33 results about "Capillary Beds" patented technology

A fat removal device includes a screen which includes passages through which fat can be extruded, to be cut or melted away from the surface of an internal organ. The device includes a blade to cut the fat or radiofrequency monopolar or bipolar electrodes to melt the fat, aspiration to remove the fat away from the screen and blade, irrigation to irrigate the screen and blade, and an electrocautery member to cauterize the capillary bed of the fat. Methods of using removing the fat layer from the surface of an internal body organ are also described.

A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.

A fat removal device includes a screen which includes passages through which fat can be extruded, to be cut or melted away from the surface of an internal organ. The device includes a blade to cut the fat or radiofrequency monopolar or bipolar electrodes to melt the fat, aspiration to remove the fat away from the screen and blade, irrigation to irrigate the screen and blade, and an electrocautery member to cauterize the capillary bed of the fat. Methods of using removing the fat layer from the surface of an internal body organ are also described.

A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.

Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriate sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.

The invention discloses a photoelectric volume wave-based breathing rate monitoring method. The method is characterized by comprising the following steps: first, acquiring a photoelectric volume wave digital signal of the change of the blood volume on a capillary bed on the surface of skin at a position to be monitored, wherein the signal is an original photoelectric volume wave signal which has not been filtered, contains breathing information and has a sampling frequency over 500 Hz; then, preprocessing an acquired photoelectric volume wave by using a mathematical morphology method; next, detecting a peak point and a valley point of each beat of a volume pulse wave by adopting a characteristic point positioning method by the preprocessed signal; later on, calculating time interval variable of each beat and the difference variable between the peak point and the valley point of each beat; and finally, detecting obtained the breathing rhythms of the time interval variable and an amplitude variable, and calculating a breathing rate.

The present invention relates to a system for measuring a micro-vascular flow distribution of a tissue portion of a mammal comprising means (101) for measuring a first indicator (MTT) for the blood flow through a capillary bed, means (102) for measuring a second indicator (CTTH) of heterogeneity of the blood flow in said capillary bed, and a first processor (110) arranged for using the first and the second indicator to estimate an extraction capacity (EC) of a substance from the blood in said capillary bed.

The invention provides a method for engraving (three-dimensional) bionic artificial bones in compound bioactive material microdomains. The method comprises the following steps: selecting orthopedics department hard biological materials and active cell tissues for growing support materials, carrying out bionics matching, and carrying out 3DMAX creation and 3D printing by adopting computer three-dimensional design, thus realizing the simulation of artificial bone materials and structures; establishing an artificial bone microcirculation structure and a blood perfusion condition; establishing osteogenesis stem cells growing environments, namely a capillary bed and a biological activity support. The capillary bed and the biological activity support manufactured by adopting the method have the advantages that the initiative response of hard materials (transplanted bones) and host bones is established, the problem of the initiative fusion between currently various biological materials comprising artificial bone materials of allogeneic bones and the host bones is solved, the clinical indication range of bone transplantation is widened, the secondary replacement of artificial joints can be avoided, and the application ranges of the artificial bones and the artificial joints can be widened.

Medical software tools platform utilizes a surgical display to provide access to specific medical software tools, such as medically-oriented applications or tools, that can assist those in the operating room, such as a surgeon or surgical team, with a surgery. In particular, an optical sensor located within an endoscopic camera may register subtle differences in color characteristics reflected from a tissue surface and in turn transmit the information to a medical image processing system. Moreover, the new tools are intended to help surgeons better determine the boundaries between healthy and diseased regions during surgical procedures. Various tools are intended to be used in procedures where indocyanine green (ICG) fluorescent dye is used. Intraoperative fluorescence imaging is commonly used during minimally invasive procedures to enable surgeons to visualize tissue perfusion and anatomical structures. The term perfusion refers to the passage of blood and tissue fluid through the capillary bed. Intraoperative fluorescence imaging can also be used to improve visualization of vessels and structures, which, in turn, may reduce the risk of complications during minimally invasive surgeries.

A method of transarterial embolization agent delivery at a low pressure is provided. The method comprises advancing a delivery device with an occlusion structure in a retracted non-occlusive configuration through a supply artery to a vascular position in the supply artery that is in the vicinity of a target anatomical structure, the target structure having terminal capillary beds, expanding the occlusion structure from the retracted non-occlusive configuration to an expanded occlusive configuration, lowering a mean arterial pressure in a vascular space distal to the expanded occlusion structure, redirecting fluid flow from the collateral vessels toward the lowered pressure vascular space and into the target anatomical structure, injecting an embolization agent through the delivery device and into the lowered pressure vascular space, and delivering the embolization agent from the lowered pressure vascular space into the target anatomical structure. Other catheter assemblies and methods of use are also disclosed.

Compositions and methods for treating subjects with disorders characterized by aberrant vascular endothelial cell growth are provided. The compositions comprise agents that are combinations of a Wnt pathway stimulator component and a Tie2 pathway repressor component. Particularly useful Wnt pathway stimulators include, but are not limited to, Wnt7b-like molecules. Particularly useful Tie2 pathway repressor components include, but are not limited to, Ang2-like molecules. The methods allow for modulation of vascular endothelial cells, vascular endothelial cell vessels, capillary bed development, and angiogenesis.

