20 results about "Collateral vessels" patented technology

This invention discloses an intestinal fungus Saccharomyces cerevisiae M7015 and its applications belong to the field of microbial technology. Saccharomyces cerevisiae The accession number for M7015 is GDMCC No. 66195. This invention first demonstrated, using a mouse subcutaneous stroma embolism model, that the aforementioned strain can promote angiogenesis; secondly, using mouse and Bama miniature pig myocardial infarction models, it was found that the aforementioned strain can promote collateral angiogenesis in ischemic areas of the heart and improve cardiac function. This invention not only fully elucidates... Saccharomyces cerevisiae M7015 promotes the formation of collateral vessels in the heart and improves cardiac function, and also reveals the broad application prospects of this bacterium in the treatment of vascular diseases.

The invention relates to an aorta covered stent. The aorta covered stent comprises a main stent, a plurality of leg-separating stents and a skirt stent. Wherein all the leg separating supports are connected with the main support, and all the leg separating supports and the main support jointly form a blood flow channel for blood circulation. The skirt support comprises a skirt framework and a skirt covering film covering the skirt framework, the skirt support is arranged outside all the leg separating supports in a sleeving mode, one end of the skirt support is connected with the main support, and the other end of the skirt support is a free end. According to the aorta covered stent, collateral vessels on a tumor body can be blocked, II-type internal leakage is avoided, blood flow of the collateral vessels is prevented from flowing back into an aneurysm cavity, continuous flushing of the blood flow to the tumor cavity is reduced, and continuous enlargement of the tumor cavity is avoided.

The invention discloses an intracranial dura mater arteriovenous fistula medical image analysis method, and relates to the technical field of medical image.The method comprises the steps that a digital subtraction angiography dynamic image sequence after interventional embolization treatment is obtained; performing motion compensation on each frame of image in the dynamic image sequence; extracting a time-varying track of the signal intensity of the contrast agent from the dynamic image sequence after motion compensation; identifying a blood vessel dynamic mode based on the track of the contrast agent signal intensity changing along with time; performing dynamic enhancement processing on the blood vessel image area in the blood vessel dynamic mode according to the hemodynamic characteristics; extracting a blood vessel signal from the dynamic image under the enhancement processing; and reconstructing a three-dimensional model under the cerebrovascular network in a three-dimensional space based on the blood vessel signal. According to the method, a reliable basis is provided for a doctor to evaluate the treatment effect, judge the residual focus or recruit the collateral vessel, misdiagnosis and misjudgment are avoided, and therefore the treatment effect and safety of a patient are improved.

The application relates to a coronary microcirculation vascular resistance acquisition method and system based on a layered myocardial model, which comprises the following steps: establishing a coronary vessel model from medical images; generating a side vessel for the coronary artery; regarding the coronary artery and the side vessel as main vessels, fitting and constructing an outer surface of a myocardial model according to the outlet position of the main vessels, establishing an inner surface of the myocardial model based on a similar principle to the outer surface, and ensuring that the volume of the model is the myocardial volume value; using an ellipsoid surface for layered interpolation; selecting a point P in the outermost layer and connecting the main vessel outlet to generate a microcirculation vessel; selecting a point T outside the current layer and cooperating with the nearest microcirculation vessel to generate a bifurcated microcirculation vessel; gradually advancing to the inner layer to form bifurcation and ensure the bifurcation number of each layer; and calculating the resistance value of the main vessel outlet. Compared with the prior art, the application considers the distribution of the coronary artery at various levels of the myocardium under real conditions, so that the calculated resistance value is more accurate and has the specificity of a patient.

The invention discloses a preparation method and application of a novel macrophage for treating myocardial infarction, and belongs to the fields of cell engineering, nanotechnology, material science, immunology and the like. According to the invention, bone marrow-derived macrophages are induced to be polarized to M2 type and are subjected to magnetic modification, so that the macrophages are endowed with the capability of efficiently expressing vascular endothelial growth factors, Mag M2-M-VEGF cells are obtained, and proliferation of endothelial cells and formation of collateral vessels are promoted through local high expression of VEGF at a myocardial infarction part, so that local ischemia injury is relieved. According to the invention, precise targeted delivery of cells is realized, local inflammatory response is inhibited, and blood perfusion in an infarction area is improved. The medicine is endowed with magnetic targeting capacity by internalizing Fe3O4 NPs and is accurately enriched in myocardial infarction tissue under the guidance of a magnetic field, M2 type polarization inhibits pro-inflammatory reaction by reducing pro-inflammatory factor release and releasing a large amount of anti-inflammatory factors, and meanwhile, VEGF is specifically secreted, angiogenesis of an infarction part is promoted, and the capillary density of an infarction region is effectively increased.

According to the multi-part image acquisition system and method for traditional Chinese medicine inspection diagnosis, the medium, the program product and the terminal provided by the invention, full-automatic closed acquisition of three traditional Chinese medicine inspection diagnosis key parts, namely a human face, a lingual surface and a lingual floor, is realized. The environment light sensor and the color temperature sensor are integrated in the closed shooting cavity, a closed-loop feedback mechanism is constructed, the light source assembly is accurately regulated and controlled, and it is ensured that the color temperature is stabilized in a medical effective interval. According to the invention, a multi-mode in-place detection mechanism is provided, infrared proximity sensing and a light-weight tongue posture light detection model are fused, whether each part is subjected to compliance exposure or not is accurately judged, posture compliance guidance is carried out, and the visibility of key signs such as sublingual collaterals in the image is remarkably improved. Through a closed shooting cavity structure and a multi-mode in-place detection and closed-loop guide mechanism, multi-part high-quality image automatic acquisition without manual intervention from user guide, illumination adjustment and quality evaluation to automatic shooting is realized.

A system and method for treating a bifurcated vessel may include a mother catheter with a mother expandable member coupled to a distal portion of a mother elongate shaft. A daughter catheter has a daughter expandable member coupled to a distal portion of a daughter elongate shaft. A therapeutic agent is carried on the daughter expandable member. Radial expansion of the daughter expandable member engages the daughter expandable member with a wall of the daughter vessel and the therapeutic agent elutes from the daughter expandable member into the wall.

A system and method for treating a bifurcated vessel may include a mother catheter with a mother expandable member coupled to a distal portion of a mother elongate shaft. A daughter catheter has a daughter expandable member coupled to a distal portion of a daughter elongate shaft. A therapeutic agent is carried on the daughter expandable member. Radial expansion of the daughter expandable member engages the daughter expandable member with a wall of the daughter vessel and the therapeutic agent elutes from the daughter expandable member into the wall.

A system for selecting a collateral vessel to perform a retrograde chronic total occlusion (CTO) treatment procedure is provided. The system includes one or more processors configured to: receive angiographic image data (120) representative of an occlusion in a target blood vessel; analyzing the angiography image data (120) to identify one or more candidate collateral vessels (1501... i) for approaching the occlusion in the target vessel in a retrograde direction; and assigning a suitability score to each candidate collateral vessel (1501... i), the suitability score representing a suitability of the vessel for performing the retrograde CTO treatment procedure on the occlusion.

The application relates to a method and system for obtaining coronary end microcirculation vascular resistance based on vascular growth, and the method comprises the following steps: acquiring medical images, and extracting a myocardial model and a coronary vascular model respectively; generating collateral vessels in the coronary vascular model; regarding all coronary vessels and collateral vessels as main vessels, and obtaining the position coordinates and the vascular radius; randomly selecting a point P in the myocardial model, connecting the point P with the outlet of the main vessel, and generating microcirculation vessels for each outlet of the main vessel; randomly selecting a point T in the point cloud file of the myocardial model, connecting the point T with the nearby microcirculation vessels, and generating multiple bifurcated microcirculation vessels, until the radius of all vessel outlets in the generated vascular tree is smaller than a preset vascular threshold; and calculating the resistance value of each outlet of the main vessel. Compared with the prior art, the coronary end microcirculation vascular resistance value calculated based on the reestablished microcirculation vascular model is more accurate and has the specificity of patients.

