34 results about "Collateral vessels" patented technology

A method is provided for analyzing the vasculature of a subject. A vessel tree is identified in an image of a region of interest. The major vessels, forming part of a standardized tree of the major vessels, are identified, and in turn the remaining vessels of the identified vessel tree are identified, thus excluding the major vessels of the standardized tree. This isolates the collateral vessels in the region of interest, and an analysis of the collateral vessels can then be performed.

Endovascular prostheses used to treat diseased blood vessels, such as arteries, are disclosed. In some embodiments, the endovascular prosthesis is configured to be implanted within the diseased blood vessels adjacent a diseased section. The endovascular prosthesis may include a selectively openable internal duct configured to sealingly receive an expandable endovascular prosthesis that extends into a side branch vessel of the diseased blood vessel.

This invention discloses an intestinal fungus Saccharomyces cerevisiae M7015 and its applications belong to the field of microbial technology. Saccharomyces cerevisiae The accession number for M7015 is GDMCC No. 66195. This invention first demonstrated, using a mouse subcutaneous stroma embolism model, that the aforementioned strain can promote angiogenesis; secondly, using mouse and Bama miniature pig myocardial infarction models, it was found that the aforementioned strain can promote collateral angiogenesis in ischemic areas of the heart and improve cardiac function. This invention not only fully elucidates... Saccharomyces cerevisiae M7015 promotes the formation of collateral vessels in the heart and improves cardiac function, and also reveals the broad application prospects of this bacterium in the treatment of vascular diseases.

A method of producing an arteriovenous (AV) fistula includes producing an anastomosis between a primary blood vessel (e.g., a vein) and a secondary blood vessel (e.g., an artery). A collateral (or competing) blood vessel in fluid communication with one of the primary blood vessel or the secondary blood vessel is identified. A reversible flow restrictor is then applied to the collateral blood vessel to reduce a blood flow rate through the collateral blood vessel. In some embodiments, the anastomosis can be produced percutaneously. In some embodiments, the reversible flow restriction (or a portion thereof) can be removed from the collateral blood vessel. In other embodiments, the reversible flow restriction (or a portion thereof) can be adjusted to allow increased blood flow therethrough while within the collateral blood vessel.

A method and systems for treating chronic total occlusions, particularly those that are difficult to treat, is disclosed. hi this approach, recanalizing the CTO is achieved using a combined antegrade and retrograde 5 approach. The proximal end of the occlusion is penetrated using an antegrade wire, using a traditional approach. Using collateral vessels, the distal end of the occlusion is crossed in a retrograde fashion. By appropriately maneuvering each member and applying radiofrequency energy between the proximal and distal ends of the occlusion, a continuous channel is created.

The invention relates to an aorta covered stent. The aorta covered stent comprises a main stent, a plurality of leg-separating stents and a skirt stent. Wherein all the leg separating supports are connected with the main support, and all the leg separating supports and the main support jointly form a blood flow channel for blood circulation. The skirt support comprises a skirt framework and a skirt covering film covering the skirt framework, the skirt support is arranged outside all the leg separating supports in a sleeving mode, one end of the skirt support is connected with the main support, and the other end of the skirt support is a free end. According to the aorta covered stent, collateral vessels on a tumor body can be blocked, II-type internal leakage is avoided, blood flow of the collateral vessels is prevented from flowing back into an aneurysm cavity, continuous flushing of the blood flow to the tumor cavity is reduced, and continuous enlargement of the tumor cavity is avoided.

The invention discloses an intracranial dura mater arteriovenous fistula medical image analysis method, and relates to the technical field of medical image.The method comprises the steps that a digital subtraction angiography dynamic image sequence after interventional embolization treatment is obtained; performing motion compensation on each frame of image in the dynamic image sequence; extracting a time-varying track of the signal intensity of the contrast agent from the dynamic image sequence after motion compensation; identifying a blood vessel dynamic mode based on the track of the contrast agent signal intensity changing along with time; performing dynamic enhancement processing on the blood vessel image area in the blood vessel dynamic mode according to the hemodynamic characteristics; extracting a blood vessel signal from the dynamic image under the enhancement processing; and reconstructing a three-dimensional model under the cerebrovascular network in a three-dimensional space based on the blood vessel signal. According to the method, a reliable basis is provided for a doctor to evaluate the treatment effect, judge the residual focus or recruit the collateral vessel, misdiagnosis and misjudgment are avoided, and therefore the treatment effect and safety of a patient are improved.

