10 results about "Mean arterial pressure" patented technology

This invention relates to the field of multi-organ dysfunction (MOD) early warning technology, specifically to an MOD early warning method for patients with severe burns. The method includes the following steps: acquiring heart rate, mean arterial pressure, respiratory rate, blood oxygen saturation, lactate concentration, and urine output per unit time; calculating the rate of lactate change at adjacent time points to form a sequence; comparing the rate of change across time intervals to obtain the difference in change; combining heart rate and blood oxygen saturation to calculate circulatory load; and counting the number of early warning triggers that meet risk conditions. In this invention, by calculating the rate of change of lactate concentration at adjacent time points and combining it with interval direction statistics, tissue metabolic changes show trend characteristics; the rate of change of urine output combined with mean arterial pressure forms a record of renal perfusion changes, providing a continuous characterization of perfusion status; heart rate and blood oxygen saturation are used to calculate circulatory load; multiple physiological signals are linked for judgment; and recurring abnormalities are expressed through the number of triggers. This improves the stability and predictability of MOD risk identification in critically burned patients.

A continuous blood pressure measurement device includes a cuff airbag pneumatically connected to an inflation / deflation unit and a pressure detection unit. The device also comprises at least one light-emitting diode, at least one photodiode, and a volume detection unit configured to convert photoplethysmogram signals into arterial volume signals. A control unit precisely tracks a predefined setpoint to achieve arterial unloading based on a volume compensation method. An extraction unit reconstructs a high-fidelity arterial blood pressure waveform and accurately determines systolic, diastolic, mean arterial pressures, and heart rate.

This invention discloses an endothelin A receptor antagonist-albumin fusion protein and its application in preventing and treating hypotension during anesthesia induction. The fusion protein is formed by chemically coupling BQ-123 with human serum albumin (HSA). BQFu significantly enhances its antihypertensive effect by prolonging the half-life of BQ-123 and improving plasma stability. Experiments show that BQFu dose-dependently inhibits the decrease in mean arterial pressure (MAP) in a propofol-induced hypotension model, with a sustained and stable effect in the high-dose group (30 mpk), shortening the recovery time to 20.8 ± 10.5 min, while maintaining BQ-123 activity. This invention provides a long-acting and safe prevention and treatment strategy for hypotension during anesthesia induction.

This invention provides a method, system, and device for monitoring anesthesia status based on multi-source physiological signal analysis, relating to the field of medical monitoring technology. The method includes: acquiring electroencephalogram (EEG) signals, real-time heart rate, heart rate variability coefficient, and real-time mean arterial pressure of a patient under anesthesia; performing preliminary filtering of the EEG signals using high-pass and low-pass filters, and normalizing the amplitude of the EEG signals to obtain new EEG signals; acquiring several modal functions; extracting multidimensional features from each modal function; forming a feature set; training a machine learning model using the feature set, and using the trained machine learning model to predict the patient's anesthesia status in real time, outputting anesthesia stage classification results; determining the comprehensive stability coefficient of the anesthesia status; determining the anesthesia depth instability fluctuation coefficient; and performing anesthesia status monitoring. According to this invention, the accuracy of anesthesia status monitoring can be improved.

The present application relates to the technical field of body position management, in particular to an aorta postoperative patient body position intelligent management pad system based on hemodynamic parameters, which introduces classification and regression tree to organize mean arterial pressure interval, systolic pressure interval, blood pressure change rate sign, exponential weighted deviation interval, cumulative deviation state, uncertainty level and body position maintenance time interval into ordered conditional branches, explicitly injects safety priority logic into body position sorting process, makes high-risk signals obtain higher weight proportion in decision chain, maps body position enumeration into discrete state by limited state machine and introduces interval member guard count and locking time, so that body position switching is no longer instantaneous judgment but triggered after continuous condition satisfaction, and the overall process forms a continuous traceable closed loop under the multi-layer superposition of rule chain, cost weight, state transition and path constraint, the body position execution process remains stability in blood flow fluctuation stage, and nursing operation consistency and controllability are significantly improved.

