50 results about "Preservative free" patented technology

The invention provides a diphenhydramine hydrochloride injection and a preparation method thereof. According to the preparation method, the diphenhydramine hydrochloride injection with stable pH value, stable chemical property and sterility assurance level SAL less than or equal to 10 <-6 > can be obtained by controlling the material of a liquid medicine pipeline and the water resistance of a medium borosilicate glass ampoule. The diphenhydramine hydrochloride injection does not contain preservatives and cannot generate safety risks.

The invention relates to the technical field of protein cosmetics, in particular to human albumin antioxidant essence and a preparation method thereof. The human albumin antioxidant essence is prepared from the following components in parts by mass: 5 to 35 parts of human albumin; 10 to 25 parts of a ginseng extract; 0.2 to 0.8 part of a humectant; 0.01 to 0.1 part of a solubilizer; 0.2-1 part of fatty acid; 0.2 to 2 parts of amino acid; and the balance of deionized water. The human albumin anti-oxidation essence provided by the invention adopts the human albumin and the ginseng extract as active ingredients, has good biocompatibility and effectiveness, and has important significance on skin oxidation resistance and skin improvement.

The present invention relates to a pharmaceutical compositions comprising human insulin that are preservative free, sterile, and stable for prolonged shelf-life for the treatment of refractory neurotrophic corneal ulcers.

The invention discloses a nasal cavity soft mist drug delivery device and method and application, and relates to the technical field of drug delivery, and the device comprises a drug delivery main body and a mist spray adapter. The method comprises the following steps: assembling the administration main body and the spray adapter; placing the assembled device horizontally or upside down, and inserting the top end of the spray adapter into the nasal cavity; a cavity filled with air is formed in the extrusion horizontal or inverted administration body, medicine generates soft mist through a micropore chip arranged in the spray adapter, and the soft mist enters the nasal cavity to be delivered and administered. The nasal cavity soft fog administration device can be applied to rhinitis, allergy, vomiting and nervous centralis related indications. According to the invention, a preservative-free single-dose sterile solution or suspension produced by blowing, filling and sealing can be efficiently and quickly atomized into soft fog moving slowly, and atomized liquid drops are small in particle size and uniform in distribution, and can be more diffused and deposited in all intranasal areas.

The invention relates to an exosome composition, application thereof and exosome eye drops, and relates to the technical field of pharmaceutical preparations, and the exosome composition is composed of a mesenchymal stem cell exosome and a rabdosia lingua extract in a weight ratio of (5-10): (13-21). The exosome composition is composed of the mesenchymal stem cell exosome and the rabdosia lophanthoides extract in a proper proportion, and the mesenchymal stem cell exosome and the rabdosia lophanthoides extract are matched for use, so that the exosome composition has an excellent treatment effect on cataract and can be applied to preparation of products such as eye drops and the like, and a new treatment means is provided for cataract patients. In addition, the exosome eye drops provided by the invention do not contain side-effect components such as preservatives and hormones, have no obvious irritation and can be used for a long time.

Preservative-free compositions comprising a complex of a corticosteroid and HPBCD for the treatment or prevention of an inflammatory disease through nasal administration.

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.

Provided herein are certain preservative-free ophthalmic formulations for post-operative ocular care. Pharmaceutical compositions, methods for treating various issues of the eyes, and methods of preparing such compositions are described. These pharmaceutical compositions may be for treating glaucoma, in preparation of eye surgery, during eye surgery, various post-op care (e.g., after cataract surgery, laser eye surgery, and the like), for treating dry eyes, and / or for promoting eyelash growth. These pharmaceutical compositions may comprise such active ingredients (APIs) as: timolol, latanoprost, brimonidine tartrate, dorzolamide, moxifloxacin HCl, dexamethasone PO4, phenylephrine HCl, lidocaine HCl, ketorolac tromethamine, bromfenac, prednisolone PO4, gatifloxacin, amniotic cytokine extract (ACE), prostaglandin E2 (PGE2), and combinations thereof.

The present invention relates to ophthalmic compositions containing tramadol or a salt thereof and substantially free of preservatives.

