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Biodegradable stent with laminated coatings

A multi-layer coating and biological technology, applied in the field of medical devices, to achieve the effect of preventing displacement, strong support, and preventing restenosis of blood vessels

Inactive Publication Date: 2011-08-17
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing technology may provide a solution to a certain aspect of the biodegradable stent, but no stent system can systematically solve all the above problems

Method used

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  • Biodegradable stent with laminated coatings
  • Biodegradable stent with laminated coatings
  • Biodegradable stent with laminated coatings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Such as figure 2 As shown, the material of the stent body provided in the embodiment of the present application is polysalicylic anhydride, a biodegradable polymer material. By means of extrusion, the polysalicylic anhydride is extruded into a pipe with an outer diameter of 3 mm and a wall thickness of 0.25 mm. Use femtosecond laser to cut the tube into a 12mm long stent, the stent structure is as follows figure 1 shown. The main body of this stent has high strength, can effectively support blood vessels, and can degrade and disappear within 2 years after being implanted in blood vessels, and the main material is degraded on the surface without generating degradation fragments.

[0031]The mixed solution of rapamycin and polylactic acid is sprayed onto the inner and outer surfaces of the stent by spraying. Since the stent has a hollow structure, the spray solution can evenly adhere to the inner and outer surfaces of the stent. By controlling the spraying time, the ...

Embodiment 2

[0037] Such as image 3 As shown, the material of the main body of the stent provided in the embodiment of the present application is polyorthoester, a biodegradable polymer material. By extrusion, the polyorthoester is extruded into a pipe with an outer diameter of 2.5 mm and a wall thickness of 0.15 mm. Use femtosecond laser to cut the tube into a 15mm long stent, the stent structure is as follows figure 1 shown. The main body of this stent has high strength, can effectively support blood vessels, and can degrade and disappear within 3 years after being implanted in blood vessels, and the main material is surface degraded without generating degradation fragments.

[0038] A 1:1 mixed solution of rapamycin and polysalicylic anhydride was sprayed onto the outer surface of the stent by spraying. When spraying, a blocking tube is placed inside the stent so that the spray solution cannot adhere to the inner surface of the stent, so that the drug coating only exists on the oute...

Embodiment 3

[0043] Such as Figure 4 As shown, the material of the stent body provided in the embodiment of the present application is polylactic acid, a biodegradable polymer material. The polylactic acid was extruded into a pipe with an outer diameter of 3 mm and a wall thickness of 0.16 mm by extrusion. Use femtosecond laser to cut the tube into a 15mm long stent, the stent structure is as follows figure 1 shown. The main body of the stent has high strength, can effectively support the blood vessel, and can degrade and disappear within 2 years after being implanted in the blood vessel.

[0044] A 1:2 mixed solution of paclitaxel and polylactic acid was sprayed onto the outer surface of the stent by spraying. When spraying, a blocking tube is placed inside the stent so that the spray solution cannot adhere to the inner surface of the stent, so that the drug coating only exists on the outer surface of the stent. By controlling the spraying time, the thickness of paclitaxel drug coati...

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Abstract

The invention belongs to the field of medical apparatus and relates to a biodegradable stent with laminated coatings. The stent comprises a stent main body with a supporting role and at least two layers selected from a medicine coating, an endothelial cell growth promotion layer and a developing control layer; the main body material of the stent is a biodegradable polymer with higher mechanical strength; after implanted into a pathological position, the stent has strong supporting force and can play a role of supporting a pathological blood vessel in a short time; the developing control layer can help a doctor accurately observe the position and the expansion consistency of the stent in the operation so as to prevent adverse events, such as displacement, instant collapse, and the like from happening; medicines for restricting neointimal hyperplasia in the medicine coating can prevent restenosis of the blood vessel after the stent is implanted for a short time; and the endothelial cell growth promotion layer can promote endothelial cells to grow on the surface of the stent to wrap the stent in the vascular endothelium so as to prevent degradable fragments of the stent from falling into the blood to cause embolism.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a biodegradable stent with multi-layer coatings, which includes a stent main body, and is characterized in that there are at least two layers of functional coatings on the surface of the stent main body. technical background [0002] As an important means of treating luminal stenosis in the human body, stents have been more and more widely used. Taking the vascular stent as an example, during the treatment process, the stent is delivered to the diseased (stenotic) blood vessel by the catheter, and then the diameter of the stent is enlarged by means of balloon expansion or self-expansion, and the stenosis is opened. [0003] The currently widely used stents are all metal materials, which remain permanently in the human body after the treatment is completed. The implantation of permanent metal stents can weaken the MRI or CT images of blood vessels. In addition, metal stents also have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61L31/02A61L31/06A61L31/10A61L31/16A61L31/18
Inventor 石秀凤孟娟李俊菲罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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