An endovascular treatment system including branch features for perfusing branch vessels such as the renal arteries, celiac arteries, and mesenteric arteries (e.g., for treating aortic aneurysms).

The invention provides application of an NCOA3 polyQ structural domain as a target spot in preparation of a medicine for relieving lower limb ischemic diseases, relates to the technical field of biomedicine, and aims to solve the problems that in the prior art, blood flow reperfusion recovery of the lower limb ischemic diseases is poor, collateral vessels are insufficient in formation, and safe and effective targeted intervention means are lacked. By constructing a mouse lower limb ischemia model, it is proved that blood flow recovery and collateral angiogenesis after ischemia are remarkably inhibited by Nco3polyQ structural domain deletion: compared with a WT mouse, postoperative blood flow perfusion of an Nco3Q / Q mouse is recovered slowly, and the blood flow of the affected side is only recovered by 60% on the 21st day after the operation; the CD31 positive region of the gastrocnemius muscle tissue on the 14th day after the operation is obviously reduced, and the mRNA expression of the blood vessel marker gene Pecam1 is reduced. On the basis, an intervention strategy aiming at the NCOA3 polyQ structural domain is used for preparing the medicine for relieving the lower limb ischemic disease, and a new treatment strategy and a potential target are provided for the ischemic limb disease.

This invention provides a biomarker for collateral circulation in CTO patients, MIA3, and its application, belonging to the field of biotechnology. This invention reveals and verifies a significant positive correlation between plasma MIA3 levels and the quality of collateral circulation formation in CTO patients, and its predictive efficacy for good collateral circulation is superior to that of the known key angiogenesis factor VEGFA. This allows MIA3 to serve as a high-value, minimally invasive molecular marker for early, non-invasive identification of a patient's collateral circulation formation potential before interventional surgery, thereby enabling risk stratification and providing an objective basis for individualized treatment decisions (such as whether more aggressive intervention is needed). This invention clarifies that MIA3 is a key link in regulating collateral angiogenesis; by targeting and upregulating MIA3 activity, collateral angiogenesis and maturation in ischemic areas can be precisely promoted, providing a novel non-pharmacological, non-surgical treatment strategy for CTO patients.

The present invention relates to an improved vascular sheath and dilator arrangement designed to increase maneuverability, procedure accuracy, and safety during vascular access. The arrangement comprises a vascular sheath with a side port and a dilator with a closed distal end and a deflection section within its lumen. This deflection section gently guides a guidewire toward a side port of the dilator, which is aligned with the side port of the vascular sheath when the dilator is correctly positioned within the sheath, thereby facilitating precise navigation of the guidewire into lateral vessels of a vascular structure. The arrangement also includes visual markers on both the vascular sheath and the dilator to ensure accurate alignment of the side ports. These features collectively improve the efficiency and safety of vascular procedures.

The invention relates to the technical field of medical instruments, and provides a branch protection balloon catheter which comprises a main branch balloon, a side branch balloon and a constraint structure, the near end of the main branch balloon is connected with the far end of a first tube body through a first tube pin, and the far end of the main branch balloon is provided with a first end; the near end of the side branch balloon is connected with the far end of the second tube body through a second tube pin, and the far end of the side branch balloon is provided with a second end head; and the limiting part is used for limiting the relative position between the main branch balloon and the second tube pin, and / or limiting the relative position between the first tube body and the second tube body. By means of the double-balloon cooperative positioning structure, the problems that the side branch blood vessel is not protected or operation is complex when a preset balloon technology is used, and positioning of a main branch instrument and a side branch balloon is difficult are solved; the method has the advantages of effectively implementing collateral vessel protection, simplifying the operation steps, shortening the operation time, improving the cooperative positioning precision of the main branch instrument and the collateral balloon, reducing the operation risk and the like.

