced; the cortical-medullary structure of thymus is disordered or disappears; the expression distribution of the Keratin 5 / Keratin 8 is abnormal; thymic cell apoptosis is increased, and lipid deposition is enhanced; the proportion of CD4 + CD8 + double positive T cells is reduced, and the proportion of DN2 / DN3 stage T cells is increased; the initial T cell output is reduced; and the immune function is reduced. The pathological mechanism is clear; the modeling period is short, and the immune senescence phenotype can be stably obtained within several days; the injury focus is controllable, and systemic stress or hormone interference is avoided; the model has high repeatability and is suitable for mechanism research and drug screening.

The invention relates to a wine stain treatment system based on stain characteristics and dual-wavelength parameter matching, and the system comprises a data collection module which is used for collecting a wine stain region parameter, a patient skin parameter and a historical treatment parameter of a patient; presetting a dual-wavelength wine stain treatment method library; the color spot mapping module is used for extracting color spot characteristic parameters from the wine color spot area parameters and determining adaptive matching values of the color spot characteristic parameters and the dual-wavelength treatment methods so as to construct a characteristic mapping matrix; the matrix optimization and adjustment module is used for extracting a core influence factor and a weighting coefficient from the skin parameters of the patient and carrying out weighting operation and adjustment on the core influence factor and the weighting coefficient and the feature mapping matrix; the treatment method matching module is used for matching with a method library according to the feature mapping matrix; and the color spot treatment module is used for setting a dual-wavelength light source to perform color spot treatment according to the acquired dual-wavelength treatment method. Compared with the prior art, the method has the advantage that the safety and the personalized adaptability of a spot treatment scheme are improved.

The application discloses a kind of characteristic chromatogram detection methods of Qinggan Jieyu granules. After the solvent and microporous filter membrane treatment of Qinggan Jieyu granules, different batches of test solution are obtained, and the chromatogram of each is obtained by preparing the reference solution; the chromatogram of different batches of test solution and reference solution is combined to obtain the characteristic chromatogram and characteristic chromatographic peak of control, and then the relative retention time of the characteristic chromatographic peak and reference berberine hydrochloride peak solution is used to obtain the relative retention time of the control characteristic chromatogram as the specified value; the chromatogram is obtained by detecting the to-be-tested granules, and S peak correction is carried out, and the detection result is obtained by comparing the specified value of relative retention time. The characteristic chromatogram detection method of Qinggan Jieyu granules established by the application is simple in operation, reliable in result, high in stability and precision, and good in repeatability; the characteristic chromatogram of Qinggan Jieyu granules provided by the application can comprehensively and effectively control the quality of the preparation, and ensure the stability, reliability and safety of the preparation.

This invention provides a method for preparing Astragalus colloidal phase, comprising the following steps: Preparing Astragalus decoction: Astragalus slices are extracted by reflux with water, filtered, and concentrated to obtain a standard Astragalus decoction; Phase separation: The standard Astragalus decoction is subjected to differential centrifugation and dialysis to obtain multiple physical phases, including a precipitate phase, a suspension phase, and a colloidal phase; Screening of active phases: The efficacy of each phase is evaluated using a renal edema model, and the phase with significant diuretic and anti-edema activity is selected as the Astragalus colloidal phase. The prepared Astragalus colloidal phase is a brownish-yellow transparent system with a particle size of 88.928 ± 0.683 nm and a PDI of 0.3516 ± 0.0162; the microstructure consists of spherical aggregates with a particle size distribution range of 30-200 nm; the yield is 23%. The colloidal phase of Astragalus membranaceus of this invention has nephroprotective and diuretic effects, and can be used in the preparation of drugs for treating renal edema. It provides a new and highly effective drug option for the treatment of related clinical diseases and the development of a new generation of innovative traditional Chinese medicine drugs for treating renal edema.

The application discloses the field of tree maintenance device, a walnut tree disease treatment injection device, including box, the outer top wall of box is fixedly connected with the hook, the inner top wall of box is fixedly connected with the collector, the side fixedly connected with the power supply of collector away from the hook, the side fixedly connected with the singlechip of power supply away from the collector, the side fixedly connected with the injection assembly of the inner wall of box away from the power supply, the bottom of box is communicated with injection port, injection port is located in the injection assembly near the power supply below, the end communicated with infusion tube of injection port away from the power supply, the end communicated with injection head of infusion tube away from injection port. The device has simple structure, is suitable for a variety of trees, according to the periodic occurrence of disease, can automatically implement drug quantitative delivery according to the number of disease occurrence without manual intervention, also can reduce the possibility of drug mixing, ensure that the drug efficacy of each time drug liquid delivery is not affected.

The present application relates to a kind of wine stain treatment systems based on the matching of stain feature and double wavelength parameters, comprising: data acquisition module, for collecting the parameters of patient's wine stain area, patient skin parameters and historical treatment parameters;Pre-set double wavelength treatment wine stain method library;Stain mapping module, for extracting stain feature parameters from wine stain area parameters, determine the matching value of stain feature parameters and each double wavelength treatment method, to construct feature mapping matrix;Matrix optimization adjustment module, for extracting core influencing factors and weighting coefficient from patient skin parameters, and with feature mapping matrix Weighted operation and adjustment;Treatment method matching module, for matching according to feature mapping matrix and method library;Stain treatment module, for setting double wavelength light source according to the double wavelength treatment method obtained, carries out stain treatment.Compared with prior art, the safety and individual adaptation degree of stain treatment scheme are improved.

This invention discloses a bloodletting pen, comprising an outer cylinder with a top plate connected to its top. A linear drive mechanism is mounted on the bottom wall of the top plate. A power transmission mechanism and a rotating plate are disposed inside the outer cylinder. A plurality of bloodletting needles are disposed on the bottom wall of the rotating plate. When the output end of the linear drive mechanism moves downward, it has two strokes. The first downward stroke drives the rotating plate to rotate via the power transmission mechanism, and the second downward stroke drives the rotating plate to move downward via the power transmission mechanism. When the output end of the linear drive mechanism moves upward back to its original position, the rotating plate returns to its initial height during the first upward stroke and remains fixed during the second upward stroke. This device can achieve automatic rotation and repositioning and controllable puncture depth, improving the operational efficiency and treatment consistency of bloodletting at multiple locations.