102 results about "Capillary hyperpermeability" patented technology

A method for determining tissue type includes quantitatively determining a tissue blood flow (TBF) by deconvoluting Q(t) and Ca(t), where Q(t) represents a curve of specific mass of contrast, and Ca(t) represents an arterial curve of contrast concentration, and quantitatively determining a tissue blood volume (TBV) by deconvoluting Q(t) and Ca(t). The method also includes quantitatively determining a tissue mean transit time (TMTT) by deconvoluting Q(t) and Ca(t), and quantitatively determining a tissue capillary permeability surface area product (TPS) by deconvoluting Q(t) and Ca(t). The method also includes determining a tissue type based on the TBF, the TBV, the TMTT, and the TPS.

A method for inhibiting VEGF stimulated endothelial cell growth, such as associated with neoplasia, and VEGF stimulated capillary permeability, such as associated with pulmonary edema are disclosed, particularly using the beta-isozyme selective PKC inhibitor, (S)-3,4-[N,N'-1,1'-((2''-ethoxy)-3'''(O)-4'''-(N,N-dimethylamino)-butane)-bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dionehydrochloridesalt.

A method for inhibiting VEGF stimulated endothelial cell growth, such as associated with macular degeneration, and VEGF stimulated capillary permeability, such as associated with macular edema are disclosed, particularly using the isozyme selective PKC inhibitor, (S)-3,4-[N,N'-1,1'-((2''-ethoxy)-3'''(O)-4'''-(N,N-dimethylamino)-butane)-bis-(3,3'-indoly 1)]-1(H)-pyrrole-2,5-dionehydrochloridesalt.

The present invention encompasses methods, apparatus, and computer based systems for identifying benign and malignant tumors in tissues such as soft tissues and particularly breast tissue using dynamic contrast-enhanced magnetic resonance imagining (DCE-MRI) and dynamic susceptibility contrast-enhanced magnetic resonance (DSC) imagining of the tumors. Some embodiments encompass the use of two dynamic MRI pulse sequences in intercalating mode during parenteral administration of an MR contrast substance, wherein one of said pulse sequences is optimized for spatial information and the other pulse sequence is adjusted for high temporal solution, the high-temporal dissolved sequence further comprising a double echo-collection sensitive towards both DCE and DSC for generating a number of different biomarker data such as pharmacokinetic biomarker data, descriptive DCE biomarkers and descriptive DSC biomarkers, and subsequently normalizing and comparing said data with corresponding data from corresponding benign and malign tumors, respectively.

The invention discloses a Chinese medicinal composition for treating perianal eczema. The medicament for oral administration comprises the following Chinese herbal medicines in part by weight: 10 to 15 parts of grassleaf sweelflag rhizome, 10 to 20 parts of red paeony root, 10 to 20 parts of largehead atractylodes rhizome, 10 to 20 parts of honeysuckle flower, 10 to 20 parts of Szechuan tangshen root, 10 to 20 parts of peach seed, 10 to 20 parts of rhubarb, 10 to 20 parts of Chinese magnoliavine fruit, 10 to 20 parts of red Indian buead, 10 to 20 parts of cortex moutan, 10 to 20 parts of oriental waterplantain rhizome, 10 to 20 parts of ricepaperplant pith, 10 to 20 parts of swordlike atractylodes rhizome, 10 to 20 parts of root of red-rooted salvia, 10 to 20 parts of fineleaf schizonepeta herb and 10 to 20 parts of baical skullcap root; and the medicament for external application comprises the following Chinese herbal medicines in part by weight: 10 to 30 parts of prepared frankincense, 10 to 30 parts of lightyellow sophora root, 10 to 30 parts of common cnidium fruit, 10 to 30 parts of spreading hedyotis herb, 10 to 30 parts of Sinkiang arnebia root, 10 to 30 parts of densefruit pittany root-bark, 10 to 30 parts of cicada slough, 10 to 30 parts of dahurian patrinia herb, 10 to 30 parts of phellodendron, 10 to 30 parts of alum, 10 to 30 parts of belvedere fruit, 10 to 30 parts of fineleaf schizonepeta herb and 10 to 30 parts of divaricate saposhnikovia root. By the Chinese medicines of the Chinese medicinal composition, liquid medicine can reach the lesion site directly, local blood circulation and lymphatic return can be accelerated, and capillary permeability can be improved so as to achieve the effects of clearing heat and drying dampness, nourishing blood and promoting blood circulation and dispelling wind and arresting itching; and the Chinese medicinal composition is easy to prepare and is worthy of clinical popularization.