A method for making a pre-packaged single-use on-demand beauty care product comprises providing a beverage filter cartridge containing a dry ingredient mixture, inserting it into a single serve beverage brewer, introducing water, brewing to produce a liquid beauty care product, and dispensing into a collection container. The dry ingredient mixture may include natural ingredients like rice, herbs, and botanicals. The beverage filter cartridge has a higher micron filter than standard paper filters. The brewer may be a Keurig or Nespresso machine, with cartridges compatible with various pod systems. The method allows for convenient production of fresh, preservative-free beauty formulations using existing beverage brewing equipment. Benefits include customization, quality control, and on-demand preparation. The liquid product can be applied to hair and scalp for cleansing, nourishing and moisturizing effects. Overall, the invention provides a novel approach to natural beauty care combining convenience and effectiveness.

The invention provides a functional monomer as shown in a formula (I), a preparation method thereof, gel prepared from the functional monomer as a raw material, a gel dressing and application of the gel dressing. According to the invention, polyvinyl alcohol, polyglutamic acid and acrylic acid are taken as gel raw materials, sodium chloride is taken as an effective component, an initiator and a cross-linking agent are added, a disulfide bond-containing compound as shown in the formula (I) is grafted, an interpenetrating gel network is formed, and the prepared gel dressing can be quickly attached to the skin and can also be easily and thoroughly removed from the surface of the skin. The gel dressing solves the problem of poor compliance of a patient, is adhered to an affected part of verruca vulgaris during use, is simple and convenient, does not contain preservatives, has no toxic or side effect on a human body, and is safe and reliable. Experimental results show that the gel dressing provided by the invention can be quickly attached to the skin and form stable adhesion, and after wart disappears, the gel dressing can be easily and thoroughly separated from the skin under the action of sodium bicarbonate and glutathione. # imgabs0 #

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed. The fluid package can be made collapsible to remove the need to vent it.

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid in the fluid package and supplying the liquid to the dispensing system. The dispensing system includes an elongated chamber including a check valve defining an anterior closure of the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibrating motor that causes oscillation of the chamber and the fluid within the chamber. The oscillation of the chamber imparts momentum to the fluid stored in the chamber, which in turn imparts force to cyclically open the valve to dispense a stream or liquid droplets. Fluid is only dispensed when the motor is oscillating, otherwise the valve is hermetically closed.

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.

The invention discloses moisturizing and anti-aging soft mask powder and a preparation and use method thereof, sodium alginate, calcium sulfate and hydroxypropyl methyl cellulose synergistically construct a stable film-forming system, and the stable film-forming system is compounded with an opuntia ficus-indica fruit extract, low-molecular sodium hyaluronate and panthenol to form a long-acting moisturizing network; meanwhile, multiple anti-aging active matters such as oligopeptide and roselle flower extract are integrated. The soft mask powder has the characteristics of rapid and smooth film formation, excellent moisturizing performance and remarkable anti-oxidation and anti-aging effects, does not contain preservatives, artificial pigments and spices, is safe and mild, and is suitable for professional nursing and daily anti-aging and moisturizing.

A preservative-free contact lens treating solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers.

The application discloses a nasal cavity soft mist drug delivery device, method and application, relates to the technical field of drug delivery, and comprises a drug delivery main body and a spray adapter. The method comprises the following steps: assembling the drug delivery main body and the spray adapter; placing or inverting the assembled device, and inserting the top end of the spray adapter into the nasal cavity; and extruding the cavity filled with air of the drug delivery main body, so that the drug generates soft mist through a micropore chip built in the spray adapter, and the soft mist enters the nasal cavity to deliver the drug. The nasal cavity soft mist drug delivery device can be applied to rhinitis, allergy, vomiting and central nervous system related indications. The single-dose sterile solution or suspension liquid without preservatives produced through blowing, filling and sealing can be efficiently and rapidly atomized into slow-moving soft mist, the atomized liquid droplets are small in size and uniform in distribution, and can be diffused and deposited in all intranasal regions.

