57 results about "Normal skin" patented technology

The invention relates to a method and equipment for detecting deflection of a galvanometer motor in a medical galvanometer scanning system. The method mainly comprises the steps that a dynamic threshold value library is established, a dynamic threshold value set matched with a current scene is called, and the dynamic threshold value set comprises an angle error threshold value, a vibration threshold value and a driver temperature threshold value; acquiring inner ring control signals in real time, wherein the inner ring control signals at least comprise a motor angle error signal, a vibration signal and a driver temperature signal; carrying out quantitative fusion on the collected signals through a multi-signal weight fusion algorithm and carrying out preliminary judgment; and comparing the preliminarily judged signals with a dynamic threshold group, judging whether each signal meets a corresponding threshold condition or not, and if all the signals meet the corresponding threshold condition, judging that the galvanometer motor deflects in place. Compared with the prior art, the precision is remarkably improved, the normal skin burn risk caused by position deviation is avoided, and the high-precision safety requirement of a medical scene is met.

The invention discloses a wart excision device which combines wart excision and medicine spraying functions, can immediately perform medicine treatment after wart excision, effectively promotes wound healing, reduces infection risk, reduces the possibility of wart recurrence, and improves thoroughness and durability of treatment. And secondly, the operation design of the device is extremely humanized, and the patient can operate the device at home without going to a hospital or a professional medical institution, so that the time and economic cost are greatly saved, and meanwhile, the psychological burden and anxiety mood of the patient caused by seeing a doctor are also relieved. The design of the adjustable blade assembly and the straight blade is adopted by the device, the cutting mode can be flexibly adjusted according to the shape and size of warts, accurate excision is achieved, damage to surrounding normal skin is reduced to the maximum extent, and therefore the pain feeling is reduced, and the size of wounds is reduced. In addition, the medicine applying assembly of the device can accurately spray medicine to the wound surface, pain is further relieved, and rapid healing of the wound is promoted.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine decoction for treating vitiligo and a preparation method thereof.The traditional Chinese medicine decoction for treating vitiligo is prepared from ten medicinal materials including notopterygium root, divaricate saposhnikovia root and the like according to the core pathogenesis of vitiligo rheumatism stagnated heat syndrome, the brand new theory of treating both black and white diseases and both black and white diseases is creatively provided, and on the basis of the theory, the traditional Chinese medicine decoction for treating vitiligo is prepared into the traditional Chinese medicine decoction for treating vitiligo. White spots and surrounding deepened skin are brought into systematic conditioning for the first time, the formula is compatible with black and white medicine pairs, black is used for treating white, white is used for treating black, overall conditioning and two-way adjustment are achieved, the white spots can recover to the normal skin color, and due to the innovative application of the two groups of black and white medicine pairs (wine-processed rhizoma chuanxiong, radix angelicae sinensis, radix rehmanniae preparata and radix paeoniae alba) in the formula, black is used for treating white, white is used for treating black, and two-way adjustment is achieved. And meanwhile, the clinical piebald skin disease symptom is also eliminated, so that the white spots recover to the normal skin color.

The utility model provides a vitiligo novel target ultraviolet light therapeutic instrument, relates to skin treatment equipment technical field, including base, console, adjusting tube and phototherapy head, the console is installed on the base, the adjusting tube connects the console and the phototherapy head, the phototherapy head is provided with ultraviolet light source inside, and the ultraviolet light source is connected with the base. The front end of the phototherapy head is provided with an adjustable light shield, so that the problems that the irradiation range of the phototherapy head cannot be adjusted, a vitiligo disease area is not targeted, and surrounding normal skin can be irradiated in the use process of an existing ultraviolet light therapeutic apparatus can be solved; and the problems that the irradiation position and angle are not easy to fix when a traditional handheld phototherapy head is used for irradiation, and the phototherapy head is directly contacted with the skin due to mistaken touch are solved.

The application belongs to the technical field of image recognition, and discloses a monkeypox virus classification method and system based on image comparison and a storage medium, which comprises an individual reference modeling module, collects normal skin and initial lesion images of a healthy side of a patient, generates a healthy texture template and an initial lesion reference library, performs gray scale normalization on the healthy texture template and the initial lesion reference library through adaptive histogram stretching, and outputs a comparison reference image group; a symptom density quantification module, acquires a current monitoring image of the patient, segments a lesion area in combination with the comparison reference image group, extracts layered features of the lesion area to generate a three-dimensional symptom density vector, extracts texture roughness of a surface of the lesion area, and constitutes a lesion quantification data set; the accuracy of disease monitoring is improved, and a clinical nursing process is optimized.