The present invention encompasses methods, apparatus, and computer based systems for identifying benign and malignant tumors in tissues such as soft tissues and particularly breast tissue using dynamic contrast-enhanced magnetic resonance imagining (DCE-MRI) and dynamic susceptibility contrast-enhanced magnetic resonance (DSC) imagining of the tumors. Some embodiments encompass the use of two dynamic MRI pulse sequences in intercalating mode during parenteral administration of an MR contrast substance, wherein one of said pulse sequences is optimized for spatial information and the other pulse sequence is adjusted for high temporal solution, the high-temporal dissolved sequence further comprising a double echo-collection sensitive towards both DCE and DSC for generating a number of different biomarker data such as pharmacokinetic biomarker data, descriptive DCE biomarkers and descriptive DSC biomarkers, and subsequently normalizing and comparing said data with corresponding data from corresponding benign and malign tumors, respectively.

The invention relates to a Chinese medicine preparation for treating chronic prostatitis, which is characterized by comprising the following raw medicines: radix rehmanniae preparata, cynomorium songaricum rupr, radix astragali, rhizoma corydalis, herba epimedii, dodder, herba ecliptae, schisandra chinensis, hedyotis diffusa, safflower, radix polygoni multiflori preparata, fructus ligustri lucidi, salvia miltiorrhiza, radix paeoniae alba, myrrh, prunella vulgaris, fructus cnidii, herba patriniae, scutellaria baicalensis georgi, angelica and cortex moutan. In the invention, Chinese herbal medicines for promoting blood circulation and removing blood stasis are adopted, the permeability of capillaries can be improved, inflammation reaction can be alleviated, the extinction and the absorption of inflammation focus can be promoted, the metabolism of connective tissues can be improved, the transformation and the absorption of hyperplastic lesions can be promoted, and atrophic connective tissues can recover. When the Chinese medicine preparation for treating chronic prostatitis is applied through rectums, the medicines can be absorbed in the rectums, enema or suppository enables the medicines to be absorbed through rectum mucosa to directly reach affected parts; and the Chinese medicine preparation can reach higher consistency in diseased prostate and has the advantages of ideal treating effect, low price and simple, convenient and practical preparation method.

The invention discloses a giant salamander mucinous protein, a preparation method and applications in cosmetics. The giant salamander mucinous protein has a molecular weight of 17000D, contains two subunits with a molecular weight of 8500D. The subunit contains 77 amino acid residues and the N end is valine-glycine-tyrosine-threonine-valine-glycine-alanine-threonine-proline-methionine-. The giant salamander mucinous protein has functions of agglutinating red blood cell activity, reducing capillary permeability, promoting cell growth and the like. Cosmetics prepared from the giant salamander mucinous protein can improve skin telangiectasis (known as couperose skin) effectively.

The invention relates to mouthwash prepared in a Chinese medical formula, and has the functions of replenishing qi, strengthening the spleen, tonifying the kidney, soothing the nerves, clearing the heat, detoxicating, clearing the damp, reducing the cellular immune response, the capillary permeability and the inflammatory exudates, and improving the immunity of the organism. The invention has the advantages of good treatment effect, high cure rate and no recurrence fundamentally; and the oral drug not only has good preventive effect, but also has good therapeutic effect.

The invention generally relates to compositions and methods for reducing capillary permeability. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH between about 5.5 and about 6.5.

The invention provides a drug for preventing and treating alopecia and belongs to the technical field of drug preparation. The drug for preventing and treating alopecia contains the following effective constituent: compound of more than one of flavonoids compound for reducing capillary permeability, calcium and vitamin C. The compound provided by the invention can be used for achieving the purposes of effectively preventing and treating alopecia and promoting the hair growth, is safe, is wide in universality, is effective in treatment and is suitable for treatment of androgen alopecia.

