26 results about "Preservative free" patented technology

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.

A method for making a pre-packaged single-use on-demand beauty care product comprises providing a beverage filter cartridge containing a dry ingredient mixture, inserting it into a single serve beverage brewer, introducing water, brewing to produce a liquid beauty care product, and dispensing into a collection container. The dry ingredient mixture may include natural ingredients like rice, herbs, and botanicals. The beverage filter cartridge has a higher micron filter than standard paper filters. The brewer may be a Keurig or Nespresso machine, with cartridges compatible with various pod systems. The method allows for convenient production of fresh, preservative-free beauty formulations using existing beverage brewing equipment. Benefits include customization, quality control, and on-demand preparation. The liquid product can be applied to hair and scalp for cleansing, nourishing and moisturizing effects. Overall, the invention provides a novel approach to natural beauty care combining convenience and effectiveness.

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed. The fluid package can be made collapsible to remove the need to vent it.

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid in the fluid package and supplying the liquid to the dispensing system. The dispensing system includes an elongated chamber including a check valve defining an anterior closure of the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibrating motor that causes oscillation of the chamber and the fluid within the chamber. The oscillation of the chamber imparts momentum to the fluid stored in the chamber, which in turn imparts force to cyclically open the valve to dispense a stream or liquid droplets. Fluid is only dispensed when the motor is oscillating, otherwise the valve is hermetically closed.

The invention discloses moisturizing and anti-aging soft mask powder and a preparation and use method thereof, sodium alginate, calcium sulfate and hydroxypropyl methyl cellulose synergistically construct a stable film-forming system, and the stable film-forming system is compounded with an opuntia ficus-indica fruit extract, low-molecular sodium hyaluronate and panthenol to form a long-acting moisturizing network; meanwhile, multiple anti-aging active matters such as oligopeptide and roselle flower extract are integrated. The soft mask powder has the characteristics of rapid and smooth film formation, excellent moisturizing performance and remarkable anti-oxidation and anti-aging effects, does not contain preservatives, artificial pigments and spices, is safe and mild, and is suitable for professional nursing and daily anti-aging and moisturizing.

The application discloses a nasal cavity soft mist drug delivery device, method and application, relates to the technical field of drug delivery, and comprises a drug delivery main body and a spray adapter. The method comprises the following steps: assembling the drug delivery main body and the spray adapter; placing or inverting the assembled device, and inserting the top end of the spray adapter into the nasal cavity; and extruding the cavity filled with air of the drug delivery main body, so that the drug generates soft mist through a micropore chip built in the spray adapter, and the soft mist enters the nasal cavity to deliver the drug. The nasal cavity soft mist drug delivery device can be applied to rhinitis, allergy, vomiting and central nervous system related indications. The single-dose sterile solution or suspension liquid without preservatives produced through blowing, filling and sealing can be efficiently and rapidly atomized into slow-moving soft mist, the atomized liquid droplets are small in size and uniform in distribution, and can be diffused and deposited in all intranasal regions.

The invention relates to extremely mild, concentrated cleansing compositions to create personal care formulations. The mildness of composition towards the skin is due to the synergy of constituent members. More specifically, the compositions comprise of cocamidopropyl PG dimonium chloride phosphate, an alkyl polyglucoside, and sophorolipids to give the superlative performance in terms of foam and lather with extreme gentleness towards the stratum corneum, the uppermost layer of the skin. The concentrated, self-preserving, ultra-mild compositions of the present invention are particularly suitable for cleansing of sensitive skin (babies and sensitive body parts), irritated skin (medically compromised) and very dry skin (senior citizens). Also process for preparing such ultra-mild cleansing composition is provided.