The invention relates to extremely mild, concentrated cleansing compositions to create personal care formulations. The mildness of composition towards the skin is due to the synergy of constituent members. More specifically, the compositions comprise of cocamidopropyl PG dimonium chloride phosphate, an alkyl polyglucoside, and sophorolipids to give the superlative performance in terms of foam and lather with extreme gentleness towards the stratum corneum, the uppermost layer of the skin. The concentrated, self-preserving, ultra-mild compositions of the present invention are particularly suitable for cleansing of sensitive skin (babies and sensitive body parts), irritated skin (medically compromised) and very dry skin (senior citizens). Also process for preparing such ultra-mild cleansing composition is provided.

The application discloses an auxiliary medical eye-care liquid with rehabilitation, health care, cleaning, moistening, nutrition and water base of snow water and a preparation method thereof. Traditional water-containing eye products such as eye lotion (eye drops) contain water ingredients, and the water ingredients are not obtained by adding natural snow water in December. The application adopts a mode of replacing the water ingredients in the original eye products such as eye lotion (eye drops) with natural snow water to realize the application. The natural snow water eye-care liquid of the application contains natural snow water and other ingredients in the original traditional products except the water ingredients. The preparation process is the same as that of the original eye products such as eye lotion (eye drops). The application has the advantages that the eye products such as eye lotion (eye drops) do not contain preservatives and have less deuterium elements.

The present invention discloses an aclidinium bromide inhalation lyophilized agent and a preparation method thereof. The present invention provides an aclidinium bromide lyophilized agent, comprising an active ingredient aclidinium bromide, a pH buffer solution, and an osmotic pressure regulator; and also provides a preparation method of the lyophilized agent. The aclidinium bromide lyophilized agent provided by the present invention does not contain a preservative, has good stability, reliable quality, and good safety. The preparation method of the present invention solves the problem that the powder inhalation dosage form is not suitable for infants and young children who do not have the ability of autonomous inhalation and patients with active breathing difficulties. The preparation method of the aclidinium bromide lyophilized agent is simple to operate and easy to industrialize.

The present disclosure provides a composition comprising temozolomide or lenalidomide, a medium chain triglyceride such as miglyol, silicon dioxide and a surfactant, wherein the composition optionally comprises an antioxidant and / or a flavoring agent, and wherein the temozolomide composition is a non-aqueous, preservative free suspension. Also provided is a method for treating cancer in a subject, such as a child or a subject suffering dysphagia and / or has difficulty swallowing.

The invention belongs to the technical field of food processing, and particularly relates to medicinal and edible plant powder suckable jelly and a preparation method thereof. The absorbable jelly with the medicinal and edible plant powder is prepared from the following raw material components in percentage by mass: 3 to 5 percent of medicinal and edible plant powder, 0.1 to 0.2 percent of carrageenan, 0.2 to 0.4 percent of konjaku flour, 0.1 to 0.2 percent of low-ester pectin, 0.05 to 0.1 percent of acidulant, 2 to 4 percent of pericarp powder, 5 to 8 percent of sugar and the balance of water. According to the invention, the fruit peel and the medicinal and edible plant powder are used as the base material, and the added fruit peel powder has the health-care effects of tonifying spleen, promoting appetite, replenishing qi and enriching blood, so that the problems that the existing jelly is rich in additives, starch jelly is poor in sucking property and the like are solved. In addition, the preparation process is simple, the raw materials are cheap and easy to obtain, preservatives are not contained, the food safety is improved, and the production cost is reduced.

The present invention discloses a preservative-free cleaning composition comprising: 20 to 70 wt% of an amphoteric surfactant, the amphoteric surfactant being a combination of an amphoteric acetate-based surfactant and a betaine-based surfactant; 5 to 25% by weight of 1, 3-butanediol; and a carrier acceptable in the personal care field. The invention provides an antiseptic-free cleaning system compounded by 1, 3-butanediol and an ampholytic surfactant, and can solve the problems of poor antiseptic effect, high antiseptic cost, limited antiseptic selection and the like of a cleaning system product.