The invention provides a medicament for treating idiopathic edema and a preparation method thereof. The medicine contains pure natural plant drugs of angelica, radix bupleuri, atractylis ovata, Alisma orientale, radix paeoniae alba, tuckahoe, grifola, rhizoma cyperi, motherwort, trumpetweed, cassia twig, and the like. In the medicament, the angelica breaks extravesated blood, nourishes new blood and relaxes vain to eliminate dampness; radix bupleuri, tuckahoe and Alisma orientale soothes liver and strengthens spleen for inducing diuresis to alleviate edema; the atractylis ovata, grifola, and the like, invigorates qi and strengthens the spleen, clears damp and promotes diuresis and blood circulation, and recuperates the body function; the plant drugs are combined to free liver qi and strengthen the spleen, smooth collaterals, avoid moisten, and eliminate edema, so as to ensure the effect of sooth liver and strengthen spleen, smooth collaterals and induce diuresis. Research shows that the medicament has the pharmacological actions of inducing diuresis, reducing capillary permeability, improving microcirculatory disturbance and increasing immunologic function, and the like, treats idiopathic edema etiologically and semeiologically, and has the advantages and characteristics of multiple levels and treatment on principal and subordinate of traditional Chinese medicine.

The invention provides a traditional Chinese medicine preparation for treating immune thrombocytopenia (ITP) and a preparation method thereof. The traditional Chinese medicine preparation comprises the following components in parts by weight: 1 part of selaginella tamariscina, 1-2 parts of acanthopanax, 1-2 parts of morinda officinalis, 1-2 parts of dandelion, 1-2 parts of pseudo-ginseng, 1-2 parts of spatholobus stem, 1-2 parts of white peony root, 1-2 parts of angelica, 1-2 parts of bighead atractylodes rhizome, 1-2 parts of red sage root, 1-2 parts of radix rehmanniae, 1-2 parts of radix astragali, 1-2 parts of dangshen, 1-2 parts of agrimony and 1-2 parts of dodder. From the perspective of modern pharmacological research, the medicines contained by the traditional Chinese medicine preparation of the invention have the effects of regulating immunity, reducing platelet destruction, promoting thrombopoiesis, reducing capillary permeability and the like, thereby achieving the purpose of treating ITP. The medicines are compatible, the formula is simple and complete and hits the pathogenesis, and the medicines play the effects of removing pathogenic heat from blood, removing blood stasis, arresting bleeding, and reinforcing the spleen and kidney, thereby reducing hemorrhage of patients with ITP and alleviating various clinical symptoms.

The invention provides an external Chinese medicine preparation for treating acne. The parts by weight of various raw materials in the preparation are: 10-15 parts of Burnet, 10-15 parts of Senecio, 10-15 parts of Rhizoma chinensis, Patonia 10-15 parts of grass, 10-15 parts of Scutellaria baicalensis, 10-15 parts of Angelica dahurica, 10-15 parts of herb, 10-15 parts of Salvia miltiorrhiza, 10-20 parts of Sophora flavescens, 10-20 parts of Baibu, 10-20 parts of Cortex Phellodendri, Cnidium 10-20 parts, Morus alba 10-20 parts, honeysuckle 10-20 parts, mint 10-20 parts. The present invention can directly reach the lesion, and external application of heat-clearing and stasis-dispelling medicine fully contacts the lesion, so as to strengthen heat-clearing and detoxifying, promote blood circulation and remove blood stasis, and promote rapid healing or disappearance of skin lesions, improve capillary permeability, thereby achieving heat-clearing, damp-drying, and blood-nourishing The effect of invigorating blood circulation, dispelling wind and relieving itching enables the medicinal ingredients of expelling wind, killing insects and promoting muscle growth through the skin to penetrate into the body to enhance the therapeutic effect and improve the curative effect.