The foam dressing is mainly used for protecting a wound surface after dressing change, a disposable traditional dressing patch needs to be replaced after dressing change every time, the consumable cost is increased, and due to the fact that the dressing patch is prone to being adhered to the wound, secondary damage to the normal skin of a patient and the wound surface of the wound can be caused by tearing the foam dressing when the wound is replaced. The foam dressing device capable of adding the medicine comprises a commercially available foam dressing basic patch, a medicine adding device and a sealing layer, the medicine adding device and the sealing layer are arranged in the foam dressing basic patch, and the foam dressing basic patch is sequentially composed of a water blocking layer, a foam layer, a bonding layer and an anti-adhesion layer structure. According to the technology, during secondary dressing change, the whole foam dressing patch does not need to be taken down or replaced, dressing change operation can be completed only by adding medicine through the medicine adding opening, consumables and related expenses are saved, and the technology is simple and convenient to operate. Damage to normal skin or wounds caused by replacement and tearing of the foam dressing is reduced, and wound healing can be promoted through the comprehensive effect.

The invention belongs to the field of medical imaging processing, and particularly relates to a medical image recognition method and system based on an optical attenuation coefficient. According to the method, high-precision classification is realized by fusing an optical attenuation coefficient (OAC) image and a probability density function (PDF) feature. According to the technical scheme, the method comprises the steps that skin three-dimensional OAC data are obtained through an SD-OCT device, unsupervised noise reduction is conducted through a 3D-Unet network, and image leveling and cutting are achieved in combination with Canny edge detection and linear fitting; counting OAC value distribution and extracting the peak value, distribution width and other characteristics of the PDF; and constructing a joint learning model, fusing the two-dimensional image features extracted by the ResNet34 and the one-dimensional PDF features extracted by the full-connection network, and outputting probabilities of AK, BCC and normal skin through a Softmax classification layer. The method has the advantages of being non-invasive and high in automation degree, the problem that similar lesion distinguishing is fuzzy is effectively solved, the classification accuracy is remarkably improved, and a standardized technical means is provided for early screening of skin cancer.

Provided are use of a bioactive protein in the preparation of a drug for treating herpes virus infection and a pharmaceutical composition for treating herpes virus infection. The pharmaceutical composition mainly comprises a bioactive protein, a matrix, a humectant, a pH regulator, and a preservative. The present invention has the following technical effects: 1) By means of a large amount of research and experimental verification, the inventors have discovered for the first time that anhydridized lactoferrin, a modified bioactive protein, has an inhibitory effect on herpes zoster virus (VZV). 2) In the pharmaceutical composition, the type and amount of excipient and the proportion of the main ingredient are reasonable. The pharmaceutical composition is administered in ointment form, in spray form, or in other dosage forms suitable for external use, has a significant therapeutic effect, has small local toxic side effects, has very low acute dermal toxicity, causes no irritation or allergy, does not interfere with normal skin functions, and is safe and effective.

The application aims to provide a medical patch, which comprises a tearable film layer for being torn under external force, a gel layer connected with the tearable film layer and containing a skin external medicine, and the like. The gel layer is provided with a plurality of cross-distributed segmentation grooves to form a plurality of gel blocks, and the tearable film layer is provided with a tear line groove. Compared with the prior art, the application can facilitate the adhesion to the affected area and reduce the area of the region with the medicine component contacting the normal skin.

The invention discloses a soluble microneedle patch for skin tumors and a preparation method and application thereof, and belongs to the technical field of soluble microneedles, gel formed by a microneedle matrix which is excellent in biocompatibility and contains disulfide bonds is injected into a microneedle mold, and the soluble microneedle patch is prepared. Then vacuumizing, centrifuging, adding viscous microneedle substrate polyacrylic acid gel, and drying to obtain the specific soluble microneedle patch of which the dissolution rate in a tumor microenvironment is obviously higher than that of normal tissues. The microneedle matrix with disulfide bonds specifically responds to the high reducibility of a tumor microenvironment, the drug is rapidly broken and released, the drug release amount in a normal skin area is reduced, stimulation to healthy tissue is avoided, potential damage to normal tissue is reduced, and more accurate targeted therapy is achieved.