An improved circulating cell counter for generating light, and for delivering this light to a site in vivo for determining the presence, absence, concentration or count of a target cell, in which a light source such as a laser diode (121) and integrated optics (153) produce a beam transmitted to an in vivo target region (165), such as a capillary bed with flowing cells in a living tissue. Based upon the movement of cells in and out of this region, a circulating cell count (192) is generated, allowing determination of the presence, absence, concentration or count of the target cell. Use with optical, magnetic, or nanobot contrast agents, and methods of use are also described.

Systems and methods for occluding one or more blood vessels in a patient using variable viscosity fluids. The variable viscosity fluids are delivered in a liquefied state to the vasculature of the patient using a catheter or a micro-catheter. The blood vessels intended to be occluded may be any blood vessel within the vasculature of the patient, including capillary blood vessels in a capillary bed of the patient. The variable viscosity fluids may be an electro-rheologic fluid responsive to an electric current provided by an electric current generator, or may be a magneto-rheologic fluid responsive to a magnetic field provided by a magnetic field generator. The electric current generator is a power source that provides current to create a potential difference between electrodes placed about the blood vessels intended to be occluded. The potential difference between the electrodes changes the electro-rheologic fluid from the liquefied to a solidified state. Alternatively, a magnetic field generator provides a magnetic field that, when present, changes the magneto-rheologic fluid from the liquefied to a solidified state. When solidified, the variable viscosity fluids provide the desired occlusion of the intended blood vessel or vessels and restricts flow therethrough the blood vessels. When liquefied, the variable viscosity fluids permit flow therethrough the blood vessels. The duration of the occlusion depends on the presence of the electric current in the case of an electro-rheologic fluid, or on the presence of the magnetic field in the case of a magneto-rheologic fluid.

The invention discloses a taxol-carried nano microbubble and a preparation method thereof. The microbubble has a membrane consisting of a lipoid bilayer and containing N2; the lipoid bilayer comprises hydrophilic groups and hydrophobic groups; the hydrophilic groups are bonded with taxol and the taxol is carried in the membrane consisting of the lipoid bilayer; and the lipoid bilayer is formed by compounding lecithin, cholesterol, polyethylene glycol (PEG)-4000, glucan, Span 80, methanol, ether, 3 percent human serum albumin, a taxol standard substance, and phosphate buffered saline (PBS) liquid. The taxol-carried nano microbubble does not have toxicity or side effect, can be used for peripheral intravenous injection, can pass through the lung and a capillary bed of the whole body (the diameter is generally less than 5 um), can be circulated to tissues of the whole body along with blood after the intravenous injection, has high stability, has a long duration in blood circulation, anddoes not influence blood flow dynamic of the whole body or a certain system.

An improved composition for treatment of ulcer-type skin conditions. The composition is primarily characterized by a combination of nitroglycerin and arginine. Other embodiments comprise emollient cream, mineral oil, tumeric powder, folic acid, vitamin B12, and zinc citrate. The composition is particulary effective in improving blood flow in the underlying capillary bed about the wound, improving nerve growth about the wound, increasing circulation, and having a standardized and more predictable therapeutic characteristic.

This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of two pluralities of microparticles, one comprising drug-carrying microparticles sized to lodge at the tumor preferably in the capillary bed of the tumor and the other comprising non-drug-carrying microparticles sized to lodge in the arterial system servicing the tumor so as to embolize the tumor.

The invention discloses a transplanting method for DAR-FUE high-density active monomer follicles, and belongs to the technical field of hair transplant. The transplanting method includes S1, dissecting and analyzing follicle tissues, analyzing microelements of hair, and detecting the health state of the hair quality; S2, designing planting angle, planting density and growth direction; S3, extracting the follicles by a double-helix extractor which rotates alternately in forward and backward directions; S4, performing fine separation on the extracted follicles under a professional microscope; S5, punching the skin at a hair transplant part by a punch positioning needle to form follicle holes, and transplanting the follicles into the follicle holes; S6, performing nursing after transplant. The transplanting method has the advantages that the transplanted hair seems like physiological hair and grows naturally later, scalp capillaries are protected to the greatest extent, damage to capillary beds is reduced, and survival rate of the follicles is increased.

Systems and methods of biometric identification of a subject have steps of providing a light source and an imager, positioning a subject hand palm facing the light source and imager, illuminating the palm with the light source, capturing an image of the palm, and determining characteristics of capillary beds in the image. The present invention may include the step of identifying the subject based on the characteristics of the capillary beds. The step of determining characteristics of capillary beds in the image may include determining locations of the capillary beds. The present invention may include the step of processing the image to filter image features of the palm other than the capillary beds. Processing the image to filter image features of the palm other than the capillary beds may include removing surface ridge pattern features and spatially filtering to remove detail with a frequency of less than a selected threshold.

