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Systems, devices and methods for non-invasive hematological measurements

An imaging device and attribute technology, which can be used in blood characterization devices, diagnostic recording/measurement, biometric identification mode based on physiological signals, etc., and can solve problems such as heavy procedures

Pending Publication Date: 2020-08-04
MASSACHUSETTS INST OF TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This procedure can be onerous for patients requiring regular WBC counts or for patients with urgent medical conditions and their caregivers
Furthermore, due to the in vitro nature of routine blood testing, there may be specific biases for some parameters due to inherent differences between measured values ​​and true physiological properties

Method used

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  • Systems, devices and methods for non-invasive hematological measurements
  • Systems, devices and methods for non-invasive hematological measurements
  • Systems, devices and methods for non-invasive hematological measurements

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example

[0298] A pilot diagnostic validation study was performed to test the a priori hypothesis that the non-invasive technique allows for the classification of patients with severe neutropenia (1,500 neutrophils / μL) . Patient population undergoing ASCT after high-dose chemotherapy was registered. The kinetics of neutrophil counts in these patients were predictable because the intensity of chemotherapy applied prior to transplantation ensured passage through the stage of severe neutropenia followed by recovery. In the framework of this study, power analysis was not performed, and a convenience sample of 10 subjects (eg, selected from the initial patient pool) was considered sufficient to test the study hypothesis. Using nonparametric tests as well as ROC curve analysis. All human reviewers analyzing data were blinded, as detailed below.

[0299] A total of 23 patients were recruited, including 16 from Massachusetts General Hospital, Boston, MA, USA, and 7 from La Paz University Ho...

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Abstract

A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 572,738, filed October 16, 2017, entitled DEVICE AND METHODS FOR NON-INVASIVE HEMATOLOGICAL MEASUREMENTS, The entire disclosure of said application is hereby incorporated by reference. [0003] statement of support [0004] This invention was made with government support under Grant No. U54EB015403 awarded by the National Institutes of Health. The government has certain rights in this invention. technical field [0005] The present disclosure generally relates to systems, devices and methods for analyzing blood cell dynamics and cell population dynamics. More specifically, the present disclosure relates to systems, devices and methods for extracting white blood cell information from non-invasive, in vivo and / or time-lapse images. Background technique [0006] White blood cells (WBCs, also known as white blood cells or leucocytes) are cells o...

Claims

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Application Information

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IPC IPC(8): A61B5/02A61B5/145G06K9/46G06T7/136
CPCA61B5/0261A61B5/489A61B5/6826A61B5/7203A61B5/7267A61B5/14546A61B5/1455G06T2207/30101G06T2207/20084G06T7/0012G16H50/70Y02A90/10G06V40/10G06V40/15G06V40/14G06T7/0014A61B2576/02G06T2207/10016G06T2207/10152G06T2207/20081
Inventor C·卡斯特罗-冈萨雷斯I·巴特沃斯A·布尔夸德A·桑切斯·费罗J·塔克-施瓦茨A·巴勃罗·特立尼达M·J·莱德斯马-卡巴约T·维特伯格
Owner MASSACHUSETTS INST OF TECH
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