The application discloses an auxiliary medical eye-care liquid with rehabilitation, health care, cleaning, moistening, nutrition and water base of snow water and a preparation method thereof. Traditional water-containing eye products such as eye lotion (eye drops) contain water ingredients, and the water ingredients are not obtained by adding natural snow water in December. The application adopts a mode of replacing the water ingredients in the original eye products such as eye lotion (eye drops) with natural snow water to realize the application. The natural snow water eye-care liquid of the application contains natural snow water and other ingredients in the original traditional products except the water ingredients. The preparation process is the same as that of the original eye products such as eye lotion (eye drops). The application has the advantages that the eye products such as eye lotion (eye drops) do not contain preservatives and have less deuterium elements.

The invention belongs to the technical field of food processing, and particularly relates to medicinal and edible plant powder suckable jelly and a preparation method thereof. The absorbable jelly with the medicinal and edible plant powder is prepared from the following raw material components in percentage by mass: 3 to 5 percent of medicinal and edible plant powder, 0.1 to 0.2 percent of carrageenan, 0.2 to 0.4 percent of konjaku flour, 0.1 to 0.2 percent of low-ester pectin, 0.05 to 0.1 percent of acidulant, 2 to 4 percent of pericarp powder, 5 to 8 percent of sugar and the balance of water. According to the invention, the fruit peel and the medicinal and edible plant powder are used as the base material, and the added fruit peel powder has the health-care effects of tonifying spleen, promoting appetite, replenishing qi and enriching blood, so that the problems that the existing jelly is rich in additives, starch jelly is poor in sucking property and the like are solved. In addition, the preparation process is simple, the raw materials are cheap and easy to obtain, preservatives are not contained, the food safety is improved, and the production cost is reduced.

Increasing concerns about cytotoxicity caused by traditional ophthalmic product preservatives have driven demand for preservative-free solutions while challenging manufacturers to maintain sterility and safety standards. Inherent user risks have been combined with random manufacturing contamination, resulting in devastating product recalls in recent years. The present invention is a bioactive, affinity filtration system for medical dispensing devices engineered to remove preservatives and contaminants from ophthalmic and other medical solutions when administered. This “just in time” filtration enables manufacturers to follow established preservative practices to ensure safety while delivering a “preservative free” solution upon administration. Without altering the therapeutic formulation, the invention combines adsorption and absorption filtration mechanisms with engineered fullerene derivatives and cellulose acetate membranes to remove preservatives like benzalkonium chloride, thimerosal, and stabilized oxychloro complexes. The invention is designed for integration into established manufacturing, packaging, and stability quality control protocols consistent with the most rigorous antimicrobial patient safety standards.

This disclosure relates, in general, to ophthalmic compositions and multi-dose systems for topically applying the compositions to a surface, for example, the ocular surface. The multi-dose systems of this disclosure may include a multi-dose preservative-free (MDPF) eye drop bottle system and an ophthalmic composition having a therapeutic agent, a viscosity modifier having a concentration of about 0.01% w / v to about 5% w / v, and a surfactant having a concentration of about 0.005% w / v to about 7% w / v, wherein the composition is preservative-free.

Provided are topically administered pharmaceutical compositions for the treatment of fungal infected eye and ear diseases, such as fungal keratitis, otitis externa or otitis media caused by fungal infection, and methods of making the same. The pharmaceutical composition comprises a triazole antifungal agent as an active ingredient, a non-aqueous solvent and an optional tension regulator, and can be a non-aqueous composition without preservatives. The non-aqueous composition has one or more of the following advantages: the non-aqueous composition is high in stability, free of preservatives and low in irritation, the concentration of antifungal drugs in local tissues is increased, the toxic and side effects of the whole body are reduced, the residence time of the antifungal drugs in the local tissues is prolonged, the administration frequency is reduced, and the compliance of patients is improved.

The present application relates to the technical field of medicine, provide a kind of for eye surgery anesthesia and disinfection ophthalmic composition and its preparation method and application.The ophthalmic composition includes: disinfectant, local anesthetic, pH adjusting agent and water for injection, without preservative;The disinfectant is selected from povidone-iodine, and the local anesthetic is selected from one or more of tetracaine hydrochloride and oxybuprocaine hydrochloride.In the ophthalmic composition of the application, by povidone-iodine, tetracaine hydrochloride and oxybucaine hydrochloride concentration, pH control and stabilizer screening, the stability of the coexistence system is improved, and anesthesia and disinfection in ophthalmic clinical operation have important contribution.