A leukotriene C4 and D4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white blood cell extravasation. Potential candidate compounds can be screened in a non-human mammal before or after administration of an inflammation inducing agent into the subarachnoid space by determining their ability to inhibit increased capillary permeability and white blood cell extravasation.

The present invention relates to a medicine for treatment of cancer intestinal obstruction and a preparation method thereof. The medicine comprises the following components by weight: 30-90 parts of clove, 10-30 parts of cinnamon, 10-40 parts of raw rhubarb, 6-12 parts of borneol, and 20-40 parts of mirabilite. The present invention has the advantages that: through external application of the invention, the medicine has the effects of tonifying spleen and warming the middle, moving qi and directing qi downward, promoting digestion and removing food retention, clearing away heat and relaxing the bowel, relieving swelling and pain, resolving hard lump, and removing stagnate and inducing menstruation; can release intestinal adhesion, increase gastrointestinal motility, improve intestinal blood circulation, reduce capillary permeability, protect the intestinal mucosal barrier and reduce bacterial translocation, promote inflammation edema recession, and inhibit the growth of enteric bacilli, and finally achieve the functions of promoting fart and cacation, diminishing inflammation and swelling, relieving abdominal distension and pain, and restoring gastrointestinal function. Proved by clinical application, the medicine has remarkable clinical efficacy, is easy, economical and safe to use, is high in patient compliance and is worthy of promotion.

The invention provides a traditional Chinese medicine enema for curing chronic prostatitis, which is prepared from the following bulk drugs in part by weight: 10-20 parts of orobanche coerulescens, 10-20 parts of poria cocos, 10-20 parts of seeds of cowherb, 10-20 parts of schisandra chinensis, 10-20 parts of herba epimedii, 10-20 parts of seeds of Chinese dodder, 10-20 parts of fructus alpiniae oxyphyllae, 10-20 parts of dogwood, 10-20 parts of oldenlandia diffusa. 10-20 parts of dandelion, 10-20 parts of prepared fleece flower root, 10-20 parts of semen plantaginis, 10-20 parts of roots of red-rooted salvia, 10-20 parts of golden cypress, 10-20 parts of rhizoma alismatis, 10-20 parts of selfheal, 10-20 parts of fructus cnidii, 10-20 parts of patrinia, 10-20 parts of Scutellaria baicalensis, 10-20 parts of roots of common peony, 10-20 parts of rhizoma smilacis glabrae, 10-20 parts of raspberry, 10-20 parts of moutan bark and 10-20 parts of Caulis Spatholobi. The traditional Chinese medicine enema and the method adopt traditional Chinese medicines of promoting blood circulation to remove blood stasis, improve capillary permeability and alleviate inflammatory response.

The invention discloses an application of globeflower flavonoids in preparation of a medicine for treating itch dermatoses. The application range of globeflower flavonoids is expanded; a novel medicine is provided for treatment of itch dermatoses; from a pharmacology experiment, the globeflower flavonoids have good prevention and treatment effects on a mice chronic eczema model, have an obvious inhibiting effect on mice delayed-type allergic reaction caused by 2,4-dinitrofluorobenzene, have obvious anti-inflammatory effect in ear swelling in mice caused by xylene, and have a significant inhibiting effect on capillary permeability increase in mice caused by glacial acetic acid; and the globeflower flavonoids can have relatively good counteraction on guinea pig pruritus caused by histamine phosphate, are low in toxicity and safe to use, and have a relatively good application prospect.