The present application provides a kind of epidermis repair gel dressings and its preparation method, it is related to dressing field.The epidermis repair gel dressings includes repair liquid, 100 parts of the repair liquid includes composite sodium hyaluronate 0.1-0.3 parts, carbomer 0.02-0.06 parts, glycerol 1-4 parts, pentanediol 1-3 parts, composite acid 0.05-0.1 parts, composite peptide 0.01-0.03 parts and the balance purified water by weight parts;The composite sodium hyaluronate is composed of sodium hyaluronate, hydrolyzed sodium hyaluronate and sodium hyaluronate crosslinked polymer;The composite acid is prepared from ursolic acid, hydroxyl asiatic acid, lipoic acid;The composite peptide is prepared from thirteen peptides and palmitoyl pentapeptide-3.The epidermis repair gel dressing of the present application has better repair effect on acne lesions, not only inhibits active propionibacterium acnes, but also can reduce the expression of inflammatory factors, can deeply repair damaged basal structure, maximumly reduce the degree of acne lesions, and restore to close normal skin.

The invention belongs to the technical field of biology, and particularly relates to application of DPP4 in treatment or diagnosis of inflammatory skin diseases characterized by skin barrier injury. According to the application disclosed by the invention, key effects of dipeptidyl peptidase-4 (DPP4) in regulating and controlling keratinocyte differentiation and maintaining normal skin barrier structures and functions are analyzed, and on the basis of AAV-mediated skin tissue keratinocyte DPP4 gene therapy, the conditions of abnormal epidermis thickening and abnormal differentiation caused by skin damage can be relieved by inducing normal differentiation of keratinocytes, so that the curative effect of the skin tissue keratinocyte DPP4 is improved, and the curative effect of the skin tissue keratinocyte DPP4 is improved. The traditional Chinese medicine composition provided by the invention can be used for promoting the repair of an epidermal barrier and improving and maintaining the steady state of the skin barrier so as to effectively improve psoriasis-like dermatitis, and a new scheme is provided for treating inflammatory dermatosis characterized by skin barrier injury. In addition, the expression level of DPP4 can be used as a diagnostic marker for inflammatory skin diseases characterized by skin barrier injury.

The invention relates to the field of medical paste dressings and stoma nursing materials, in particular to an antibacterial leakage-proof patch for stoma and a preparation method of the antibacterial leakage-proof patch. The invention aims to solve the technical problems that the antibacterial durability is insufficient, a biological membrane is easy to form and the micro-ecological balance of skin is damaged. The prepared patch is composed of a back lining layer, an absorption layer, a pH responsive antibacterial layer and a release layer which are sequentially stacked from top to bottom. Wherein the pH responsive antibacterial layer contains a pH responsive microcapsule loaded with an antibacterial agent; the wall material of the microcapsule can be dissolved in an alkaline environment, and the core material is a nano-silver and chitosan quaternary ammonium salt composite antibacterial agent. When the local environment is changed from weak acidity to alkalinity due to infection of the skin around the stoma, the microcapsules are rapidly swelled and broken, high-concentration nano-silver and chitosan quaternary ammonium salt are released, and the bactericidal effect is achieved; under the weak acid condition, the antibacterial agent in the microcapsule is only slowly and continuously released, the basic antibacterial effect is maintained, and normal microbial flora balance of the skin is protected.

This invention discloses a mixture of artemisia annua extract and rosemary extract and its application in the field of dermatology. The invention provides a mixture of artemisia annua extract and rosemary extract, a preparation method, and applications. This mixture can regulate the function of macrophages and epidermal cells, enhancing the phagocytic capacity of macrophages and initiating normal skin immune defense. Simultaneously, it can inhibit the overexpression of inflammatory factors, increase the expression of tight junction proteins in epidermal cells, and restore the skin barrier.

A pharmacological agent and method for treatment of cancer and vascular-related disorders of skin and colon are described. The pharmacological agent, which is a small molecule that targets and inhibits both RhoJ and CDC42 signaling, demonstrates potent anti-vascular effects in normal skin, colon, and tumors, combined with low toxicity, especially as compared to BRAF inhibitors (such as, vemurafenib used in melanoma treatments), selective CDC42 inhibitors (such as CASIN), and VEGF inhibitors (known as anti-vascular agents, such as, for example, linifanib). As such, the pharmacological agent is particularly suited for applications related to treating cancer, as well as disorders of the skin and colon that exhibit increased vasculature.

