578 results about "Anesthetic Agent" patented technology

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release material prolonging the release of the local anesthetic and optionally and a pharmaceutically acceptable, i.e., non-toxic, augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable without the augmenting agent.

Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.

A formulation for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a non-toxic augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent. In preferred embodiments, the controlled release material is a low molecular weight, acid-terminated polymer. A further aspect of the invention is directed to such formulations which release the local anesthetic in two phases, the first a rapid "bolus" to initiate anesthesia and a second, slower release to maintain anesthesia.

An intradermal patch having a permeable backing coated with a polyvinylpyrrolidone-based hydrogel and containing one or more local anesthetics. The patch is breathable, non-irritating upon application and removal, soothing, and sterile. The patch is useful for treating the pain associated with non-intact skin indications.

An apparatus for locating and anesthetizing a nerve enables an anesthesiologist to perform a nerve blockade procedure without an assistant. An anesthetic-filled syringe is releasably mounted to a hands-free, foot-actuated, hydraulic syringe controller. An electric current generator is mounted to the syringe controller and operatively connected to a needle of the syringe. A hands-free, foot-actuated current generator controller determines an amperage of an electrical stimulus output to the needle. The current generator includes audible and visual displays for informing the anesthesiologist of the output amperage. Because the syringe controller and current generator controller allow hands-free operation, an anesthesiologist can continuously use both hands to manipulate and hold the needle in a patient.

A system for measuring a metabolic parameter. The system includes an integrated airway adapter capable of monitoring any combination of respiratory flow, O₂ concentration, and concentrations of one or more of CO₂, N₂O, and an anesthetic agent in real time, breath by breath. Respiratory flow may be monitored with differential pressure flow meters under diverse inlet conditions through improved sensor configurations which minimize phase lag and dead space within the airway. Molecular oxygen concentration may be monitored by way of luminescence quenching techniques. Infrared absorption techniques may be used to monitor one or more of CO₂, N₂O, and anesthetic agents.

The invention provides a system and method utilizing, among other things, fluorescence spectroscopy in the ultraviolet portion of the electromagnetic spectrum to determine chemical species and concentrations. The basic measuring system includes optics, a spectrograph, a detector, and an energy source (“head” components), along with a computer and control electronics and power source capable of generating and detecting unique fluorescence signatures for individual and unique mixtures of chemical substances including, for example, prescribed and/or compounded medications, alcohol products, food types, synthetic drugs, narcotics, perfumes, liquids, and the like.

A method and system for objectively scoring intra-operative pain during general anaesthesia based on the patient's mean arterial pressure and heart rate. The index is used for closed-loop control of the intra-operative analgesia through adjustment of the drug infusion level according to fuzzy logic. It is further displayed along with other components of anaesthesia and important patient data on a monitoring display for presentation to medical staff.

A method for monitoring anesthetization of a patient, includes the steps of removably connecting a plurality of electrodes to the scalp of the patient and administering sufficient anesthesia to the patient so that the patient attains a plane of anesthesia selected by an operator. The brain waves of the patient are then amplified and digitized after the patient has been anesthetized, before beginning the medical procedure, to obtain a first set of digital data. The brain waves of the patient are then amplified and digitized during the medical procedure to provide a second set of digital data and the first and second sets of digital data are analyzed in at least one of a time domain and a frequency domain. Separate trajectories are then computed from the data analysis trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI). A system for providing anesthesia to a patient, includes a plurality of electrodes, a first arrangement allowing an operator to administer anesthesia to the patient until the patient has attained a selected plane of anesthesia and a second arrangement coupled to the electrodes for amplifying and digitizing brain waves of the patient after the patient has been anesthetized, before the medical procedure has been begun to obtain a first set of digital data, the second arrangement amplifying and digitizing ongoing brain waves of the patient during the medical procedure to provide a second set of digital data in combination with a third arrangement analyzing the first and second sets of digital data in at least one of a time domain and a frequency domain, a fourth arrangement computing from the data analysis separate trajectories for at least two different indices of a state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI), a fifth arrangement providing control signals when any of the trajectories indicates that the patient is deviating from the selected plane of anesthesia and a sixth arrangement automatically adjusting two different anesthetic agents administered to the patient based on the control signal to restore the patient to the selected plane of anesthesia.

An integrated airway adapter capable of monitoring any combination of respiratory flow, O₂ concentration, and concentrations of one or more of CO₂, N₂O, and an anesthetic agent in real time, breath by breath. Respiratory flow may be monitored with differential pressure flow meters under diverse inlet conditions through improved sensor configurations which minimize phase lag and dead space within the airway. Molecular oxygen concentration may be monitored by way of luminescence quenching techniques. Infrared absorption techniques may be used to monitor one or more of CO₂, N₂O, and anesthetic agents.

An electronic anesthesia delivery apparatus having a chassis including a first anesthetic agent chamber and a second anesthetic agent chamber, each of the first and second chambers including an anesthetic agent therein. At least one electronically controlled valve is in fluid communication with each of the first agent chamber and the second agent chamber and an oxygen source. The oxygen source is in fluid communication with each of the at least one electronically controlled valves. A touchscreen graphic display having controls corresponding to each of the at least one electronically controlled valves for controlling flow rate and concentration of anesthesia.

A method and system is provided for detecting the depth of anesthesia wherein at least one anesthetic agent is absorbed in a patient's bloodstream during the administration of anesthesia, which includes sampling a patient's expired breath; analyzing the breath for concentration of at least one substance indicative of the anesthetic agent using sensor technology such as free (unmetabolized) anesthetic agent or its metabolites; determining the effect of the agent based on that concentration; and determining depth of anesthesia based thereon. The method also detects endogenous compounds such as ketones and ammonia in exhaled breath as well as other pathologic organisms.