A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Medical software tools platform utilizes a surgical display to provide access to specific medical software tools, such as medically-oriented applications or tools, that can assist those in the operating room, such as a surgeon or surgical team, with a surgery. In particular, an optical sensor located within an endoscopic camera may register subtle differences in color characteristics reflected from a tissue surface and in turn transmit the information to a medical image processing system. Moreover, the new tools are intended to help surgeons better determine the boundaries between healthy and diseased regions during surgical procedures. Various tools are intended to be used in procedures where indocyanine green (ICG) fluorescent dye is used. Intraoperative fluorescence imaging is commonly used during minimally invasive procedures to enable surgeons to visualize tissue perfusion and anatomical structures. The term perfusion refers to the passage of blood and tissue fluid through the capillary bed. Intraoperative fluorescence imaging can also be used to improve visualization of vessels and structures, which, in turn, may reduce the risk of complications during minimally invasive surgeries.

An improved method of treatment of ulcer-type skin conditions. The method is primarily characterized by applying a combination of nitroglycerin and arginine. The composition may be applied topically or injectablely. Also, the method provides for the skin wound to be substantially free from debridement or washing. Further, the skin wound is typically covered with some breathable adhesive such that the wound is exposed to surrounding air and remains substantially free from undue moisture. This treatment regimen is particularly effective in improving blood flow in the underlying capillary bed about the wound, improving nerve growth about the wound, increasing circulation, and having a standardized and more predictable therapeutic characteristic.

Success of in vitro vasculogenesis has been limited to structuring relatively small leaky capillary networks and short scaffold-supported vascular-like, tubes that have in some cases, stimulated limited vasculogenesis in vivo. These attempts lacked the structural design millions of years of evolution has established in creating vascular structures. Many mathematical models have taken an approach at computing the anastomosis and patterning found in the vascular branching systems present tissue structures. These attempts at modeling a vascular tree system fall far short in being able to reproduce the structural specificity need for specialized tissue structure such as lung and kidney tissues. I define this vascular tree network as a blood vascular system that includes the capillary bed system, which supplies blood to and from a tissue structure.By using what I term as reverse bioengineering, vascular trees can be created on scaffolds designed using image data obtained from select in vivo vascular networks. With these reverse bioengineered vascular trees the genesis of tissues reproducing these and other selected tissue structure can be supported.

The invention discloses a taxol-carried nano microbubble and a preparation method thereof. The microbubble has a membrane consisting of a lipoid bilayer and containing N2; the lipoid bilayer comprises hydrophilic groups and hydrophobic groups; the hydrophilic groups are bonded with taxol and the taxol is carried in the membrane consisting of the lipoid bilayer; and the lipoid bilayer is formed by compounding lecithin, cholesterol, polyethylene glycol (PEG)-4000, glucan, Span 80, methanol, ether, 3 percent human serum albumin, a taxol standard substance, and phosphate buffered saline (PBS) liquid. The taxol-carried nano microbubble does not have toxicity or side effect, can be used for peripheral intravenous injection, can pass through the lung and a capillary bed of the whole body (the diameter is generally less than 5 um), can be circulated to tissues of the whole body along with blood after the intravenous injection, has high stability, has a long duration in blood circulation, and does not influence blood flow dynamic of the whole body or a certain system.

An apparatus useful for the rapid collection of blood from a subject (e.g., a blood vessel, such as the vein, artery or capillary bed of a bovine subject) and dispensing the blood therefrom into a test or collection device. In general, the apparatus comprises: (a) a body having a chamber formed therein, said chamber having an inlet and outlet, with said chamber configured to draw blood therein; (b) a hollow barrel connected to said chamber outlet; (c) an ejector operatively associated with said barrel; (d) a hollow needle connected to said body, with said hollow needle in fluid communication with said chamber through said inlet, so that blood can be rapidly drawn into said chamber through said needle. The needle is optionally removed and blood dispensed from the body into a test or collection device by actuating the ejector.

The present invention relates to a system for measuring a micro-vascular flow distribution of a tissue portion of a mammal comprising means (101) for measuring a first indicator (MTT) for the blood flow through a capillary bed, means (102) for measuring a second indicator (CTTH) of heterogeneity of the blood flow in said capillary bed, and a first processor (110) arranged for using the first and the second indicator to estimate an extraction capacity (EC) of a substance from the blood in said capillary bed.

Medical software tools platform utilizes a surgical display to provide access to specific medical software tools, such as medically-oriented applications or tools, that can assist those in the operating room, such as a surgeon or surgical team, with a surgery. In particular, an optical sensor located within an endoscopic camera may register subtle differences in color characteristics reflected from a tissue surface and in turn transmit the information to a medical image processing system. Moreover, the new tools are intended to help surgeons better determine the boundaries between healthy and diseased regions during surgical procedures. Various tools are intended to be used in procedures where indocyanine green (ICG) fluorescent dye is used. Intraoperative fluorescence imaging is commonly used during minimally invasive procedures to enable surgeons to visualize tissue perfusion and anatomical structures. The term perfusion refers to the passage of blood and tissue fluid through the capillary bed. Intraoperative fluorescence imaging can also be used to improve visualization of vessels and structures, which, in turn, may reduce the risk of complications during minimally invasive surgeries.