Application of penehyclidine hydrochloride in preparing medicament for treating haemorrhagic shock

Abstract

The invention discloses application of penehyclidine hydrochloride in preparation of a medicine for treating a hemorrhagic shock disease. Hemorrhagic shock has a pathological change that the central venous pressure, the peripheral mean arterial pressure and the cardiac output are all obviously reduced and the middle-light microcirculatory disturbance appears, the medicine for treating the hemorrhagic shock disease can be liquid and can also be solid, and the mass percent concentration of the penehyclidine hydrochloride in the medicine is between 0.01 and 2 percent. The application effect is proved through the influence of a penehyclidine hydrochloride water solution on a canine hemorrhagic shock model.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the new medical application of penehyclidine hydrochloride, in particular to the application of penehyclidine hydrochloride in the preparation of medicines for treating hemorrhagic shock disease. The pathological changes of the hemorrhagic shock disease are that central venous pressure, peripheral mean arterial pressure and cardiac output all decrease significantly, and moderate to mild microcirculatory disturbance occurs. Background technique [0002] Penehyclidine hydrochloride, English name Penehyclidine Hydrochloride, chemical name 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy)quinuclidine hydrochloride, molecular formula C 20 h 29 NO 2 • HCl, molecular weight 351.92. [0003] Penehyclidine hydrochloride is a new type of anticholinergic drug with selective M 1 , M 3 and N 1 , N 2 Receptor antagonism, has a strong anticholinergic effect on the central and peripheral, an...

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6% hydroxyethyl starch dissolved in 0.9% NaCl is usually well tolerated as a osmotic expansion agent, but it can prolong the bleedi

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