Biological compatibility surface coating of implantation type medical instruments and coating method thereof

Abstract

The invention discloses a biological compatibility surface coater and self-assembling coating method of planted medical apparatus, which is characterized by the following: the coater is prepared by self-assembling coating method layer by layer, which accelerates esoderma and resists thrombus constituted by two or more macromolecular materials with certain positive and negative load; the positive load material is chitose, chitin, polylysine and so on; the negative load material is disebrin, hyaluronic acid, alginic acid, polyamino acid and so on; the crosslinker and biological active factor or drug can be added to accelerate the growth of the cell; the coater satisfies the request of biologically medical transplantation.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a biocompatible surface coating of implantable medical devices and a self-assembly coating method thereof. Background technique [0002] With the development of medical technology, biomedical composite materials have become the most active field in the research and development of biomedical materials. Biomedical materials are a class of special functional materials used for diagnosis, treatment or repair, replacement or artificial regeneration of body cells, tissues and organs, and their functions cannot be replaced by drugs. Traditional medical metal materials are not biologically active, and are not easy to be firmly combined with tissues. In the physiological environment or after being implanted in the body, they are affected by the physiological environment, resulting in the release of metal ions or monomers, causing adverse effects on the body. Therefore...

AI Technical Summary

Problems solved by technology

Various organic and inorganic materials currently used clinically, such as stainless steel, nickel-titanium alloy, polyester, aliphatic polyester and PMMA, etc., cannot fully meet the above requirements.

[0006] There have been a lot of reports in other studies that natural polysaccharides represented by chitosan and polyamino acids represented by polylysine and other positively charged polymer materials have good biocompatibility. On the surface of the material, it has the effect of accelerating the endothelialization of the material surface, but these materials are often water-soluble and are easily lost in blood vessels

However, polyanionic materials represented by heparin and sulfonated chitosan have good antithrombotic properties, but they are also water-soluble and have the problem of loss.