The application relates to a coronary microcirculation vascular resistance acquisition method and system based on a layered myocardial model, which comprises the following steps: establishing a coronary vessel model from medical images; generating a side vessel for the coronary artery; regarding the coronary artery and the side vessel as main vessels, fitting and constructing an outer surface of a myocardial model according to the outlet position of the main vessels, establishing an inner surface of the myocardial model based on a similar principle to the outer surface, and ensuring that the volume of the model is the myocardial volume value; using an ellipsoid surface for layered interpolation; selecting a point P in the outermost layer and connecting the main vessel outlet to generate a microcirculation vessel; selecting a point T outside the current layer and cooperating with the nearest microcirculation vessel to generate a bifurcated microcirculation vessel; gradually advancing to the inner layer to form bifurcation and ensure the bifurcation number of each layer; and calculating the resistance value of the main vessel outlet. Compared with the prior art, the application considers the distribution of the coronary artery at various levels of the myocardium under real conditions, so that the calculated resistance value is more accurate and has the specificity of a patient.

The present invention relates, in part, to shadow detection and shadow verification with respect to data sets obtained from intravascular imaging data collection. The method can use local adaptive thresholding and scan line level analysis with respect to candidate shadow regions to determine a set of candidate shadows for verification or rejection. In one embodiment, the shadows are stent strut shadows, guidewire shadows, collateral vessel shadows, or other shadows.

The utility model discloses an improved single-bend soft head, relates to the technical field of medical instruments, and aims to solve the problems that an elbow at the front end of an existing puncture needle is in a reverse hook shape due to large radian and is not easy to follow up after entering a blood vessel along the puncture needle, and the head end is in the reverse hook shape when a guide wire is withdrawn. And the head end of the guide wire is broken and left in a blood vessel due to cutting by the sharp head end of a puncture needle. The front end of the connecting pipe is fixedly connected with a connector, the front end of the connector is provided with a first guide wire, the front end of the first guide wire is fixedly connected with a second guide wire, the second guide wire is in a large-angle arc shape, the first guide wire (3) is made of hard materials, and the second guide wire (4) is made of soft materials. According to the improved single-bend soft head, the radian of the head bend is increased, follow-up of a guide wire is better facilitated after a puncture needle successfully punctures a blood vessel, the head end is made of the soft material, vascular intima is not prone to being damaged, the head end has the radian, the head end is not prone to entering a non-target collateral vessel, and the head end can easily enter a target collateral vessel selectively under perspective; and the retracement guide wire is not easy to cut by the sharp head end of the puncture needle.

The invention discloses a preparation method and application of a novel macrophage for treating myocardial infarction, and belongs to the fields of cell engineering, nanotechnology, material science, immunology and the like. According to the invention, bone marrow-derived macrophages are induced to be polarized to M2 type and are subjected to magnetic modification, so that the macrophages are endowed with the capability of efficiently expressing vascular endothelial growth factors, Mag M2-M-VEGF cells are obtained, and proliferation of endothelial cells and formation of collateral vessels are promoted through local high expression of VEGF at a myocardial infarction part, so that local ischemia injury is relieved. According to the invention, precise targeted delivery of cells is realized, local inflammatory response is inhibited, and blood perfusion in an infarction area is improved. The medicine is endowed with magnetic targeting capacity by internalizing Fe3O4 NPs and is accurately enriched in myocardial infarction tissue under the guidance of a magnetic field, M2 type polarization inhibits pro-inflammatory reaction by reducing pro-inflammatory factor release and releasing a large amount of anti-inflammatory factors, and meanwhile, VEGF is specifically secreted, angiogenesis of an infarction part is promoted, and the capillary density of an infarction region is effectively increased.

According to the multi-part image acquisition system and method for traditional Chinese medicine inspection diagnosis, the medium, the program product and the terminal provided by the invention, full-automatic closed acquisition of three traditional Chinese medicine inspection diagnosis key parts, namely a human face, a lingual surface and a lingual floor, is realized. The environment light sensor and the color temperature sensor are integrated in the closed shooting cavity, a closed-loop feedback mechanism is constructed, the light source assembly is accurately regulated and controlled, and it is ensured that the color temperature is stabilized in a medical effective interval. According to the invention, a multi-mode in-place detection mechanism is provided, infrared proximity sensing and a light-weight tongue posture light detection model are fused, whether each part is subjected to compliance exposure or not is accurately judged, posture compliance guidance is carried out, and the visibility of key signs such as sublingual collaterals in the image is remarkably improved. Through a closed shooting cavity structure and a multi-mode in-place detection and closed-loop guide mechanism, multi-part high-quality image automatic acquisition without manual intervention from user guide, illumination adjustment and quality evaluation to automatic shooting is realized.