Increasing concerns about cytotoxicity caused by traditional ophthalmic product preservatives have driven demand for preservative-free solutions while challenging manufacturers to maintain sterility and safety standards. Inherent user risks have been combined with random manufacturing contamination, resulting in devastating product recalls in recent years. The present invention is a bioactive, affinity filtration system for medical dispensing devices engineered to remove preservatives and contaminants from ophthalmic and other medical solutions when administered. This “just in time” filtration enables manufacturers to follow established preservative practices to ensure safety while delivering a “preservative free” solution upon administration. Without altering the therapeutic formulation, the invention combines adsorption and absorption filtration mechanisms with engineered fullerene derivatives and cellulose acetate membranes to remove preservatives like benzalkonium chloride, thimerosal, and stabilized oxychloro complexes. The invention is designed for integration into established manufacturing, packaging, and stability quality control protocols consistent with the most rigorous antimicrobial patient safety standards.

The present invention belongs to the technical field of lubricating materials, and specifically relates to a human body lubricating liquid and a preparation method and application thereof. The raw materials of the human body lubricating liquid include: compound polyol, hyaluronate, konjac glucomannan, chitosan quaternary ammonium salt, xanthan gum, pH regulator and water. The lubricating liquid of the present invention has excellent and lasting lubricating effect, does not contain preservatives, has good antibacterial and mildew-proof properties, is easy to clean, has excellent biocompatibility with human skin, and does not cause allergies, irritation and other uncomfortable effects.

This disclosure relates, in general, to ophthalmic compositions and multi-dose systems for topically applying the compositions to a surface, for example, the ocular surface. The multi-dose systems of this disclosure may include a multi-dose preservative-free (MDPF) eye drop bottle system and an ophthalmic composition having a therapeutic agent, a viscosity modifier having a concentration of about 0.01% w / v to about 5% w / v, and a surfactant having a concentration of about 0.005% w / v to about 7% w / v, wherein the composition is preservative-free.

Provided are topically administered pharmaceutical compositions for the treatment of fungal infected eye and ear diseases, such as fungal keratitis, otitis externa or otitis media caused by fungal infection, and methods of making the same. The pharmaceutical composition comprises a triazole antifungal agent as an active ingredient, a non-aqueous solvent and an optional tension regulator, and can be a non-aqueous composition without preservatives. The non-aqueous composition has one or more of the following advantages: the non-aqueous composition is high in stability, free of preservatives and low in irritation, the concentration of antifungal drugs in local tissues is increased, the toxic and side effects of the whole body are reduced, the residence time of the antifungal drugs in the local tissues is prolonged, the administration frequency is reduced, and the compliance of patients is improved.

The present application relates to the technical field of medicine, provide a kind of for eye surgery anesthesia and disinfection ophthalmic composition and its preparation method and application.The ophthalmic composition includes: disinfectant, local anesthetic, pH adjusting agent and water for injection, without preservative;The disinfectant is selected from povidone-iodine, and the local anesthetic is selected from one or more of tetracaine hydrochloride and oxybuprocaine hydrochloride.In the ophthalmic composition of the application, by povidone-iodine, tetracaine hydrochloride and oxybucaine hydrochloride concentration, pH control and stabilizer screening, the stability of the coexistence system is improved, and anesthesia and disinfection in ophthalmic clinical operation have important contribution.

The present disclosure encompasses methods and compositions for extended-release formulations for treating ophthalmic conditions. These formulations comprise a pharmaceutical agent, a cationic polymer, a non-ionic polymer, and a pharmaceutical carrier and are essentially preservative free. The formulations provided herein are particularly useful for sustained and controlled release of drugs and have low side effects.

The invention relates to the technical field of cosmetics, and particularly discloses an aerosol type moisturizer without preservative components and a preparation process of the aerosol type moisturizer. The invention relates to an aerosol type moisturizer without preservative components, which is prepared from the following raw materials in percentage by mass: 0.35 to 0.63 percent of moisturizing composition, 0.05 to 0.1 percent of ergothioneine embedded particles, 0.05 to 0.3 percent of rutin components, 0.1 to 0.3 percent of prebiotics, 0.8 to 1.2 percent of propellants and the balance of water. The anti-corrosion component-free aerosol type moisturizing water does not contain preservatives, is relatively high in safety, is friendly to sensitive skin, can efficiently replenish water, moisturize and relieve skin, has the effects of resisting radiation oxidation and preventing blue light, and can meet the daily skin care management requirements of office workers.