The invention relates to the technical field of cosmetics, and particularly discloses an aerosol type moisturizer without preservative components and a preparation process of the aerosol type moisturizer. The invention relates to an aerosol type moisturizer without preservative components, which is prepared from the following raw materials in percentage by mass: 0.35 to 0.63 percent of moisturizing composition, 0.05 to 0.1 percent of ergothioneine embedded particles, 0.05 to 0.3 percent of rutin components, 0.1 to 0.3 percent of prebiotics, 0.8 to 1.2 percent of propellants and the balance of water. The anti-corrosion component-free aerosol type moisturizing water does not contain preservatives, is relatively high in safety, is friendly to sensitive skin, can efficiently replenish water, moisturize and relieve skin, has the effects of resisting radiation oxidation and preventing blue light, and can meet the daily skin care management requirements of office workers.

The application provides a functional monomer shown in formula (I), a preparation method thereof, a gel prepared from the functional monomer, a gel dressing and application of the gel dressing. The application uses polyvinyl alcohol, polyglutamic acid and acrylic acid as gel raw materials, adds sodium chloride as an effective component, adds initiators and crosslinking agents, grafts a compound shown in formula (I) containing a disulfide bond, forms an interpenetrating gel network, and the prepared gel dressing can be quickly attached to the skin and can be easily and completely removed from the skin surface. The gel dressing solves the problem of poor patient compliance, and the gel dressing can be attached to the common warts when used, which is simple and convenient, does not contain preservatives, is completely non-toxic and non-side effect to the human body, and is safe and reliable. Experimental results show that the gel dressing provided by the application can be quickly attached to the skin and form stable adhesion, and can be easily and completely separated from the skin under the action of sodium bicarbonate and glutathione after the warts disappear.

The invention discloses a mosquito repellent paste capable of quickly relieving itching, a preparation method and an application. The mosquito repellent paste is prepared from the following components in percentage by mass: 1-100% of camellia seed oil; 1%-50% of a wormwood extract; 1%-50% of a mint extract; 1%-20% of borneol; 1%-20% of mentholum; 1%-20% of sweet almond oil; 1%-20% of jojoba oil; the mosquito-repelling paste does not contain preservatives, artificial pigments and synthetic essence, and the mosquito-repelling, itching-relieving and skin-repairing functions are achieved through the synergistic effect of the vegetable oil matrix and the plant active ingredients. The wormwood extract and the mint extract are compounded to form a natural mosquito repelling barrier, the repelling rate of common mosquitoes (such as aedes and culex) is larger than or equal to 95% (within 4 hours), and the protection time reaches 4-6 hours.

To provide formulations for providing pain relief in humans and animals by administering a preservative-free intranasal dose of a local anesthetic formulation for the treatment of tri-geminal neuralgia, facial neuropathic pain, facial cancer induced neuropathic pain, migraine pain, and cluster headache pain.SOLUTION: A nasal spray formulation comprises from about 5% to about 30% w / v of a locally active sodium channel blocker, from about 0.25% to about 5% w / v of a buffering agent, and from about 5% to about 99% w / v of a pharmaceutically acceptable carrier for nasal administration. The nasal spray formulation is preferably contained in a mechanical multi-dose pump which sprays a unit dose of the nasal spray formulation with a wide plume and small droplet size, and the unit dose is administered by actuating the mechanical multi-dose spray pump device and spraying a certain amount of the nasal spray formulation into each nostril of a human subject. Preferably, the nasal spray formulation does not include a preservative.SELECTED DRAWING: None

The disclosure provides tablets for a mouthrinse containing fluoride, an effervescent agent comprising an acid and a base, a water soluble lubricant, a binder, and a sensory modifying agent. The tablets are free of preservatives and free et alcohol. In certain embodiments, the effervescent agent contains citric acid and sodium bicarbonate. The water soluble lubricant may include polyethylene glycol (PEG), potassium sorbate, sodium benzoate, calcium sorbate, PEG with one or more of trisodium citrate, calcium ascorbate, and mixtures thereof. The binder may include sodium carboxymethyl cellulose, mannitol, polyvinylpolypyrrolidone, microcrystalline cellulose, colloidal silicon dioxide, and combinations thereof.