The present invention relates to a micro-electrical stimulation scar band comprising: an upper mat; a lower mat; and a pair of wires spaced apart from each other along the circumferential direction of the outer surface of the lower mat and formed to be wound, wherein the wires form one closed ring. By continuously providing micro-electrical stimulation to a lesion part such as a wound or a scar without an external power source, the effects of promoting and activating healing of the wound, removing the scar, and regenerating the wound into normal skin can be achieved.

The invention discloses a drug-loaded patch for photodynamic treatment of skin diseases and a preparation method of the drug-loaded patch, and relates to the technical field of medical treatment. Comprising the following steps: extracting a two-dimensional lesion pattern of a skin surface disease area; and printing the photosensitizer drug solution onto the patch by taking the two-dimensional lesion pattern as a printing mother set to obtain the drug-loaded patch for photodynamic treatment of skin diseases. The medicine carrying patch can accurately act on a lesion area in a skin disease area, accurate delivery and positioning of medicine are achieved, the bioavailability of photosensitizer medicine is improved to the maximum extent, the clinical use cost is reduced, and normal skin tissue in the disease area is prevented from being interfered by all-directional medicine smearing. During illumination, the photodynamic therapy process is completely concentrated in a lesion area, additional shading treatment is not needed, the normal healthy skin can be effectively prevented from being affected by photodynamic therapy, and the side effects of photodynamic therapy and drugs are reduced.

The utility model discloses a visual negative pressure drainage dressing and a flushing negative pressure suction device, the visual negative pressure drainage dressing comprises a self-adhesive medical film and a foam drainage material, the self-adhesive medical film and the foam drainage material are of an integrated structure, and the visual medical dressing is provided with a drainage window and an observation window; when the visual medical dressing is used, after the protective paper is torn off and removed, the visual medical dressing is pasted to normal skin around a wound to form a closed wound treatment cavity; the foam drainage material is arranged in the mounting cavity, and a first through hole and a second through hole are formed in the foam drainage material; the flushing pipe penetrates through the drainage window and then is arranged at the bottom of the foam drainage material; and the negative pressure suction tube is arranged on the flushing tube in a sleeving manner. Due to the integrated design, the medical negative pressure drainage dressing is transparent and visual, medical staff can conveniently observe changes of a wound surface at any time, and the negative pressure drainage dressing can be used for rapidly installing and sealing the wound surface and rapidly installing and washing a drainage tube.

This invention discloses an integrated nanorobot system for medical aesthetics, belonging to the field of minimally invasive and non-invasive diagnostic and treatment technology in civilian medical aesthetics. The system uses glucose-modified PCL with a glucose grafting rate of 20-25 wt% as its core substrate, adaptable to a particle size range of 100-200 nm (median 150 nm). It is a non-disassembly integrated structure with a γ-polyglutamic acid modification layer on the main surface. It embeds six functional units: precise skin detection, precise drug delivery, minimally invasive ablation, repair and regeneration, pore cleansing, and safety regulation. Each unit communicates with the safety regulation unit via carbon nanotube nano-conduction links. The safety regulation unit and the γ-polyglutamic acid modification layer work together through specific logic to construct a pH dual-redundancy control logic specific to medical aesthetic scenarios. The false trigger rate on normal skin is ≤0.05%, cytotoxicity and mucosal irritation are both grade 0, and the degradation cycle is 14±2 days. The system has a mature and reproducible manufacturing process, with a yield rate of ≥93% in 100g-level small-scale preparation. All performance indicators meet the authoritative standards of FDA / ISO medical aesthetic devices. It is specifically designed for superficial medical aesthetic repair of the human epidermis / mucous membranes, solving the technical pain points of traditional medical aesthetic devices such as single function, low precision, and many complications. It realizes a one-stop closed-loop operation of "detection-treatment-repair" and has strong clinical applicability.