The invention provides an external traditional Chinese medicinal preparation for treating acne rosacea. The preparation is prepared from the following bulk drugs in parts by weight: 10-20 parts of garden burnet, 10-20 parts of climbing groundsel herb, 10-20 parts of sapindus, 10-20 parts of dahurian patrinia herb, 10-20 parts of scutellaria baicalensis, 10-20 parts of angelica root, 10-20 parts of rhizoma atractylodis, 10-20 parts of salviae miltiorrhizae, 10-20 parts of rhizoma bletillae, 10-20 parts of sophora flavescens, 10-20 parts of stemona, 10-20 parts of cortex phellodendri, 10-20 parts of fructus cnidii, 10-20 parts of cortex mori radicis, 10-20 parts of honeysuckle, and 10-20 parts of mint. The external traditional Chinese medicinal preparation can directly reach the focus, is applied for clearing heat to remove stasis, can be directly contacted with the focus to strengthen the effects of clearing heat and removing toxicity, activating blood circulation to remove stasis, and promoting skin lesion to quickly heal or resolve, can be used for improving the permeability of blood capillaries to achieve the effects of clearing heat and drying dampness, nourishing and activating blood, dispelling wind and arresting itching, so that medicinal components for dispelling wind and killing bacteria, promoting pus discharge and tissue regeneration can infiltrate into a body in a transcutaneous manner, so that the treatment effect can be strengthened, and the curative effect can be improved.

The invention discloses a medicine for treating chronic stomach disease and its preparation method, which comprises mixing Os Sepiae, gynostemma pentaphylla triterpenes, seabuckthorn fruit, immature bitter orange, white atractylodes rhizome, corktree bark, corydalis tuber, licorice root, disintegrating, grilling and concentrating into grease.

The invention relates to a traditional Chinese medicine composition for treating allergic rhinitis. The traditional Chinese medicine composition is prepared from radices lithospermi, scutellaria baicalensis, radix isatidis, mint, white atractylodes rhizome, violet magnolia, cortex phellodendri, cortex moutan radicis, centipeda minima and radices sileris. The medicine composition is a nasal cavity drug feeding preparation; the medicine is directly absorbed by the mucous membrane of the nasal cavity and can quickly relieve the symptom. An experimental result shows that the increase of the mucosal capillary permeability due to allergic reaction can be improved, and the effect is better than that of livostin nasal spray.

The invention provides an oral medicine for effectively treating urticaria. The oral medicine is prepared from the following Chinese herbal medicines of starwort root, hypoglauca yam, jujube bark, bamboo leaf, beautiful sweetgum fruit, dragon bone, sophora flower, large-leaved gentian, long-noded pit viper, shrubalthea bark, Chinese atractylodes, phellodendron, selinum japenious seed, divaricate saposhnikovia root, scorpio, sweet wormwood herb, waxgourd peel, weeping forsythia, tuckahoe, belvedere fruit, red peony root, dangshen, large-head atractylodes rhizome, sinkiang arnebia root, garden balsam stem, fineleaf schizonepeta herb, Chinese mugwort leaf, cassia bark, tree peony bark, safflower, honeysuckle flower and baikal skullcap root. The oral medicine for effectively treating urticaria can quickly eliminate pruritus, promote blood circulation to remove blood stasis, soften hardness, dissipate scabs, improve skin microcirculation, promote cell regeneration, repair pathological cell, stimulate the organic immunocyte to produce specific antibody, reduce susceptibility of an organism to outside materials, reduce capillary permeability, reduce leakage of the oral liquid, improve immunity of a body, make amends to ensure that the skin keratinocytes divide properly, activate skin care cells to completely improve skin symptoms and effectively prevent relapses of urticaria.

The invention relates to pure Chinese medicinal capsules for treating urticaria. The pure Chinese medicinal capsules are prepared from the following Chinese medicinal raw materials: belvedere fruit, fineleaf schizonepeta herb, divaricate saposhnikovia root, liquoric root, Chinese honeylocust spine, common ducksmeat herb, ephedra, weeping forsythia, rice bean, cicada slough, lightyellow sophora root, Chinese angelica, densefruit pittany root-bark, turmeric, sweet wormwood herb, sessile stemona root, polygonum multiflorum thunb., Szechuan lovage rhizome, peach seed, safflower, Mongolian dandelion herb, red paeony root and largehead atractylodes rhizome. The Chinese medicinal capsules are quick in response and good in curative effect, can remove the cause of diseases, eliminate pruritus quickly, promote blood circulation and remove blood stasis, soften hard lumps and eliminate scabs, improve the microcirculation of skin, promote cytothesis, repair lesion cells, relieve itching and pain quickly, restore normal skin, clear heat, expel damp and relieve itching, stimulate immune cells of organisms to generate specific antibodies, reduce the sensibility of the organisms on external substances and capillary permeability, reduce seepage, clear pathogenesis, eliminate severe pruritus, activate skin care cells, improve skin symptoms completely and prevent the diseases from relapsing effectively.

