7 results about "Human herpes" patented technology

The present invention is directed to the use of antiviral agents, in particular valomaciclovir stearate and its polymorph Form A, as well as H2G (omaciclovir) to treat multiple sclerosis in combination with other agents, as well as the use of these agents to treat diseases and conditions such as chronic mononucleosis, long COVID, chronic fatigue syndrome, fibromyalgia, Crohn's disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, Graves' disease, Alzheimer's disease, mesial temporal lobe seizures, Epstein-Barr-virus-linked autism, or an Epstein-Barr-virus-linked cancer.

Provided are human herpesvirus affinity ligands and related compositions including affinity resins.

The present invention relates to the field of immunotherapy, in particular to diseases associated with Epstein-Barr virus (EBV, also known as human gamma herpesvirus 4), such as cancer or post-transplant lymphoproliferative disease, in particular to adoptive T cell therapy or T cell receptor (TCR) gene therapy. The present invention provides a combination of nucleic acids encoding at least two TCR constructs or corresponding proteins or host cells, wherein each TCR construct is capable of specifically binding to its respective epitope in the context of a respective MHC I, and wherein the epitopes are derived from different antigens expressed by the same infectious agent or cancer, such as EBV antigens. The present invention further provides specific nucleic acids encoding a TCR alpha chain construct (TRA) and / or a TCR beta chain construct (TRB) of a TCR construct specific for an epitope complexed with human MHC I, wherein the epitope is an epitope of an Epstein-Barr virus protein, the TCR construct being specific for an epitope from LMP2A, LMP1 or EBNA3C. Proteins encoded by said nucleic acids, corresponding host cells, as well as pharmaceutical compositions and kits are also an object of the present invention.

Human herpesviruses can infect barrier and immune cells of the intestinal tract to cause microbiome dysbiosis and inflammation. Microbiome dysbiosis can affect the availability of nutrients required for normal brain function. Inflammation can compromise the intestinal barrier and lead to microbial translocation. Microbial translocation can cause brain infection or a mimicry auto-immune response. The embodiments restrict herpesvirus activity and injury by 1) the oral administration of exosomes containing factors to inhibit viral activity and restore homeostasis, and 2) the oral administration of recombinant bacteria that produce exosomes containing factors to inhibit viral activity and restore homeostasis. Another embodiment is the treatment of alpha-HHVs mediated intestinal dysfunction by nucleoside analogs, such as famciclovir, which may be combined with anti-viral exosome therapy.

Oligomer nucleotides, compositions, methods, kits, and uses are provided for detecting or quantifying a Human Cytomegalovirus virus 1 (CMV (human herpesvirus 5, HHV5) nucleic acid, e.g., using nucleic acid amplification and hybridization assays. Multiphase amplification of a CMV target sequence is also described. The oligomer nucleotides, compositions, methods, kits, and uses can be used to amplify and / or detect the UL56 gene of CMV.

The invention discloses a primer combination for simultaneously detecting eight herpes viruses by a single tube, a PCR (Polymerase Chain Reaction) detection system and application, and relates to the technical field of herpes virus detection. Aiming at eight human herpes viruses, the invention provides a corresponding primer combination and an octuple PCR detection system, the detection sensitivity to single and mixed infection of the herpes viruses reaches 1 * 10 < 4 > copies (50 mu L system), non-specific amplification is avoided, and the eight human herpes viruses can be detected at the same time. When the system is used for detecting 30 cell samples, one EBV sample is detected to be positive, the rest EBV samples are detected to be negative, the result is consistent with the result obtained by using an EBV rapid visual detection system established in an earlier stage of a laboratory, and very high accuracy is achieved.

The invention discloses a kit for multi-typing detection of human herpes viruses HHV-1 to HHV-8, and the kit comprises a group of nucleic acid combination which comprises 9 pairs of RPA (recombinase polymerase amplification) primers which are respectively and specifically combined with target genes of HHV-1 to HHV-8 and an EC (exogenous internal control), wherein each pair of primers comprises a forward primer and a reverse primer; wherein the 5'ends of the reverse primers of all the 9 pairs of primers are marked with biotin; the 5'ends of forward primers of the HHV-1, the HHV-4 and the HHV-7 are marked with first haptens; the 5'end of the forward primer of the HHV-2, the HHV-5 and the HHV-8 is marked with a second hapten; the positive primers of the HHV-3 and the HHV-6 are marked with a third hapten at the 5'end; a fourth hapten is marked at the 5'end of the forward primer of the EC; the invention relates to an RPA (recombinase polymerase amplification) reaction buffer solution which comprises the following components in concentration: 40-60 mM of Tris-HCl, 80-140 mM of potassium acetate, 10-20 mM of magnesium acetate, 3-8% (w / v) of polyethylene glycol and 0.5-2.0 M of betaine. And a plurality of lateral chromatography test strips.