The invention relates to the technical field of gel, in particular to wound nursing gel with double-effect repair functions of healing promotion and scar inhibition and a preparation method of the wound nursing gel. According to the preparation method disclosed by the invention, through the mutual cooperation of the modified astragalus polysaccharide, namely the precise navigation of a conjugate formed by collagen targeting peptide-astragalus polysaccharide, the deep anti-inflammatory regulation of dipotassium glycyrrhizinate and the high-quality template guidance of recombinant humanized III-type collagen, the traditional passive repair is upgraded to active guided repair; the contradiction between the healing speed and the healing quality is coordinated from the source. According to the invention, the wound closure can be obviously accelerated (the early healing rate is improved by about 3 times), and scars can be inhibited fundamentally. Experiments prove that the proportion of type III collagen of new dermis can be increased to be close to the normal skin level (about 42%), and collagen fibers are highly ordered in arrangement (the orientation degree reaches 0.91), so that physiological regeneration instead of pathological scar repair in a real sense is realized.

The invention belongs to the technical field of image recognition, and discloses a monkey pox virus classification method and system based on image comparison and a storage medium, and the method comprises an individual reference construction module which is used for collecting normal skin and initial lesion images of the uninjured side of a patient, and generating a healthy texture template and a lesion initial reference library; performing gray normalization on the health texture template and the focus initial reference library through adaptive histogram stretching, and outputting a comparison reference image group; the symptom density quantification module is used for acquiring a current monitoring image of a patient, segmenting a focus area by combining and comparing the reference image group, extracting layered features of the focus area to generate a three-dimensional symptom density vector, extracting texture roughness of the surface of the focus area, and forming a focus quantification data set; the accuracy of disease monitoring is improved, and the clinical nursing process is optimized.

The present invention relates to a whitening composition comprising a whitening effective amount of a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, m and n are as defined in the description and in the claims, or a tautomer, stereoisomer, hydrate, solvate, salt or polymorph thereof. The invention also relates to a compound of formula (I2) or a tautomer, a stereoisomer, a hydrate, a solvate, a salt or a polymorph thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the description and the claims. The invention also relates to the use of at least one compound of formula (I) or any subset thereof or a mixture thereof as a decolorizing agent. The invention also relates to the use of at least one compound of formula (I) or any subset thereof or a whitening composition for preventing and / or reducing normal skin pigmentation. The invention also relates to the use of at least one compound or a whitening composition according to a first aspect for reducing melanin content in melanocytes, reducing melanin synthesis, compromising melanin transport and / or compromising distribution of melanin in an upper layer of a substrate layer. (I) (I2)

The present invention provides a method and system for testing subjects for qualified soothing efficacy of cosmetics, comprising: dividing subjects into a normal skin group and a sensitive skin group according to subjective and semi-subjective evaluation methods for cosmetic soothing efficacy testing; obtaining a skin index value for each subject, wherein the skin index value is selected from a hemoglobin concentration value, a heme concentration value, or a skin α value; performing data processing on the hemoglobin concentration value, the heme concentration value, or the skin α value according to a confusion matrix method to obtain a standard threshold value for screening subjects for qualified soothing efficacy by the hemoglobin concentration value, the heme concentration value, or the skin α value; selecting any of the above skin index values ​​as a detection index value, comparing the skin index value of each subject with the standard threshold value, and determining subjects with skin values ​​above the standard threshold value as having sensitive skin, i.e., qualified subjects for the soothing efficacy test. The testing method can quickly, objectively, and accurately screen qualified soothing efficacy subjects.

The application discloses a microneedle, a preparation method, a microneedle patch and application. The microneedle comprises a shell of a cross-linked hydrophilic polymer, a negatively charged substance filled in a cavity surrounded by the shell, and verteporfin arranged on the outer surface of the shell and / or the shell layer. The cross-linked hydrophilic polymer comprises a plurality of inflammation-responsive linkers. The microneedle patch containing the microneedle is programmed to promote faster wound healing, repair normal skin function, prevent or reduce scar formation, and has a significant alleviating effect on the formed hyperplastic scar.

The application discloses a probe for detecting irregular wound surface bioelectricity and an analyzer thereof, which comprises a skin bioelectricity probe (1) and a wound bioelectricity probe (2), the skin bioelectricity probe (1) is provided with a skin probe (11), the bioelectricity probe (2) is provided with a wound probe (21), the skin probe (11) and the wound probe (21) are made of metal materials, the skin probe (11) is tightly attached to normal skin, the wound probe (21) is arranged in the edge of a wound (3) and is in contact with the tissue of the wound (3), the skin probe (11) is connected with a first output lead, the wound probe (21) is connected with a second output lead, and the first output lead and the second output lead output the bioelectricity potential difference between the normal skin and the wound (3). The application provides the probe for detecting irregular wound surface bioelectricity and the analyzer thereof, is used for detecting the bioelectricity potential difference between the normal skin and the wound, and is convenient for doctors to evaluate the healing ability of the wound surface.