The invention relates to an external ointment for treating herpes zoster. The herpes zoster is caused by abundant liver fire in the traditional Chinese medicinal science, there are many traditional Chinese medicinal medicines and western medicinal medicines for treating the herpes zoster, a sequela which is pain is left after the herpes zoster is healed by above medicines, and the ointment has the characteristics of short time for treating the herpes zoster and no left pain. The quick-acting detoxifcation herpes zoster eliminating ointment which is based on the traditional Chinese medicinal science to eliminate western medicinal symptoms adopts Gentiana scabra Bunge, Rhizoma Coptidis and Amur Corktree Bark to resist inflammation, resist viruses, reduce the capillary vessel permeability, decrease the tissue fluid exudation, promote phagecytes to remove antigens, inhibit antibodies, eliminate immune compounds and inhibit immune reactions, adopts radix bupleuri to be compatible with the Gentiana scabra Bunge to course the liver, benefit the bladder, clear heat and purge fire, adopts Boswellia carteri to be compatible with myrrh to invigorate the blood circulation, dispel stasis, resolve tetany, relieve pains, change local blood circulation and promote inflammation absorption, and adopts Chinese lobelia herb, gypsum and stalactite to clear heat and detoxify. The ointment is bitter and cold, can descend and sink, can lower fire, is successful in rapid anti-inflammation through concentrated medicine power, and enables no pains to be left.

The invention belongs to the technical field of plant extraction and especially relates to a grapefruit extracting method. The grapefruit extracting method disclosed by the invention comprises the following steps: a) smashing grapefruit whole fruit to obtain homogenate; b) performing micro-jet extraction on the homogenate to obtain extractive. The extracting method has advantages of high extracting efficiency, small damage to an effective ingredient of general flavones in the grapefruit, ability in keeping functional components of the grapefruit, energy conservation and environmental friendliness. A mass fraction of the general flavones of the grapefruit extractive obtained by the extracting method can reach 50%, a content of the effective ingredient of the general flavones is high, and grapefruit function exerting is facilitated; experiments show that the grapefruit extractive has a strong anti-allergy function and especially shows obvious anti-inflammation and antibacterial functionsin the aspects of resisting delayed hypersensitivity and reducing capillary permeability. The invention further provides application of the grapefruit extractive obtained by the extracting method inpreparing anti-allergy products, anti-inflammation products and / or antibacterial products.

An application of the common flavone extracted from secundspike elsholtzia herb in preparing the anti-inflammatory medicine for treating pyelonephritis, nephritis, hepatitides, enteritis colitis, gastritis, pharyngolaryngitis and arthritis is disclosed.

The invention discloses a traditional Chinese medicine externally applied lotion used for treating perianal eczema, and an application method thereof. The traditional Chinese medicine externally applied lotion is prepared from, cortex phellodendri, radix sophorae flavescentis, cortex dictamni, fructus kochiae, fructus cnidii, and licorice. According to the application method, the raw material ingredients are delivered into a stainless steel basin, and cold water is added for 0.5h of immersion; an obtained mixture is boiled to be boiling with strong fire, and is subjected to decoction for another 20min with mild fire; an obtained solution is cooled to 36 to 40 DEG C, hip bathing of infected parts is carried out for 15 to 20min, two times each day, wherein one treatment course takes 7 days. The traditional Chinese medicine externally applied lotion is capable of reaching focus of infection directly; accelerating local blood circulation and lymphatic return; improving vascular permeability of blood capillary; realizing transdermal penetration of medicinal compositions which are capable of dispelling wind and killing parasite, and promoting detoxication and tissue generation; clearing away heat and drying dampness; dispelling wind and arresting itching; and improving curative effects. Excellent curative effects are achieved; the ingredients are cheap and easily available; and the traditional Chinese medicine externally applied lotion is worthy of clinical popularization.