The invention discloses mulberry blueberry wine and a production process thereof, and belongs to the technical field of food processing. Mulberry fruits and blueberries are taken as main raw materials, and the mulberry blueberry wine is made after washing, stalk removal, crushing, enzymolysis, fermentation, aging, clarification, filtration, cold treatment, sterilization, microfiltration, filling and packaging. The obtained mulberry blueberry wine is transparent, good in color, flavor and taste, typical and outstanding in flavor, clear in wine color, soft in taste, slightly sweet in your mouth,mellow in taste, fragrant in smell and lasting in aftertaste. The mulberry blueberry wine has effects of improving eyesight, tonifying the kidney, nourishing yin and moisturizing the lung, nourishingthe stomach and engendering liquid and enhancing the body immunity, the effect of benefitting by a small amount of drinking is achieved, and the mulberry blueberry wine has good industrialization prospects.