A system and method for treating a bifurcated vessel may include a mother catheter with a mother expandable member coupled to a distal portion of a mother elongate shaft. A daughter catheter has a daughter expandable member coupled to a distal portion of a daughter elongate shaft. A therapeutic agent is carried on the daughter expandable member. Radial expansion of the daughter expandable member engages the daughter expandable member with a wall of the daughter vessel and the therapeutic agent elutes from the daughter expandable member into the wall.

The invention discloses an aneurysm endo-covered stent, the technical solution of which is as follows: it comprises a plurality of groups of metal rods and biofilms, wherein the plurality of groups of metal rods form a lantern-shaped skeletal stent body, the biofilm covers the outer surface at the middle position of the stent body, the thickness of the biofilm is 8-24 μm, one end of the stent body is connected with a pushing device, the pushing device comprises a guide wire and a delivery catheter sleeved on the guide wire, an opening mechanism is further arranged on the inner side of the biofilm, the opening mechanism is used to open the biofilm so that the biofilm completely blocks the aneurysm neck, the front end of the guide wire is welded to one end of the opening mechanism by hot-melt metal; the blood flow from the tumor-bearing artery to the aneurysm is reduced by the arranged biofilm, and the blood flow impact is reduced; and the invention is arranged between the aneurysm and the tumor-bearing artery to solve the problem of blockage of the side branch blood vessels of the stent segment caused by the conventional covered stent.

A system and method for treating a bifurcated vessel may include a mother catheter with a mother expandable member coupled to a distal portion of a mother elongate shaft. A daughter catheter has a daughter expandable member coupled to a distal portion of a daughter elongate shaft. A therapeutic agent is carried on the daughter expandable member. Radial expansion of the daughter expandable member engages the daughter expandable member with a wall of the daughter vessel and the therapeutic agent elutes from the daughter expandable member into the wall.

A system for selecting a collateral vessel to perform a retrograde chronic total occlusion (CTO) treatment procedure is provided. The system includes one or more processors configured to: receive angiographic image data (120) representative of an occlusion in a target blood vessel; analyzing the angiography image data (120) to identify one or more candidate collateral vessels (1501... i) for approaching the occlusion in the target vessel in a retrograde direction; and assigning a suitability score to each candidate collateral vessel (1501... i), the suitability score representing a suitability of the vessel for performing the retrograde CTO treatment procedure on the occlusion.

The application relates to a method and system for obtaining coronary end microcirculation vascular resistance based on vascular growth, and the method comprises the following steps: acquiring medical images, and extracting a myocardial model and a coronary vascular model respectively; generating collateral vessels in the coronary vascular model; regarding all coronary vessels and collateral vessels as main vessels, and obtaining the position coordinates and the vascular radius; randomly selecting a point P in the myocardial model, connecting the point P with the outlet of the main vessel, and generating microcirculation vessels for each outlet of the main vessel; randomly selecting a point T in the point cloud file of the myocardial model, connecting the point T with the nearby microcirculation vessels, and generating multiple bifurcated microcirculation vessels, until the radius of all vessel outlets in the generated vascular tree is smaller than a preset vascular threshold; and calculating the resistance value of each outlet of the main vessel. Compared with the prior art, the coronary end microcirculation vascular resistance value calculated based on the reestablished microcirculation vascular model is more accurate and has the specificity of patients.

An endovascular treatment system including branch features for perfusing branch vessels such as the renal arteries, celiac arteries, and mesenteric arteries (e.g., for treating aortic aneurysms).

A method and systems for treating chronic total occlusions, particularly those that are difficult to treat, is disclosed. hi this approach, recanalizing the CTO is achieved using a combined antegrade and retrograde approach. The proximal end of the occlusion is penetrated using an antegrade wire, using a traditional approach. Using collateral vessels, the distal end of the occlusion is crossed in a retrograde fashion. By appropriately maneuvering each member and applying radiofrequency energy between the proximal and distal ends of the occlusion, a continuous channel is created.

