3 results about "Endothelial cell growth" patented technology

The invention discloses a gene modified fibroblast as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. Researches find that fibroblasts modified by the TIMP1 gene can stably secrete TIMP1 protein, the TIMP1 can promote the fibroblasts to secrete COL1A1 and Fibronectin, and the COL1A1 and the Fibronectin cooperate with each other to play a role in inhibiting growth of vascular endothelial cells, so that ingrowth of blood vessels in the intervertebral disc degeneration process is inhibited. And pathological angiogenesis in the degenerated intervertebral disc can be inhibited in a long-acting and targeted manner, so that the degeneration of the intervertebral disc is delayed.

The invention relates to the technical field of novel functional and structural materials, and discloses a preparation method of a piezoelectric response antibacterial / endothelial cell growth promoting coating material, the coating material takes a titanium alloy as a matrix, an alkali heat treatment technology is utilized to form a microstructure with a large number of OH <-> in pores on the surface of the titanium alloy, and a cation exchange method is utilized to prepare the piezoelectric response antibacterial / endothelial cell growth promoting coating material. Zinc ions are fixed to the surface of the titanium alloy, then a zinc-based metal organic framework is generated on the surface of the titanium alloy through an in-situ synthesis method, and finally the HZnO nanometer material which is stably combined and is of a hollow structure is obtained on the surface of the titanium alloy through a high-temperature calcination method. The HZnO nano material has piezoelectric characteristics, can generate micro-current and ROS, has the effects of promoting growth of endothelial cells and resisting bacteria, and further shows excellent anticoagulation and antibacterial effects. In addition, the composite coating has slow physiological degradability, and degradation products are non-toxic. The method is simple in preparation process and has potential application prospects in the field of novel functional and structural materials.

A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis.