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Biodegradable bracket with multiple drugs

A biological and pharmaceutical technology, applied in the field of medical equipment, can solve problems such as inability to meet clinical treatment and asynchrony

Inactive Publication Date: 2013-05-22
深圳市昕力医疗设备开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The release and function of these three functional components are not synchronized and cannot meet the requirements of clinical treatment.

Method used

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  • Biodegradable bracket with multiple drugs
  • Biodegradable bracket with multiple drugs
  • Biodegradable bracket with multiple drugs

Examples

Experimental program
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Effect test

Embodiment

[0029] The material of the main body of the stent provided in the embodiments of the application selects the biodegradable polymer material polylactic acid. Through the extrusion method, the polylactic acid was extruded into a pipe with an outer diameter of 3 mm and a wall thickness of 0.16 mm. A femtosecond laser is used to cut the tube into a stent with a length of 15 mm. The main body of the stent has high strength, can effectively support the blood vessel, and can be degraded and disappeared within 2 years after implanting the blood vessel.

[0030] The surface of the prepared stent body is punched with a laser. Because of the nanometer size of the holes and the interconnection between the holes, once the solution of the functional component that promotes the growth of endothelial cells contacts the surface, it will immediately penetrate into the micropores. The drug load in the micropores can be easily controlled by the concentration of the drug. Dry the solvent after dipp...

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Abstract

The invention provides a biodegradable bracket with multiple drugs, belongs to the field of medical equipment and relates to a biodegradable bracket with a single coating. Besides support function, the bracket further comprises the single coating which contains anti-proliferative drugs, anti-inflammation and anti-immune drugs, drugs for promoting endothelial cells to grow and a developing agent. The bracket main body is made of biodegradable polymers of which mechanical strength is high. After implanted on a pathological position, the bracket has strong support force, so that action of supporting the pathological vessels in short time can be achieved. Because of the developing agent, doctors can accurately obverse the position and the expansion consistency of the bracket during operation, and displacement or other adverse events can be prevented; the anti-proliferative drugs can prevent the vessels from becoming narrow in short time after the bracket is implanted; and the drugs for promoting the endothelial cells to grow can promote the endothelial cells to grow on the surface of the bracket and can cover the bracket in the endothelium of the vessels, so that embolism phenomenon caused by degradation fragments of the bracket dropping in blood can be prevented.

Description

technical field [0001] The invention belongs to the field of medical equipment and relates to a biodegradable bracket with a single coating, which includes a bracket main body, and is characterized in that there is a layer of functional coating on the surface of the bracket main body. technical background [0002] As an important means of treating luminal stenosis in the human body, stents have been more and more widely used. Taking the vascular stent as an example, during the treatment process, the stent is delivered to the diseased (stenotic) blood vessel by the catheter, and then the diameter of the stent is enlarged by means of balloon expansion or self-expansion, and the stenosis is opened. [0003] The currently widely used stents are all metal materials, which remain permanently in the human body after the treatment is completed. Permanent metal stents can weaken MRI or CT images of blood vessels. In addition, metal stents also have the disadvantages of interfering w...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/18A61L31/08A61L31/14A61L31/04A61L31/06A61L31/10
Inventor 陈旺王燕芬张棋
Owner 深圳市昕力医疗设备开发有限公司
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