To provide a multi-dose ocular fluid delivery device.SOLUTION: Aspects of the fluid delivery device include a fluid package and an actuator. The fluid package includes a reservoir 406 of an ophthalmic formulation, an aperture 402, and a valve member 404 for sealing the aperture when fluid is not being expelled through the aperture. The actuator is configured to operate the valve member to at least reduce, if not prevent, entry of external substances or contaminants into the reservoir such that the ophthalmic drug present in the reservoir does not require a preservative (e.g., such as when a preservative-free ophthalmic drug is present in the reservoir). Also provided are methods of using the devices in fluid delivery applications, and kits containing components of the devices.SELECTED DRAWING: Figure 4

The present disclosure encompasses methods and compositions for extended-release formulations for treating ophthalmic conditions. These formulations comprise a pharmaceutical agent, a cationic polymer, a non-ionic polymer, and a pharmaceutical carrier and are essentially preservative free. The formulations provided herein are particularly useful for sustained and controlled release of drugs and have low side effects.

The present invention relates to a liquid dispenser with an opening by tip mechanism, of the type without preservatives for bottles of blowing, filling and sealing, with a dual-function membrane for the air-and-liquid passage control, with a pierceable silicone seal that ensures sterilization at all times by being in storage position and when opening the bottle.

The present invention relates to an ophthalmic composition containing tramadol or a salt thereof, in which the ophthalmic composition does not substantially contain a preservative.

The utility model discloses a nasal cavity soft mist administration device, which relates to the technical field of administration devices and comprises an administration main body and a mist spray adapter, the spray adapter is connected with the end part of the dosing main body; a concave part is arranged on the administration main body, and divides an inner cavity of the administration main body into a first accommodating cavity and a second accommodating cavity which are communicated with each other; a micro-pore chip is loaded on the spray adapter, and the micro-pore chip is arranged right opposite to the end part of the drug administration main body. The nasal cavity soft fog administration device provided by the utility model is portable to use, and can efficiently and quickly atomize a single-dose sterile solution or suspension which does not contain preservatives into soft fog which moves slowly, and atomized liquid drops are small in particle size and uniform in distribution.

The present invention relates to a spray device comprising a nozzle body (2) and a substantially flat membrane layer (6) suspended over a nozzle cavity (3) for generating microjets, especially for pharmaceutical applications, particularly preservative-free formulations. The nozzle body (2,8) contains an antimicrobial barrier, in particular a microvalve (23,24) between a fluid supply channel (9) and said cavity (3).

An object of the present invention is to provide a preparation technique for providing an aqueous liquid preparation containing brimonidine and / or a salt thereof with preservative efficacy of at least a level at which a bacteriostatic action is recognized, without blending a preservative.SOLUTION: An aqueous liquid preparation containing brimonidine and / or a salt thereof, edetic acid and / or a salt thereof, and a buffering agent can have preservative efficacy at a level at which at least a bacteriostatic action is observed, even if it does not substantially contain a preservative.SELECTED DRAWING: None

The present disclosure provides a composition comprising temozolomide or lenalidomide, a medium chain triglyceride (e.g., miglyol), silica, and a surfactant wherein the composition optionally comprises an antioxidant and / or a flavouring agent, and wherein the temozolomide composition is a non-aqueous, preservative-free suspension. Also provided are methods for treating cancer in a subject (e.g., a child or a subject with and / or with dysphagia).