This invention discloses a simulated upper arm artery blood pressure ultrasound phantom device and a method for verifying ultrasound blood pressure measurement technology. The device includes: simulated blood circulating through tubing via a peristaltic pump from a buffer tank, a flow meter, the simulated upper arm artery blood pressure ultrasound phantom, to a reservoir. The peristaltic pump and buffer tank work together to achieve constant flow and pulsating modes. An airbag pressurizer is connected to the upper air chamber of the reservoir to pressurize the tubing, providing a base pressure simulating the human mean arterial pressure. The pulsating mode of the peristaltic pump simulates the pulsating pressure changes within the systolic and diastolic pressure ranges of human blood pressure, and these changes are displayed and recorded in real time via a pressure transmitter and a connected digital oscilloscope. The simulated upper arm artery blood pressure ultrasound phantom allows the internally implanted simulated arteries to radially expand and contract with pressure pulsation, simulating the dynamic behavior of the human upper arm artery, thus verifying the ultrasound blood pressure measurement technology.

This invention relates to the field of medical artificial intelligence technology and discloses a method for predicting the resuscitation status of patients with septic shock. The method includes: acquiring state parameters of the patient with septic shock; preprocessing the acquired state parameters to obtain input parameters; obtaining training data based on a critical care database; training a prediction model using the training data; inputting the input parameters into the trained prediction model to obtain a first prediction probability; and performing binary classification on the first prediction probability to obtain a final prediction result. The state parameters include target parameters, which include multiple variables such as mean arterial pressure, arterial blood lactate, base excess, pH, bicarbonate, and anion gap. This method and system for predicting the resuscitation status of patients with septic shock can prospectively output the overall probability of achieving resuscitation targets at the 6th hour using conventionally available multidimensional clinical information within 0-2 hours after admission to the ICU.

This invention relates to the field of blood purification control technology, and discloses a CRRT fluid management decision-making system and method based on hemodynamic monitoring, comprising: a blood flow acquisition module for acquiring systolic blood pressure, mean arterial pressure, and heart rate to form a current hemodynamic dataset and determine a baseline dataset; a grading determination module for determining the hemodynamic grade based on the current hemodynamic dataset and the baseline dataset; a dehydration boundary module for determining the hard boundary of the net dehydration rate; a dehydration command module for generating and trimming net dehydration commands; a pump control linkage module for writing net dehydration commands and linkage adjustment of replacement fluid flow rate and dialysate flow rate; a safety control module for entering or de-entering a safety mode and updating the net dehydration command; and a termination and takeover module for outputting a stop control command or a manual takeover flag. This invention achieves automatic decision-making and orderly execution of net dehydration operations under safe conditions during continuous blood purification.

A method for diagnosing or predicting preeclampsia in a pregnant woman or determining whether a pregnant woman is at risk of developing preeclampsia is provided, comprising: a) obtaining at least one (such as two or more) maternal or fetal parameter or factor of the pregnant woman selected from the group comprising: (i) one or more of mean arterial pressure, BMI at sampling, ΔBMI, gestational age, and ΔBMI / GA; (ii) maternal age; (iii) one or more of urinary protein level and ratio of urinary protein level (such as total urinary protein) to urinary creatinine level; (iv) one or more of history of preeclampsia in previous pregnancies and having received antihypertensive medication; and (v) any combination of (i)-(iv), b) determining whether the pregnant woman has misfolded proteins or misfolded protein aggregates in her urine, and c) combining the at least one maternal or fetal parameter or factor obtained in step a) with the level of misfolded proteins or misfolded protein aggregates in the pregnant woman's urine to diagnose or predict preeclampsia or determine the risk of preeclampsia.

Provided herein are compositions, such as suitable for subcutaneous administration, and methods for modulating mean arterial pressure (MAP) in an individual using a mixed V1A receptor agonist-antagonist.