Traditional Chinese medicine instant granules for resisting HPV and improving immune functions and preparation method thereof

A traditional Chinese medicine, functional technology, applied in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of increasing incidence of condyloma acuminatum, increasing morbidity and mortality, and loss of HPV infection, achieving enhanced The effect of immune function, shortening the course of disease, and improving the rate of wall breaking

Inactive Publication Date: 2015-04-22
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The epidemiological screening of HPV infection in my country has not seen a large-scale report, but the incidence of genital warts among sexually transmitted diseases caused by HPV infection is rising rapidly. There are about 131,500 newly discovered cervical cancers in my country every year. The incidence and mortality of cervical cancer are increasing, and the age of cervical cancer incidence is younger. It can be foreseen that HPV infection will cause huge losses in my country.
[0005] However, there is no clinically effective anti-HPV specific drug, and it is very difficult for doctors to treat it.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Take 30g of astragalus, 30g of sealwort, 20g of rehmannia glutinosa, 20g of dodder and 10g of cooked rhubarb, dry the above-mentioned Chinese medicinal materials at 40°C to constant weight, and then pulverize them in an ultrafine pulverizer (BFM-100 type), The ultrafine powdered Chinese herbal medicine powder is obtained, the particle size of which is 0.1-75 μm, and the particle size distribution center D50≈10-15 μm.

[0031] (2) Making soft material: After mixing the Chinese medicinal material powder, lactose, disintegrant starch and binder starch in step (1), add food preservative citric acid, mix well, and obtain the mixture; The weight ratio of powder, diluent, disintegrant, binder and food preservative is 5:45:25:25:0.3;

[0032] (3) Fluidized granulation and granulation: put the mixture of step (2) into a granulator for granulation, obtain dry coarse granules, sieve, granulate, and take 30-60 mesh granules to obtain anti-HPV And Chinese medicine granules to i...

Embodiment 2

[0042] The male patient, 20 years old, had a large area of ​​plantar warts on the soles of the feet, and the effect of repeated freezing was not good. This traditional Chinese medicine granule for anti-HPV and improving immune function was given, 1 bag each time (10 grams per bag), 2 times a day, for 2 weeks After further consultation, the volume of the warts decreased, and some small warts disappeared. There was no obvious adverse reaction during the medication, and the warts all disappeared after continuing to take this medicine for 1 month.

[0043] It can be seen that the use of the present invention can effectively resist HPV and achieve the purpose of treatment.

Embodiment 3

[0045] The patient was female, 28 years old, with condyloma acuminata on the vulva and perianal area. After electrocautery, this traditional Chinese medicine granule was combined with 1 bag (10 grams per bag), 2 times a day. After 20 days, she had no new skin lesions. No obvious adverse reaction, continue to take this medicine 3 months, during the disease without recurrence, drug withdrawal. Follow up a case by regular visits to March, no recurrence.

[0046] It can be seen that the use of the present invention can improve the immunity of patients and effectively reduce recurrence.

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Abstract

The invention discloses traditional Chinese medicine instant granules for resisting HPV and improving immune functions and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine instant granules for resisting HPV and improving the immune functions consist of astragalus membranaceus, manyflower solomonseal rhizome, prepared radix rehmanniae, Chinese dodder seeds and prepared rhubarb according to a mass ratio of 3:3:2:2:1 in sequence. The traditional Chinese medicine instant granules take astragalus membranaceus, manyflower solomonseal rhizome and prepared radix rehmanniae according to a mass ratio of 3:3:2 for medicine use, have significant functions of resisting virus and enhancing the body immunity, can be used for treating various viral skin diseases such as verruca vulgaris, toe wart, verruca plana and condyloma acuminate, and can be used for shortening the disease course and effectively reducing recurrence. According to the traditional Chinese medicine instant granules disclosed by the invention, an ultra-fine powder crushing technology is adopted, complete cells cannot exist in powder basically, and the wall-breaking rate ratio of medicinal material cells can be greatly improved, so that the medicine absorption rate can be effectively increased, and the biological availability and medicine effects of the pills can be improved. The medicinal material powder is small in particle size, good in uniformity, rapid in in-vitro release and more in dissolved effective components, and can be used for significantly improving the curative effects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine granule for resisting HPV and improving immune function and a preparation method thereof. Background technique [0002] Human papillomavirus (HPV) is a small DNA virus belonging to the human papillary polyoma virus. Humans are its only host, and the host cells are skin and mucosal epithelial cells. Human papillomavirus infects the squamous epithelium, leading to the proliferation of the squamous epithelium of the human skin and mucous membranes, causing various skin warts in humans, manifested as common warts, plantar warts, flat warts, and perianal genital warts (also known as condyloma acuminata). [0003] Warts can be transmitted through direct or indirect contact, and most perianal and genital warts are transmitted through sexual contact. Warts can occur at any age, and the incidence rate gradually increases wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/16A61P31/20A61P37/04A61P17/12
Inventor 付丹丹杨君余文发王慧敏董亭方田中伟
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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