The present invention provides an improved vascular sheath and dilator assembly designed to enhance operability, accuracy, and safety during vascular access. [Solution] This assembly comprises a vascular sheath with side ports and a dilator featuring a closed distal end and an in-luminal deflection section. The deflection section smoothly reguides the guidewire toward the dilator's side port, which aligns with the side port of the vascular sheath, when the dilator is properly positioned within the vascular sheath, thereby facilitating precise navigation of the guidewire to the side vessels of the vascular structure. The assembly also incorporates visual markers in both the vascular sheath and the dilator to ensure accurate alignment of the side ports. These features, together, improve the overall effectiveness and safety of vascular procedures.

The invention discloses an adherent delivery and perfusion device for drugs in injured blood vessels, and belongs to the technical field of medical instruments. The local drug delivery device and an anchoring mechanism work cooperatively, anchoring is combined with local adherent drug delivery, so that slipping and displacement of the system can be prevented, and accurate quantitative drug release and absorption at a target lesion part are realized; the anchoring mechanism realizes two working modes of targeted local delivery of a treatment substance for blocking blood flow and targeted local delivery of a treatment substance for not blocking blood flow by means of a blood flow blocking anchoring balloon and a non-blood flow blocking net-shaped medicine elution balloon, and the two working modes can be used for local anchoring of a main branch blood vessel or a side branch blood vessel. The design of the filling holes can accurately adjust the types and doses of the medicines. The blood flow blocking mode can realize local high-concentration administration, and the non-blocking mode can control vasodilation and administration time. Through the synergistic effect of the functions, the system can optimize the operation process, improve the operation efficiency and achieve accurate and quantitative drug delivery.

The scraping therapy comb plate comprises a comb plate body, a plurality of first groove bodies and a plurality of second groove bodies are formed in one side of the comb plate body in the horizontal direction in a staggered mode, and a collateral vessel scraping therapy part is formed in the comb plate body through the first groove bodies and the second groove bodies; a hanging mechanism is arranged at the corner of the comb plate body and comprises a connecting part and a hanging part. A plurality of first grooves and a plurality of second grooves are formed in one side of the comb plate body in the horizontal direction in a staggered mode, so that more collateral and vein scraping parts are provided with protruding structural bodies with different shapes, when the structure is used for scraping, pressing scraping and sweeping can be better conducted according to the veins of the human body, and the scraping effect is good. Meanwhile, according to the scheme, the hanging mechanism is arranged, the hanging mechanism can enable the comb plate body to be stored in a hanging mode, the storage modes are enriched, and meanwhile the hanging mechanism is utilized, so that the comb plate body is more diversified in use and operation.

In part, the disclosure relates to intravascular data collection systems and the software-based visualization and display of intravascular data relating to detected side branches and side branch obstruction. An estimate of side branch diameter can be made based on a vessel profile or a maximum diameter of a vessel at a distal and proximal location relative to the side branch. A amount of side branch obstruction may be determined by comparing an observed side branch diameter with in the image data with the estimated side branch diameter. In addition, an amount of blood flow obstruction may also be determined.

Disclosed in the present invention is an occlusion apparatus, which comprises a first disc body, a second disc body, a waist portion, and a connecting portion, wherein the first disc body and the second disc body are connected by means of the waist portion; the first disc body is configured to be placed on a first side of a site to be occluded; the second disc body is configured to be placed on a second side of said site; the waist portion penetrates through said site; the connecting portion is disposed on a side of the first disc body and / or the second disc body close to said site, and the connecting portion is configured to be fixedly connected to a peripheral tissue of said site. The present invention can achieve precise occlusion of said site, and can enable the first disc body, the second disc body, and the waist portion to adhere well to the wall of the peripheral tissue of said site. Moreover, the occlusion apparatus can be prevented from falling off, and the use of the occlusion apparatus can prevent excessive occlusion, so that obstruction of the blood flow in a collateral vessel at said site can be prevented, thereby avoiding paralysis.