The present invention provides an artificial skin containing a basement membrane and a preparation method. The method uses dermal fibroblasts, keratinocytes, and the structural components of the basement membrane to prepare the artificial skin containing a basement membrane. In this method, the structural components of the basement membrane, extracellular matrix components, and components required to maintain cell growth are added to the dermal fibroblasts. These components can promote the growth and proliferation of the dermal fibroblasts, or can serve as scaffold materials for the dermal fibroblasts, or can enhance intercellular adhesion and cell-matrix adhesion, or can stimulate and promote the secretion of some extracellular matrix components by dermal cells or epidermal cells to form a basement membrane between the dermis and epidermis, thereby strengthening the connection between the dermis and epidermis. The artificial skin comprises an epidermis, a basement membrane, and a dermis, contains living cells, and has a structure similar to normal skin. It can be used to treat skin wounds caused by various traumas and to prepare skin models.

The invention relates to the technical field of skin injury detection, in particular to a burn condition evaluation method and system based on burn area and burn depth, comprising the following steps: acquiring a wound depth image and calculating a height difference sequence, dividing intervals according to the sequence to form a height level, constructing a wound triangular mesh and generating a height mesh data set, according to the method, the depth difference between the wound surface and the normal skin is extracted, the height sequence is formed, the fluctuation state is continuously quantified, the hierarchy is constructed according to the height features, the depth and depth structure is clearer, the depth and depth are more accurate, and the burn area depth level combination quantity is generated. A three-dimensional grid is used for expressing a curved surface form, deformation details are accurately presented, damage distribution is presented by calculating a three-dimensional area and combining depth partitions, area proportions are summarized according to anatomical areas and combining depth grades, and therefore area measurement and calculation are more accurate, depth judgment is more objective, and overall load evaluation is more stable.

The invention belongs to the technical field of hand and foot nursing, and discloses a non-corrosive body surface cutin hyperplasia nursing patch as well as a preparation method and application thereof. The nursing patch is sequentially provided with a three-layer basic structure including a bacteriostatic functional layer, a flexible substrate and a breathable protective layer from the skin contact side to the outer side, the bacteriostatic functional layer is compounded by clotrimazole, bifonazole and ketoconazole, and the mass ratio of clotrimazole to bifonazole to ketoconazole is (1-2): (1.5-2.5): (0.6-1.5). According to the non-corrosive body surface cutin hyperplasia nursing patch, the root of cutin abnormal hyperplasia is cut off through the antibacterial components, meanwhile, cutin is mildly softened and ablated, and normal skin barriers are not damaged.

The application discloses a skin and clothes anti-contact device which comprises a first retractable main rod and a second retractable main rod, the first retractable main rod and the second retractable main rod each comprise a first telescopic end and a second telescopic end, and the first retractable main rod and the second retractable main rod are connected through an extension and contraction structure; the bottom of the first telescopic end and the second telescopic end is respectively provided with a supporting structure, the bottom of the supporting structure is respectively provided with a sticking structure, and the top of the first telescopic end and the second telescopic end is respectively provided with a rotary supporting and fixing structure. The supporting structure is pasted on the normal skin surface of a human body by means of the sticking structure, the rotary supporting and fixing structure is closely attached to clothes, and the fine-toothed protrusions can increase the friction with the clothes. According to the skin damage area of a patient, the extension and contraction structure is adjusted to expand the length, so that the distance between the first retractable main rod and the second retractable main rod is adjusted, and the supporting area can be flexibly adjusted to adapt to different skin damage areas.

To provide agents or compositions for improving or variegating normal bacterial flora of skin, in particular, to provide agents or compositions for improving or variegating normal bacterial flora of skin which exhibit bacteriostatic or bactericidal activities only to harmful bacteria without damaging useful normal bacteria of human skin.SOLUTION: Disclosed is an agent for improving or variegating normal bacterial flora of skin which comprises lactoferrin or salt thereof as an effective ingredient. Also disclosed is a pharmaceutical composition or cosmetic composition comprising the agent for improving or variegating normal bacterial flora of skin.SELECTED DRAWING: None