The invention provides application of an NCOA3 polyQ structural domain as a target spot in preparation of a medicine for relieving lower limb ischemic diseases, relates to the technical field of biomedicine, and aims to solve the problems that in the prior art, blood flow reperfusion recovery of the lower limb ischemic diseases is poor, collateral vessels are insufficient in formation, and safe and effective targeted intervention means are lacked. By constructing a mouse lower limb ischemia model, it is proved that blood flow recovery and collateral angiogenesis after ischemia are remarkably inhibited by Nco3polyQ structural domain deletion: compared with a WT mouse, postoperative blood flow perfusion of an Nco3Q / Q mouse is recovered slowly, and the blood flow of the affected side is only recovered by 60% on the 21st day after the operation; the CD31 positive region of the gastrocnemius muscle tissue on the 14th day after the operation is obviously reduced, and the mRNA expression of the blood vessel marker gene Pecam1 is reduced. On the basis, an intervention strategy aiming at the NCOA3 polyQ structural domain is used for preparing the medicine for relieving the lower limb ischemic disease, and a new treatment strategy and a potential target are provided for the ischemic limb disease.

This invention provides a biomarker for collateral circulation in CTO patients, MIA3, and its application, belonging to the field of biotechnology. This invention reveals and verifies a significant positive correlation between plasma MIA3 levels and the quality of collateral circulation formation in CTO patients, and its predictive efficacy for good collateral circulation is superior to that of the known key angiogenesis factor VEGFA. This allows MIA3 to serve as a high-value, minimally invasive molecular marker for early, non-invasive identification of a patient's collateral circulation formation potential before interventional surgery, thereby enabling risk stratification and providing an objective basis for individualized treatment decisions (such as whether more aggressive intervention is needed). This invention clarifies that MIA3 is a key link in regulating collateral angiogenesis; by targeting and upregulating MIA3 activity, collateral angiogenesis and maturation in ischemic areas can be precisely promoted, providing a novel non-pharmacological, non-surgical treatment strategy for CTO patients.

Exemplary embodiments comprise AV fistulas and other anastomotic devices for creating new or reinforcing existing side-branch vessels, and / or bridging neighboring vessels together. An exemplary embodiment may comprise a sidewall port, such as a flanged sidewall port, and / or flow frame design, such as a partially bare, flexible stent or a whisk, for purposes of creating a transmural flow. Another exemplary embodiment may comprise a compliant vessel support to aid in the transition from device to vessel and / or vessel to device, and to promote vessel dilation.

The present invention relates to an improved vascular sheath and dilator arrangement designed to increase maneuverability, procedure accuracy, and safety during vascular access. The arrangement comprises a vascular sheath with a side port and a dilator with a closed distal end and a deflection section within its lumen. This deflection section gently guides a guidewire toward a side port of the dilator, which is aligned with the side port of the vascular sheath when the dilator is correctly positioned within the sheath, thereby facilitating precise navigation of the guidewire into lateral vessels of a vascular structure. The arrangement also includes visual markers on both the vascular sheath and the dilator to ensure accurate alignment of the side ports. These features collectively improve the efficiency and safety of vascular procedures.

The invention provides an interventional catheter assembly, and belongs to the technical field of medical instruments. The catheter assembly comprises a conveying catheter body, and the conveying catheter body is provided with a first conveying catheter cavity arranged in the axial direction and used for conveying a treatment instrument to a treatment part; a second conveying pipe cavity parallel to the first conveying pipe cavity is further formed in the conveying pipe body, a penetrating hole communicated with the outside is formed in the second conveying pipe cavity, and a supporting micro-catheter is arranged in the second conveying pipe cavity in a sliding mode and used for penetrating into a collateral vessel of the common carotid artery from the conveying pipe body through the penetrating hole. The supporting micro catheter is provided with a positioning component which is used for preventing the conveying catheter body from displacing at the intersection of the common carotid artery and the aortic arch when the treatment instrument is conveyed, so that the position stability of the conveying catheter body is guaranteed when the treatment instrument is conveyed to a treatment part through the first conveying catheter cavity; the catheter is mainly used for solving the technical problem that an instrument is inconvenient to convey due to insufficient supporting performance of an existing catheter.

A guide wire insertion method for inserting a guide wire into a blood vessel having a main vessel and a side branch branched from the main vessel. The method includes providing a guide wire having a knuckle advance suppressing structure; inserting the guide wire into a main vessel of a blood vessel of a patient and pushing a distal end of the guide wire toward an affected part; after the distal end of the guide wire is caught by a side branch of the blood vessel, generating a knuckle at a distal end portion of the guide wire, and removing the distal end of the guide wire from the side branch, and pushing the distal end portion toward the affected part in the main vessel while maintaining the knuckle.

