The invention relates to a plaster for treating skin stubborn dermatitis. The plaster is prepared from the following raw materials: medical vaseline, liquid paraffin, lanolin, dried alum, chlortrimeton, dexamethasone, borneol, white pepper and cefazolin. The invention has the advantages as follows: the plaster can treat various skin stubborn dermatitis diseases, such as tinea manuum and beriberi,neurodermatitis, eczema, psoriasis, tinea versicolor, decrustation of hands and feet, verruca vulgaris, impetigo, yellow-water sores, dermatitis rhus, acute universal eczema, herpes simplex, chilblain, syphilis, chancre, nucha carbunde, scldhed, snake-head furuncle, snake venom, herpes zoster, pustule, scabies, universal eczema, pityriasis simplex, rotten feet, fungal infection of the hand, innominate inflanunatory of unknown origin, burn due to hot liquid or fire, incised wound, incised wound and genital herpes in sexually transmitted diseases, has efficacy of killing parasites to relieve itching, removing necrotic tissue to promote tissue regeneration, detoxifying and dispelling cold and dispelling wind and eliminating dampness, and is less in dosage, quick in effectiveness and convenient to use.