The invention relates to a ligusticum wallichii rheumatalgia-relieving and blood-circulating plaster which is prepared from the following raw materials: ligusticum wallichii, angelica sinensis, monkshood, kusnezoff monkshood root, semen strychni, frankincense, myrrh, radix angelicae pubescentis, phryma leptostachya, pangolin scales, resina draconis, homalomena rhizome and eucommia Bark. The preparation method comprises the following steps of: in the thirteen tastes of traditional Chinese herbs, grinding frankincense, myrrh and resina draconis into fine powder, sieving and uniformly mixing the fine powder; cutting the rest ten tastes of traditional Chinese herbs such as angelica sinensis into small pieces, frying the pieces to be dried in a pan with 2500 to 4000 g of sesame oil, removing slag, filtering and refining the sesame oil till sesame oil forms balls when dripped; adding 1200 to 210 g of red lead to the oil, uniformly stirring the oil, collecting the paste and soaking the paste into water; taking the paste out of water, melting the paste by slow fire, adding the fine powder and uniformly stirring the fine powder; laying the paste on a piece of cloth and then applying the cloth on the affected part. The invention has the advantages of short course, convenient use, capabilities of promoting blood circulation and removing blood stasis, removing pathogenic wind and cold, activating meridians and stopping pain, relaxing tendons and muscles and setting fractures. The invention is a cure for treating the diseases such as neck pain, shoulder pain, backache and leg pain and fracture caused by obstruction of blood circulation and collateral obstruction of wind-cold.