The invention relates to the technical field of medical instruments, and provides a branch protection balloon catheter which comprises a main branch balloon, a side branch balloon and a constraint structure, the near end of the main branch balloon is connected with the far end of a first tube body through a first tube pin, and the far end of the main branch balloon is provided with a first end; the near end of the side branch balloon is connected with the far end of the second tube body through a second tube pin, and the far end of the side branch balloon is provided with a second end head; and the limiting part is used for limiting the relative position between the main branch balloon and the second tube pin, and / or limiting the relative position between the first tube body and the second tube body. By means of the double-balloon cooperative positioning structure, the problems that the side branch blood vessel is not protected or operation is complex when a preset balloon technology is used, and positioning of a main branch instrument and a side branch balloon is difficult are solved; the method has the advantages of effectively implementing collateral vessel protection, simplifying the operation steps, shortening the operation time, improving the cooperative positioning precision of the main branch instrument and the collateral balloon, reducing the operation risk and the like.

The present invention provides an improved vascular sheath and dilator assembly designed to enhance operability, accuracy, and safety during vascular access. [Solution] This assembly comprises a vascular sheath with side ports and a dilator featuring a closed distal end and an in-luminal deflection section. The deflection section smoothly reguides the guidewire toward the dilator's side port, which aligns with the side port of the vascular sheath, when the dilator is properly positioned within the vascular sheath, thereby facilitating precise navigation of the guidewire to the side vessels of the vascular structure. The assembly also incorporates visual markers in both the vascular sheath and the dilator to ensure accurate alignment of the side ports. These features, together, improve the overall effectiveness and safety of vascular procedures.

The invention discloses an adherent delivery and perfusion device for drugs in injured blood vessels, and belongs to the technical field of medical instruments. The local drug delivery device and an anchoring mechanism work cooperatively, anchoring is combined with local adherent drug delivery, so that slipping and displacement of the system can be prevented, and accurate quantitative drug release and absorption at a target lesion part are realized; the anchoring mechanism realizes two working modes of targeted local delivery of a treatment substance for blocking blood flow and targeted local delivery of a treatment substance for not blocking blood flow by means of a blood flow blocking anchoring balloon and a non-blood flow blocking net-shaped medicine elution balloon, and the two working modes can be used for local anchoring of a main branch blood vessel or a side branch blood vessel. The design of the filling holes can accurately adjust the types and doses of the medicines. The blood flow blocking mode can realize local high-concentration administration, and the non-blocking mode can control vasodilation and administration time. Through the synergistic effect of the functions, the system can optimize the operation process, improve the operation efficiency and achieve accurate and quantitative drug delivery.

The scraping therapy comb plate comprises a comb plate body, a plurality of first groove bodies and a plurality of second groove bodies are formed in one side of the comb plate body in the horizontal direction in a staggered mode, and a collateral vessel scraping therapy part is formed in the comb plate body through the first groove bodies and the second groove bodies; a hanging mechanism is arranged at the corner of the comb plate body and comprises a connecting part and a hanging part. A plurality of first grooves and a plurality of second grooves are formed in one side of the comb plate body in the horizontal direction in a staggered mode, so that more collateral and vein scraping parts are provided with protruding structural bodies with different shapes, when the structure is used for scraping, pressing scraping and sweeping can be better conducted according to the veins of the human body, and the scraping effect is good. Meanwhile, according to the scheme, the hanging mechanism is arranged, the hanging mechanism can enable the comb plate body to be stored in a hanging mode, the storage modes are enriched, and meanwhile the hanging mechanism is utilized, so that the comb plate body is more diversified in use and operation.

A method of producing an arteriovenous (AV) fistula includes producing an anastomosis between a primary blood vessel (e.g., a vein) and a secondary blood vessel (e.g., an artery). A collateral (or competing) blood vessel in fluid communication with one of the primary blood vessel or the secondary blood vessel is identified. A reversible flow restrictor is then applied to the collateral blood vessel to reduce a blood flow rate through the collateral blood vessel. In some embodiments, the anastomosis can be produced percutaneously. In some embodiments, the reversible flow restriction (or a portion thereof) can be removed from the collateral blood vessel. In other embodiments, the reversible flow restriction (or a portion thereof) can be adjusted to allow increased blood flow therethrough while within the collateral blood vessel.